Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
Cruise
 (6)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Departures: Sep 2026 to Aug 2028
Visit: Spain, France, Italy, Greece, Croatia
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,060
Suite
$13,274
From
A$9,060
Save 1,531
Per Person
View Trip
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Departure: 26 June 2027
Visit: Spain, Morocco, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,524
Oceanview
$2,995
Balcony
$3,492
Suite
$9,660
From
A$2,524
Save 1,668
Per Person
View Trip
Cruise
 (13)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 11 June 2027
Visit: Spain, Corsica, Italy, Malta (+4 more), Montenegro, Croatia, Greece, Sicily
First Come, First Served Offer
Exclusive Savings
Inside
$5,224
Oceanview
$5,729
Balcony
$6,422
Suite
$13,926
From
A$5,224
Per Person
View Trip
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Departure: 03 October 2027
Visit: Spain, France, Monaco, Italy, Corsica, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
$4,529
Oceanview
$4,801
Balcony
$8,681
Suite
$11,232
From
A$4,529
Save 2,091
Per Person
View Trip
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 25 August 2028
Visit: Spain, France, Italy
Exclusive Savings
Inside
$2,229
Oceanview
$2,526
Balcony
$2,872
Suite
$5,941
From
A$2,229
Per Person
View Trip
Cruise
 (13)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 23 June 2028
Visit: Spain, Corsica, Italy, Malta (+4 more), Montenegro, Croatia, Greece, Sicily
Exclusive Savings
Inside
$6,243
Oceanview
$6,936
Balcony
$7,926
Suite
$14,658
From
A$6,243
Per Person
View Trip
Cruise
 (3)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 September 2026
Visit: Spain, France, Italy, Sicily, Greece, Croatia, Montenegro
Fare Saver
Exclusive Savings
Inside
$4,102
Oceanview
$4,201
Balcony
$6,528
Suite
$7,221
From
A$4,102
Per Person
View Trip
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2026 to Sep 2028
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,529
Oceanview
$1,786
Balcony
$2,240
Suite
$2,652
From
A$1,529
Per Person
View Trip
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,686
Oceanview
$2,241
Balcony
$2,874
Suite
$3,270
From
A$1,686
Per Person
View Trip
Cruise
 (1)

15 Days (14 Nights) Bilbao to Rome
Cruise Line: Oceania Cruises
Departure: 30 August 2026
Visit: Spain, Portugal, France, Italy
Your World Inclusions
Exclusive Savings
Inside
$4,195
Oceanview
$4,467
Balcony
$6,881
Suite
$9,113
From
A$4,195
Save 4,365
Per Person
View Trip
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Visit: Spain, Gibraltar, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$3,170
Oceanview
$4,002
Balcony
$4,695
Suite
$8,580
From
A$3,170
Per Person
View Trip
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
$2,130
Balcony
$3,754
Suite
$4,852
From
A$2,130
Per Person
View Trip
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy, Croatia
First Come, First Served Offer
Exclusive Savings
Inside
$5,214
Oceanview
$5,679
Balcony
$6,659
Suite
$13,124
From
A$5,214
Per Person
View Trip
Cruise
 (3)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Departure: 30 September 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily, Malta
Your World Inclusions
Exclusive Savings
Inside
$5,492
Oceanview
$6,113
Balcony
$9,449
Suite
$11,904
From
A$5,492
Save 2,118
Per Person
View Trip
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 07 May 2028
Visit: Spain, France, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,549
Oceanview
$1,806
Balcony
$2,405
Suite
$2,672
From
A$1,549
Per Person
View Trip
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Departures: Sep 2026 to Jul 2028
Visit: Spain, France, Monaco, Italy
Viking Savings Event
Bonus Shipboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,964
Suite
$6,414
From
A$3,964
Save 1,405
Per Person
View Trip
Cruise
 (2)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Princess
Departure: 05 September 2028
Visit: Spain, France, Corsica, Italy (+5 more), Malta, Montenegro, Greece, Sicily, Croatia
Princess Standard
Exclusive Savings
Inside
$3,812
Oceanview
$4,613
Balcony
$4,301
Suite
$6,055
From
A$3,812
Per Person
View Trip
Cruise
 (4)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Departure: 29 September 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia
Azamara Always Included
Exclusive Savings
Inside
$6,983
Oceanview
$7,738
Balcony
$9,600
Suite
$14,470
From
A$6,983
Save 116
Per Person
View Trip
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Departures: Feb 2027 to Mar 2028
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
Viking Savings Event
Bonus Shipboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,062
Suite
$6,414
From
A$4,062
Save 1,397
Per Person
View Trip
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro, Croatia, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,399
From
A$9,399
Per Person
View Trip
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Departure: 27 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$3,444
Oceanview
$3,784
Balcony
$6,247
Suite
$8,634
From
A$3,444
Save 2,066
Per Person
View Trip
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Departure: 24 March 2028
Visit: Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,947
Oceanview
$4,325
Balcony
$6,663
Suite
$9,515
From
A$3,947
Save 2,083
Per Person
View Trip
Cruise
 (1)

17 Days (16 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 April 2028
Visit: Spain, Portugal, Tunisia, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$14,553
From
A$14,553
Save 297
Per Person
View Trip
Cruise
 (1)

7 Days (6 Nights) Malaga to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 27 February 2027
Visit: Spain, Sardinia, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,042
From
A$5,042
Save 103
Per Person
View Trip
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Departures: Jun 2026 to Sep 2026
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,120
Oceanview
$2,431
Balcony
$3,659
Suite
$8,665
From
A$2,120
Save 1,389
Per Person
View Trip
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Departure: 17 October 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Just Cruise Fare
Exclusive Savings
Inside
$2,018
Oceanview
-
Balcony
$2,852
Suite
$3,239
From
A$2,018
Per Person
View Trip
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Departure: 11 June 2027
Visit: Spain, Corsica, Italy
First Come, First Served Offer
Exclusive Savings
Inside
$2,071
Oceanview
$2,259
Balcony
$2,407
Suite
$5,169
From
A$2,071
Per Person
View Trip
Cruise
 (1)

5 Days (4 Nights) Valencia to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 September 2026
Visit: Spain, Sardinia, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$964
Suite
-
From
A$964
Per Person
View Trip
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Departures: May 2027 to Sep 2027
Visit: Spain, France, Italy, Sicily
Just Cruise Fare
Exclusive Savings
Inside
$2,152
Oceanview
-
Balcony
$2,733
Suite
$3,016
From
A$2,152
Per Person
View Trip
Cruise
 (4)

11 Days (10 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Departure: 31 October 2027
Visit: Spain, Italy, Sicily, Montenegro, Croatia
Azamara Always Included
Exclusive Savings
Inside
$5,715
Oceanview
$6,969
Balcony
$8,606
Suite
$12,545
From
A$5,715
Save 94
Per Person
View Trip
Results: 1-30 of 200

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