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Sicily Cruises

Are you looking for a cruise to Sicily? Choose from 339 unique cruise itineraries to Sicily, departing from Amalfi, Antalya, Athens, Barcelona, Bari and more. September is the most popular month to cruise to Sicily and we have over 2,378 departures available from twenty of the world's leading cruise lines.
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339 Cruises (2,378 Cruise Departures)
2 Day Mediterranean with MSC Cruises
Cruise

2 Days (1 Nights) La Goulette to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 31 July 2025
Countries Visited: Tunisia, Sicily
One Way Cruise Offer
INSIDE
$102
OCEANVIEW
-
BALCONY
$192
SUITE
-
From (per person) 102
View Trip
8 Day Greek Isles & Italy Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departures: Oct 2025 to Oct 2026
Countries Visited: Italy, Sicily, Greece
Latest Offer
INSIDE
$1,321
OCEANVIEW
$1,542
BALCONY
$1,667
SUITE
$2,340
Save (per person) 1,184
From (per person) 1,321
View Trip
9 Day Mind and Taste Buds Awake with the Mucem in the Mediterranean with Ponant
Cruise
 (2)

9 Days (8 Nights) Rome to Athens
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 09 October 2025
Countries Visited: Italy, Sicily, Greece
INSIDE
-
OCEANVIEW
-
BALCONY
$6,920
SUITE
$12,920
From (per person) 6,920
View Trip
10 Day Authentic Mediterranean shores with Ponant
Cruise
 (1)

10 Days (9 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 October 2026
Countries Visited: Malta, Sicily, Italy
INSIDE
-
OCEANVIEW
$6,950
BALCONY
$7,320
SUITE
$13,630
From (per person) 6,950
View Trip
8 Day Greece & Italy Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Athens to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 15 August 2025
Countries Visited: Greece, Sicily, Spain
Latest OfferExclusive Solo Offer
INSIDE
$1,341
OCEANVIEW
$1,521
BALCONY
$1,644
SUITE
-
Save (per person) 657
From (per person) 1,341
View Trip
8 Day Iberian Peninsula & Sicily with Ponant
Cruise
 (1)

8 Days (7 Nights) Malaga to Valletta
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 28 April 2026
Countries Visited: Spain, Sicily, Malta
INSIDE
-
OCEANVIEW
-
BALCONY
$5,250
SUITE
$9,730
From (per person) 5,250
View Trip
8 Day Mykonos Moons to Spanish Sunrises with Virgin Voyages
Cruise

8 Days (7 Nights) Athens to Barcelona
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 19 October 2025
Countries Visited: Greece, Sicily, Spain
Swing Into Savings Best Rate
INSIDE
$1,681
OCEANVIEW
$1,835
BALCONY
$1,835
SUITE
$4,690
From (per person) 1,681
View Trip
8 Day Italian Sojourn with Viking Cruises
Cruise

8 Days (7 Nights) Venice to Rome
Operated By: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+8 more), Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vela, Viking Vesta
Departures: Sep 2025 to Aug 2027
Countries Visited: Italy, Croatia, Sicily
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$3,499
SUITE
$4,499
Save (per person) 1,550
From (per person) 3,499
View Trip
6 Day Italian Escape with Ponant
Cruise
 (2)

6 Days (5 Nights) Valletta to Amalfi
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 17 November 2025
Countries Visited: Malta, Sicily, Italy
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$3,630
SUITE
$6,400
From (per person) 3,630
View Trip
9 Day Epicurean Delights: The Food & Wine of Sicily with Ponant
Cruise

9 Days (8 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 11 April 2026
Countries Visited: Malta, Sicily, Italy
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$9,860
SUITE
$18,260
From (per person) 9,860
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 22 September 2025
Countries Visited: Italy, Greece, Sicily
INSIDE
$1,753
OCEANVIEW
-
BALCONY
$2,604
SUITE
$2,903
From (per person) 1,753
View Trip
11 Day Mediterranean Crossroads with Emerald Cruises
New ReleaseCruise
 (3)

11 Days (10 Nights) Athens to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 09 November 2025
Countries Visited: Greece, Sicily, Malta
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$11,294
Save (per person) 11,596
From (per person) 11,294
View Trip
8 Day Island Odyssey: Malta, Sicily & the Greek Isles with Scenic
New ReleaseCruise

