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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 353 departures available from eighteen of the world's leading cruise lines.
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157 Cruises (353 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: Mar 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,099
Suite
$9,499
From
US$6,099
Save 500
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,225
Oceanview
$1,375
Balcony
$1,550
Suite
$1,825
From
US$1,225
Per Person
View Trip
11 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Las Palmas de Gran Canaria to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 02 April 2027
Visit: Spain, Morocco, Italy
Inside
$1,074
Oceanview
$1,211
Balcony
$1,349
Suite
$2,436
From
US$1,074
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,235
Oceanview
$1,435
Balcony
$1,610
Suite
$1,985
From
US$1,235
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 24 January 2026
Visit: Spain, Sardinia, Malta, Tunisia, Sicily, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,810
Suite
$6,860
From
US$5,810
Save 2,490
Per Person
View Trip
10 Day Mediterranean Horizons with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 07 October 2027
Visit: Spain, France, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,599
Suite
$8,999
From
US$8,599
Save 13,599
Per Person
View Trip
25 Day Greek Isles, Malta & Croatia With History Channel with Holland America
Cruise
 (2)

25 Days (24 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 28 August 2027
Visit: Spain, Malta, Greece, Turkey (+4 more), Montenegro, Sicily, Italy, Croatia
Book Early & Have It All Fare Option
Inside
$4,419
Oceanview
$4,949
Balcony
$6,069
Suite
$9,359
From
US$4,419
Per Person
View Trip
11 Day Italian Celebration with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,599
Suite
$8,649
From
US$7,599
Save 13,599
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (6)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Always Included
Inside
$3,429
Oceanview
$4,009
Balcony
$4,599
Suite
$7,169
From
US$3,429
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$3,879
From
US$3,879
Per Person
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ship: Viking Vela
Departure: 08 October 2025
Visit: Spain, France, Italy, Greece, Croatia
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$8,399
Suite
$12,999
From
US$8,399
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy, Greece, Montenegro, Croatia
Explore With More
Inside
$2,019
Oceanview
$2,209
Balcony
$2,789
Suite
$7,169
From
US$2,019
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Inside
$2,859
Oceanview
$3,209
Balcony
$3,609
Suite
$8,259
From
US$2,859
Per Person
View Trip
11 Day Fall In The Roman Empire with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 08 October 2027
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,099
Oceanview
$3,949
Balcony
$4,699
Suite
$6,699
From
US$3,099
Save 3,099
Per Person
View Trip
11 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Prima
Departure: 07 May 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Inside
-
Oceanview
-
Balcony
-
Suite
$6,859
From
US$6,859
Per Person
View Trip
20 Day An Extended Journey Of Sunlit Sophistication & Spectacular Shorelines with Explora Journeys
Cruise

20 Days (19 Nights) Barcelona to Venice
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 25 March 2026
Visit: Spain, France, Corsica, Italy (+5 more), Malta, Sicily, Greece, Montenegro, Croatia
Sky & Sea
Inside
-
Oceanview
-
Balcony
$11,585
Suite
$12,675
From
US$11,585
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 07 November 2025
Visit: Spain, France, Italy
Inside
-
Oceanview
$349
Balcony
-
Suite
-
From
US$349
Per Person
View Trip
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
Set, Sail and Save Offer
Inside
$2,016
Oceanview
$2,287
Balcony
$2,511
Suite
$5,715
From
US$2,016
Per Person
View Trip
11 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 18 September 2027
Visit: Spain, Morocco, Portugal, Sardinia, Italy
Exclusive Savings
Inside
$1,776
Oceanview
$1,997
Balcony
$2,090
Suite
$5,115
From
US$1,776
Save 1,039
Per Person
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia (+5 more), Corsica, Sicily, Greece, Montenegro, Croatia
Explore With More
Inside
-
Oceanview
$6,039
Balcony
-
Suite
$11,059
From
US$11,059
Per Person
View Trip
10 Day Epicurean Odyssey with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 27 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$2,499
Oceanview
$2,749
Balcony
$4,299
Suite
$6,299
From
US$2,499
Save 2,499
Per Person
View Trip
11 Day Greek Isles & Malta Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Apr 2026 to Oct 2027
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$1,658
Oceanview
$1,858
Balcony
$2,131
Suite
$5,179
From
US$1,658
Save 1,043
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Musica
Departures: Apr 2026 to Apr 2027
Visit: Spain, Morocco, Italy
Inside
$824
Oceanview
$921
Balcony
$1,064
Suite
$1,624
From
US$824
Per Person
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jul 2026 to Aug 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Book Early & Have It All Fare Option
Inside
$2,204
Oceanview
$2,404
Balcony
$3,254
Suite
$4,054
From
US$2,204
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Alicante to Genoa
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 07 October 2026
Visit: Spain, Sardinia, Italy
Inside
$250
Oceanview
$300
Balcony
$460
Suite
$700
From
US$250
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 June 2027
Visit: Spain, Corsica, Italy
Inside
$1,389
Oceanview
$1,489
Balcony
$1,739
Suite
$4,139
From
US$1,389
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Apr 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,134
Oceanview
$1,314
Balcony
$1,574
Suite
$1,844
From
US$1,134
Per Person
View Trip
12 Day Best Of Italy, France & Spain with Celebrity Cruises
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 24 May 2027
Visit: Spain, Corsica, France, Italy, Sicily
Exclusive Savings
Inside
$1,881
Oceanview
$2,023
Balcony
$2,242
Suite
$5,172
From
US$1,881
Save 1,079
Per Person
View Trip
11 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2027 to Aug 2027
Visit: Spain, Morocco, Portugal, Corsica, Italy
Exclusive Savings
Inside
$1,428
Oceanview
$1,649
Balcony
$1,742
Suite
$4,767
From
US$1,428
Save 1,050
Per Person
View Trip
11 Day A Journey Of Unique Architecture Seamlessely Blending Culture & Scenic Beauty with Explora Journeys
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 03 May 2026
Visit: Spain, Gibraltar, Colombia, France, Monaco, Italy
Sky & Sea
Inside
-
Oceanview
-
Balcony
$7,605
Suite
$8,755
From
US$7,605
Per Person
View Trip
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