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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? August is the most popular month to cruise between Spain and Italy and there are 218 departures available from sixteen of the world's leading cruise lines.
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115 Cruises (218 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2024 to Aug 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,667
OCEANVIEW
$1,815
BALCONY
$1,982
SUITE
$2,667
From 1,667
View Trip
21 Day Western Mediterranean & Adriatic Explorer with Princess
Cruise
 (2)

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy (+5 more), Sicily, Malta, Greece, Montenegro, Croatia
INSIDE
$5,051
OCEANVIEW
$5,259
BALCONY
$6,899
SUITE
$7,643
From 5,051
View Trip
11 Day Marvelous Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Corsica
Exclusive Deal
INSIDE
-
OCEANVIEW
$9,774
BALCONY
-
SUITE
-
Save 2,086
From 9,774
View Trip
11 Day Radiant Spain & Italy with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 03 August 2024
Countries Visited: Spain, France, Monaco, Italy
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,359
SUITE
-
Save 2,071
From 8,359
View Trip
23 Day Jet Set Journey with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 03 August 2024
Countries Visited: Spain, France, Monaco, Italy (+3 more), Sicily, Malta, Greece
Exclusive Deal
INSIDE
$11,836
OCEANVIEW
$13,668
BALCONY
$15,806
SUITE
-
Save 2,094
From 11,836
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$8,010
Save 2,031
From 4,129
View Trip
11 Day French, Spanish & Italian Rivieras with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
-
OCEANVIEW
$2,919
BALCONY
$3,907
SUITE
$4,065
From 2,919
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,807
OCEANVIEW
$10,569
BALCONY
$15,608
SUITE
$21,152
Save 2,073
From 9,807
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
INSIDE
$1,375
OCEANVIEW
-
BALCONY
$1,631
SUITE
$2,147
From 1,375
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,090
OCEANVIEW
$6,552
BALCONY
$7,241
SUITE
$9,540
From 6,090
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
24 Day Mediterranean Tapestry & Empires with Holland America
Cruise
 (1)

24 Days (23 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 June 2024
Countries Visited: Spain, France, Italy, Sicily (+6 more), Malta, Tunisia, Greece, Turkey, Albania, Croatia
Have It All Offer
INSIDE
$7,573
OCEANVIEW
$7,781
BALCONY
$9,533
SUITE
-
From 7,573
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Greece (+2 more), Croatia, Montenegro
Have It All Offer
INSIDE
$3,941
OCEANVIEW
$4,139
BALCONY
$5,278
SUITE
$7,159
From 3,941
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,216
OCEANVIEW
$3,678
BALCONY
$4,368
SUITE
$6,091
From 3,216
View Trip
9 Day Mediterranean Marvels & Matches: Monte Carlo Masters with Seabourn
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Venture
Departure: 05 April 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,403
SUITE
$25,055
From 10,403
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$2,641
OCEANVIEW
$2,711
BALCONY
$2,971
SUITE
$6,785
From 2,641
View Trip
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,618
SUITE
$9,261
From 11,425
View Trip
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 17 August 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$1,850
OCEANVIEW
$2,031
BALCONY
$2,278
SUITE
$5,677
Save 2,330
From 1,850
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$384
OCEANVIEW
$463
BALCONY
$542
SUITE
$958
From 384
View Trip
11 Day Blooming Mediterranean with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 08 May 2025
Countries Visited: Spain, Tunisia, Malta, Greece (+2 more), Sicily, Italy
Exclusive Deal
INSIDE
$5,488
OCEANVIEW
$6,557
BALCONY
$7,626
SUITE
$10,765
Save 2,042
From 5,488
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ships: MSC Magnifica, MSC Splendida
Departures: May 2024 to Nov 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$601
BALCONY
$691
SUITE
$965
From 601
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$614
BALCONY
$742
SUITE
$1,267
From 614
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sicily
INSIDE
$2,726
OCEANVIEW
$2,974
BALCONY
$3,370
SUITE
$7,231
From 2,726
View Trip
11 Day Europe - Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Dawn
Departure: 07 October 2024
Countries Visited: Spain, France, Italy, Sicily (+4 more), Greece, Montenegro, Slovenia, Croatia
Free At Sea Offer
INSIDE
$3,326
OCEANVIEW
$3,675
BALCONY
$4,769
SUITE
$5,148
From 3,326
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Offer
INSIDE
$2,777
OCEANVIEW
$3,151
BALCONY
$3,496
SUITE
$9,486
Save 3,517
From 2,777
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$530
OCEANVIEW
$659
BALCONY
$758
SUITE
$1,104
From 530
View Trip
8 Day A Journey From Tarragona To Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 September 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,994
SUITE
$9,261
From 9,969
View Trip
8 Day A Journey Of Riviera Reveries And Italian Icons with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 26 August 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,994
SUITE
$9,261
From 13,964
View Trip
13 Day Vita Est Bona with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 24 August 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Sardinia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$9,523
SUITE
$10,140
Save 10,557
From 9,523
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 29 April 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
$717
OCEANVIEW
$855
BALCONY
$1,004
SUITE
$1,330
From 717
View Trip
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