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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 307 departures available from seventeen of the world's leading cruise lines.
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146 Cruises (307 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: Jun 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,999
Suite
$9,999
From
US$6,999
Save 1,000
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 May 2026
Visit: Spain, France, Italy, Corsica, Sicily
Inside
$2,639
Oceanview
$2,969
Balcony
$4,239
Suite
$5,866
From
US$2,639
Per Person
View Trip
11 Day Springtime Sunshine with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 April 2028
Visit: Spain, Sardinia, Corsica, France, Monaco, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,196
Suite
$6,718
From
US$4,196
Save 4,402
Per Person
View Trip
15 Day Mediterranean Odyssey: Spain, Italy and the French Riviera with Scenic
New ReleaseCruise

15 Days (14 Nights) Malaga to Rome
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 21 April 2027
Visit: Spain, France, Monaco, Italy, Corsica
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,564
Suite
$24,488
From
US$15,564
Save 19,426
Per Person
View Trip
15 Day Maritime Memories In The Med with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 January 2028
Visit: Spain, Morocco, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,398
Suite
$7,696
From
US$4,398
Save 4,600
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 May 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$1,429
Oceanview
$1,619
Balcony
$1,779
Suite
$3,009
From
US$1,429
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 25 April 2026
Visit: Spain, Italy
Inside
$333
Oceanview
$413
Balcony
$563
Suite
-
From
US$333
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Apr 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Princess Premier
Exclusive Savings
Inside
$1,244
Oceanview
$1,644
Balcony
$1,889
Suite
$2,084
From
US$1,244
Save 175
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 20 August 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
Bonus Onboard Credit
Inside
$2,019
Oceanview
$2,219
Balcony
$2,449
Suite
$5,079
From
US$2,019
Per Person
View Trip
13 Day French & Italian Treasures with Oceania Cruises
Cruise
 (3)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 30 September 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily, Malta
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,436
Oceanview
$3,713
Balcony
$6,246
Suite
$8,044
From
US$3,436
Save 3,962
Per Person
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Sep 2026
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,106
Oceanview
$2,347
Balcony
$2,304
Suite
$7,331
From
US$2,106
Save 1,773
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Inside
$2,499
Oceanview
$2,699
Balcony
$3,169
Suite
$5,299
From
US$2,499
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Barcelona to Trieste
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$464
Oceanview
$564
Balcony
$644
Suite
$1,094
From
US$464
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Sep 2027
Visit: Spain, France, Italy, Sicily
Inside
$919
Oceanview
$1,659
Balcony
$1,329
Suite
$1,469
From
US$919
Per Person
View Trip
11 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2027 to Aug 2027
Visit: Spain, Morocco, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,122
Oceanview
$2,384
Balcony
$2,609
Suite
$8,481
From
US$2,122
Save 1,535
Per Person
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Inside
$2,129
Oceanview
$2,484
Balcony
$2,959
Suite
$4,870
From
US$2,129
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,204
Oceanview
$1,354
Balcony
$1,579
Suite
$1,794
From
US$1,204
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 25 April 2026
Visit: Spain, France, Corsica, Italy
Princess Premier
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,734
From
US$3,734
Save 67
Per Person
View Trip
11 Day Greek Isles & Malta Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ships: Celebrity Equinox
Departures: Apr 2026 to Oct 2027
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,162
Oceanview
$2,386
Balcony
$2,516
Suite
$4,521
From
US$2,162
Save 1,605
Per Person
View Trip
22 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy, Croatia
Inside
$3,899
Oceanview
$4,249
Balcony
$5,449
Suite
$11,543
From
US$3,899
Per Person
View Trip
12 Day Around Italy's Boot: Italy, Dalmatia & Venice with Holland America
Cruise
 (3)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 September 2026
Visit: Spain, France, Italy, Sicily, Greece, Croatia, Montenegro
Fare Saver
Exclusive Savings
Inside
$3,234
Oceanview
-
Balcony
-
Suite
-
From
US$3,234
Save 55
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Barcelona to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$461
Oceanview
$541
Balcony
$671
Suite
$1,121
From
US$461
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 04 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$2,452
Oceanview
$2,985
Balcony
$3,189
Suite
$4,644
From
US$2,452
Save 67
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (4)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$5,282
Oceanview
$5,311
Balcony
-
Suite
-
From
US$5,282
Save 137
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,339
Oceanview
$1,887
Balcony
$1,887
Suite
$2,071
From
US$1,339
Per Person
View Trip
8 Day Spain, France & Italy with Seabourn
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 25 September 2027
Visit: Spain, France, Corsica, Sardinia, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,678
Suite
$9,427
From
US$5,678
Save 101
Per Person
View Trip
10 Day Ramblas & The Rivieras with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 September 2026
Visit: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,361
Suite
-
From
US$5,361
Save 5,637
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,164
Oceanview
$1,484
Balcony
$1,659
Suite
$1,764
From
US$1,164
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 June 2027
Visit: Spain, Corsica, Italy
Bonus Onboard Credit
Inside
$1,189
Oceanview
$1,319
Balcony
$1,369
Suite
$2,879
From
US$1,189
Per Person
View Trip
8 Day Italy & Croatia Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 08 May 2027
Visit: Spain, Italy, Croatia
Bonus Onboard Credit
Exclusive Savings
Inside
$1,090
Oceanview
$1,233
Balcony
$1,603
Suite
$2,251
From
US$1,090
Save 541
Per Person
View Trip
Results: 1-30 of 146

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