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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 313 departures available from seventeen of the world's leading cruise lines.
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153 Cruises (313 Cruise Departures)
11 Day Radiant Rivieras with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 November 2026
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$3,421
Oceanview
$4,003
Balcony
$3,829
Suite
$5,381
From
US$3,421
Save 3,577
Per Person
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,592
Oceanview
$2,786
Balcony
$3,901
Suite
$4,871
From
US$2,592
Save 2,706
Per Person
View Trip
10 Day Ramblas & The Rivieras with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 September 2026
Visit: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,215
Suite
-
From
US$5,215
Save 5,483
Per Person
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Inside
$2,129
Oceanview
$2,484
Balcony
$2,959
Suite
$4,870
From
US$2,129
Per Person
View Trip
10 Day Seaside Splendor with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 November 2027
Visit: Spain, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,130
Suite
$5,652
From
US$3,130
Save 3,268
Per Person
View Trip
8 Day Canary Islands with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 05 April 2027
Visit: Spain, Morocco, Italy
Inside
$569
Oceanview
$729
Balcony
$849
Suite
$2,285
From
US$569
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 May 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$1,429
Oceanview
$1,619
Balcony
$1,779
Suite
$3,749
From
US$1,429
Per Person
View Trip
8 Day Relaxation & Romance with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 01 April 2028
Visit: Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,660
Suite
$5,163
From
US$3,660
Save 3,838
Per Person
View Trip
8 Day Culinary Towns & Villages with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 November 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,206
Suite
$6,186
From
US$5,206
Save 10,392
Per Person
View Trip
13 Day Southern Europe Sojourn with Oceania Cruises
Cruise

13 Days (12 Nights) Barcelona to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 25 June 2026
Visit: Spain, France, Monaco, Corsica (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,700
Suite
$8,233
From
US$5,700
Save 5,998
Per Person
View Trip
10 Day Islands & Empires with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 29 October 2027
Visit: Spain, Italy, Sicily, Malta, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,323
Suite
$5,845
From
US$3,323
Save 3,475
Per Person
View Trip
10 Day Italy, France & Croatia Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 07 May 2026
Visit: Spain, France, Italy, Croatia, Montenegro
Exclusive Savings
Inside
$1,672
Oceanview
$1,952
Balcony
$2,684
Suite
$4,301
From
US$1,672
Save 793
Per Person
View Trip
15 Day Culinary Coasts with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy (+4 more), Sardinia, Sicily, Montenegro, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,800
Suite
$13,996
From
US$13,800
Save 21,298
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Malaga to Genoa
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 03 October 2026
Visit: Spain, Portugal, Sardinia, Italy
Inside
-
Oceanview
-
Balcony
$1,199
Suite
-
From
US$1,199
Per Person
View Trip
8 Day Luminous Mediterranean with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 October 2026
Visit: Spain, France, Italy
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,521
Suite
$4,488
From
US$3,521
Save 4,077
Per Person
View Trip
10 Day Mediterranean Masterpieces with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 02 June 2027
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,761
Suite
$6,331
From
US$3,761
Save 3,937
Per Person
View Trip
8 Day Barcelona to Rome with Silversea
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 01 November 2026
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$3,760
Balcony
$4,400
Suite
$9,280
From
US$3,760
Save 940
Per Person
View Trip
19 Day Italia In Full with Regent Seven Seas
Cruise

19 Days (18 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy (+5 more), Sicily, Sardinia, Montenegro, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,982
Suite
$16,207
From
US$14,982
Save 23,516
Per Person
View Trip
12 Day Idyllic Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 07 July 2028
Visit: Spain, Corsica, Italy, Sardinia
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,031
Suite
$17,650
From
US$15,031
Save 18,959
Per Person
View Trip
11 Day Springtime Sunshine with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 April 2028
Visit: Spain, Sardinia, Corsica, France, Monaco, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,196
Suite
$6,718
From
US$4,196
Save 4,402
Per Person
View Trip
13 Day Mediterranean Nights with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 September 2026
Visit: Spain, France, Italy, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,242
Suite
$13,202
From
US$11,242
Save 17,056
Per Person
View Trip
11 Day Italian Celebration with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,644
Suite
$9,673
From
US$8,644
Save 14,954
Per Person
View Trip
15 Day Mediterranean Odyssey: Spain, Italy and the French Riviera with Scenic
New ReleaseCruise

15 Days (14 Nights) Malaga to Rome
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 21 April 2027
Visit: Spain, France, Monaco, Italy, Corsica
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,564
Suite
$24,488
From
US$15,564
Save 19,426
Per Person
View Trip
12 Day Cultures of the Mediterranean Barcelona to Civitavecchia with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2027 to Sep 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$8,721
Balcony
-
Suite
$12,019
From
US$8,721
Save 11,269
Per Person
View Trip
8 Day Spellbinding Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 16 April 2027
Visit: Spain, France, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,513
Suite
$5,453
From
US$3,513
Save 3,685
Per Person
View Trip
8 Day Spain, France & Italy with Seabourn
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 25 September 2027
Visit: Spain, France, Corsica, Sardinia, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,345
Suite
$8,594
From
US$5,345
Save 94
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: May 2027 to Sep 2027
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$954
Oceanview
$1,184
Balcony
$1,443
Suite
$2,088
From
US$954
Save 495
Per Person
View Trip
12 Day Picturesque Panoramas with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 August 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,527
Suite
$10,997
From
US$9,527
Save 15,871
Per Person
View Trip
10 Day Eclipse The Ordinary with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 July 2027
Visit: Spain, Malta, Sicily, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,768
Suite
$10,454
From
US$9,768
Save 15,130
Per Person
View Trip
12 Day Epicurean Spotlight On Wine with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 18 September 2026
Visit: Spain, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,822
Suite
$11,292
From
US$9,822
Save 15,576
Per Person
View Trip
Results: 121-150 of 153

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