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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 283 departures available from eighteen of the world's leading cruise lines.
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138 Cruises (283 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+2 more), Viking Star, Viking Vesta
Departures: Mar 2026 to Jul 2027
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,999
SUITE
$9,499
Save (per person) 500
From (per person) 5,999
View Trip
16 Day Barcelona to Civitavecchia with Silversea
Cruise

16 Days (15 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 25 July 2026
Countries Visited: Spain, Corsica, France, Monaco (+1 more), Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,100
From (per person) 9,100
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2026
Countries Visited: Spain, France, Italy, Corsica (+2 more), Sardinia, Sicily
Fleetwide SaleExclusive Deal
INSIDE
$2,199
OCEANVIEW
$2,449
BALCONY
$3,599
SUITE
$4,899
Save (per person) 2,199
From (per person) 2,199
View Trip
11 Day A Journey Of Unique Architecture Seamlessely Blending Culture & Scenic Beauty with Explora Journeys
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 03 May 2026
Countries Visited: Spain, Gibraltar, Colombia, France (+2 more), Monaco, Italy
Best Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
$7,480
SUITE
$8,585
From (per person) 7,480
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$6,299
OCEANVIEW
-
BALCONY
$10,599
SUITE
-
Save (per person) 6,299
From (per person) 6,299
View Trip
8 Day Mediterranean with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 01 March 2026
Countries Visited: Spain, Gibraltar, France, Italy
Summer Swing Sale
INSIDE
$865
OCEANVIEW
$913
BALCONY
$1,090
SUITE
$1,165
From (per person) 865
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Sep 2026
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Deal
INSIDE
$1,668
OCEANVIEW
$1,886
BALCONY
$2,088
SUITE
$4,695
Save (per person) 912
From (per person) 1,668
View Trip
22 Day An Extended Journey Of Iconic Sophistication And Sparkling Cerulean Seas with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 July 2025
Countries Visited: Spain, France, Monaco, Corsica (+3 more), Sardinia, Italy, Sicily
Explora Extended Journey SavingBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$24,905
From (per person) 24,905
View Trip
11 Day Highlights of Spain, Morocco & Italy with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Santa Cruz de Tenerife to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 08 April 2026
Countries Visited: Spain, Morocco, Corsica, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,107
BALCONY
-
SUITE
$10,829
Save (per person) 8,283
From (per person) 8,107
View Trip
22 Day An Extended Journey Of Luscious Landscapes And Historic Scenery with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 08 September 2025
Countries Visited: Spain, Monaco, France, Italy (+3 more), Corsica, Sardinia, Sicily
Explora Extended Journey SavingBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
$17,095
SUITE
$35,290
From (per person) 17,095
View Trip
13 Day Mediterranean Nights with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 September 2026
Countries Visited: Spain, France, Italy, Malta
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$10,599
SUITE
$11,899
Save (per person) 15,999
From (per person) 10,599
View Trip
8 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 26 April 2026
Countries Visited: Spain, Malta, Greece, Croatia (+2 more), Montenegro, Italy
INSIDE
$1,279
OCEANVIEW
$1,579
BALCONY
$2,379
SUITE
$2,389
From (per person) 1,279
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: May 2026 to Sep 2026
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sicily
Latest OfferExclusive Solo Offer
INSIDE
$1,188
OCEANVIEW
$1,362
BALCONY
$1,654
SUITE
$2,319
Save (per person) 597
From (per person) 1,188
View Trip
8 Day A Journey Through Sparkling Bays & Riviera Radiance with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Countries Visited: Spain, Sardinia, France, Italy
Explora Early Booking BenefitBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
$4,380
SUITE
$5,055
From (per person) 4,380
View Trip
22 Day An Extended Journey Through Mediterranean Charm, Rugged Beauty And Iconic Culture with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 22 September 2025
Countries Visited: Spain, France, Italy, Sicily (+4 more), Tunisia, Monaco, Sardinia, Corsica
Explora Extended Journey SavingBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$20,805
From (per person) 20,805
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Countries Visited: Spain, Sardinia, Tunisia, Malta (+2 more), Sicily, Italy
INSIDE
$3,059
OCEANVIEW
$3,559
BALCONY
$4,439
SUITE
$6,599
From (per person) 3,059
View Trip
12 Day Western Mediterranean From Barcelona To Venice with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departure: 28 September 2025
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
INSIDE
$2,200
OCEANVIEW
$3,589
BALCONY
$3,989
SUITE
$4,419
From (per person) 2,200
View Trip
11 Day Radiant Rivieras with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 November 2026
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$3,299
OCEANVIEW
$4,049
BALCONY
$4,699
SUITE
$6,799
Save (per person) 3,299
From (per person) 3,299
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (5)

