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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April is the most popular month to cruise between Spain and Italy and there are 329 departures available from seventeen of the world's leading cruise lines.
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158 Cruises (329 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: May 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,999
Suite
$9,499
From
US$6,999
Save 1,000
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,672
Oceanview
$4,293
Balcony
$4,924
Suite
$7,669
From
US$3,672
Save 87
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,778
From
US$3,778
Save 111
Per Person
View Trip
11 Day Iconic Italy & the French Riviera with Scenic
New ReleaseCruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 24 September 2028
Visit: Spain, France, Monaco, Italy
Fly Free Premium Economy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,225
Suite
$17,601
From
US$15,225
Save 16,165
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (4)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$4,807
Oceanview
$5,311
Balcony
$6,213
Suite
$12,790
From
US$4,807
Save 122
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Apr 2026 to Sep 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,497
From
US$5,497
Save 283
Per Person
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,398
Oceanview
$2,640
Balcony
$3,513
Suite
$4,774
From
US$2,398
Save 2,500
Per Person
View Trip
11 Day Fall In The Roman Empire with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 08 October 2027
Visit: Spain, France, Monaco, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,033
Oceanview
$3,857
Balcony
$4,585
Suite
$6,525
From
US$3,033
Save 3,165
Per Person
View Trip
9 Day Italy Intensive Cruise: Portofino, Florence & Porto Santo Stefano with Azamara Cruises
Cruise
 (3)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 09 April 2026
Visit: Spain, France, Italy
Azamara Always Included
Inside
$2,109
Oceanview
$2,463
Balcony
$2,928
Suite
$5,189
From
US$2,109
Per Person
View Trip
15 Day Iberia Celebration with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Bilbao to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 August 2026
Visit: Spain, Portugal, France, Italy
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,308
Oceanview
$3,599
Balcony
$5,490
Suite
$7,454
From
US$3,308
Save 5,690
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 28 September 2026
Visit: Spain, France, Monaco, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,720
Balcony
$7,280
Suite
$6,960
From
US$6,720
Save 1,680
Per Person
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia (+5 more), Corsica, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,096
From
US$9,096
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence & Dubrovnik with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 September 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia
Azamara Always Included
Exclusive Savings
Inside
$3,461
Oceanview
$3,849
Balcony
$4,741
Suite
$7,128
From
US$3,461
Save 78
Per Person
View Trip
8 Day Mediterranean with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 01 March 2026
Visit: Spain, Gibraltar, France, Italy
Princess Standard
Inside
$988
Oceanview
$1,140
Balcony
-
Suite
$2,140
From
US$988
Per Person
View Trip
10 Day Spring In Southern Europe with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 26 April 2027
Visit: Spain, Sardinia, Sicily, Greece, Italy, Croatia
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,546
Oceanview
$2,789
Balcony
$4,292
Suite
$6,135
From
US$2,546
Save 2,652
Per Person
View Trip
15 Day Southern Mediterranean Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 07 December 2026
Visit: Spain, France, Italy, Sicily, Tunisia, Malta
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
$5,710
Balcony
$8,160
Suite
$9,434
From
US$5,710
Save 12,888
Per Person
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (8)

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Mar 2026 to Jul 2028
Visit: Spain, France, Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,498
Suite
$10,998
From
US$7,498
Save 1,300
Per Person
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France, Greece, Turkey
Inside
-
Oceanview
$5,889
Balcony
$9,011
Suite
$14,149
From
US$5,889
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Barcelona to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$579
Oceanview
$729
Balcony
$799
Suite
$1,239
From
US$579
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 May 2026
Visit: Spain, Corsica, Sicily, Italy, Greece, Montenegro, Croatia
Inside
$2,329
Oceanview
$2,509
Balcony
$3,059
Suite
$6,876
From
US$2,329
Per Person
View Trip
10 Day Eclipse The Ordinary with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 July 2027
Visit: Spain, Malta, Sicily, Italy, Sardinia
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,886
Suite
$9,572
From
US$8,886
Save 14,212
Per Person
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+5 more), Italy, Greece, Montenegro, Croatia, Malta
Inside
$3,529
Oceanview
-
Balcony
$6,295
Suite
$8,819
From
US$3,529
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,215
From
US$4,215
Save 124
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Inside
$3,199
Oceanview
$2,829
Balcony
$2,939
Suite
$6,292
From
US$2,829
Per Person
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jul 2026 to Aug 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,404
Oceanview
$2,554
Balcony
$3,209
Suite
$5,335
From
US$2,404
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: May 2026 to Sep 2026
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,136
Oceanview
$1,281
Balcony
$1,561
Suite
$3,206
From
US$1,136
Save 685
Per Person
View Trip
11 Day Spain, Portugal & France Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 24 July 2027
Visit: Spain, Gibraltar, Portugal, Corsica, Italy
Exclusive Savings
Inside
$1,776
Oceanview
$2,019
Balcony
$2,101
Suite
$5,296
From
US$1,776
Save 1,007
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Inside
$2,399
Oceanview
$2,689
Balcony
$3,959
Suite
$6,113
From
US$2,399
Per Person
View Trip
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
With Love From the World
Inside
$1,881
Oceanview
$2,364
Balcony
$2,331
Suite
$5,535
From
US$1,881
Per Person
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (2)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Feb 2026 to Apr 2026
Visit: Spain, France, Italy
Inside
$253
Oceanview
-
Balcony
$259
Suite
$711
From
US$253
Per Person
View Trip
Results: 1-30 of 158

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