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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 729 unique cruise itineraries with 1196 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 831 departures starting between May 2026 and November 2028.
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729 Cruises (831 Cruise Departures)
9 Day Historical Cities of the Mediterranean with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Athens
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 01 June 2026
Visit: Malta, Sicily, Italy, Greece
Inside
-
Oceanview
-
Balcony
$7,540
Suite
$14,120
From
US$7,540
Per Person
View Trip
19 Day Mediterranean & North Africa Voyage: Portugal, Morocco & Italy with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Lisbon to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 November 2026
Visit: Portugal, Morocco, Spain, Gibraltar, France, Italy
Azamara Always Included
Inside
$4,209
Oceanview
$4,699
Balcony
$5,649
Suite
$9,119
From
US$4,209
Per Person
View Trip
8 Day Grecian & Roman Gems with Seabourn
Cruise
 (1)

8 Days (7 Nights) Athens to Rome
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 25 October 2026
Visit: Greece, Albania, Italy
Yours to Explore
Inside
-
Oceanview
$6,299
Balcony
$8,999
Suite
$13,799
From
US$6,299
Per Person
View Trip
11 Day Radiant Rivieras with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 November 2026
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
$2,625
Oceanview
$3,360
Balcony
$3,710
Suite
$4,865
From
US$2,625
Save 4,873
Per Person
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Inside
-
Oceanview
$3,499
Balcony
$4,669
Suite
$5,459
From
US$3,499
Per Person
View Trip
18 Day Mediterranean & Egypt Cruise: Italy, Greece & Malta with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Visit: Italy, Sicily, Greece, Egypt, Malta
Azamara Always Included
Inside
$3,699
Oceanview
$4,239
Balcony
$4,899
Suite
$7,569
From
US$3,699
Per Person
View Trip
11 Day Spain Intensive Voyage with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 07 November 2026
Visit: Spain, Gibraltar, Portugal
Azamara Always Included
Inside
$2,439
Oceanview
$2,789
Balcony
$3,069
Suite
$4,529
From
US$2,439
Per Person
View Trip
9 Day Peaceful Islands and Ancient Treasures of the Mediterranean with Ponant
Cruise
 (2)

9 Days (8 Nights) Valletta to Athens
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 17 August 2027
Visit: Malta, Sicily, Italy, Greece
Inside
-
Oceanview
-
Balcony
$6,910
Suite
$12,870
From
US$6,910
Per Person
View Trip
6 Day Sicilian interlude with Ponant
Cruise
 (2)

6 Days (5 Nights) Palermo to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 June 2027
Visit: Sicily, Italy, Malta
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
8 Day Mediterranean Cruise: Italy & Greece with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Visit: Italy, Sicily, Greece
Azamara Always Included
Inside
$1,569
Oceanview
$1,489
Balcony
$1,759
Suite
$2,689
From
US$1,489
Per Person
View Trip
13 Day Passage To Portugal with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Monte Carlo to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 12 July 2026
Visit: Monaco, France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Exclusive Savings
Inside
$2,850
Oceanview
$3,225
Balcony
$5,512
Suite
$6,712
From
US$2,850
Save 4,748
Per Person
View Trip
11 Day Mediterranean Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Your World Inclusions
Exclusive Savings
Inside
$2,730
Oceanview
-
Balcony
$3,605
Suite
$4,900
From
US$2,730
Save 5,068
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Bonus Onboard Credit
Value Fare
Cunard Fare
Inside
$1,359
Oceanview
$1,409
Balcony
$1,779
Suite
-
From
US$1,359
Per Person
View Trip
10 Day A Journey From Italian Gems To Spain’s Southern Coast with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 05 March 2027
Visit: Italy, France, Corsica, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$5,180
From
US$5,180
Per Person
View Trip
9 Day Tribute to Maria Callas with Ponant
Cruise
 (2)

9 Days (8 Nights) Athens to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 29 September 2027
Visit: Greece, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$9,230
Suite
$16,470
From
US$9,230
Per Person
View Trip
17 Day Treasures Of Greece & Andalusia with Seabourn
Cruise
 (1)

