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333 Cruises (1,577 Cruise Departures)
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: Sep 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
From
US$8,635
Per Person
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departures: Sep 2026 to Oct 2027
Visit: Peru, Ecuador, Galapagos
From
US$14,190
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco
Inside
$1,379
Oceanview
$1,549
Balcony
$1,855
Suite
-
From
US$1,379
Per Person
View Trip
17 Day Patagonia & the Chilean Fjords with Scenic
New ReleaseCruise

17 Days (16 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 November 2027
Visit: Argentina, Uruguay, Chile
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,914
Suite
$23,130
From
US$18,914
Save 4,631
Per Person
View Trip
23 Day Brazil Coast, Cabo Verde & Canary Islands Crossing with Seabourn
Cruise

23 Days (22 Nights) Rio de Janeiro to Genoa
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 20 April 2028
Visit: Brazil, Cape Verde, Spain, Morocco, Italy
Inside
-
Oceanview
-
Balcony
$11,999
Suite
$16,999
From
US$11,999
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Inside
$1,857
Oceanview
$1,915
Balcony
$2,053
Suite
$13,609
From
US$1,857
Per Person
View Trip
131 Day Grand World Voyage with Holland America
Cruise

131 Days (130 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Volendam
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru (+29 more), Chile, Pitcairn Islands, French Polynesia, Samoa, Fiji, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, Mauritius, Reunion, South Africa, Namibia, Gambia, Senegal, Cape Verde, Spain, Morocco, Portugal, France, Holland, Norway, Denmark, England, Puerto Rico
Advantage Fare
Inside
$29,119
Oceanview
$32,219
Balcony
$55,519
Suite
-
From
US$29,119
Per Person
View Trip
11 Day Emblematic South American Shores and Cities with Ponant
Cruise

11 Days (10 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Ponant
Ships: L'Austral, Le Boreal
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Brazil
Inside
-
Oceanview
$7,130
Balcony
$7,700
Suite
$13,030
From
US$7,130
Per Person
View Trip
16 Day Hidden Galapagos & Peru with Tauck
Tour + Cruise

16 Days Lima to Quito
Operated By: Tauck
Ship: Silver Origin
Departures: Apr 2027 to Oct 2027
Visit: Peru, Ecuador, Galapagos
From
US$17,990
Per Person
View Trip
7 Day Independent Galapagos Cruise Aboard the Galapagos Legend with Globus
New ReleaseTour + Cruise

7 Days Quito to Guayaquil
Operated By: Globus
Departures: Jul 2026 to Dec 2026
Visit: Ecuador, Galapagos
From
US$5,199
Per Person
View Trip
17 Day Machu Picchu & Mayan Ruins with Regent Seven Seas
Cruise

17 Days (16 Nights) Lima to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 10 March 2027
Visit: Peru, Ecuador, Costa Rica, Panama (+4 more), Honduras, Belize, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,099
Suite
$15,999
From
US$15,099
Save 15,099
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visit: Brazil
Inside
$869
Oceanview
$833
Balcony
$953
Suite
$1,409
From
US$833
Per Person
View Trip
10 Day Galápagos - North, Central, & South Islands aboard the Eden with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,623
Save 1,156
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Rio de Janeiro to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Inside
$1,930
Oceanview
-
Balcony
-
Suite
-
From
US$1,930
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Inside
$2,005
Oceanview
$2,209
Balcony
-
Suite
$8,915
From
US$2,005
Per Person
View Trip
13 Day Highlights of Peru with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

13 Days Lima to Quito
Operated By: Trafalgar
Departures: Sep 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$7,217
Save 258
Per Person
View Trip
21 Day Valparaiso to Puerto Williams with Silversea
Cruise

21 Days (20 Nights) Valparaiso to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 15 November 2027
Visit: Chile, Argentina, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$42,200
From
US$42,200
Save 3,500
Per Person
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama, Aruba, USA
Bonus Onboard Credit
Inside
$3,099
Oceanview
$4,499
Balcony
$5,099
Suite
$11,329
From
US$3,099
Per Person
View Trip
83 Day South America Discovery with Cunard
Cruise

83 Days (82 Nights) London to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 10 January 2027
Visit: England, Bermuda, USA, Turks and Caicos Islands (+10 more), Barbados, Brazil, Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba, Portugal
Bonus Onboard Credit
Inside
$13,159
Oceanview
$18,259
Balcony
$20,219
Suite
$39,679
From
US$13,159
Per Person
View Trip
10 Day Classic Galapagos: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,050
Save 2,041
Per Person
View Trip
6 Day Ocean Voyage: Callao - Valparaiso with Ponant
Cruise

