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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$3,924
Oceanview
$4,211
Balcony
$6,459
Suite
$8,954
From
A$3,924
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 04 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Just Cruise Fare
Exclusive Savings
Inside
$4,251
Oceanview
$4,966
Balcony
$6,052
Suite
$7,943
From
A$4,251
Per Person
View Trip
8 Day Canary Islands with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 05 April 2027
Visit: Spain, Morocco, Italy
Exclusive Savings
Inside
$980
Oceanview
$1,227
Balcony
$1,554
Suite
-
From
A$980
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 04 August 2028
Visit: Spain, France, Corsica, Italy
Exclusive Savings
Inside
$2,229
Oceanview
$2,526
Balcony
$2,773
Suite
$5,941
From
A$2,229
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 26 September 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$2,003
Oceanview
$2,350
Balcony
$2,775
Suite
$3,419
From
A$2,003
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 June 2027
Visit: Spain, Corsica, Italy, Malta, Montenegro, Croatia
First Come, First Served Offer
Exclusive Savings
Inside
$4,004
Oceanview
$4,419
Balcony
$4,815
Suite
$9,874
From
A$4,004
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: Jun 2026 to Oct 2027
Visit: Spain, France, Italy, Sicily
Just Cruise Fare
Exclusive Savings
Inside
$1,527
Oceanview
$2,807
Balcony
$2,047
Suite
$2,405
From
A$1,527
Per Person
View Trip
8 Day Costa Brave & Italy with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 October 2026
Visit: Spain, France, Corsica, Italy, Sardinia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$2,725
Balcony
$3,758
Suite
$4,893
From
A$2,725
Save 2,975
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Sep 2027 to Aug 2028
Visit: Spain, France, Italy, Corsica
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,529
Oceanview
$1,786
Balcony
$2,385
Suite
$2,652
From
A$1,529
Per Person
View Trip
13 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence, Rome & Venice with Azamara Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 March 2027
Visit: Spain, France, Italy, Sicily, Montenegro, Croatia
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Exclusive Savings
Inside
$3,812
Oceanview
$5,135
Balcony
$5,517
Suite
$7,820
From
A$3,812
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia, Corsica, Sicily
Exclusive Savings
Inside
$3,212
Oceanview
$3,568
Balcony
-
Suite
-
From
A$3,212
Per Person
View Trip
8 Day A Journey Of Mediterranean Elegance From Secluded Coves To Renaissance Splendour with Explora Journeys
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 18 September 2028
Visit: Spain, Sardinia, Italy, Monaco, France
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,610
From
A$7,610
Save 155
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 18 July 2026
Visit: Spain, France, Corsica, Italy
Sanctuary Collection
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,994
From
A$4,994
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: Jun 2026 to Sep 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,569
Oceanview
$1,819
Balcony
$2,991
Suite
$4,185
From
A$1,569
Save 924
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 15 September 2028
Visit: Spain, France, Corsica, Italy
Exclusive Savings
Inside
$2,377
Oceanview
$2,526
Balcony
$2,773
Suite
$5,941
From
A$2,377
Per Person
View Trip
13 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence & Venice with Azamara Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 08 June 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$6,362
Oceanview
$7,078
Balcony
$8,704
Suite
$12,536
From
A$6,362
Save 97
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 10 October 2026
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,884
Oceanview
$2,379
Balcony
$3,024
Suite
$3,438
From
A$1,884
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$3,429
Oceanview
$3,786
Balcony
-
Suite
-
From
A$3,429
Per Person
View Trip
22 Day Greece, Turkey, Italy And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey (+4 more), Italy, Malta, Montenegro, Croatia
Exclusive Savings
Inside
$6,441
Oceanview
$7,134
Balcony
$8,421
Suite
$15,153
From
A$6,441
Per Person
View Trip
25 Day Greek Isles, Malta & Croatia with Holland America
Cruise
 (3)

25 Days (24 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 28 August 2027
Visit: Spain, Malta, Greece, Turkey (+4 more), Montenegro, Sicily, Italy, Croatia
Fare Saver
Exclusive Savings
Inside
$6,861
Oceanview
$7,673
Balcony
$9,385
Suite
$14,434
From
A$6,861
Per Person
View Trip
10 Day Ramblas & The Rivieras with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 13 September 2028
Visit: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Your World Inclusions
Exclusive Savings
Inside
$4,077
Oceanview
$5,153
Balcony
$6,104
Suite
$8,742
From
A$4,077
Save 2,113
Per Person
View Trip
8 Day Spain, France & Italy Cruise: Palamos, Marseille & Rome with Azamara Cruises
Cruise
 (4)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 08 April 2028
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$2,340
Oceanview
$2,536
Balcony
$3,114
Suite
$4,369
From
A$2,340
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Exclusive Savings
Inside
$3,568
Oceanview
$4,103
Balcony
$4,706
Suite
-
From
A$3,568
Per Person
View Trip
17 Day France & Italy Combination Cruise: Saint-tropez, Portofino & Florence with Azamara Cruises
Cruise
 (5)

17 Days (16 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 23 September 2028
Visit: Spain, France, Corsica, Italy, Sardinia
Azamara Always Included
Exclusive Savings
Inside
$6,063
Oceanview
$6,573
Balcony
$8,082
Suite
$11,424
From
A$6,063
Per Person
View Trip
10 Day A Journey Along Spain’s Coast To The Italian Rivieras with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 24 January 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,531
From
A$7,531
Save 154
Per Person
View Trip
8 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Visit: Spain, France, Italy
Azamara Always Included
Exclusive Savings
Inside
$2,380
Oceanview
$2,753
Balcony
$3,057
Suite
$4,732
From
A$2,380
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2027 to Aug 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,587
Oceanview
$1,845
Balcony
$2,280
Suite
$2,726
From
A$1,587
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (5)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$4,835
Oceanview
$5,580
Balcony
$10,009
Suite
-
From
A$4,835
Save 74
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Just Cruise Fare
Exclusive Savings
Inside
$2,107
Oceanview
-
Balcony
$2,718
Suite
$2,926
From
A$2,107
Per Person
View Trip
13 Day Total Eclipse of the (Med) with Virgin Voyages
Cruise
 (2)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 10 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
Inside
$2,892
Oceanview
$3,405
Balcony
$3,576
Suite
$9,395
From
A$2,892
Per Person
View Trip
Results: 31-60 of 200

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