17 Days (16 Nights) Athens to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 25 October 2026
Visit: Greece, Albania, Italy, Corsica, Sardinia, Spain, Portugal
Yours to Explore
Inside
-
Oceanview
$12,399
Balcony
$16,999
Suite
$25,299
From
US$12,399
Per Person
View Trip
8 Day Italy And France with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain
Bonus Onboard Credit
Value Fare
Inside
$1,239
Oceanview
$1,289
Balcony
$1,429
Suite
$3,029
From
US$1,239
Per Person
View Trip
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Inside
$1,959
Oceanview
$2,029
Balcony
$2,549
Suite
$3,859
From
US$1,959
Per Person
View Trip
11 Day Coastal Mediterranean Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Valletta
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 10 September 2026
Visit: Italy, France, Spain, Malta
Your World Inclusions
Exclusive Savings
Inside
$2,890
Oceanview
$3,315
Balcony
$4,717
Suite
$6,205
From
US$2,890
Save 3,908
Per Person
View Trip
8 Day Gastronomic Journey Through Iberian Coasts with Ponant
Cruise
 (2)

8 Days (7 Nights) Lisbon to Barcelona
Cruise Line: Ponant
Ship: Le Boreal
Departure: 25 April 2027
Visit: Portugal, Spain
Inside
-
Oceanview
$6,490
Balcony
$6,850
Suite
$11,470
From
US$6,490
Per Person
View Trip
8 Day Spain Intensive Cruise: Malaga, Valencia & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Malaga to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 17 April 2027
Visit: Spain, Gibraltar
Azamara Always Included
Inside
$2,179
Oceanview
$2,489
Balcony
$3,279
Suite
$5,259
From
US$2,179
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Value Fare
Inside
$2,399
Oceanview
$2,699
Balcony
$2,859
Suite
$6,119
From
US$2,399
Per Person
View Trip
10 Day Authentic Mediterranean shores with Ponant
Cruise
 (2)

10 Days (9 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 October 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
$8,510
Balcony
$8,980
Suite
$18,710
From
US$8,510
Per Person
View Trip
15 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (8)

15 Days (14 Nights) Barcelona to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Visit: Spain, France, Italy, Sicily, Greece
Azamara Always Included
Inside
$2,999
Oceanview
$3,399
Balcony
$3,919
Suite
$6,149
From
US$2,999
Per Person
View Trip
11 Day Enchanting Greece & the Amalfi Coast with Emerald Cruises
New ReleaseCruise
 (3)

11 Days (10 Nights) Athens to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 17 October 2026
Visit: Greece, Sicily, Malta, Italy
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$25,145
From
US$25,145
Save 1,800
Per Person
View Trip
6 Day Spain & France Cruise: Barcelona, Saint-Tropez & Nice with Azamara Cruises
Cruise
 (3)

6 Days (5 Nights) Barcelona to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 May 2026
Visit: Spain, France
Azamara Always Included
Inside
-
Oceanview
-
Balcony
-
Suite
$3,219
From
US$3,219
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
Yours to Explore
Inside
-
Oceanview
$7,399
Balcony
-
Suite
$14,299
From
US$7,399
Per Person
View Trip
6 Day From Riviera Glamour to Corsican Charm with Ponant
Cruise
 (2)

6 Days (5 Nights) Barcelona to Nice
Cruise Line: Ponant
Ship: Le Boreal
Departure: 02 May 2027
Visit: Spain, France, Corsica
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,730
From
US$3,940
Per Person
View Trip
8 Day Italy, Algeria & Spain Cruise: Trapani, Algiers & Granada with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Malaga
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 02 December 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain
Azamara Always Included
Inside
$1,739
Oceanview
$1,959
Balcony
$2,619
Suite
$3,749
From
US$1,739
Per Person
View Trip
10 Day Mysteries Of History with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 May 2027
Visit: Italy, Sicily, Greece, Turkey
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,699
Oceanview
$2,949
Balcony
$4,499
Suite
$6,399
From
US$2,699
Save 2,699
Per Person
View Trip
Results: 1-30 of 729

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