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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 339 departures available from seventeen of the world's leading cruise lines.
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168 Cruises (339 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: May 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,799
Suite
$9,499
From
US$6,799
Save 1,000
Per Person
View Trip
8 Day Cultures & Cuisines with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,499
Suite
$9,799
From
US$9,499
Save 9,499
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 26 April 2026
Visit: Spain, Malta, Greece, Montenegro, Croatia, Italy
Inside
$709
Oceanview
$989
Balcony
$1,479
Suite
$3,829
From
US$709
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily, Italy
Inside
$1,169
Oceanview
$1,169
Balcony
$1,349
Suite
$6,159
From
US$1,169
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2027
Visit: Spain, France, Italy, Sicily
Inside
$569
Oceanview
$1,219
Balcony
$799
Suite
$1,019
From
US$569
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia, Corsica, Sicily
Inside
$2,309
Oceanview
$2,389
Balcony
$2,709
Suite
$4,689
From
US$2,309
Per Person
View Trip
8 Day Italy And Adriatic with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro
Inside
$1,249
Oceanview
$1,399
Balcony
$1,629
Suite
$3,009
From
US$1,249
Per Person
View Trip
11 Day Canary Islands with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Las Palmas de Gran Canaria to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 02 April 2027
Visit: Spain, Morocco, Italy
Inside
$1,167
Oceanview
$1,327
Balcony
$1,437
Suite
$2,239
From
US$1,167
Per Person
View Trip
9 Day Canary Islands with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 04 April 2027
Visit: Spain, Morocco, Italy
Inside
$869
Oceanview
$1,029
Balcony
$1,061
Suite
$1,651
From
US$869
Per Person
View Trip
11 Day Italy, Montenegro & Croatia Cruise: Rome, Kotor & Dubrovnik with Azamara Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 31 October 2027
Visit: Spain, Italy, Sicily, Montenegro, Croatia
Azamara Always Included
Inside
$2,809
Oceanview
$3,419
Balcony
$4,219
Suite
$6,149
From
US$2,809
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 25 April 2026
Visit: Spain, Italy
Inside
-
Oceanview
-
Balcony
$505
Suite
$955
From
US$505
Per Person
View Trip
11 Day Spain, Portugal & France Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 24 July 2027
Visit: Spain, Gibraltar, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,324
Oceanview
$2,610
Balcony
$2,718
Suite
$6,869
From
US$2,324
Save 1,376
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 May 2026
Visit: Spain, France, Italy, Corsica, Sicily
Inside
$1,659
Oceanview
$1,709
Balcony
$2,109
Suite
$5,369
From
US$1,659
Per Person
View Trip
10 Day Italian Interlude with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 March 2028
Visit: Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,599
Oceanview
$2,849
Balcony
$4,399
Suite
$6,299
From
US$2,599
Save 2,599
Per Person
View Trip
13 Day Total Eclipse of the (Med) with Virgin Voyages
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 10 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
Limited Time Offer
Inside
$3,144
Oceanview
$3,036
Balcony
$3,144
Suite
$8,160
From
US$3,036
Per Person
View Trip
10 Day Italy, France & Croatia Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 07 May 2026
Visit: Spain, France, Italy, Croatia, Montenegro
Exclusive Savings
Inside
$1,007
Oceanview
$1,065
Balcony
$3,059
Suite
$6,584
From
US$1,007
Save 545
Per Person
View Trip
10 Day Mediterranean Masterpieces with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 02 June 2027
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,849
Suite
$6,799
From
US$3,849
Save 3,849
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2027 to Aug 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,089
Oceanview
$1,289
Balcony
$1,614
Suite
$1,919
From
US$1,089
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: May 2026 to Sep 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$916
Oceanview
$1,016
Balcony
$1,238
Suite
$2,634
From
US$916
Save 755
Per Person
View Trip
11 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2027 to Aug 2027
Visit: Spain, Morocco, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,349
Oceanview
$2,549
Balcony
$2,716
Suite
$5,950
From
US$2,349
Save 1,574
Per Person
View Trip
11 Day Greece, Italy & Croatia with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 05 June 2027
Visit: Spain, Sicily, Greece, Croatia, Italy
Bonus Onboard Credit
Exclusive Savings
Inside
$1,568
Oceanview
$2,008
Balcony
$2,367
Suite
$3,548
From
US$1,568
Save 692
Per Person
View Trip
19 Day Italia In Full with Regent Seven Seas
Cruise

19 Days (18 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy (+5 more), Sicily, Sardinia, Montenegro, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,049
Suite
$22,349
From
US$21,049
Save 21,049
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Bonus Onboard Credit
Inside
$3,049
Oceanview
$2,869
Balcony
$3,639
Suite
-
From
US$2,869
Per Person
View Trip
22 Day Greece, Turkey, Italy And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey (+4 more), Italy, Malta, Montenegro, Croatia
Bonus Onboard Credit
Inside
$3,519
Oceanview
$3,969
Balcony
$4,659
Suite
-
From
US$3,519
Per Person
View Trip
8 Day Spellbinding Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 16 April 2027
Visit: Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,599
Suite
$5,599
From
US$3,599
Save 3,599
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Sep 2027
Visit: Spain, France, Italy, Sicily
Inside
$579
Oceanview
-
Balcony
$829
Suite
$1,059
From
US$579
Per Person
View Trip
10 Day Romantic Locales & Canals with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,799
Oceanview
$3,049
Balcony
$4,699
Suite
$6,599
From
US$2,799
Save 2,799
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 03 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,066
Oceanview
$1,121
Balcony
$1,353
Suite
$2,328
From
US$1,066
Save 726
Per Person
View Trip
11 Day Radiant Rivieras with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 November 2026
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$4,649
Balcony
$3,605
Suite
$4,865
From
US$4,649
Save 4,649
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Bonus Onboard Credit
Inside
$1,359
Oceanview
$1,409
Balcony
$1,779
Suite
-
From
US$1,359
Per Person
View Trip
Results: 1-30 of 168

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