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Cruises from Palermo

Choose from 14 unique cruises starting in Palermo, and traveling to Athens, Barcelona, Buenos Aires, Miami, Nice and more. October is the most popular month to join a cruise from Palermo and you can select from 213 departures available from two leading cruise lines.
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Duration
5 Days
27 Days
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14 Cruises (213 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Sicily, Spain, France, Italy
Inside
$821
Oceanview
$921
Balcony
$1,101
Suite
-
From
US$821
Per Person
View Trip
6 Day Sicilian interlude with Ponant
Cruise
 (2)

6 Days (5 Nights) Palermo to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 June 2027
Visit: Sicily, Italy, Malta
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Jun 2026 to Nov 2026
Visit: Sicily, Spain, France, Italy
Inside
$947
Oceanview
$1,015
Balcony
$1,265
Suite
$1,735
From
US$947
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departures: Oct 2026 to Mar 2028
Visit: Sicily, Tunisia, Spain, France, Italy
Inside
$614
Oceanview
$814
Balcony
$914
Suite
$1,654
From
US$614
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Jan 2028
Visit: Sicily, Malta, Spain, France, Italy
Inside
$791
Oceanview
$951
Balcony
$1,081
Suite
$1,601
From
US$791
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 November 2027
Visit: Sicily, Malta, Spain, France, Italy
Inside
$1,021
Oceanview
$1,181
Balcony
$1,311
Suite
$1,831
From
US$1,021
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
-
Suite
$4,231
From
US$4,231
Per Person
View Trip
8 Day Under Sail from Sicily to the Riviera with Ponant
Cruise

8 Days (7 Nights) Palermo to Nice
Cruise Line: Ponant
Ship: Le Ponant
Departure: 24 August 2027
Visit: Sicily, Italy, France
Inside
-
Oceanview
$12,790
Balcony
$19,470
Suite
$22,420
From
US$12,790
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: Jun 2026 to Nov 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
$961
Oceanview
$1,127
Balcony
$1,181
Suite
$1,695
From
US$961
Per Person
View Trip
27 Day Mediterranean with MSC Cruises
Cruise

27 Days (26 Nights) Palermo to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain (+4 more), Gibraltar, Morocco, Portugal, USA
Inside
-
Oceanview
$2,558
Balcony
$3,009
Suite
-
From
US$2,558
Per Person
View Trip
8 Day Under Sail from Sicily to the Greek Islands with Ponant
Cruise

8 Days (7 Nights) Palermo to Athens
Cruise Line: Ponant
Ship: Le Ponant
Departure: 08 June 2027
Visit: Sicily, Italy, Greece
Inside
-
Oceanview
$12,050
Balcony
$19,470
Suite
$21,690
From
US$12,050
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Meraviglia, MSC Virtuosa
Departures: Jun 2026 to Nov 2027
Visit: Sicily, Italy, France, Spain, Tunisia
Drinks & WiFi Package
Inside
$964
Oceanview
$1,140
Balcony
$1,304
Suite
$2,430
From
US$964
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Palermo to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 12 November 2027
Visit: Sicily, Italy, France, Spain, Brazil
Drinks & WiFi Package
Inside
-
Oceanview
-
Balcony
-
Suite
$8,575
From
US$8,575
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Palermo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain
Inside
$369
Oceanview
-
Balcony
$599
Suite
-
From
US$369
Per Person
View Trip
Results: 14 results

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