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Cruises from Palermo

Choose from 14 unique cruises starting in Palermo, and traveling to Athens, Buenos Aires, Miami, Nice, Santos and more. October, June and November are the most popular months to join a cruise from Palermo and you can select from 225 departures available from two leading cruise lines.
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6 Days
27 Days
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14 Cruises (225 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 November 2027
Visit: Sicily, Malta, Spain, France, Italy
Inside
$1,021
Oceanview
$1,181
Balcony
$1,311
Suite
$1,831
From
US$1,021
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Euribia, MSC Splendida
Departures: Apr 2026 to Mar 2028
Visit: Sicily, Tunisia, Spain, France, Italy
Drinks & WiFi Package
Inside
$720
Oceanview
$951
Balcony
$965
Suite
$1,575
From
US$720
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Palermo to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 12 November 2027
Visit: Sicily, Italy, France, Spain, Brazil
Drinks & WiFi Package
Inside
-
Oceanview
-
Balcony
-
Suite
$8,575
From
US$8,575
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
-
Suite
$4,231
From
US$4,231
Per Person
View Trip
6 Day Sicilian interlude with Ponant
Cruise
 (2)

6 Days (5 Nights) Palermo to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 June 2027
Visit: Sicily, Italy, Malta
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Jan 2028
Visit: Sicily, Malta, Spain, France, Italy
Inside
$791
Oceanview
$951
Balcony
$1,081
Suite
$1,601
From
US$791
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Sicily, Spain, France, Italy
Inside
$848
Oceanview
$1,210
Balcony
$1,158
Suite
$1,598
From
US$848
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Sicily, Spain, France, Italy
Inside
$761
Oceanview
$861
Balcony
$1,041
Suite
-
From
US$761
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Meraviglia, MSC Virtuosa
Departures: May 2026 to Nov 2027
Visit: Sicily, Italy, France, Spain, Tunisia
Inside
$790
Oceanview
$950
Balcony
$1,133
Suite
$2,350
From
US$790
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: May 2026 to Nov 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
$865
Oceanview
$1,090
Balcony
$1,116
Suite
$1,641
From
US$865
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 29 April 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
-
Oceanview
-
Balcony
$1,499
Suite
$1,819
From
US$1,499
Per Person
View Trip
8 Day Under Sail from Sicily to the Riviera with Ponant
Cruise

8 Days (7 Nights) Palermo to Nice
Cruise Line: Ponant
Ship: Le Ponant
Departure: 24 August 2027
Visit: Sicily, Italy, France
Inside
-
Oceanview
$10,810
Balcony
$18,350
Suite
$19,850
From
US$10,810
Per Person
View Trip
27 Day Mediterranean with MSC Cruises
Cruise

27 Days (26 Nights) Palermo to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain (+4 more), Gibraltar, Morocco, Portugal, USA
Inside
$1,961
Oceanview
$2,477
Balcony
$2,613
Suite
-
From
US$1,961
Per Person
View Trip
8 Day Under Sail from Sicily to the Greek Islands with Ponant
Cruise

8 Days (7 Nights) Palermo to Athens
Cruise Line: Ponant
Ship: Le Ponant
Departure: 08 June 2027
Visit: Sicily, Italy, Greece
Inside
-
Oceanview
$12,050
Balcony
$19,470
Suite
$21,690
From
US$12,050
Per Person
View Trip
Results: 14 results

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