Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to Portugal

Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? November is the most popular month to cruise between Italy and Portugal and there are 56 departures available from eleven of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
6 Days
40 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$400pp
$34,290pp
Countries
Show More...
Filter Results
28 Cruises (56 Cruise Departures)
11 Day Roman Holiday with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 27 November 2027
Visit: Italy, Corsica, France, Spain, Gibraltar, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,741
Oceanview
$3,565
Balcony
$4,293
Suite
$6,233
From
US$2,741
Save 2,857
Per Person
View Trip
37 Day Ultimate Mediterranean: From Balkan Gems To Spain with Seabourn
Cruise

37 Days (36 Nights) Venice to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 09 October 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+7 more), Greece, Turkey, Malta, Sicily, Sardinia, Spain, Portugal
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$30,951
Suite
$45,259
From
US$30,951
Save 548
Per Person
View Trip
15 Day Fusina (Venice) to Lisbon with Silversea
Cruise

15 Days (14 Nights) Venice to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 07 October 2026
Visit: Italy, Slovenia, Croatia, Sicily (+4 more), Malta, Sardinia, Spain, Portugal
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,920
Suite
-
From
US$10,920
Save 4,680
Per Person
View Trip
11 Day Culinary Wonders with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 August 2027
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,389
Suite
$12,516
From
US$11,389
Save 11,809
Per Person
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Visit: Italy, France, Spain, Portugal
Your World Inclusions
Exclusive Savings
Inside
$1,890
Oceanview
$2,100
Balcony
$3,083
Suite
$4,238
From
US$1,890
Save 3,508
Per Person
View Trip
16 Day Italy, France & Spain Cruise: Rome, Barcelona & Seville with Azamara Cruises
Cruise
 (3)

16 Days (15 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 December 2027
Visit: Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$3,561
Oceanview
$4,454
Balcony
$5,608
Suite
$8,392
From
US$3,561
Save 68
Per Person
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Visit: Italy, Sicily, Sardinia, Spain, Gibraltar, Portugal
Have It All Fare Option
Inside
$2,499
Oceanview
$2,499
Balcony
$3,095
Suite
$4,075
From
US$2,499
Per Person
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Visit: Italy, Monaco, Spain, Gibraltar, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,293
Suite
$6,669
From
US$4,293
Save 4,505
Per Person
View Trip
40 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

40 Days (39 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 November 2027
Visit: Italy, Greece, Cyprus, Turkey (+6 more), Egypt, Sicily, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$9,991
Oceanview
$12,339
Balcony
$15,249
Suite
$22,233
From
US$9,991
Save 208
Per Person
View Trip
13 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 21 November 2027
Visit: Italy, France, Spain, Morocco, Portugal
All-Inclusive Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,210
Suite
$10,210
From
US$7,210
Save 3,090
Per Person
View Trip
15 Day Italy, French Riviera & Spain Collectors' Voyage with Holland America
Cruise
 (3)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Visit: Italy, France, Gibraltar, Spain, Morocco, Portugal
Fare Saver
Inside
$2,464
Oceanview
$2,594
Balcony
$3,222
Suite
-
From
US$2,464
Per Person
View Trip
18 Day Italy, Spain & Portugal Cruise: Florence, Nice & Seville with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 October 2027
Visit: Italy, Monaco, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$10,894
Oceanview
$11,961
Balcony
$14,057
Suite
$15,221
From
US$10,894
Save 295
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,090
Oceanview
$5,381
Balcony
$8,534
Suite
$11,492
From
US$5,090
Save 5,308
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain, Morocco, Portugal
Azamara Always Included
Exclusive Savings
Inside
$4,623
Oceanview
$5,438
Balcony
$6,427
Suite
$10,424
From
US$4,623
Save 96
Per Person
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Visit: Italy, Corsica, Spain, Morocco, Portugal
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$7,540
Balcony
-
Suite
$10,688
From
US$7,540
Save 10,050
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise
 (1)

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,400
Suite
$14,300
From
US$8,400
Per Person
View Trip
11 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 22 November 2027
Visit: Italy, Spain, Morocco, Portugal
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,440
Balcony
$6,000
Suite
$5,520
From
US$5,440
Save 1,360
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visit: Italy, Corsica, Sardinia, Spain, Portugal
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
$7,617
Balcony
$9,033
Suite
$14,653
From
US$7,617
Save 137
Per Person
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visit: Italy, Sicily, Malta, Tunisia, Algeria, Spain, Portugal
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,177
Suite
$19,591
From
US$15,177
Save 19,113
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Lisbon
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 03 May 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Inside
$459
Oceanview
-
Balcony
$829
Suite
-
From
US$459
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Lyra (+4 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Vela
Departures: Mar 2027 to Sep 2028
Visit: Italy, Croatia, Sicily, Monaco (+4 more), France, Spain, Morocco, Portugal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,697
Suite
$20,497
From
US$13,697
Save 300
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$505
Oceanview
$655
Balcony
$835
Suite
$1,671
From
US$505
Per Person
View Trip
9 Day Journey of Cultural Gems & Golden Shores with Explora Journeys
Cruise

9 Days (8 Nights) Genoa to Lisbon
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 15 April 2027
Visit: Italy, France, Spain, Morocco, Portugal
Inside
-
Oceanview
-
Balcony
-
Suite
$6,115
From
US$6,115
Per Person
View Trip
22 Day Canals, Canaries & Colosseum with Oceania Cruises
Cruise
 (1)

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 August 2027
Visit: Italy, Croatia, Greece, Sicily (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$6,414
Oceanview
$6,754
Balcony
$10,634
Suite
$14,805
From
US$6,414
Save 6,684
Per Person
View Trip
21 Day Summer Splendor with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 June 2027
Visit: Italy, Sicily, Sardinia, Corsica (+5 more), France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$5,922
Oceanview
$6,456
Balcony
$10,433
Suite
$14,070
From
US$5,922
Save 6,176
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Libra (+8 more), Viking Lyra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Jan 2027 to Sep 2028
Visit: Italy, Monaco, France, Spain, Morocco, Portugal
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$5,998
Suite
$9,398
From
US$5,998
Save 600
Per Person
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Visit: Italy, France, Spain, Gibraltar, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,328
Suite
$15,210
From
US$14,328
Save 14,870
Per Person
View Trip
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Visit: Italy, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
All-Inclusive Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$8,640
Balcony
$9,270
Suite
$17,560
From
US$8,640
Save 960
Per Person
View Trip
Results: 28 results

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Albania Corsica Croatia Cyprus Egypt England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Slovenia Spain Tunisia Turkey USA

Cities

Cruises from Genoa Cruises from Rome Cruises from Venice

Routes

Cruises from Rome to Lisbon

Country Routes

Cruises from Italy to Portugal

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations