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Mediterranean Luxury Cruises

Explore the best luxury cruises sailing in and around the Mediterranean. Choose from 604 unique cruise itineraries with 2 past traveler reviews from 10 leading cruise lines. September is the most popular month to join a luxury cruise sailing in and around the Mediterranean with 654 departures starting between February 2026 and October 2028.
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604 Cruises (654 Cruise Departures)
9 Day Historical Cities of the Mediterranean with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Athens
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 01 June 2026
Visit: Malta, Sicily, Italy, Greece
Inside
-
Oceanview
-
Balcony
$7,540
Suite
$14,120
From
US$7,540
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Nice & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 December 2027
Visit: Italy, France, Spain
Azamara Always Included
Inside
$1,609
Oceanview
$2,029
Balcony
$2,569
Suite
$3,859
From
US$1,609
Per Person
View Trip
11 Day Nice to Lisbon with Silversea
Cruise

11 Days (10 Nights) Nice to Lisbon
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 11 August 2027
Visit: France, Spain, Gibraltar, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,320
Balcony
$6,510
Suite
$14,200
From
US$5,320
Save 2,280
Per Person
View Trip
11 Day Spanish Sapphire Shores with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 24 March 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,642
Suite
$10,161
From
US$8,642
Save 14,356
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 05 March 2026
Visit: Spain, France, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,280
Suite
$19,570
From
US$7,040
Save 1,760
Per Person
View Trip
9 Day Splendours of Sicily, Italy and the French Riviera with Scenic
New ReleaseCruise

9 Days (8 Nights) Valletta to Nice
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 May 2027
Visit: Malta, Sicily, Italy, Corsica, France, Monaco
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,991
Suite
$14,453
From
US$9,991
Save 13,599
Per Person
View Trip
20 Day Marvels Of The Mediterranean with Oceania Cruises
Cruise

20 Days (19 Nights) Lisbon to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 26 September 2027
Visit: Portugal, Spain, France, Italy (+4 more), Sicily, Tunisia, Malta, Greece
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,349
Suite
$11,696
From
US$8,349
Save 8,749
Per Person
View Trip
11 Day Mediterranean Delights with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Valletta to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 20 July 2026
Visit: Malta, Sicily, Tunisia
Wave Offer
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,904
From
US$8,904
Save 12,686
Per Person
View Trip
8 Day Greece & Italy Cruise: Olympia, Catania & Amalfi Coast (salerno) with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Athens to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 26 February 2028
Visit: Greece, Sicily, Italy
Azamara Always Included
Inside
$1,539
Oceanview
$1,949
Balcony
$2,489
Suite
$3,779
From
US$1,539
Per Person
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departures: Oct 2026 to Oct 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Inside
$1,779
Oceanview
$2,109
Balcony
$2,565
Suite
$3,700
From
US$1,779
Per Person
View Trip
11 Day Croissants & Cannoli with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,937
Oceanview
$3,180
Balcony
$4,877
Suite
$6,914
From
US$2,937
Save 3,061
Per Person
View Trip
8 Day Under Sail from the Riviera to Sicily with Ponant
Cruise

8 Days (7 Nights) Nice to Palermo
Cruise Line: Ponant
Ship: Le Ponant
Departure: 01 June 2027
Visit: France, Italy, Sicily
Inside
-
Oceanview
$10,700
Balcony
$17,240
Suite
$19,210
From
US$10,700
Per Person
View Trip
6 Day Palma De Mallorca to Nice with Silversea
Cruise

6 Days (5 Nights) Palma de Mallorca to Nice
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 27 April 2026
Visit: Spain, France
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$2,640
Balcony
$2,940
Suite
$2,860
From
US$2,640
Save 1,760
Per Person
View Trip
10 Day Miro To Michelangelo with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 24 August 2026
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,135
From
US$9,135
Save 15,263
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: La Goulette, Valletta & Siracusa with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Athens to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 February 2028
Visit: Greece, Egypt, Cyprus, Turkey
Azamara Always Included
Exclusive Savings
Inside
$3,858
Oceanview
$4,518
Balcony
$5,352
Suite
$7,360
From
US$3,858
Save 91
Per Person
View Trip
15 Day Iberian Peninsula Cruise: Portugal & Spain with Azamara Cruises
Cruise
 (8)

