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Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? November is the most popular month to cruise between Italy and Portugal and there are 60 departures available from twelve of the world's leading cruise lines.
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32 Cruises (60 Cruise Departures)
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$672
Oceanview
$743
Balcony
$854
Suite
$1,671
From
US$672
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$6,099
Balcony
$8,849
Suite
$11,699
From
US$6,099
Save 6,099
Per Person
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Visit: Italy, Sicily, Sardinia, Spain, Gibraltar, Portugal
Have It All Fare Option
Inside
$2,099
Oceanview
$2,199
Balcony
$2,949
Suite
-
From
US$2,099
Per Person
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Visit: Italy, Corsica, Spain, Morocco, Portugal
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$10,711
From
US$10,711
Save 2,179
Per Person
View Trip
16 Day Italy, France & Spain Cruise: Rome, Barcelona & Seville with Azamara Cruises
Cruise
 (3)

16 Days (15 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 December 2027
Visit: Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Inside
$3,629
Oceanview
$4,549
Balcony
$5,739
Suite
$8,609
From
US$3,629
Per Person
View Trip
13 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 21 November 2027
Visit: Italy, France, Spain, Morocco, Portugal
All-Inclusive Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,200
Suite
$10,900
From
US$7,200
Save 3,500
Per Person
View Trip
22 Day A Journey Across The Mediterranean’s Edge & Into The Atlantic with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Rome to Lisbon
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 February 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
-
Suite
$10,745
From
US$10,745
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain, Morocco, Portugal
Azamara Always Included
Inside
-
Oceanview
$4,799
Balcony
$5,549
Suite
$9,289
From
US$4,799
Per Person
View Trip
15 Day Italy, French Riviera & Spain Collectors' Voyage with Holland America
Cruise
 (3)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Visit: Italy, France, Gibraltar, Spain, Morocco, Portugal
Fare Saver
Inside
$1,504
Oceanview
$1,604
Balcony
$2,104
Suite
-
From
US$1,504
Per Person
View Trip
10 Day Western Mediterranean Cruise From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 23 October 2027
Visit: Italy, France, Spain, Portugal
Inside
$2,169
Oceanview
$2,749
Balcony
$2,949
Suite
$3,629
From
US$2,169
Per Person
View Trip
11 Day Roman Holiday with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,799
Oceanview
$3,649
Balcony
$4,399
Suite
$6,399
From
US$2,799
Save 2,799
Per Person
View Trip
15 Day Rivieras, Minarets & More with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2026
Visit: Italy, France, Spain, Morocco, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,099
Suite
-
From
US$7,099
Save 7,099
Per Person
View Trip
21 Day Summer Splendor with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 June 2027
Visit: Italy, Sicily, Sardinia, Corsica (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,049
Oceanview
$6,599
Balcony
$10,699
Suite
$14,449
From
US$6,049
Save 6,049
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise
 (1)

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,400
Suite
$14,300
From
US$8,400
Per Person
View Trip
40 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

40 Days (39 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 November 2027
Visit: Italy, Greece, Cyprus, Turkey (+6 more), Egypt, Sicily, France, Spain, Gibraltar, Portugal
Azamara Always Included
Inside
$10,719
Oceanview
$12,619
Balcony
$15,619
Suite
$22,819
From
US$10,719
Per Person
View Trip
22 Day Canals, Canaries & Colosseum with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 August 2027
Visit: Italy, Croatia, Greece, Sicily (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,749
Oceanview
$7,099
Balcony
$10,899
Suite
$15,199
From
US$6,749
Save 6,749
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
Yours to Explore
Inside
-
Oceanview
$7,399
Balcony
$9,499
Suite
$15,584
From
US$7,399
Per Person
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Visit: Italy, France, Spain, Portugal
Your World Inclusions
Exclusive Savings
Inside
$1,890
Oceanview
$2,100
Balcony
$3,150
Suite
$4,340
From
US$1,890
Save 3,508
Per Person
View Trip
9 Day Journey of Cultural Gems & Golden Shores with Explora Journeys
Cruise

9 Days (8 Nights) Genoa to Lisbon
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 15 April 2027
Visit: Italy, France, Spain, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
-
Suite
$6,115
From
US$6,115
Per Person
View Trip
8 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise

8 Days (7 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 08 May 2026
Visit: Italy, Spain, Portugal
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$4,500
Balcony
-
Suite
-
From
US$4,500
Save 3,500
Per Person
View Trip
15 Day Fusina (Venice) to Lisbon with Silversea
Cruise

15 Days (14 Nights) Venice to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 07 October 2026
Visit: Italy, Slovenia, Croatia, Sicily (+4 more), Malta, Sardinia, Spain, Portugal
All-Inclusive Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,200
Suite
$24,200
From
US$11,200
Save 2,500
Per Person
View Trip
37 Day Ultimate Mediterranean: From Balkan Gems To Spain with Seabourn
Cruise

37 Days (36 Nights) Venice to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 09 October 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+7 more), Greece, Turkey, Malta, Sicily, Sardinia, Spain, Portugal
Yours to Explore
Inside
-
Oceanview
-
Balcony
$33,599
Suite
$46,099
From
US$33,599
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Lyra (+4 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Vela
Departures: Mar 2027 to Sep 2028
Visit: Italy, Croatia, Sicily, Monaco (+4 more), France, Spain, Morocco, Portugal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,697
Suite
$20,997
From
US$13,697
Save 300
Per Person
View Trip
11 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 22 November 2027
Visit: Italy, Spain, Morocco, Portugal
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,300
Balcony
$6,000
Suite
$5,500
From
US$5,300
Save 1,500
Per Person
View Trip
17 Day Riviera Yacht Harbors Of France & Spain with Seabourn
Cruise

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 11 November 2028
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
$10,699
Suite
$17,999
From
US$10,699
Per Person
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia, Algeria, Spain, Portugal
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,636
Suite
$20,081
From
US$14,636
Save 3,124
Per Person
View Trip
24 Day Exploring Dalmatian Gems, France & Spain with Seabourn
Cruise

24 Days (23 Nights) Venice to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 04 November 2028
Visit: Italy, Croatia, Malta, Monaco (+4 more), France, Spain, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
$15,599
Suite
$26,099
From
US$15,599
Per Person
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,099
Suite
$13,999
From
US$13,099
Save 13,099
Per Person
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Visit: Italy, Monaco, Spain, Gibraltar, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,649
Suite
$6,849
From
US$4,649
Save 4,649
Per Person
View Trip
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Visit: Italy, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$8,600
Balcony
$9,300
Suite
$16,800
From
US$8,600
Save 1,500
Per Person
View Trip
Results: 1-30 of 32

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