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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 323 departures available from eighteen of the world's leading cruise lines.
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166 Cruises (323 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: Sep 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,399
Suite
$8,999
From
US$6,399
Save 1,000
Per Person
View Trip
11 Day Canary Islands with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Las Palmas de Gran Canaria to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 02 April 2027
Visit: Spain, Morocco, Italy
Inside
$1,167
Oceanview
$1,267
Balcony
$1,397
Suite
$2,239
From
US$1,167
Per Person
View Trip
8 Day Spain, France & Italy Cruise: Palamos, Marseille & Rome with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 08 April 2028
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Inside
$1,609
Oceanview
$1,739
Balcony
$2,149
Suite
$3,019
From
US$1,609
Per Person
View Trip
11 Day Italy, Montenegro & Croatia Cruise: Rome, Kotor & Dubrovnik with Azamara Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 31 October 2027
Visit: Spain, Italy, Sicily, Montenegro, Croatia
Azamara Always Included
Inside
$3,989
Oceanview
$4,859
Balcony
$5,999
Suite
$8,759
From
US$3,989
Per Person
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 15 August 2026
Visit: Spain, Sicily, Greece, Turkey, Italy
Exclusive Savings
Inside
$1,745
Oceanview
$1,852
Balcony
$2,012
Suite
$3,679
From
US$1,745
Save 1,029
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Amalfi & Venice with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 24 April 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Inside
$3,079
Oceanview
$3,579
Balcony
$4,549
Suite
$6,969
From
US$3,079
Per Person
View Trip
19 Day An Extended Journey From A Riviera New Year To The Mediterranean’s Deep Soul with Explora Journeys
Cruise
 (1)

19 Days (18 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 28 December 2026
Visit: Spain, France, Italy, Sicily, Malta, Tunisia
Inside
-
Oceanview
-
Balcony
-
Suite
$9,715
From
US$9,715
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily, Italy
Inside
$799
Oceanview
$899
Balcony
$1,199
Suite
$2,359
From
US$799
Per Person
View Trip
9 Day France, Monaco & Italy Cruise: Cannes, Monte Carlo & Portofino with Azamara Cruises
Cruise
 (3)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 September 2028
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Inside
$2,019
Oceanview
$2,189
Balcony
$2,699
Suite
$3,809
From
US$2,019
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,209
Oceanview
$1,559
Balcony
$1,959
Suite
$2,209
From
US$1,209
Per Person
View Trip
8 Day Canary Islands with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 05 April 2027
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
$727
Balcony
$1,064
Suite
-
From
US$727
Per Person
View Trip
8 Day Spain, France & Italy Cruise: Barcelona, Nice & Portovenere with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 02 June 2028
Visit: Spain, France, Italy
Azamara Always Included
Inside
$2,049
Oceanview
$2,329
Balcony
$2,729
Suite
$4,129
From
US$2,049
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 03 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,236
Oceanview
$1,340
Balcony
$1,688
Suite
$2,389
From
US$1,236
Save 656
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Inside
$2,809
Oceanview
$2,869
Balcony
$4,329
Suite
$5,469
From
US$2,809
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia, Corsica, Sicily
Inside
$1,499
Oceanview
$1,699
Balcony
$1,999
Suite
-
From
US$1,499
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 04 August 2028
Visit: Spain, France, Corsica, Italy, Malta, Montenegro, Croatia
Cunard Fare
Value Fare
Inside
$2,969
Oceanview
$3,329
Balcony
$3,914
Suite
$7,379
From
US$2,969
Per Person
View Trip
8 Day Italy And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Inside
$1,329
Oceanview
$1,449
Balcony
$1,629
Suite
$2,649
From
US$1,329
Per Person
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (3)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 June 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Book Early & Have It All Fare Option
Inside
$2,584
Oceanview
$2,964
Balcony
$3,454
Suite
$5,524
From
US$2,584
Per Person
View Trip
9 Day Canary Islands with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 04 April 2027
Visit: Spain, Morocco, Italy
Inside
$928
Oceanview
$1,061
Balcony
$1,061
Suite
$1,651
From
US$928
Per Person
View Trip
8 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Visit: Spain, France, Italy
Azamara Always Included
Inside
$1,619
Oceanview
$1,679
Balcony
$1,609
Suite
$2,669
From
US$1,609
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 04 August 2028
Visit: Spain, France, Corsica, Italy
Cunard Fare
Value Fare
Inside
$1,629
Oceanview
$1,764
Balcony
$2,124
Suite
$4,149
From
US$1,629
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2027 to Sep 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,239
Oceanview
-
Balcony
$1,629
Suite
$1,819
From
US$1,239
Per Person
View Trip
13 Day Dalmatian Diversion with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 03 October 2027
Visit: Spain, France, Monaco, Italy, Corsica, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,349
Oceanview
$3,549
Balcony
$6,449
Suite
$8,349
From
US$3,349
Save 3,349
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 10 September 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
Bonus Onboard Credit
Value Fare
Inside
$2,219
Oceanview
$2,389
Balcony
$2,609
Suite
$5,999
From
US$2,219
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Value Fare
Inside
$2,399
Oceanview
$2,699
Balcony
$2,859
Suite
$6,119
From
US$2,399
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2027 to Aug 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,079
Oceanview
$1,279
Balcony
$1,559
Suite
$1,869
From
US$1,079
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2027
Visit: Spain, France, Italy, Sicily
Inside
$619
Oceanview
$1,679
Balcony
$1,019
Suite
$1,349
From
US$619
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$999
Oceanview
$1,369
Balcony
$1,579
Suite
$1,749
From
US$999
Per Person
View Trip
15 Day Italy And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro, Croatia, Malta
Inside
$1,299
Oceanview
-
Balcony
-
Suite
$3,549
From
US$1,299
Per Person
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Feb 2027 to Jul 2028
Visit: Spain, France, Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,998
Suite
$9,498
From
US$6,998
Save 1,700
Per Person
View Trip
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