6 Days (5 Nights) Lima to Valparaiso
Cruise Line: Ponant
Ship: L'Austral
Departure: 30 October 2026
Visit: Peru, Chile
Inside
-
Oceanview
$1,590
Balcony
$1,700
Suite
$2,490
From
US$1,590
Per Person
View Trip
91 Day South America Discovery with Cunard
Cruise

91 Days (90 Nights) Hamburg to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 January 2027
Visit: Germany, Holland, Belgium, England (+13 more), Bermuda, USA, Turks and Caicos Islands, Barbados, Brazil, Uruguay, Argentina, Chile, Peru, Ecuador, Panama, Aruba, Portugal
Bonus Onboard Credit
Value Fare
Inside
$14,289
Oceanview
$19,779
Balcony
$21,799
Suite
$42,999
From
US$14,289
Per Person
View Trip
15 Day Cartagena to Valparaiso with Silversea
Cruise

15 Days (14 Nights) Cartagena to Valparaiso
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 15 January 2028
Visit: Colombia, Panama, Ecuador, Peru, Chile
All-Inclusive Fare
Inside
-
Oceanview
$8,000
Balcony
$9,600
Suite
-
From
US$8,000
Per Person
View Trip
8 Day Galápagos – Central and East Islands aboard the Reina Silvia Voyager (Cruise Only) with G Adventures
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Operated By: G Adventures
Departures: Jun 2026 to Dec 2027
Visit: Galapagos
Exclusive Savings
From
US$5,587
Save 1,862
Per Person
View Trip
22 Day South America, Canary Islands & Spain with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Seville
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 06 April 2027
Visit: Brazil, Cape Verde, Spain, Morocco
Inside
-
Oceanview
-
Balcony
-
Suite
$10,539
From
US$10,539
Per Person
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Visit: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,049
Suite
$25,049
From
US$24,049
Save 24,049
Per Person
View Trip
15 Day San Cristobal to San Cristobal with Silversea
Cruise

15 Days (14 Nights) Quito to Quito
Cruise Line: Silversea
Ship: Silver Origin
Departure: 29 August 2026
Visit: Galapagos, Ecuador
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
-
Suite
$31,300
From
US$31,300
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2026 to Mar 2027
Visit: Argentina, Chile
Flash Sale
Exclusive Savings
From
US$9,799
Save 400
Per Person
View Trip
22 Day Secrets Of The Selva with Regent Seven Seas
Cruise

22 Days (21 Nights) Rio de Janeiro to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 26 February 2028
Visit: Brazil, Saint Lucia, Saint Kitts and Nevis, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,599
Suite
$23,699
From
US$22,599
Save 22,599
Per Person
View Trip
37 Day Antarctic Voyage with South America and Galápagos Islands with APT
New ReleaseTour + Cruise

37 Days Guayaquil to Rio de Janeiro or Quito to Rio de Janeiro
Operated By: APT
Ships: Seabourn Venture
Departures: Jan 2027 to Jan 2028
Visit: Ecuador, Galapagos, Peru, Argentina, Antarctica, Brazil
Inside
-
Oceanview
-
Balcony
$38,945
Suite
$40,845
From
US$38,945
Per Person
View Trip
Results: 241-270 of 333

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South & Central America Cruises

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Travel Styles

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Cities

Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Manaus Cruises from Marseille Cruises from Panama City Cruises from Puerto Williams Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Ushuaia Cruises from Valencia Cruises from Valparaiso

Routes

Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Athens Cruises from Barcelona to Lisbon Cruises from Barcelona to London Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to San Antonio Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Fort Lauderdale to London Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to Rome Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Los Angeles to Miami Cruises from Los Angeles to Los Angeles Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Lisbon Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Quito Cruises from Reykjavik to London Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Trieste Cruises from Rome to London Cruises from Rome to Lisbon Cruises from Rome to Miami Cruises from Rome to Athens Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Diego to Fort Lauderdale Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Vancouver to Los Angeles Cruises from Venice to Athens Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from USA to Germany Cruises from Italy to England Cruises from England to Holland Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Iceland to USA Cruises from Puerto Rico to USA Cruises from Iceland to Holland Cruises from Portugal to France Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from Iceland to Canada Cruises from England to Canada Cruises from England to Germany Cruises from Brazil to Portugal Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Canada to England Cruises from French Polynesia to New Zealand Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Italy Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from Iceland to England Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

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