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Sicily Luxury Cruises

Explore Sicily on one of 207 luxury cruises, departing from Antalya, Athens, Barcelona, Bologna, Dubrovnik and more. May, June and October are the most popular months to cruise to Sicily and we have over 241 departures available from eleven of the world's leading cruise lines specialising in luxury cruises.
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207 Cruises (241 Cruise Departures)
11 Day Made in Italy, the Luxury Edition with Ponant
Cruise
 (2)

11 Days (10 Nights) Florence to Venice
Cruise Line: Ponant
Ship: Le Boreal
Departure: 08 September 2027
Visit: Italy, Sicily
Inside
-
Oceanview
$16,120
Balcony
$17,010
Suite
$32,020
From
US$16,120
Per Person
View Trip
11 Day Italy Intensive Cruise: Venice, Sicily & Amalfi with Azamara Cruises
Cruise
 (3)

11 Days (10 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 05 May 2027
Visit: Italy, Montenegro, Sicily
Azamara Always Included
Inside
$3,549
Oceanview
$4,089
Balcony
$5,339
Suite
$8,149
From
US$3,549
Per Person
View Trip
8 Day Greece & Italy Cruise: Olympia, Catania & Amalfi Coast (salerno) with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 26 February 2028
Visit: Greece, Sicily, Italy
Azamara Always Included
Inside
$1,539
Oceanview
$1,949
Balcony
$2,549
Suite
$3,879
From
US$1,539
Per Person
View Trip
12 Day Italy Intensive Cruise: Bologna, Sicily & Amalfi with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 16 May 2027
Visit: Italy, Montenegro, Sicily
Azamara Always Included
Inside
$3,939
Oceanview
$4,529
Balcony
$6,209
Suite
$8,579
From
US$3,939
Per Person
View Trip
8 Day Mediterranean Cruise: Italy & Greece with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Visit: Italy, Sicily, Greece
Azamara Always Included
Inside
$1,419
Oceanview
$1,629
Balcony
$1,919
Suite
$2,949
From
US$1,419
Per Person
View Trip
10 Day Malta, Sicily & Amalfi Coast with Emerald Cruises
New ReleaseCruise
 (3)

10 Days (9 Nights) Rome to Valletta
Cruise Line: Emerald Cruises
Ships: Emerald Azzurra, Emerald Kaia
Departures: May 2027 to Oct 2027
Visit: Italy, Sicily, Malta
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$7,900
Balcony
-
Suite
$10,679
From
US$7,900
Save 1,447
Per Person
View Trip
8 Day Iberian Peninsula & Sicily with Ponant
Cruise
 (1)

8 Days (7 Nights) Malaga to Valletta
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 28 April 2026
Visit: Spain, Sicily, Malta
Inside
-
Oceanview
-
Balcony
$6,260
Suite
$11,700
From
US$6,260
Per Person
View Trip
6 Day Sicilian interlude with Ponant
Cruise
 (2)

6 Days (5 Nights) Palermo to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 June 2027
Visit: Sicily, Italy, Malta
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
9 Day Legendary Shores of Italy and Croatia with Ponant
Cruise
 (2)

9 Days (8 Nights) Venice to Rome
Cruise Line: Ponant
Ship: Le Boreal
Departure: 20 May 2027
Visit: Italy, Croatia, Sicily
Inside
-
Oceanview
$6,300
Balcony
$6,630
Suite
$12,350
From
US$6,300
Per Person
View Trip
8 Day Authentic Mediterranean Shores with Ponant
Cruise
 (1)

8 Days (7 Nights) Valletta to Valletta
Cruise Line: Ponant
Ships: Le Bougainville, Le Dumont d’Urville
Departures: Apr 2027 to May 2027
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$5,690
Suite
$10,580
From
US$5,690
Per Person
View Trip
9 Day Legendary Shores of Italy and Croatia with Ponant
Cruise
 (2)

9 Days (8 Nights) Rome to Venice
Cruise Line: Ponant
Ship: Le Boreal
Departure: 12 May 2027
Visit: Italy, Sicily, Croatia
Inside
-
Oceanview
$6,650
Balcony
$7,010
Suite
$13,080
From
US$6,650
Per Person
View Trip
9 Day A Celebration of Art Featuring the 61st Venice Biennale with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Venice
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 01 July 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$9,530
Suite
$16,550
From
US$9,530
Per Person
View Trip
9 Day Tribute to Maria Callas with Ponant
Cruise
 (2)

9 Days (8 Nights) Athens to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 29 September 2027
Visit: Greece, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$9,230
Suite
$16,470
From
US$9,230
Per Person
View Trip
10 Day Authentic Mediterranean shores with Ponant
Cruise
 (2)

10 Days (9 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 October 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
$8,510
Balcony
$8,980
Suite
$18,710
From
US$8,510
Per Person
View Trip
9 Day Authentic Mediterranean Shores with Ponant
Cruise
 (2)

