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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 339 departures available from seventeen of the world's leading cruise lines.
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168 Cruises (339 Cruise Departures)
8 Day A Journey Across Mediterranean Masterpieces with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 06 July 2026
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$5,625
From
US$5,625
Per Person
View Trip
9 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 20 August 2027
Visit: Spain, France, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,313
Oceanview
$1,693
Balcony
$2,002
Suite
$3,023
From
US$1,313
Save 624
Per Person
View Trip
15 Day Culinary Coasts with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy (+4 more), Sardinia, Sicily, Montenegro, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,149
Suite
$17,349
From
US$17,149
Save 17,149
Per Person
View Trip
8 Day Barcelona to Rome with Silversea
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 01 November 2026
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,400
Balcony
$5,600
Suite
$10,400
From
US$5,400
Save 1,500
Per Person
View Trip
8 Day Best Of Italy & French Riviera with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 06 August 2027
Visit: Spain, France, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,154
Oceanview
$1,484
Balcony
$1,753
Suite
$2,623
From
US$1,154
Save 559
Per Person
View Trip
10 Day Toast To Toulon with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 31 August 2027
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,199
Suite
$10,599
From
US$10,199
Save 10,199
Per Person
View Trip
8 Day Luminous Mediterranean with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 October 2026
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,999
Suite
$4,680
From
US$2,999
Save 2,999
Per Person
View Trip
9 Day Barcelona to Civitavecchia (Rome) with Silversea
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 21 May 2027
Visit: Spain, Sardinia, Sicily, Malta, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,900
Suite
$11,000
From
US$6,900
Save 2,500
Per Person
View Trip
7 Day A Journey From Catalan Colours To Roman Grandeur with Explora Journeys
Cruise

7 Days (6 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 27 May 2026
Visit: Spain, France, Sardinia, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$5,015
From
US$5,015
Per Person
View Trip
8 Day Barcelona to Rome with Silversea
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 07 September 2026
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,500
Balcony
$7,400
Suite
$10,800
From
US$6,500
Save 1,500
Per Person
View Trip
15 Day Mediterranean Odyssey: Spain, Italy and the French Riviera with Scenic
New ReleaseCruise

15 Days (14 Nights) Malaga to Rome
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 21 April 2027
Visit: Spain, France, Monaco, Italy, Corsica
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,144
Suite
$24,248
From
US$15,144
Save 4,151
Per Person
View Trip
11 Day Iconic Italy & the French Riviera with Scenic
New ReleaseCruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 24 September 2028
Visit: Spain, France, Monaco, Italy
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,998
Suite
$16,326
From
US$13,998
Save 2,247
Per Person
View Trip
8 Day Spain, France & Italy with Seabourn
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Sep 2027 to Aug 2028
Visit: Spain, France, Corsica, Sardinia, Italy
Yours to Explore
Inside
-
Oceanview
-
Balcony
$5,499
Suite
$8,999
From
US$5,499
Per Person
View Trip
8 Day A Journey of New Year Festivities through the Splendid Mediterranean with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 26 December 2027
Visit: Spain, France, Italy, Corsica
Inside
-
Oceanview
-
Balcony
-
Suite
$5,590
From
US$5,590
Per Person
View Trip
15 Day Maritime Memories In The Med with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 January 2028
Visit: Spain, Morocco, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,499
Suite
$7,899
From
US$4,499
Save 4,499
Per Person
View Trip
15 Day Southern Mediterranean Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 07 December 2026
Visit: Spain, France, Italy, Sicily, Tunisia, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,249
Suite
$12,599
From
US$12,249
Save 12,249
Per Person
View Trip
9 Day Splendid Summer Sun with Oceania Cruises
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 July 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,699
Suite
$5,999
From
US$3,699
Save 3,699
Per Person
View Trip
29 Day Hidden Gems Of France, Italy, Croatia & Slovenia with Seabourn
Cruise

29 Days (28 Nights) Barcelona to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 07 October 2028
Visit: Spain, France, Sardinia, Corsica (+8 more), Monaco, Italy, Sicily, Malta, Montenegro, Croatia, Greece, Slovenia
Inside
-
Oceanview
-
Balcony
$20,899
Suite
$33,499
From
US$20,899
Per Person
View Trip
Results: 151-168 of 168

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