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Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? November is the most popular month to cruise between Italy and Portugal and there are 57 departures available from eleven of the world's leading cruise lines.
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29 Cruises (57 Cruise Departures)
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Visit: Italy, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$7,200
Balcony
$7,830
Suite
$16,080
From
US$7,200
Save 800
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
$667
Oceanview
$775
Balcony
$874
Suite
$1,671
From
US$667
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$4,848
Oceanview
$5,381
Balcony
$8,000
Suite
$11,153
From
US$4,848
Save 5,050
Per Person
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Visit: Italy, Monaco, Spain, Gibraltar, Portugal
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,196
Suite
$6,427
From
US$4,196
Save 4,402
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise
 (1)

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,400
Suite
$14,300
From
US$8,400
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,514
Suite
$11,429
From
US$7,514
Save 135
Per Person
View Trip
18 Day Italy, Spain & Portugal Cruise: Florence, Nice & Seville with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 October 2027
Visit: Italy, Monaco, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$4,347
Oceanview
$5,006
Balcony
$6,287
Suite
$9,420
From
US$4,347
Save 92
Per Person
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Visit: Italy, Corsica, Spain, Morocco, Portugal
Wave Offer
Exclusive Savings
Inside
-
Oceanview
$7,346
Balcony
-
Suite
$10,494
From
US$7,346
Save 10,244
Per Person
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Visit: Italy, France, Spain, Portugal
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,430
Oceanview
$2,647
Balcony
$3,956
Suite
$5,440
From
US$2,430
Save 2,968
Per Person
View Trip
15 Day Rivieras, Minarets & More with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2026
Visit: Italy, France, Spain, Morocco, Portugal
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$5,173
Oceanview
-
Balcony
$6,340
Suite
$15,552
From
US$5,173
Save 5,425
Per Person
View Trip
22 Day Canals, Canaries & Colosseum with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 August 2027
Visit: Italy, Croatia, Greece, Sicily (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$6,317
Oceanview
$6,657
Balcony
$10,537
Suite
$14,805
From
US$6,317
Save 6,581
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain, Morocco, Portugal
Azamara Always Included
Exclusive Savings
Inside
$4,196
Oceanview
$4,924
Balcony
$5,816
Suite
$9,405
From
US$4,196
Save 83
Per Person
View Trip
11 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 22 November 2027
Visit: Italy, Spain, Morocco, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$4,880
Balcony
$5,440
Suite
$5,120
From
US$4,880
Save 1,220
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Lyra (+4 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Vela
Departures: Mar 2027 to Sep 2028
Visit: Italy, Croatia, Sicily, Monaco (+4 more), France, Spain, Morocco, Portugal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,697
Suite
$19,997
From
US$13,697
Save 700
Per Person
View Trip
15 Day Italy, French Riviera & Spain Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Visit: Italy, France, Gibraltar, Spain, Morocco, Portugal
Fare Saver
Inside
$2,554
Oceanview
$2,604
Balcony
$3,202
Suite
$4,133
From
US$2,554
Per Person
View Trip
13 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 21 November 2027
Visit: Italy, France, Spain, Morocco, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,580
Suite
$8,480
From
US$6,580
Save 2,820
Per Person
View Trip
40 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

40 Days (39 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 November 2027
Visit: Italy, Greece, Cyprus, Turkey (+6 more), Egypt, Sicily, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$9,991
Oceanview
$12,339
Balcony
$15,249
Suite
$22,233
From
US$9,991
Save 208
Per Person
View Trip
37 Day Ultimate Mediterranean: From Balkan Gems To Spain with Seabourn
Cruise

37 Days (36 Nights) Venice to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 09 October 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+7 more), Greece, Turkey, Malta, Sicily, Sardinia, Spain, Portugal
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,071
Suite
$37,232
From
US$23,071
Save 388
Per Person
View Trip
16 Day Italy, France & Spain Cruise: Rome, Barcelona & Seville with Azamara Cruises
Cruise
 (3)

16 Days (15 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 December 2027
Visit: Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$3,561
Oceanview
$4,454
Balcony
$5,608
Suite
$8,392
From
US$3,561
Save 68
Per Person
View Trip
21 Day Summer Splendor with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 June 2027
Visit: Italy, Sicily, Sardinia, Corsica (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$5,971
Oceanview
$6,456
Balcony
$10,190
Suite
$14,070
From
US$5,971
Save 6,227
Per Person
View Trip
11 Day Roman Holiday with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,741
Oceanview
$3,565
Balcony
$4,293
Suite
$6,233
From
US$2,741
Save 2,857
Per Person
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (2)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Visit: Italy, Sicily, Sardinia, Spain, Gibraltar, Portugal
Fare Saver
Inside
$2,299
Oceanview
$2,399
Balcony
$3,144
Suite
$4,164
From
US$2,299
Per Person
View Trip
21 Day Rome to Lisbon with Silversea
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Visit: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
$11,100
Balcony
$12,300
Suite
$20,300
From
US$11,100
Per Person
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia, Algeria, Spain, Portugal
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,958
Suite
$19,591
From
US$10,958
Save 18,632
Per Person
View Trip
11 Day Culinary Wonders with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 August 2027
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,743
Suite
$9,870
From
US$8,743
Save 15,055
Per Person
View Trip
15 Day Fusina (Venice) to Lisbon with Silversea
Cruise

15 Days (14 Nights) Venice to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 07 October 2026
Visit: Italy, Slovenia, Croatia, Sicily (+4 more), Malta, Sardinia, Spain, Portugal
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$7,910
Balcony
$9,170
Suite
$14,180
From
US$7,910
Save 3,390
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Libra (+8 more), Viking Lyra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Jan 2027 to Sep 2028
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,998
Suite
$9,398
From
US$5,998
Save 500
Per Person
View Trip
9 Day Journey of Cultural Gems & Golden Shores with Explora Journeys
Cruise

9 Days (8 Nights) Genoa to Lisbon
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 15 April 2027
Visit: Italy, France, Spain, Morocco, Portugal
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$6,495
Suite
$7,545
From
US$6,495
Per Person
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,722
Suite
$10,702
From
US$9,722
Save 15,476
Per Person
View Trip
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