9 Days (8 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 06 June 2027
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
$6,300
Balcony
$6,630
Suite
$12,350
From
US$6,300
Per Person
View Trip
8 Day Under Sail from Sicily to the Riviera with Ponant
Cruise

8 Days (7 Nights) Palermo to Nice
Cruise Line: Ponant
Ship: Le Ponant
Departure: 24 August 2027
Visit: Sicily, Italy, France
Inside
-
Oceanview
$10,810
Balcony
$18,350
Suite
$19,850
From
US$10,810
Per Person
View Trip
11 Day Mediterranean Delights with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Valletta to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 20 July 2026
Visit: Malta, Sicily, Tunisia
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$10,456
From
US$10,456
Save 1,039
Per Person
View Trip
11 Day Yachting Sicily to Elba via the Amalfi Coast with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Valletta to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 30 June 2027
Visit: Italy, Sicily, Malta
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$8,247
Balcony
-
Suite
$11,037
From
US$8,247
Save 1,898
Per Person
View Trip
12 Day Adriatic, Sicily & the Amalfi Coast with Scenic
New ReleaseCruise

12 Days (11 Nights) Venice to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departures: Jun 2028 to Sep 2028
Visit: Italy, Croatia, Sicily
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,673
Suite
$18,234
From
US$15,673
Save 2,322
Per Person
View Trip
8 Day Island Odyssey: Malta, Sicily & the Greek Isles with Scenic
New ReleaseCruise

8 Days (7 Nights) Valletta to Athens
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 June 2026
Visit: Malta, Sicily, Greece
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,569
Suite
$13,939
From
US$10,569
Save 1,071
Per Person
View Trip
12 Day Adriatic, Sicily & the Amalfi Coast with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Venice
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 18 July 2028
Visit: Italy, Sicily, Croatia
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,474
Suite
$18,035
From
US$15,474
Save 2,321
Per Person
View Trip
8 Day Under Sail from Sicily to the Greek Islands with Ponant
Cruise

8 Days (7 Nights) Palermo to Athens
Cruise Line: Ponant
Ship: Le Ponant
Departure: 08 June 2027
Visit: Sicily, Italy, Greece
Inside
-
Oceanview
$12,050
Balcony
$19,470
Suite
$21,690
From
US$12,050
Per Person
View Trip
8 Day Under Sail from the Riviera to Sicily with Ponant
Cruise

8 Days (7 Nights) Nice to Palermo
Cruise Line: Ponant
Ship: Le Ponant
Departure: 01 June 2027
Visit: France, Italy, Sicily
Inside
-
Oceanview
$11,380
Balcony
$18,350
Suite
$20,450
From
US$11,380
Per Person
View Trip
12 Day Sicily, the Amalfi Coast & Rome - Northbound with Tauck
Tour + Cruise

12 Days Malta to Rome
Operated By: Tauck
Ships: Le Bougainville, Le Dumont d’Urville
Departures: May 2026 to Oct 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$12,990
Suite
$16,990
From
US$12,990
Per Person
View Trip
11 Day 5th Opera Festival at Sea with Ponant
Cruise

11 Days (10 Nights) Venice to Nice
Cruise Line: Ponant
Ships: Le Boreal, Le Bougainville, Le Dumont d’Urville
Departures: Jun 2026 to Sep 2027
Visit: Italy, Sicily, France
Inside
-
Oceanview
$7,870
Balcony
$8,290
Suite
$15,440
From
US$7,870
Per Person
View Trip
6 Day A Journey Of Sculpted Isles & Timeless Civilisations with Explora Journeys
Cruise

6 Days (5 Nights) Athens to Valletta
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 24 April 2026
Visit: Greece, Sicily, Malta
Inside
-
Oceanview
-
Balcony
-
Suite
$3,300
From
US$3,300
Per Person
View Trip
10 Day Malta, Sicily & Amalfi Coast with Emerald Cruises
New ReleaseCruise

10 Days (9 Nights) Valletta to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 05 May 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$11,650
From
US$11,650
Per Person
View Trip
12 Day Rome, the Amalfi Coast & Sicily with Tauck
Tour + Cruise

12 Days Rome to Malta
Operated By: Tauck
Ships: Le Bougainville, Le Dumont d’Urville
Departures: Apr 2026 to Oct 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Italy, Sicily, Malta
Inside
-
Oceanview
-
Balcony
$12,490
Suite
$16,490
From
US$12,490
Per Person
View Trip
8 Day Mystical Italy & Croatia with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 20 June 2027
Visit: Italy, Sicily, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,149
Suite
$10,299
From
US$9,149
Save 9,149
Per Person
View Trip
11 Day Ancient Civilisations, from Italy to Greece with Ponant
Cruise

11 Days (10 Nights) Rome to Athens
Cruise Line: Ponant
Ship: Le Champlain
Departure: 01 October 2026
Visit: Italy, Sicily, Greece
Inside
-
Oceanview
-
Balcony
$10,400
Suite
$18,590
From
US$10,400
Per Person
View Trip
Results: 1-30 of 207

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