Home > Cruises > Europe Cruises > Mediterranean Cruises > Sicily > Cruises from Palermo

Cruises from Palermo

Choose from 14 unique cruises starting in Palermo, and traveling to Athens, Barcelona, Buenos Aires, Miami, Nice and more. October is the most popular month to join a cruise from Palermo and you can select from 226 departures available from two leading cruise lines.
Filter Results
Departures
Show More...
Duration
5 Days
27 Days
Countries Visited
End City
Ship Features
Operators
Price
$500pp
$12,050pp
Countries
Show More...
Filter Results
14 Cruises (226 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Sicily, Spain, France, Italy
Inside
$820
Oceanview
$920
Balcony
$1,100
Suite
-
From
US$820
Per Person
View Trip
6 Day Sicilian interlude with Ponant
Cruise
 (2)

6 Days (5 Nights) Palermo to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 June 2027
Visit: Sicily, Italy, Malta
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Meraviglia, MSC Virtuosa
Departures: May 2026 to Nov 2027
Visit: Sicily, Italy, France, Spain, Tunisia
Inside
$933
Oceanview
$1,030
Balcony
$1,230
Suite
$2,314
From
US$933
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Jan 2028
Visit: Sicily, Malta, Spain, France, Italy
Inside
$791
Oceanview
$951
Balcony
$1,081
Suite
$1,601
From
US$791
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 29 April 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
-
Oceanview
-
Balcony
$1,499
Suite
$1,819
From
US$1,499
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Sicily, Spain, France, Italy
Exclusive Savings
Inside
$940
Oceanview
$1,110
Balcony
$1,240
Suite
$1,690
From
US$940
Save 54
Per Person
View Trip
8 Day Under Sail from Sicily to the Riviera with Ponant
Cruise

8 Days (7 Nights) Palermo to Nice
Cruise Line: Ponant
Ship: Le Ponant
Departure: 24 August 2027
Visit: Sicily, Italy, France
Inside
-
Oceanview
$10,810
Balcony
$17,240
Suite
$19,850
From
US$10,810
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Euribia, MSC Splendida
Departures: Mar 2026 to Mar 2028
Visit: Sicily, Tunisia, Spain, France, Italy
Inside
$721
Oceanview
$951
Balcony
$981
Suite
$1,617
From
US$721
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Inside
$1,911
Oceanview
-
Balcony
$2,531
Suite
$4,122
From
US$1,911
Per Person
View Trip
27 Day Mediterranean with MSC Cruises
Cruise

27 Days (26 Nights) Palermo to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain (+4 more), Gibraltar, Morocco, Portugal, USA
Inside
$2,242
Oceanview
$2,558
Balcony
-
Suite
$7,082
From
US$2,242
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Palermo to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 12 November 2027
Visit: Sicily, Italy, France, Spain, Brazil
Drinks & WiFi Package
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,335
From
US$8,335
Save 240
Per Person
View Trip
8 Day Under Sail from Sicily to the Greek Islands with Ponant
Cruise

8 Days (7 Nights) Palermo to Athens
Cruise Line: Ponant
Ship: Le Ponant
Departure: 08 June 2027
Visit: Sicily, Italy, Greece
Inside
-
Oceanview
$12,050
Balcony
$19,470
Suite
$21,690
From
US$12,050
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: May 2026 to Nov 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
$865
Oceanview
$1,078
Balcony
$1,045
Suite
$1,675
From
US$865
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Palermo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain
Inside
-
Oceanview
-
Balcony
$559
Suite
-
From
US$559
Per Person
View Trip
Results: 14 results

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Cruises Luxury Cruises Short Break Cruises

Trip Lengths

10 Day 2 Week 3 Week 7 Day

Departure Months

March April May June July August September October November December January February

Cities

Palermo

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations