Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 618 unique cruise itineraries with 1183 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 681 departures starting between March 2026 and October 2028.
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618 Cruises (681 Cruise Departures)
Cruise
 (1)

9 Days (8 Nights) Valletta to Athens
Cruise Line: Ponant
Departure: 01 June 2026
Visit: Malta, Sicily, Italy, Greece
Inside
-
Oceanview
-
Balcony
$7,540
Suite
$14,120
From
US$7,540
Per Person
View Trip
Cruise
 (3)

8 Days (7 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Departure: 22 May 2027
Visit: Spain, Gibraltar, Portugal
Azamara Always Included
Inside
$2,279
Oceanview
$2,540
Balcony
$3,307
Suite
$5,237
From
US$2,279
Per Person
View Trip
Cruise
 (6)

15 Days (14 Nights) London to London
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 31 March 2028
Visit: England, Spain, Italy, Sardinia
Inside
$3,039
Oceanview
$4,139
Balcony
$4,389
Suite
$9,450
From
US$3,039
Per Person
View Trip
Cruise
 (2)

11 Days (10 Nights) Florence to Malaga
Cruise Line: Ponant
Ship: Le Boreal
Departure: 03 October 2027
Visit: Italy, Monaco, France, Spain
Inside
-
Oceanview
$6,990
Balcony
$7,350
Suite
$13,610
From
US$6,990
Per Person
View Trip
Cruise

13 Days (12 Nights) Nice to Nice
Cruise Line: Silversea
Departure: 13 April 2027
Visit: France, Corsica, Sardinia, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,740
Balcony
$7,140
Suite
$11,570
From
US$5,740
Save 2,460
Per Person
View Trip
Cruise

12 Days (11 Nights) Nice to Nice
Cruise Line: Silversea
Departure: 01 June 2027
Visit: France, Spain, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,950
Balcony
$7,210
Suite
$14,280
From
US$5,950
Save 2,550
Per Person
View Trip
Cruise
 (8)

8 Days (7 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Departure: 05 December 2026
Visit: Italy, Sicily, Greece
Azamara Always Included
Inside
$1,499
Oceanview
$1,709
Balcony
$2,019
Suite
$3,035
From
US$1,499
Per Person
View Trip
Cruise
 (1)

11 Days (10 Nights) Lisbon to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 06 April 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,880
Suite
$8,700
From
US$5,880
Save 2,520
Per Person
View Trip
Cruise

23 Days (22 Nights) Lisbon to Rome
Cruise Line: Regent Seven Seas
Departure: 11 August 2027
Visit: Portugal, Spain, Morocco, France (+4 more), Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,126
Suite
$20,821
From
US$18,126
Save 30,772
Per Person
View Trip
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,514
Suite
$11,429
From
US$7,514
Save 135
Per Person
View Trip
Cruise
 (3)

11 Days (10 Nights) Monte Carlo to Barcelona
Cruise Line: Oceania Cruises
Departure: 19 October 2026
Visit: Monaco, Italy, Sardinia, Sicily, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,400
Oceanview
$2,584
Balcony
$3,981
Suite
$5,533
From
US$2,400
Save 3,598
Per Person
View Trip
Cruise
 (3)

11 Days (10 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Departure: 16 June 2026
Visit: Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$2,612
Oceanview
$2,961
Balcony
$4,019
Suite
$5,716
From
US$2,612
Save 57
Per Person
View Trip
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Inside
$2,399
Oceanview
$2,699
Balcony
$2,909
Suite
$5,867
From
US$2,399
Per Person
View Trip
New ReleaseCruise

11 Days (10 Nights) Lisbon to Barcelona
Cruise Line: Emerald Cruises
Departure: 08 October 2026
Visit: Portugal, Spain, Morocco
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$10,313
From
US$10,313
Save 12,877
Per Person
View Trip
Cruise
 (3)

8 Days (7 Nights) Malaga to Barcelona
Cruise Line: Azamara Cruises
Departure: 17 April 2027
Visit: Spain, Gibraltar
Azamara Always Included
Inside
$2,179
Oceanview
$2,431
Balcony
$3,197
Suite
$5,118
From
US$2,179
Per Person
View Trip
Cruise
 (2)

6 Days (5 Nights) Barcelona to Nice
Cruise Line: Ponant
Ship: Le Boreal
Departure: 02 May 2027
Visit: Spain, France, Corsica
Inside
-
Oceanview
$3,720
Balcony
$3,910
Suite
$7,270
From
US$3,720
Per Person
View Trip
Cruise
 (8)

18 Days (17 Nights) Athens to Barcelona
Cruise Line: Azamara Cruises
Departure: 12 December 2026
Visit: Greece, Egypt, Malta, Sicily, Italy, Spain
Azamara Always Included
Exclusive Savings
Inside
$3,989
Oceanview
$4,551
Balcony
$5,211
Suite
$8,402
From
US$3,989
Save 80
Per Person
View Trip
Cruise
 (1)

15 Days (14 Nights) Lisbon to Rome
Cruise Line: Oceania Cruises
Departure: 26 August 2027
Visit: Portugal, Spain, France, Sardinia, Tunisia, Sicily, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$4,110
Oceanview
$4,498
Balcony
$7,311
Suite
$10,124
From
US$4,110
Save 4,288
Per Person
View Trip
Cruise
 (8)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Departure: 03 March 2027
Visit: Italy, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,927
Oceanview
$3,363
Balcony
$3,829
Suite
$5,905
From
US$2,927
Save 62
Per Person
View Trip
Cruise

15 Days (14 Nights) Dubrovnik to Barcelona
Cruise Line: Seabourn
Departure: 11 September 2027
Visit: Croatia, Montenegro, Sicily, Italy, Monaco, France, Spain
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,692
Suite
$15,689
From
US$9,692
Save 167
Per Person
View Trip
Cruise
 (2)

9 Days (8 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 06 June 2027
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
$6,300
Balcony
$6,630
Suite
$12,350
From
US$6,300
Per Person
View Trip
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 21 November 2027
Visit: Italy, France, Spain, Morocco, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,580
Suite
$8,480
From
US$6,580
Save 2,820
Per Person
View Trip
Cruise

10 Days (9 Nights) Lisbon to Rome
Cruise Line: Silversea
Departure: 06 September 2027
Visit: Portugal, Spain, France, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,240
Balcony
$6,720
Suite
$6,400
From
US$6,240
Save 1,560
Per Person
View Trip
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Departure: 04 January 2027
Visit: Italy, France, Spain, Portugal
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,430
Oceanview
$2,647
Balcony
$3,956
Suite
$5,440
From
US$2,430
Save 2,968
Per Person
View Trip
Cruise
 (8)

15 Days (14 Nights) Barcelona to Athens
Cruise Line: Azamara Cruises
Departure: 28 November 2026
Visit: Spain, France, Italy, Sicily, Greece
Azamara Always Included
Exclusive Savings
Inside
$2,969
Oceanview
$3,357
Balcony
$3,987
Suite
$6,344
From
US$2,969
Save 50
Per Person
View Trip
Cruise
 (3)

16 Days (15 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Departure: 04 December 2027
Visit: Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$3,561
Oceanview
$4,454
Balcony
$5,608
Suite
$8,392
From
US$3,561
Save 68
Per Person
View Trip
New ReleaseCruise
 (3)

11 Days (10 Nights) Rome to Athens
Cruise Line: Emerald Cruises
Departure: 02 May 2026
Visit: Italy, Sicily, Malta, Greece
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,912
From
US$9,912
Save 12,578
Per Person
View Trip
Cruise
 (3)

8 Days (7 Nights) Barcelona to Nice
Cruise Line: Azamara Cruises
Departure: 26 May 2026
Visit: Spain, France
Azamara Always Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,576
Suite
-
From
US$2,576
Save 63
Per Person
View Trip
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Departure: 10 July 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,918
Suite
$10,996
From
US$9,918
Save 15,680
Per Person
View Trip
Cruise

15 Days (14 Nights) Istanbul to Barcelona
Cruise Line: Oceania Cruises
Departure: 17 October 2026
Visit: Turkey, Greece, Croatia, Montenegro (+4 more), Sicily, Italy, France, Spain
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,317
Suite
$10,082
From
US$7,317
Save 7,681
Per Person
View Trip
Results: 1-30 of 618

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