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Cruises from Rome to Lisbon

Are you looking for a cruise from Rome to Lisbon? November is the most popular month to cruise between Rome and Lisbon and there are 38 departures available from nine of the world's leading cruise lines.
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$29,590pp
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18 Cruises (38 Cruise Departures)
11 Day Culinary Wonders with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 August 2027
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,799
Suite
$9,949
From
US$8,799
Save 14,799
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (6)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain, Morocco, Portugal
Inside
$4,029
Oceanview
$4,729
Balcony
$5,579
Suite
$9,009
From
US$4,029
Per Person
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Visit: Italy, France, Spain, Portugal
Exclusive Savings
Inside
$2,699
Oceanview
$2,999
Balcony
$4,499
Suite
$6,199
From
US$2,699
Save 2,699
Per Person
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (2)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Visit: Italy, Sicily, Sardinia, Spain, Gibraltar, Portugal
Inside
$1,614
Oceanview
$1,764
Balcony
$2,464
Suite
$3,614
From
US$1,614
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Libra (+8 more), Viking Lyra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Nov 2026 to Sep 2028
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,948
Suite
$8,998
From
US$5,948
Save 200
Per Person
View Trip
18 Day Italy, Spain & Portugal Cruise: Florence, Nice & Seville with Azamara Cruises
Cruise
 (6)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 October 2027
Visit: Italy, Monaco, France, Spain, Gibraltar, Portugal
Inside
$4,969
Oceanview
$5,709
Balcony
$7,149
Suite
$10,669
From
US$4,969
Per Person
View Trip
15 Day Rivieras, Minarets & More with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2026
Visit: Italy, France, Spain, Morocco, Portugal
Exclusive Savings
Inside
$4,999
Oceanview
$6,049
Balcony
$7,099
Suite
$10,299
From
US$4,999
Save 4,999
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
$9,200
Suite
$17,000
From
US$9,200
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
Sail Into Savings Offer
Inside
-
Oceanview
$5,798
Balcony
$7,598
Suite
$13,498
From
US$5,798
Per Person
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Visit: Italy, Corsica, Spain, Morocco, Portugal
Fly Free Economy
Exclusive Savings
Inside
-
Oceanview
$8,663
Balcony
-
Suite
$11,876
From
US$8,663
Save 8,927
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (3)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Exclusive Savings
Inside
$4,999
Oceanview
$5,499
Balcony
$8,199
Suite
$11,499
From
US$4,999
Save 4,999
Per Person
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia, Algeria, Spain, Portugal
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,750
Suite
$23,150
From
US$14,750
Save 14,840
Per Person
View Trip
15 Day Italy, French Riviera & Spain Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Visit: Italy, France, Gibraltar, Spain, Morocco, Portugal
Inside
$2,304
Oceanview
$2,504
Balcony
-
Suite
-
From
US$2,304
Per Person
View Trip
21 Day Rome to Lisbon with Silversea
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Gibraltar, Morocco, Portugal
Inside
-
Oceanview
$12,000
Balcony
$13,400
Suite
$22,600
From
US$12,000
Per Person
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,899
Suite
$10,699
From
US$8,899
Save 14,299
Per Person
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Visit: Italy, Monaco, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,299
Suite
$6,599
From
US$4,299
Save 4,299
Per Person
View Trip
13 Day Rome to Lisbon with Silversea
Cruise

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Visit: Italy, Monaco, France, Spain, Portugal
Inside
-
Oceanview
-
Balcony
$8,150
Suite
$13,000
From
US$8,150
Per Person
View Trip
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Visit: Italy, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
Inside
-
Oceanview
$10,300
Balcony
$10,700
Suite
$16,800
From
US$10,300
Per Person
View Trip
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