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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 310 departures available from seventeen of the world's leading cruise lines.
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152 Cruises (310 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: Jun 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,999
Suite
$9,499
From
US$6,999
Save 1,000
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,164
Oceanview
$1,454
Balcony
$1,609
Suite
$1,759
From
US$1,164
Per Person
View Trip
8 Day Etruscan Waterways with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 21 April 2026
Visit: Spain, France, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$2,735
Oceanview
-
Balcony
$3,657
Suite
-
From
US$2,735
Save 2,863
Per Person
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (8)

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Mar 2026 to Jul 2028
Visit: Spain, France, Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,398
Suite
$10,198
From
US$7,398
Save 1,400
Per Person
View Trip
10 Day Epicurean Odyssey with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 27 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,499
Oceanview
$2,693
Balcony
$4,196
Suite
$6,136
From
US$2,499
Save 2,499
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 02 August 2027
Visit: Spain, France, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,030
Oceanview
$1,290
Balcony
$1,560
Suite
$2,250
From
US$1,030
Save 521
Per Person
View Trip
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
With Love From the World
Inside
$1,881
Oceanview
$2,151
Balcony
$2,331
Suite
$5,535
From
US$1,881
Per Person
View Trip
11 Day Croissants & Cannoli with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$2,937
Oceanview
$3,180
Balcony
$4,877
Suite
$6,914
From
US$2,937
Save 3,061
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (4)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$4,807
Oceanview
$5,311
Balcony
-
Suite
-
From
US$4,807
Save 122
Per Person
View Trip
15 Day Southern Mediterranean Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 07 December 2026
Visit: Spain, France, Italy, Sicily, Tunisia, Malta
Exclusive Savings
Inside
-
Oceanview
$6,200
Balcony
$7,082
Suite
$8,013
From
US$6,200
Save 13,398
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 12 April 2026
Visit: Spain, Morocco, Italy
Bonus Onboard Credit
Inside
-
Oceanview
$895
Balcony
$1,175
Suite
-
From
US$895
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence & Dubrovnik with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 September 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia
Azamara Always Included
Exclusive Savings
Inside
$3,480
Oceanview
$3,868
Balcony
$4,761
Suite
$7,157
From
US$3,480
Save 79
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 10 April 2027
Visit: Spain, France, Italy
Bonus Onboard Credit
Inside
$949
Oceanview
$1,129
Balcony
-
Suite
$1,719
From
US$949
Per Person
View Trip
22 Day Greece, Turkey, Italy And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey (+4 more), Italy, Malta, Montenegro, Croatia
Inside
$3,519
Oceanview
$3,969
Balcony
$4,559
Suite
$9,068
From
US$3,519
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 19 May 2026
Visit: Spain, France, Monaco, Italy
Last Minute Fare
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$6,950
Suite
$11,120
From
US$6,950
Per Person
View Trip
13 Day Total Eclipse of the (Med) with Virgin Voyages
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 10 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
With Love From the World
Inside
$3,228
Oceanview
$3,468
Balcony
$3,588
Suite
$7,188
From
US$3,228
Per Person
View Trip
8 Day Italy And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Inside
$1,589
Oceanview
$1,439
Balcony
$1,549
Suite
$3,079
From
US$1,439
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 21 June 2027
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,016
Oceanview
$1,275
Balcony
$1,545
Suite
$2,325
From
US$1,016
Save 520
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy, Greece, Montenegro, Croatia
Inside
$2,369
Oceanview
$2,499
Balcony
$4,149
Suite
$6,163
From
US$2,369
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 04 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$2,452
Oceanview
$2,985
Balcony
$3,189
Suite
$4,644
From
US$2,452
Save 67
Per Person
View Trip
8 Day Cultures & Cuisines with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,071
Suite
$7,365
From
US$7,071
Save 12,327
Per Person
View Trip
8 Day Mediterranean with Total Solar Eclipse with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Visit: Spain, Gibraltar, Italy
Princess Standard
Sanctuary Collection
Inside
$2,284
Oceanview
$3,044
Balcony
$3,591
Suite
$4,498
From
US$2,284
Per Person
View Trip
12 Day A Journey Of Creative Spirit & Enchanting Canals with Explora Journeys
Cruise

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 02 April 2026
Visit: Spain, Italy, Malta, Sicily, Greece, Montenegro, Croatia
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$6,935
Suite
$7,835
From
US$6,935
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,672
Oceanview
$4,293
Balcony
$4,924
Suite
$7,669
From
US$3,672
Save 87
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 September 2027
Visit: Spain, France, Italy, Corsica
Princess Standard
Sanctuary Collection
Inside
$1,144
Oceanview
$1,494
Balcony
$1,689
Suite
$2,069
From
US$1,144
Per Person
View Trip
10 Day Romantic Locales & Canals with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,740
Oceanview
$2,982
Balcony
$4,583
Suite
$6,426
From
US$2,740
Save 2,858
Per Person
View Trip
8 Day Regal Retreat with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 June 2027
Visit: Spain, France, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,993
Suite
$6,777
From
US$5,993
Save 11,205
Per Person
View Trip
8 Day Malta, Croatia And Montenegro with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy
Inside
$949
Oceanview
$1,049
Balcony
$1,199
Suite
$2,979
From
US$949
Per Person
View Trip
8 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 13 April 2026
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
-
Balcony
$995
Suite
-
From
US$995
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Barcelona to Trieste
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$641
Oceanview
$741
Balcony
$821
Suite
$1,271
From
US$641
Per Person
View Trip
Results: 1-30 of 152

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