8 Days (7 Nights) Valletta to Athens
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 June 2026
Countries Visited: Malta, Sicily, Greece
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$11,625
SUITE
$14,705
Save (per person) 11,705
From (per person) 11,625
View Trip
9 Day A Circumnavigation of Sicily - with Smithsonian Journeys with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Valletta
Cruise Line: Ponant
Ships: Le Bougainville, Le Dumont d’Urville
Departures: Aug 2025 to Aug 2026
Countries Visited: Malta, Sicily, Tunisia
INSIDE
-
OCEANVIEW
-
BALCONY
$8,370
SUITE
$14,040
From (per person) 8,370
View Trip
9 Day A Celebration of Art Featuring the 61st Venice Biennale with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Venice
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 01 July 2026
Countries Visited: Malta, Sicily, Italy
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,450
SUITE
$15,500
From (per person) 8,450
View Trip
11 Day Italy Intensive Cruise: Venice, Sicily & Amalfi with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 05 May 2027
Countries Visited: Italy, Montenegro, Sicily
INSIDE
$2,759
OCEANVIEW
$3,179
BALCONY
$4,139
SUITE
$5,979
From (per person) 2,759
View Trip
12 Day Italy Cruise: Venice, Sicily & Rome with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 August 2026
Countries Visited: Italy, Sicily, Montenegro
INSIDE
$4,109
OCEANVIEW
$4,539
BALCONY
$5,459
SUITE
$7,389
From (per person) 4,109
View Trip
8 Day Mediterranean Cruise: Italy & Greece with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Countries Visited: Italy, Sicily, Greece
INSIDE
$1,699
OCEANVIEW
$1,959
BALCONY
$2,519
SUITE
$3,959
From (per person) 1,699
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Palermo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 01 October 2025
Countries Visited: Sicily, Malta, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$459
SUITE
-
From (per person) 459
View Trip
11 Day Ancient Civilisations, from Italy to Greece with Ponant
Cruise

11 Days (10 Nights) Rome to Athens
Cruise Line: Ponant
Ship: Le Champlain
Departure: 01 October 2026
Countries Visited: Italy, Sicily, Greece
INSIDE
-
OCEANVIEW
-
BALCONY
$8,950
SUITE
$16,710
From (per person) 8,950
View Trip
12 Day Italy Intensive Cruise: Bologna, Sicily & Amalfi with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 16 May 2027
Countries Visited: Italy, Montenegro, Sicily
INSIDE
$3,279
OCEANVIEW
$3,779
BALCONY
$4,739
SUITE
$6,819
From (per person) 3,279
View Trip
12 Day Sicily, the Amalfi Coast & Rome with Tauck
Cruise

12 Days (11 Nights) Malta to Rome
Operated By: Tauck
Departures: Oct 2025 to Oct 2026
Countries Visited: Malta, Sicily, Italy
From (per person) 12,490
View Trip
8 Day Italian Sojourn with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Venice
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Oct 2025 to Jul 2027
Countries Visited: Italy, Sicily, Croatia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$3,599
SUITE
$4,499
Save (per person) 850
From (per person) 3,599
View Trip
10 Day Malta, Sicily & Amalfi Coast with Emerald Cruises
New ReleaseCruise

10 Days (9 Nights) Valletta to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2026 to Jul 2026
Countries Visited: Malta, Sicily, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$7,138
BALCONY
-
SUITE
$9,761
Save (per person) 10,281
From (per person) 7,138
View Trip
11 Day Mediterranean Delights with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Valletta to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 20 July 2026
Countries Visited: Malta, Sicily, Tunisia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$7,728
BALCONY
-
SUITE
$10,649
Save (per person) 7,962
From (per person) 7,728
View Trip
8 Day Italian Treasures: Amalfi Coast, Sicily and Malta with Scenic
New ReleaseCruise

8 Days (7 Nights) Rome to Valletta
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 07 June 2026
Countries Visited: Italy, Sicily, Malta
2 for 1 Fares + Fly Free Premium Economy
INSIDE
-
OCEANVIEW
-
BALCONY
$11,765
SUITE
-
Save (per person) 11,775
From (per person) 11,765
View Trip
11 Day Rome, Florence, Mykonos & More with Virgin Voyages
Cruise

11 Days (10 Nights) Rome to Athens
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 31 August 2026
Countries Visited: Italy, Sicily, Greece
Swing Into Savings Best Rate
INSIDE
$1,821
OCEANVIEW
$2,090
BALCONY
$2,501
SUITE
$5,740
From (per person) 1,821
View Trip
9 Day Cruising Southern Italy and Sicily - with Smithsonian Journeys with Ponant
Cruise

9 Days (8 Nights) Valletta to Livorno
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Aug 2025 to Sep 2026
Countries Visited: Malta, Sicily, Italy
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,220
SUITE
$13,750
From (per person) 8,220
View Trip
11 Day 5th Opera Festival at Sea with Ponant
Cruise

11 Days (10 Nights) Venice to Nice
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 22 June 2026
Countries Visited: Italy, Sicily, France
INSIDE
-
OCEANVIEW
-
BALCONY
$12,950
SUITE
$22,030
From (per person) 12,950
View Trip
10 Day Malta, Sicily & Amalfi Coast with Emerald Cruises
New ReleaseCruise

10 Days (9 Nights) Rome to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 11 July 2026
Countries Visited: Italy, Sicily, Malta
2 for 1 Fare + Fly Free Economy2 for 1 Fares
INSIDE
-
OCEANVIEW
$7,138
BALCONY
-
SUITE
$9,761
Save (per person) 7,352
From (per person) 7,138
View Trip
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