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Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? October and November are the most popular months to cruise between Italy and Portugal and there are 61 departures available from thirteen of the world's leading cruise lines.
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35 Cruises (61 Departures)
35 Cruises (61 Departures)
Departures
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Duration
7 Days
40 Days
Start & End Cities
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Price
$700pp
$37,168pp
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13 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 21 November 2027
Visits: Italy, France, Spain, Morocco, Portugal
Exclusive Savings
Balcony
$6,300
Suite
$11,800
From (Per Person)
US$6,300
Save 4,200
Per Person
View Trip
40 Day Venice To Lisbon Grand Voyage with Azamara Cruises
Cruise
 (4)

40 Days (39 Nights) Venice to Lisbon
Cruise Line: Azamara
Ship: Azamara Journey
Departure: 10 November 2027
Visits: Italy, Greece, Cyprus, Turkey +6 more, Egypt, Sicily, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$10,867
Oceanview
$13,062
Balcony
$16,197
Suite
$23,721
From (Per Person)
US$10,867
Save 572
Per Person
View Trip
17 Day Rome to Lisbon with Silversea
Cruise
 (1)

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visits: Italy, Sicily, Tunisia, Sardinia +4 more, Spain, Gibraltar, Morocco, Portugal
Balcony
$8,600
Suite
$14,300
From (Per Person)
US$8,600
Per Person
View Trip
11 Day Spain Intensive Cruise: Palma, Malaga & Seville with Azamara Cruises
Cruise
 (5)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Azamara
Ship: Azamara Quest
Departure: 29 April 2028
Visits: Italy, Sardinia, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$2,317
Oceanview
$2,517
Balcony
$3,077
Suite
$4,331
From (Per Person)
US$2,317
Save 122
Per Person
View Trip
11 Day Roman Holiday with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania
Ship: Oceania Marina
Departure: 27 November 2027
Visits: Italy, Corsica, France, Spain, Gibraltar, Portugal
Your World Inclusions
Exclusive Savings
Inside
$2,949
Oceanview
$3,749
Balcony
$4,399
Suite
$6,399
From (Per Person)
US$2,949
Save 2,949
Per Person
View Trip
21 Day Summer Splendor with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania
Ship: Oceania Nautica
Departure: 27 June 2027
Visits: Italy, Sicily, Sardinia, Corsica +5 more, France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Exclusive Savings
Inside
$6,349
Oceanview
$6,649
Balcony
$11,049
Suite
$14,599
From (Per Person)
US$6,349
Save 6,349
Per Person
View Trip
20 Day Mediterranean Isles Legacy with Oceania Cruises
Cruise
 (1)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania
Ship: Oceania Sirena
Departure: 02 December 2026
Visits: Italy, Corsica, France, Spain, Gibraltar, Morocco, Portugal
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,999
Suite
$17,949
From (Per Person)
US$8,999
Save 8,999
Per Person
View Trip
12 Day Mediterranean Rivieras with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 27 October 2026
Visits: Italy, Corsica, Spain, Morocco, Portugal
Exclusive Savings
Oceanview
$8,790
Suite
$11,711
From (Per Person)
US$8,790
Save 855
Per Person
View Trip
16 Day Italy, France & Spain Cruise: Rome, Barcelona & Seville with Azamara Cruises
Cruise
 (4)

16 Days (15 Nights) Rome to Lisbon
Cruise Line: Azamara
Ship: Azamara Journey
Departure: 04 December 2027
Visits: Italy, France, Spain, Gibraltar, Portugal
Azamara Always Included
Exclusive Savings
Inside
$3,581
Oceanview
$4,464
Balcony
$5,595
Suite
$8,321
From (Per Person)
US$3,581
Save 188
Per Person
View Trip
10 Day Spain's Southern Coast & Riviera Gems with Seabourn
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 01 November 2026
Visits: Italy, Corsica, Sardinia, Spain, Portugal
Bonus Onboard Credit
Oceanview
$7,398
Balcony
$9,903
Suite
-
From (Per Person)
US$7,398
Per Person
View Trip
10 Day Western Mediterranean Cruise From Rome To Lisbon with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 23 October 2027
Visits: Italy, France, Spain, Portugal
Inside
$1,959
Oceanview
$2,489
Balcony
$2,949
Suite
$3,709
From (Per Person)
US$1,959
Per Person
View Trip
18 Day Mediterranean & Iberian New Year Cruise: Italy, Spain & Morocco with Azamara Cruises
Cruise
 (8)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara
Ship: Azamara Onward
Departure: 22 December 2026
Visits: Italy, Spain, Morocco, Portugal
Azamara Always Included
Inside
-
Oceanview
$6,009
Balcony
$6,809
Suite
$11,249
From (Per Person)
US$6,009
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visits: Italy, Spain, Portugal
Inside
$741
Oceanview
$791
Balcony
$901
Suite
$1,681
From (Per Person)
US$741
Per Person
View Trip
22 Day A Journey Across The Mediterranean’s Edge & Into The Atlantic with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Rome to Lisbon
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 February 2027
Visits: Italy, Sicily, Tunisia, Algeria, Spain, Morocco, Portugal
Suite
$11,510
From (Per Person)
US$11,510
Per Person
View Trip
17 Day Riviera Yacht Harbors Of France & Spain with Seabourn
Cruise

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 11 November 2028
Visits: Italy, Monaco, France, Spain, Morocco, Portugal
Bonus Onboard Credit
Balcony
$11,598
Suite
$18,898
From (Per Person)
US$11,598
Per Person
View Trip
18 Day Civitavecchia to Lisbon with Crystal Cruises
New ReleaseCruise

