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Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? November is the most popular month to cruise between Italy and Portugal and there are 37 departures available from twelve of the world's leading cruise lines.
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43 Days
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26 Cruises (37 Cruise Departures)
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Countries Visited: Italy, Malta, Sicily, Tunisia (+3 more), Sardinia, Spain, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$9,500
BALCONY
$10,200
SUITE
$16,800
From (per person) 9,500
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Countries Visited: Italy, Corsica, Spain, Morocco (+1 more), Portugal
2 for 1 Fares2 for 1 Fare + Fly Free Economy
INSIDE
-
OCEANVIEW
$8,663
BALCONY
-
SUITE
$11,876
Save (per person) 8,927
From (per person) 8,663
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Countries Visited: Italy, Monaco, Spain, Gibraltar (+1 more), Portugal
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,299
SUITE
$6,599
Save (per person) 4,299
From (per person) 4,299
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Algeria, Spain, Portugal
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$13,950
SUITE
$22,350
Save (per person) 15,640
From (per person) 13,950
View Trip
11 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 18 November 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$1,791
OCEANVIEW
$1,951
BALCONY
$2,350
SUITE
$3,000
From (per person) 1,791
View Trip
15 Day Rivieras, Minarets & More with Oceania Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2026
Countries Visited: Italy, France, Spain, Morocco (+1 more), Portugal
Exclusive Deal
INSIDE
$4,999
OCEANVIEW
$6,049
BALCONY
$7,099
SUITE
$10,299
Save (per person) 4,999
From (per person) 4,999
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Countries Visited: Italy, Spain, Morocco, Portugal
INSIDE
$3,849
OCEANVIEW
$4,419
BALCONY
$5,779
SUITE
$8,979
From (per person) 3,849
View Trip
43 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

43 Days (42 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 October 2026
Countries Visited: Italy, Greece, Turkey, Egypt (+7 more), Malta, Sicily, Monaco, France, Spain, Gibraltar, Portugal
INSIDE
$9,209
OCEANVIEW
$10,649
BALCONY
$13,099
SUITE
$17,199
From (per person) 9,209
View Trip
21 Day Dalmatian Coast, Italy & Spain Collectors' Voyage with Holland America
Cruise
 (2)

21 Days (20 Nights) Trieste to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 14 May 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+5 more), Sicily, Sardinia, Spain, Gibraltar, Portugal
Exclusive Deal
INSIDE
$3,559
OCEANVIEW
$3,959
BALCONY
$5,359
SUITE
$7,159
From (per person) 3,559
View Trip
13 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 01 November 2025
Countries Visited: Italy, Sicily, Spain, Morocco (+1 more), Portugal
INSIDE
$1,211
OCEANVIEW
-
BALCONY
$1,581
SUITE
$1,811
From (per person) 1,211
View Trip
21 Day Empires & Explorers with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Monaco, France, Spain, Portugal, Morocco
Exclusive Deal
INSIDE
$5,199
OCEANVIEW
$5,699
BALCONY
$9,199
SUITE
-
Save (per person) 5,199
From (per person) 5,199
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Venice to Lisbon
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira, Viking Neptune
Departures: Nov 2026 to Aug 2027
Countries Visited: Italy, Croatia, Sicily, Monaco (+4 more), France, Spain, Morocco, Portugal
Viking $1,299 Air DealViking $1,499 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,447
SUITE
$17,897
Save (per person) 1,300
From (per person) 12,447
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Countries Visited: Italy, Spain, Portugal
Escape To Sea
INSIDE
$730
OCEANVIEW
$850
BALCONY
$956
SUITE
$1,661
From (per person) 730
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (2)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Countries Visited: Italy, Sicily, Sardinia, Spain (+2 more), Gibraltar, Portugal
Exclusive Deal
INSIDE
$1,809
OCEANVIEW
$1,959
BALCONY
$2,659
SUITE
$3,709
From (per person) 1,809
View Trip
18 Day Italy, Spain & Portugal Cruise: Florence, Nice & Seville with Azamara Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 October 2027
Countries Visited: Italy, Monaco, France, Spain (+2 more), Gibraltar, Portugal
INSIDE
$4,969
OCEANVIEW
$5,709
BALCONY
$7,149
SUITE
$10,189
From (per person) 4,969
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (3)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain (+3 more), Gibraltar, Morocco, Portugal
Exclusive Deal
INSIDE
$4,999
OCEANVIEW
$5,499
BALCONY
$8,199
SUITE
$11,499
Save (per person) 4,999
From (per person) 4,999
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Countries Visited: Italy, France, Spain, Portugal
Exclusive Deal
INSIDE
$2,699
OCEANVIEW
$2,999
BALCONY
$4,499
SUITE
$6,199
Save (per person) 2,699
From (per person) 2,699
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Countries Visited: Italy, France, Spain, Gibraltar (+1 more), Portugal
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$8,799
SUITE
$10,499
Save (per person) 14,199
From (per person) 8,799
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Lisbon
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 13 May 2026
Countries Visited: Italy, France, Spain, Portugal
One Way Cruise Offer
INSIDE
-
OCEANVIEW
$629
BALCONY
-
SUITE
-
From (per person) 629
View Trip
10 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sky
Departure: 14 October 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$1,149
OCEANVIEW
$1,349
BALCONY
$2,569
SUITE
$5,369
From (per person) 1,149
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ships: Seabourn Encore, Seabourn Quest
Departures: Nov 2025 to Nov 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+1 more), Portugal
A Sail To Remember
INSIDE
-
OCEANVIEW
$4,844
BALCONY
$4,342
SUITE
$7,819
From (per person) 4,342
View Trip
17 Day Rome to Lisbon with Silversea
Cruise

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,400
From (per person) 9,400
View Trip
9 Day Journey of Cultural Gems & Golden Shores with Explora Journeys
Cruise

9 Days (8 Nights) Genoa to Lisbon
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 15 April 2027
Countries Visited: Italy, France, Spain, Morocco (+1 more), Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$6,160
SUITE
$7,515
From (per person) 6,160
View Trip
21 Day Rome to Lisbon with Silversea
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Gibraltar, Morocco, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$10,600
BALCONY
$12,000
SUITE
$16,200
From (per person) 10,600
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira, Viking Neptune
Departures: Nov 2026 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain (+2 more), Morocco, Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,948
SUITE
$8,998
Save (per person) 700
From (per person) 5,948
View Trip
13 Day Rome to Lisbon with Silversea
Cruise

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, Monaco, France, Spain (+1 more), Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,400
From (per person) 10,400
View Trip
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