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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 330 departures available from seventeen of the world's leading cruise lines.
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159 Cruises (330 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+6 more), Viking Mars, Viking Saturn, Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: Jun 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,799
Suite
$9,999
From
US$6,799
Save 1,000
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 10 September 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
Bonus Onboard Credit
Inside
$2,189
Oceanview
$2,389
Balcony
$2,879
Suite
$5,658
From
US$2,189
Per Person
View Trip
8 Day Yachting Havens with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 May 2026
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,430
From
US$9,430
Save 9,968
Per Person
View Trip
8 Day Amalfi Coast, Africa & Iberia with Viking Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Ships: Viking Libra, Viking Sea (+2 more), Viking Star, Viking Vela
Departures: Feb 2027 to Mar 2028
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,899
Suite
$4,299
From
US$2,899
Save 50
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 26 April 2026
Visit: Spain, Malta, Greece, Montenegro, Croatia, Italy
Inside
$779
Oceanview
-
Balcony
$2,368
Suite
$2,465
From
US$779
Per Person
View Trip
13 Day Dalmatian Diversion with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 03 October 2027
Visit: Spain, France, Monaco, Italy, Corsica, Montenegro, Croatia
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,231
Oceanview
$3,571
Balcony
$5,850
Suite
$8,275
From
US$3,231
Save 3,367
Per Person
View Trip
25 Day Greek Isles, Malta & Croatia with Holland America
Cruise
 (3)

25 Days (24 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 28 August 2027
Visit: Spain, Malta, Greece, Turkey (+4 more), Montenegro, Sicily, Italy, Croatia
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,540
Oceanview
$4,883
Balcony
$6,941
Suite
$9,303
From
US$4,540
Save 69
Per Person
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 15 August 2026
Visit: Spain, Sicily, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,001
Oceanview
$2,074
Balcony
$2,529
Suite
$4,816
From
US$2,001
Save 1,142
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Bonus Onboard Credit
Inside
$3,049
Oceanview
$2,869
Balcony
$3,639
Suite
-
From
US$2,869
Per Person
View Trip
12 Day Cultures of the Mediterranean Barcelona to Civitavecchia with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2027 to Sep 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
$9,373
Balcony
-
Suite
$12,350
From
US$9,373
Save 1,179
Per Person
View Trip
22 Day Greece, Turkey, Italy And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey (+4 more), Italy, Malta, Montenegro, Croatia
Bonus Onboard Credit
Inside
$3,619
Oceanview
$3,969
Balcony
$4,659
Suite
-
From
US$3,619
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 September 2026
Visit: Spain, Corsica, France, Italy
Princess Standard
Inside
$1,569
Oceanview
$1,989
Balcony
$2,539
Suite
$2,789
From
US$1,569
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 19 May 2026
Visit: Spain, France, Monaco, Italy
Last Minute Fare
All-Inclusive Plus Fare
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$7,050
Suite
$12,500
From
US$7,050
Per Person
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$2,445
Oceanview
$2,881
Balcony
$3,512
Suite
$4,210
From
US$2,445
Save 54
Per Person
View Trip
8 Day Barcelona to Civitavecchia (Rome) with Silversea
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 November 2027
Visit: Spain, France, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$6,900
Suite
$10,100
From
US$6,900
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 25 April 2026
Visit: Spain, France, Corsica, Italy
Princess Standard
Princess Premier
Inside
$1,310
Oceanview
$1,810
Balcony
$2,060
Suite
$3,311
From
US$1,310
Per Person
View Trip
11 Day Spain, Portugal & France Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 24 July 2027
Visit: Spain, Gibraltar, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,324
Oceanview
$2,610
Balcony
$2,718
Suite
$6,815
From
US$2,324
Save 1,376
Per Person
View Trip
10 Day Toast To Toulon with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 31 August 2027
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,406
Suite
$10,798
From
US$10,406
Save 10,792
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2027
Visit: Spain, France, Italy, Sicily
Inside
$729
Oceanview
$1,079
Balcony
$1,129
Suite
$1,349
From
US$729
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 04 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$2,607
Oceanview
$2,985
Balcony
$3,189
Suite
$4,721
From
US$2,607
Save 72
Per Person
View Trip
8 Day Spellbinding Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 16 April 2027
Visit: Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,513
Suite
$5,453
From
US$3,513
Save 3,685
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (5)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$2,905
Oceanview
$3,352
Balcony
$4,622
Suite
$8,871
From
US$2,905
Save 64
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2027 to Aug 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Inside
$1,119
Oceanview
$1,339
Balcony
$1,539
Suite
$1,819
From
US$1,119
Per Person
View Trip
9 Day Canary Islands with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 04 April 2027
Visit: Spain, Morocco, Italy
Inside
$811
Oceanview
$971
Balcony
$1,061
Suite
$1,651
From
US$811
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,339
Oceanview
$1,887
Balcony
$1,887
Suite
$2,071
From
US$1,339
Per Person
View Trip
8 Day A Journey From Elegance & Cultural Essence To Glamour & Antiquities with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 14 September 2026
Visit: Spain, Sardinia, Corsica, France, Italy
Sky & Sea
Inside
-
Oceanview
-
Balcony
-
Suite
$5,985
From
US$5,985
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 12 April 2026
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
-
Balcony
$1,027
Suite
-
From
US$1,027
Per Person
View Trip
15 Day Maritime Memories In The Med with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 January 2028
Visit: Spain, Morocco, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,398
Suite
$7,696
From
US$4,398
Save 4,600
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Bonus Onboard Credit
Inside
$1,359
Oceanview
$1,499
Balcony
$1,989
Suite
-
From
US$1,359
Per Person
View Trip
5 Day A Journey Through Riviera Elegance & Coastal Splendour with Explora Journeys
Cruise
 (1)

5 Days (4 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 25 April 2026
Visit: Spain, Monaco, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$2,640
From
US$2,640
Per Person
View Trip
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