15 Days (14 Nights) Barcelona to Venice
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Jul 2025 to Jul 2027
Countries Visited: Spain, France, Monaco, Italy (+2 more), Sicily, Croatia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$6,898
SUITE
$10,998
Save (per person) 1,000
From (per person) 6,898
View Trip
25 Day Greek Isles, Malta & Croatia With History Channel with Holland America
Cruise
 (2)

25 Days (24 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 28 August 2027
Countries Visited: Spain, Malta, Greece, Turkey (+4 more), Montenegro, Sicily, Italy, Croatia
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,949
BALCONY
$6,069
SUITE
$9,359
From (per person) 4,419
View Trip
8 Day Mediterranean with Total Solar Eclipse with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Countries Visited: Spain, Gibraltar, Italy
Exclusive DealSummer Swing Sale
INSIDE
$2,110
OCEANVIEW
$2,840
BALCONY
$3,560
SUITE
$3,910
From (per person) 2,110
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departure: 20 September 2025
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive DealSummer Swing Sale
INSIDE
$1,240
OCEANVIEW
$1,360
BALCONY
$1,640
SUITE
$1,840
From (per person) 1,240
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 22 September 2025
Countries Visited: Spain, France, Corsica, Italy
Latest OfferFlash Deal
INSIDE
$1,038
OCEANVIEW
$1,147
BALCONY
$1,545
SUITE
$2,510
From (per person) 1,680
View Trip
13 Day French & Italian Treasures with Oceania Cruises
Cruise
 (3)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 30 September 2026
Countries Visited: Spain, France, Italy, Corsica (+3 more), Sardinia, Sicily, Malta
Fleetwide SaleExclusive Deal
INSIDE
$3,599
OCEANVIEW
$3,999
BALCONY
$6,199
SUITE
$8,599
Save (per person) 3,599
From (per person) 3,599
View Trip
8 Day Etruscan Waterways with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 21 April 2026
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
Exclusive Deal
INSIDE
$2,599
OCEANVIEW
$3,149
BALCONY
$3,599
SUITE
$5,099
Save (per person) 2,599
From (per person) 2,599
View Trip
10 Day Ramblas & The Rivieras with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 September 2026
Countries Visited: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,199
SUITE
$6,949
Save (per person) 4,199
From (per person) 4,199
View Trip
12 Day Around Italy's Boot: Italy, Dalmatia & Venice with Holland America
Cruise
 (2)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 September 2026
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Croatia, Montenegro
Exclusive Deal
INSIDE
$2,239
OCEANVIEW
$2,439
BALCONY
$3,489
SUITE
$4,239
From (per person) 2,239
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Musica
Departures: Apr 2026 to Apr 2027
Countries Visited: Spain, Morocco, Italy
Escape To Sea
INSIDE
$824
OCEANVIEW
$934
BALCONY
$1,044
SUITE
$1,554
From (per person) 824
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 15 August 2026
Countries Visited: Spain, Sicily, Greece, Turkey (+1 more), Italy
Exclusive Deal
INSIDE
$1,666
OCEANVIEW
$1,831
BALCONY
$2,154
SUITE
$5,093
Save (per person) 900
From (per person) 1,666
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (2)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Countries Visited: Spain, France, Monaco, Italy (+3 more), Sicily, Montenegro, Slovenia
INSIDE
$3,979
OCEANVIEW
$4,379
BALCONY
$5,399
SUITE
$6,589
From (per person) 3,979
View Trip
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