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Cruises from Rome to Lisbon

Are you looking for a cruise from Rome to Lisbon? July and November are the most popular months to cruise between Rome and Lisbon and there are 39 departures available from nine of the world's leading cruise lines.
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20 Cruises (39 Cruise Departures)
21 Day Summer Splendor with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 June 2027
Visit: Italy, Sicily, Sardinia, Corsica (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Exclusive Savings
Inside
$5,973
Oceanview
$6,458
Balcony
$10,047
Suite
$14,121
From
US$5,973
Save 6,225
Per Person
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Visit: Italy, Corsica, Spain, Morocco, Portugal
Fly Free Economy
Exclusive Savings
Inside
-
Oceanview
$8,510
Balcony
-
Suite
$11,658
From
US$8,510
Save 9,080
Per Person
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,840
Suite
$10,604
From
US$8,840
Save 14,558
Per Person
View Trip
11 Day Roman Holiday with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal
Your World Inclusions
Exclusive Savings
Inside
$2,741
Oceanview
$3,566
Balcony
$4,293
Suite
$6,233
From
US$2,741
Save 2,857
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise
 (1)

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$9,700
Suite
$15,400
From
US$9,700
Per Person
View Trip
15 Day Italy, French Riviera & Spain Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Visit: Italy, France, Gibraltar, Spain, Morocco, Portugal
Book Early & Have It All Fare Option
Inside
$2,304
Oceanview
$2,354
Balcony
$2,904
Suite
$3,741
From
US$2,304
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (3)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Exclusive Savings
Inside
$4,901
Oceanview
$5,386
Balcony
$8,005
Suite
$11,206
From
US$4,901
Save 5,097
Per Person
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia, Algeria, Spain, Portugal
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,353
Suite
$22,501
From
US$14,353
Save 15,237
Per Person
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Visit: Italy, Monaco, Spain, Gibraltar, Portugal
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,195
Suite
$6,620
From
US$4,195
Save 4,403
Per Person
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Visit: Italy, France, Spain, Portugal
Fall Upgrade Offer
Your World Inclusions
Exclusive Savings
Inside
$2,645
Oceanview
$2,742
Balcony
$3,227
Suite
$4,876
From
US$2,645
Save 54
Per Person
View Trip
13 Day Rome to Lisbon with Silversea
Cruise

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Visit: Italy, Monaco, France, Spain, Portugal
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$9,700
Suite
$13,900
From
US$9,700
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain, Morocco, Portugal
Azamara Always Included
Exclusive Savings
Inside
$3,953
Oceanview
$4,632
Balcony
$5,457
Suite
$8,784
From
US$3,953
Save 76
Per Person
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (2)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Visit: Italy, Sicily, Sardinia, Spain, Gibraltar, Portugal
Book Early & Have It All Fare Option
Inside
$1,899
Oceanview
$1,999
Balcony
$2,599
Suite
$3,933
From
US$1,899
Per Person
View Trip
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Visit: Italy, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$7,040
Balcony
$7,680
Suite
$14,160
From
US$7,040
Save 1,760
Per Person
View Trip
11 Day Culinary Wonders with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 August 2027
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,645
Suite
$9,772
From
US$8,645
Save 14,953
Per Person
View Trip
18 Day Italy, Spain & Portugal Cruise: Florence, Nice & Seville with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 October 2027
Visit: Italy, Monaco, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$4,477
Oceanview
$5,137
Balcony
$6,417
Suite
$9,560
From
US$4,477
Save 92
Per Person
View Trip
15 Day Rivieras, Minarets & More with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2026
Visit: Italy, France, Spain, Morocco, Portugal
Fall Upgrade Offer
Your World Inclusions
Exclusive Savings
Inside
$4,884
Oceanview
$5,175
Balcony
$5,902
Suite
$8,133
From
US$4,884
Save 115
Per Person
View Trip
21 Day Rome to Lisbon with Silversea
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
$13,500
Balcony
$15,600
Suite
$27,100
From
US$13,500
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Libra (+8 more), Viking Lyra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Jan 2027 to Sep 2028
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,998
Suite
$9,498
From
US$5,998
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
More Moments On Us Offer
Exclusive Savings
Inside
-
Oceanview
$5,897
Balcony
$7,661
Suite
$13,247
From
US$5,897
Save 102
Per Person
View Trip
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