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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
8 Day A Journey of New Year Festivities through the Splendid Mediterranean with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 26 December 2027
Visit: Spain, France, Italy, Corsica
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,060
From
A$8,060
Save 165
Per Person
View Trip
15 Day Culinary Coasts with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy (+4 more), Sardinia, Sicily, Montenegro, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,393
Suite
$24,667
From
A$24,393
Save 2,447
Per Person
View Trip
11 Day Italian Tapestry with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 26 March 2029
Visit: Spain, France, Italy, Sardinia, Malta, Sicily
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,049
Suite
$16,156
From
A$14,049
Save 2,251
Per Person
View Trip
12 Day Idyllic Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 07 July 2028
Visit: Spain, Corsica, Italy, Sardinia
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,878
Suite
$23,759
From
A$19,878
Save 5,867
Per Person
View Trip
8 Day Ballet Of The Riviera with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 June 2028
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,097
Suite
$13,283
From
A$12,097
Save 2,223
Per Person
View Trip
8 Day Culinary Towns & Villages with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 November 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,545
Suite
$12,222
From
A$11,545
Save 2,215
Per Person
View Trip
8 Day Relaxing Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 06 August 2027
Visit: Spain, France, Italy, Corsica
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,379
Suite
$7,066
From
A$4,379
Save 2,101
Per Person
View Trip
8 Day A Journey Through Sparkling Bays & Riviera Radiance with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Visit: Spain, Sardinia, France, Italy
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,448
From
A$7,448
Save 172
Per Person
View Trip
18 Day Tradition Of Taste with Regent Seven Seas
Cruise

18 Days (17 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 22 July 2028
Visit: Spain, France, Italy, Sardinia (+4 more), Sicily, Malta, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$29,506
Suite
$31,319
From
A$29,506
Save 2,544
Per Person
View Trip
10 Day Mediterranean Horizons with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 07 October 2027
Visit: Spain, France, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,335
Suite
$18,109
From
A$17,335
Save 2,325
Per Person
View Trip
10 Day Ramblas & The Rivieras with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 September 2026
Visit: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,788
Suite
-
From
A$8,788
Save 2,232
Per Person
View Trip
12 Day Poetry In Motion with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Explorer
Departure: 25 August 2028
Visit: Spain, France, Monaco, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,535
Suite
$21,054
From
A$18,535
Save 2,345
Per Person
View Trip
12 Day Picturesque Panoramas with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 August 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,803
Suite
$17,890
From
A$16,803
Save 2,307
Per Person
View Trip
8 Day Spain, Provence & Tuscany with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 08 October 2028
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,078
Suite
$6,648
From
A$4,078
Save 2,112
Per Person
View Trip
8 Day Regal Retreat with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 June 2027
Visit: Spain, France, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,029
Suite
$13,715
From
A$13,029
Save 2,241
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 28 September 2026
Visit: Spain, France, Monaco, Italy
Last Minute Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$7,595
Balcony
$8,967
Suite
$8,771
From
A$7,595
Save 155
Per Person
View Trip
16 Day Catalonia & Mediterranean Islands - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

16 Days Barcelona to Rome
Operated By: Scenic
Ship: Scenic Ikon
Departure: 03 July 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Spain, Corsica, Italy, Sardinia
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,390
Suite
$31,271
From
A$27,390
Save 6,020
Per Person
View Trip
8 Day A Journey From Elegance & Cultural Essence To Glamour & Antiquities with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 14 September 2026
Visit: Spain, Sardinia, Corsica, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,403
From
A$9,403
Save 192
Per Person
View Trip
8 Day Mediterranean Harmony with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 05 April 2029
Visit: Spain, France, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,961
Suite
$13,706
From
A$11,961
Save 2,219
Per Person
View Trip
12 Day Epicurean Spotlight On Wine with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 18 September 2026
Visit: Spain, Monaco, Italy
Exquisite Escapes
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,481
Suite
$9,365
From
A$8,481
Save 11,029
Per Person
View Trip
12 Day Best Of Italy, France & Spain with Celebrity Cruises
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 24 May 2027
Visit: Spain, Corsica, France, Italy, Sicily
Exclusive Savings
Inside
$3,042
Oceanview
$3,158
Balcony
$4,000
Suite
$9,049
From
A$3,042
Save 1,963
Per Person
View Trip
8 Day A Journey Across Mediterranean Masterpieces with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 06 July 2026
Visit: Spain, Tunisia, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,379
From
A$8,379
Save 171
Per Person
View Trip
11 Day Mediterranean Highlights: Sardinia, Ibiza & the Riviera with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Palma to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Kaia
Departure: 17 May 2028
Visit: Spain, Sardinia, Corsica, Monaco, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$12,715
Balcony
-
Suite
$16,635
From
A$12,715
Save 3,230
Per Person
View Trip
15 Day An Extended Journey From Catalan Vitality To Gilded Venetian Grandeur with Explora Journeys
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Explora Journeys
Ship: Explora VI
Departure: 14 August 2028
Visit: Spain, Tunisia, Sicily, Italy, Albania, Croatia
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$14,259
From
A$14,259
Save 291
Per Person
View Trip
11 Day Golden Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 29 January 2029
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,105
Suite
$10,024
From
A$8,105
Save 7,345
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 10 April 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
$1,473
Oceanview
$1,720
Balcony
-
Suite
$2,720
From
A$1,473
Per Person
View Trip
8 Day A Journey Of Iconic Islands & Coastal Wonders with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: Jun 2027 to Oct 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,350
From
A$7,350
Save 162
Per Person
View Trip
9 Day Barcelona to Civitavecchia (Rome) with Silversea
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 21 May 2027
Visit: Spain, Sardinia, Sicily, Malta, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,643
Suite
$18,620
From
A$9,643
Save 2,657
Per Person
View Trip
15 Day Ages Of Mediterranean with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 19 September 2028
Visit: Spain, France, Italy, Sicily, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,461
Suite
$24,000
From
A$22,461
Save 2,409
Per Person
View Trip
11 Day Luminous Italy with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 01 April 2028
Visit: Spain, France, Monaco, Italy, Sardinia, Sicily
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,910
Suite
$16,154
From
A$13,910
Save 2,250
Per Person
View Trip
Results: 151-180 of 200

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