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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 326 departures available from seventeen of the world's leading cruise lines.
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157 Cruises (326 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: May 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,999
Suite
$9,499
From
US$6,999
Save 1,000
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy, Greece, Montenegro, Croatia
Inside
$2,369
Oceanview
$2,499
Balcony
$4,149
Suite
$6,163
From
US$2,369
Per Person
View Trip
10 Day Epicurean Odyssey with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 27 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,499
Oceanview
$2,693
Balcony
$4,196
Suite
$6,136
From
US$2,499
Save 2,499
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Inside
$1,209
Oceanview
-
Balcony
$1,709
Suite
$1,867
From
US$1,209
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$1,349
Oceanview
$1,499
Balcony
$1,969
Suite
$3,759
From
US$1,349
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 04 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$2,258
Oceanview
$2,937
Balcony
$3,237
Suite
$4,615
From
US$2,258
Save 61
Per Person
View Trip
8 Day Italy And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Inside
$1,369
Oceanview
$1,439
Balcony
$1,549
Suite
$3,079
From
US$1,369
Per Person
View Trip
15 Day Italy, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Inside
$2,489
Oceanview
$2,719
Balcony
$2,929
Suite
$6,184
From
US$2,489
Per Person
View Trip
11 Day Fall In The Roman Empire with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 08 October 2027
Visit: Spain, France, Monaco, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,033
Oceanview
$3,857
Balcony
$4,585
Suite
$6,525
From
US$3,033
Save 3,165
Per Person
View Trip
15 Day Mediterranean Odyssey: Spain, Italy and the French Riviera with Scenic
New ReleaseCruise

15 Days (14 Nights) Malaga to Rome
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 21 April 2027
Visit: Spain, France, Monaco, Italy, Corsica
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,118
Suite
$24,488
From
US$14,118
Save 20,872
Per Person
View Trip
10 Day Eclipse The Ordinary with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 July 2027
Visit: Spain, Malta, Sicily, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,886
Suite
$9,572
From
US$8,886
Save 14,212
Per Person
View Trip
10 Day Seaside Splendor with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 November 2027
Visit: Spain, Sardinia, Tunisia, Sicily, Malta, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,130
Suite
$5,652
From
US$3,130
Save 3,268
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 05 May 2026
Visit: Spain, Tunisia, Sicily, Italy
Inside
$419
Oceanview
$529
Balcony
$629
Suite
$1,269
From
US$419
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 May 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$1,179
Oceanview
$1,399
Balcony
$1,649
Suite
$2,589
From
US$1,179
Per Person
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (8)

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Mar 2026 to Jul 2028
Visit: Spain, France, Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,698
Suite
$11,098
From
US$7,698
Save 1,300
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Apr 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Princess Premier
Sanctuary Collection
Inside
$1,114
Oceanview
$1,514
Balcony
$1,639
Suite
$2,099
From
US$1,114
Per Person
View Trip
8 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 13 April 2026
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
-
Balcony
$995
Suite
-
From
US$995
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Inside
$3,199
Oceanview
$2,829
Balcony
$2,939
Suite
$6,292
From
US$2,829
Per Person
View Trip
12 Day Picturesque Panoramas with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 August 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,331
Suite
$10,801
From
US$9,331
Save 15,667
Per Person
View Trip
11 Day Greek Isles & Malta Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ships: Celebrity Equinox
Departures: Apr 2026 to Oct 2027
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,082
Oceanview
$2,326
Balcony
$2,378
Suite
$6,134
From
US$2,082
Save 1,415
Per Person
View Trip
13 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence & Venice with Azamara Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 08 June 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$5,204
Oceanview
$5,796
Balcony
$7,144
Suite
$10,326
From
US$5,204
Save 125
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2026 to Jul 2026
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,374
Oceanview
$1,744
Balcony
$2,089
Suite
$2,469
From
US$1,374
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 21 June 2027
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,128
Oceanview
$1,388
Balcony
$1,695
Suite
$2,825
From
US$1,128
Save 408
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Valencia to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 September 2026
Visit: Spain, Sardinia, Italy
Inside
$369
Oceanview
$449
Balcony
$549
Suite
$1,069
From
US$369
Per Person
View Trip
8 Day Italy And Adriatic with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro
Inside
$1,229
Oceanview
$1,379
Balcony
$1,529
Suite
$3,459
From
US$1,229
Per Person
View Trip
15 Day Spain, France, Italy, Croatia & Malta with Seabourn
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 25 September 2027
Visit: Spain, France, Corsica, Sardinia (+5 more), Italy, Sicily, Malta, Montenegro, Croatia
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,355
Suite
$15,686
From
US$9,355
Save 164
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 17 October 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
$1,179
Oceanview
-
Balcony
$1,639
Suite
$1,925
From
US$1,179
Per Person
View Trip
10 Day Italian Interlude with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 March 2028
Visit: Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,545
Oceanview
$2,788
Balcony
$4,291
Suite
$6,134
From
US$2,545
Save 2,653
Per Person
View Trip
15 Day Maritime Memories In The Med with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 January 2028
Visit: Spain, Morocco, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,398
Suite
$7,696
From
US$4,398
Save 4,600
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,429
Oceanview
$1,916
Balcony
$1,984
Suite
$2,187
From
US$1,429
Per Person
View Trip
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