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Crystal
Ship: Crystal Symphony
Departure: 01 October 2027
Visits: Italy, Sicily, Malta, Tunisia +4 more, Monaco, Corsica, Spain, Portugal
Exclusive Savings
Oceanview
$7,624
Balcony
$10,477
Suite
$11,152
From (Per Person)
US$7,624
Save 2,576
Per Person
View Trip
11 Day Civitavecchia (Rome) to Lisbon with Silversea
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 22 November 2027
Visits: Italy, Spain, Morocco, Portugal
Exclusive Savings
Oceanview
$4,920
Balcony
$5,700
Suite
$5,220
From (Per Person)
US$4,920
Save 3,280
Per Person
View Trip
17 Day Traversing 'The Med': A Mediterranean Feast with Aurora Expeditions
New ReleaseCruise

17 Days (16 Nights) Naples to Lisbon
Cruise Line: Aurora Expeditions
Ship: Douglas Mawson
Departure: 28 September 2026
Visits: Italy, Sardinia, Corsica, France, Spain, Morocco, Portugal
Oceanview
$16,595
Balcony
$17,495
Suite
-
From (Per Person)
US$16,595
Per Person
View Trip
8 Day Bolero Breeze with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 November 2028
Visits: Italy, Spain, Portugal
Exclusive Savings
Balcony
$5,799
Suite
$6,949
From (Per Person)
US$5,799
Save 10,799
Per Person
View Trip
18 Day Dalmation Soul & Andalusia with Oceania Cruises
Cruise

18 Days (17 Nights) Trieste to Lisbon
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 20 July 2028
Visits: Italy, Croatia, Montenegro, Greece +4 more, Sicily, France, Spain, Portugal
Your World Inclusions
Exclusive Savings
Balcony
$7,599
Suite
$12,099
From (Per Person)
US$7,599
Save 7,599
Per Person
View Trip
15 Day Spain, Portugal & the Mediterranean with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Viking
Ships: Viking Jupiter, Viking Libra +8 more, Viking Lyra, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela
Departures: Jan 2027 to Sep 2028
Visits: Italy, Monaco, France, Spain, Morocco, Portugal
Exclusive Savings
Balcony
$6,098
Suite
$9,098
From (Per Person)
US$6,098
Save 900
Per Person
View Trip
24 Day Exploring Dalmatian Gems, France & Spain with Seabourn
Cruise

24 Days (23 Nights) Venice to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 04 November 2028
Visits: Italy, Croatia, Malta, Monaco +4 more, France, Spain, Morocco, Portugal
Bonus Onboard Credit
Balcony
$17,398
Suite
$27,898
From (Per Person)
US$17,398
Per Person
View Trip
15 Day Rome to Lisbon with Silversea
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Visits: Italy, Malta, Sicily, Tunisia, Sardinia, Spain, Portugal
Oceanview
$5,150
Balcony
$6,350
Suite
$15,900
From (Per Person)
US$5,150
Per Person
View Trip
12 Day Treasures of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 May 2027
Visits: Italy, Sicily, Malta, Tunisia, Algeria, Spain, Portugal
Exclusive Savings
Balcony
$14,636
Suite
$20,081
From (Per Person)
US$14,636
Save 3,124
Per Person
View Trip
15 Day Fusina (Venice) to Lisbon with Silversea
Cruise

15 Days (14 Nights) Venice to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 07 October 2026
Visits: Italy, Slovenia, Croatia, Sicily +4 more, Malta, Sardinia, Spain, Portugal
Exclusive Savings
Oceanview
$11,200
Balcony
$11,830
Suite
-
From (Per Person)
US$11,200
Save 4,800
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Lisbon
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 27 May 2027
Visits: Italy, France, Spain, Portugal
Inside
-
Oceanview
-
Balcony
-
Suite
$1,329
From (Per Person)
US$1,329
Per Person
View Trip
9 Day Journey of Cultural Gems & Golden Shores with Explora Journeys
Cruise

9 Days (8 Nights) Genoa to Lisbon
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 15 April 2027
Visits: Italy, France, Spain, Morocco, Portugal
Suite
$6,440
From (Per Person)
US$6,440
Per Person
View Trip
11 Day Italian & Spanish Treasures with Oceania Cruises
Cruise

11 Days (10 Nights) Amalfi to Lisbon
Cruise Line: Oceania
Ship: Oceania Allura
Departure: 27 July 2028
Visits: Italy, France, Spain, Portugal
Your World Inclusions
Exclusive Savings
Balcony
$4,699
Suite
$7,549
From (Per Person)
US$4,699
Save 4,699
Per Person
View Trip
11 Day Renaissance To Algarve Sun with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Oceania
Ship: Oceania Sonata
Departure: 08 April 2028
Visits: Italy, France, Spain, Gibraltar, Portugal
Your World Inclusions
Exclusive Savings
Balcony
$5,699
Suite
$7,699
From (Per Person)
US$5,699
Save 5,699
Per Person
View Trip
22 Day Adriatic & Mediterranean Discovery with Viking Cruises
Cruise

22 Days (21 Nights) Venice to Lisbon
Cruise Line: Viking
Ships: Viking Jupiter, Viking Lyra +4 more, Viking Mira, Viking Neptune, Viking Saturn, Viking Vela
Departures: Mar 2027 to Sep 2028
Visits: Italy, Croatia, Sicily, Monaco +4 more, France, Spain, Morocco, Portugal
Exclusive Savings
Balcony
$13,697
Suite
$21,197
From (Per Person)
US$13,697
Save 700
Per Person
View Trip
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