15 Days (14 Nights) Lisbon to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 February 2027
Visit: Portugal, Spain, Gibraltar, Morocco
Azamara Always Included
Exclusive Savings
Inside
$3,538
Oceanview
$4,033
Balcony
$4,586
Suite
$7,331
From
US$3,538
Save 71
Per Person
View Trip
8 Day Italy And France with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain
Inside
$1,059
Oceanview
$1,149
Balcony
$1,299
Suite
$3,079
From
US$1,059
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia, Corsica, Sicily
Inside
$2,359
Oceanview
$2,439
Balcony
$2,759
Suite
$5,609
From
US$2,359
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Florence, Nice & Barcelona with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 27 May 2027
Visit: Italy, France, Spain
Azamara Always Included
Inside
$2,099
Oceanview
$2,347
Balcony
$3,084
Suite
$4,917
From
US$2,099
Per Person
View Trip
9 Day Italy, France & Tunisia with Seabourn
Cruise

9 Days (8 Nights) Genoa to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 30 April 2027
Visit: Italy, Corsica, Sardinia, Tunisia, Sicily
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,480
Suite
$9,428
From
US$5,480
Save 95
Per Person
View Trip
8 Day France And Italy with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2026 to Sep 2026
Visit: Italy, France
Inside
$1,159
Oceanview
$1,249
Balcony
$1,339
Suite
$2,739
From
US$1,159
Per Person
View Trip
10 Day Spain Intensive Cruise: Seville, Malaga & Barcelona with Azamara Cruises
Cruise
 (3)

10 Days (9 Nights) Lisbon to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 20 September 2027
Visit: Portugal, Spain, Gibraltar
Azamara Always Included
Exclusive Savings
Inside
$3,061
Oceanview
$3,410
Balcony
$4,312
Suite
$6,379
From
US$3,061
Save 68
Per Person
View Trip
13 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 21 November 2027
Visit: Italy, France, Spain, Morocco, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,580
Suite
$8,480
From
US$6,580
Save 2,820
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Visit: Spain, France, Italy
Inside
$1,269
Oceanview
$1,249
Balcony
$1,449
Suite
$2,559
From
US$1,249
Per Person
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Istanbul to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 11 May 2026
Visit: Turkey, Greece, Sicily, Spain, France, Italy, Corsica
Inside
$3,279
Oceanview
-
Balcony
-
Suite
$9,433
From
US$3,279
Per Person
View Trip
10 Day A Journey of Iberian Scenery & Moorish Charm with Explora Journeys
Cruise

10 Days (9 Nights) Barcelona to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 03 April 2027
Visit: Spain, Morocco, Portugal
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$5,690
Suite
$6,415
From
US$5,690
Per Person
View Trip
11 Day Havens Of Italy & Spain with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Monte Carlo to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 October 2026
Visit: Monaco, Italy, Sardinia, Sicily, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,400
Oceanview
$2,584
Balcony
$3,981
Suite
$5,533
From
US$2,400
Save 3,598
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,560
Suite
$4,240
From
US$4,240
Save 4,160
Per Person
View Trip
6 Day An Autumn Escape: Côte d’Azur, Italian Riviera & Corsica with Ponant
Cruise
 (1)

6 Days (5 Nights) Nice to Florence
Cruise Line: Ponant
Ship: Le Boreal
Departure: 28 September 2027
Visit: France, Italy, Corsica
Inside
-
Oceanview
$3,940
Balcony
$4,150
Suite
$7,720
From
US$3,940
Per Person
View Trip
6 Day Spain & France Cruise: Barcelona, Saint-Tropez & Nice with Azamara Cruises
Cruise
 (3)

6 Days (5 Nights) Barcelona to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 May 2026
Visit: Spain, France
Azamara Always Included
Inside
-
Oceanview
$2,029
Balcony
$2,449
Suite
-
From
US$2,029
Per Person
View Trip
Results: 1-30 of 604

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