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Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? November is the most popular month to cruise between Italy and Portugal and there are 37 departures available from eleven of the world's leading cruise lines.
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26 Cruises (37 Cruise Departures)
10 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sky
Departure: 25 June 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$1,065
OCEANVIEW
$1,286
BALCONY
$2,116
SUITE
-
From (per person) 1,065
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Venice to Lisbon
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira, Viking Neptune
Departures: Nov 2026 to Aug 2027
Countries Visited: Italy, Croatia, Sicily, Monaco (+4 more), France, Spain, Morocco, Portugal
Viking $1,299 Air DealViking $1,499 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,897
SUITE
$17,497
Save (per person) 1,700
From (per person) 11,897
View Trip
11 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 18 November 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$1,860
OCEANVIEW
$2,010
BALCONY
$2,391
SUITE
$3,251
From (per person) 1,860
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Algeria, Spain, Portugal
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$29,590
SUITE
$46,390
From (per person) 29,590
View Trip
21 Day Empires & Explorers with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Monaco, France, Spain, Portugal, Morocco
Exclusive Deal
INSIDE
$5,199
OCEANVIEW
$6,299
BALCONY
$8,999
SUITE
$12,399
Save (per person) 5,199
From (per person) 5,199
View Trip
11 Day Invitation To Iberia with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 January 2027
Countries Visited: Italy, France, Spain, Portugal
Exclusive Deal
INSIDE
$2,699
OCEANVIEW
$2,999
BALCONY
$4,499
SUITE
$6,199
Save (per person) 2,699
From (per person) 2,699
View Trip
11 Day Western Mediterranean: Idyllic Isles & Hidden Gems with Holland America
Cruise
 (2)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Countries Visited: Italy, Sicily, Sardinia, Spain (+2 more), Gibraltar, Portugal
Exclusive Deal
INSIDE
$1,809
OCEANVIEW
$1,959
BALCONY
$2,659
SUITE
$3,709
From (per person) 1,809
View Trip
15 Day Rivieras, Minarets & More with Oceania Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 28 April 2026
Countries Visited: Italy, France, Spain, Morocco (+1 more), Portugal
Exclusive Deal
INSIDE
$4,999
OCEANVIEW
$6,049
BALCONY
$6,799
SUITE
$9,799
Save (per person) 4,999
From (per person) 4,999
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Countries Visited: Italy, Corsica, Spain, Morocco (+1 more), Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,663
BALCONY
-
SUITE
$11,876
Save (per person) 8,927
From (per person) 8,663
View Trip
13 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 01 November 2025
Countries Visited: Italy, Sicily, Spain, Morocco (+1 more), Portugal
INSIDE
$1,191
OCEANVIEW
$1,541
BALCONY
$1,631
SUITE
$1,891
From (per person) 1,191
View Trip
15 Day Italy, French Riviera & Spain Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Countries Visited: Italy, France, Gibraltar, Spain (+2 more), Morocco, Portugal
Exclusive Deal
INSIDE
$2,314
OCEANVIEW
$2,614
BALCONY
$3,364
SUITE
-
From (per person) 2,314
View Trip
21 Day Dalmatian Coast, Italy & Spain Collectors' Voyage with Holland America
Cruise
 (2)

21 Days (20 Nights) Trieste to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 14 May 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+5 more), Sicily, Sardinia, Spain, Gibraltar, Portugal
Exclusive Deal
INSIDE
$3,559
OCEANVIEW
$3,859
BALCONY
$5,259
SUITE
$7,059
From (per person) 3,559
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira, Viking Neptune
Departures: Nov 2026 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain (+2 more), Morocco, Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,798
SUITE
$8,998
Save (per person) 1,100
From (per person) 5,798
View Trip
11 Day Tuscan Summer with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 July 2026
Countries Visited: Italy, France, Spain, Gibraltar (+1 more), Portugal
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$8,799
SUITE
$10,499
Save (per person) 14,199
From (per person) 8,799
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Lisbon
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 13 May 2026
Countries Visited: Italy, France, Spain, Portugal
One Way Cruise Offer
INSIDE
$509
OCEANVIEW
$629
BALCONY
-
SUITE
-
From (per person) 509
View Trip
43 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (3)

43 Days (42 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 October 2026
Countries Visited: Italy, Greece, Turkey, Egypt (+7 more), Malta, Sicily, Monaco, France, Spain, Gibraltar, Portugal
INSIDE
$9,209
OCEANVIEW
$10,649
BALCONY
$13,099
SUITE
$17,199
From (per person) 9,209
View Trip
10 Day Caesars & Conquistadors with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 15 June 2027
Countries Visited: Italy, Monaco, Spain, Gibraltar (+1 more), Portugal
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,699
SUITE
$6,799
Save (per person) 4,699
From (per person) 4,699
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Countries Visited: Italy, Spain, Morocco, Portugal
INSIDE
$3,849
OCEANVIEW
$4,419
BALCONY
$5,779
SUITE
$8,979
From (per person) 3,849
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (3)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain (+3 more), Gibraltar, Morocco, Portugal
Exclusive Deal
INSIDE
$4,999
OCEANVIEW
$5,499
BALCONY
$8,199
SUITE
$11,499
Save (per person) 4,999
From (per person) 4,999
View Trip
13 Day Rome to Lisbon with Silversea
Cruise

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, Monaco, France, Spain (+1 more), Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,900
From (per person) 9,900
View Trip
21 Day Rome to Lisbon with Silversea
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Gibraltar, Morocco, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$10,000
BALCONY
$11,600
SUITE
$38,000
From (per person) 10,000
View Trip
10 Day Western Mediterranean From Rome To Lisbon with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Sky
Departure: 14 October 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$1,319
OCEANVIEW
$1,650
BALCONY
$2,839
SUITE
$5,769
From (per person) 1,319
View Trip
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Countries Visited: Italy, Malta, Sicily, Tunisia (+3 more), Sardinia, Spain, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$9,200
BALCONY
$9,900
SUITE
$14,200
From (per person) 9,200
View Trip
17 Day Rome to Lisbon with Silversea
Cruise

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,400
From (per person) 9,400
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ships: Seabourn Encore, Seabourn Quest
Departures: Nov 2025 to Nov 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+1 more), Portugal
A Sail To Remember
INSIDE
-
OCEANVIEW
$5,184
BALCONY
$3,654
SUITE
$7,904
From (per person) 3,654
View Trip
11 Day Rome to Lisbon with Silversea
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 17 May 2025
Countries Visited: Italy, France, Spain, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$9,600
BALCONY
$10,400
SUITE
$10,000
From (per person) 9,600
View Trip
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