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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
11 Day Greece, Italy & Croatia with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 05 June 2027
Visit: Spain, Sicily, Greece, Croatia, Italy
Exclusive Savings
Inside
$2,382
Oceanview
$2,818
Balcony
$3,240
Suite
$5,567
From
A$2,382
Save 1,118
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC World Asia
Departure: 11 December 2026
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,055
Suite
-
From
A$1,055
Per Person
View Trip
11 Day Springtime Sunshine with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 April 2028
Visit: Spain, Sardinia, Corsica, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,512
Suite
$10,421
From
A$6,512
Save 2,158
Per Person
View Trip
12 Day Cultures of the Mediterranean Barcelona to Civitavecchia with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2027 to Sep 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$12,971
Balcony
-
Suite
$17,357
From
A$12,971
Save 3,226
Per Person
View Trip
8 Day A Journey of Iconic Islands & Coastal Wonders with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 17 May 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,982
From
A$6,982
Save 143
Per Person
View Trip
15 Day Catalonia, Italy & the French Riviera - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

15 Days Barcelona to Rome
Operated By: Scenic
Ship: Scenic Ikon
Departure: 20 September 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Spain, France, Monaco, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$26,263
Suite
$29,791
From
A$26,263
Save 4,997
Per Person
View Trip
10 Day Western Mediterranean: Spain, Morocco & Italy with Holland America
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Zuiderdam
Departure: 17 February 2028
Visit: Spain, Morocco, Sardinia, Italy
Fare Saver
Exclusive Savings
Inside
$1,593
Oceanview
$1,811
Balcony
$2,346
Suite
$3,494
From
A$1,593
Per Person
View Trip
21 Day Song Of The Mediterranean with Regent Seven Seas
Cruise

21 Days (20 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Explorer
Departure: 25 August 2028
Visit: Spain, France, Monaco, Italy (+4 more), Sardinia, Sicily, Greece, Montenegro
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$33,284
Suite
$36,087
From
A$33,284
Save 2,616
Per Person
View Trip
10 Day Toast To Toulon with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 31 August 2027
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,082
Suite
$15,631
From
A$15,082
Save 2,278
Per Person
View Trip
11 Day Chanson Du Soleil with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 22 July 2028
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,132
Suite
$18,739
From
A$17,132
Save 2,318
Per Person
View Trip
8 Day Mediterranean Symphony with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 19 September 2028
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,254
Suite
$12,518
From
A$11,254
Save 2,206
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 21 June 2027
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,424
Oceanview
$1,980
Balcony
$2,278
Suite
$3,726
From
A$1,424
Save 784
Per Person
View Trip
8 Day A Journey Through The Picturesque Mediterranean & Historic Beauty Of The Sparkling Riviera with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: Jun 2026 to Aug 2026
Visit: Spain, France, Italy, Sardinia, Corsica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,379
From
A$8,379
Save 201
Per Person
View Trip
11 Day A Journey From The Vibrant Shores Of Catalonia To The Grandeur Of Venice with Explora Journeys
Cruise

11 Days (10 Nights) Barcelona to Venice
Cruise Line: Explora Journeys
Ship: Explora IV
Departure: 21 October 2028
Visit: Spain, Malta, Sicily, Italy, Montenegro, Slovenia
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,178
From
A$9,178
Save 187
Per Person
View Trip
18 Day Discover Timeless Horizons: Tenerife to Italy with Emerald Cruises
New ReleaseCruise

18 Days (17 Nights) Tenerife to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Kaia
Departure: 20 April 2028
Visit: Spain, Morocco, Sardinia, Corsica, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$21,107
Balcony
-
Suite
$27,967
From
A$21,107
Save 5,383
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 02 August 2027
Visit: Spain, France, Italy, Sicily
Exclusive Savings
Inside
$1,571
Oceanview
$2,020
Balcony
$2,367
Suite
$3,902
From
A$1,571
Save 843
Per Person
View Trip
9 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 20 August 2027
Visit: Spain, France, Italy, Sicily
Exclusive Savings
Inside
$1,875
Oceanview
$2,350
Balcony
$2,710
Suite
$4,725
From
A$1,875
Save 951
Per Person
View Trip
15 Day Culinary Mediterranean with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 24 August 2028
Visit: Spain, France, Monaco, Italy, Greece, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,579
Suite
$24,980
From
A$23,579
Save 2,431
Per Person
View Trip
8 Day A Journey Through Mediterranean Beauty, Artistic Spirit & Eternal Charms with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ships: Explora II, Explora I
Departures: Aug 2026 to Oct 2028
Visit: Spain, Tunisia, Malta, Sicily, Italy
A Spontaneous Summer Invitation
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,595
From
A$6,595
Save 181
Per Person
View Trip
8 Day Barcelona to Rome with Silversea
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 01 November 2026
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
Last Minute Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,635
Balcony
$6,125
Suite
$15,778
From
A$5,635
Save 115
Per Person
View Trip
8 Day Luminous Mediterranean with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 31 October 2026
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,245
Suite
$5,638
From
A$4,245
Save 2,095
Per Person
View Trip
8 Day Spain, France & Italy with Seabourn
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Sep 2027 to Aug 2028
Visit: Spain, France, Corsica, Sardinia, Italy
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,423
Suite
$12,891
From
A$7,423
Save 172
Per Person
View Trip
10 Day Eclipse The Ordinary with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 July 2027
Visit: Spain, Malta, Sicily, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$27,203
From
A$27,203
Save 2,527
Per Person
View Trip
9 Day Splendid Summer Sun with Oceania Cruises
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 09 July 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,110
Suite
$7,884
From
A$5,110
Save 2,120
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 08 December 2026
Visit: Spain, Morocco, Italy
Exclusive Savings
Inside
$1,098
Oceanview
$1,267
Balcony
$1,544
Suite
$2,455
From
A$1,097
Per Person
View Trip
8 Day A Journey Through Cultural Elegance & Timeless Discovery with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora VI
Departure: 14 August 2028
Visit: Spain, Tunisia, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,502
From
A$7,502
Save 153
Per Person
View Trip
8 Day Autumn In Europe with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 29 September 2028
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,980
Suite
$12,940
From
A$10,980
Save 2,200
Per Person
View Trip
15 Day Southern Mediterranean Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 07 December 2026
Visit: Spain, France, Italy, Sicily, Tunisia, Malta
Exclusive Savings
Inside
-
Oceanview
$16,486
Balcony
$18,221
Suite
$18,642
From
A$16,486
Save 2,294
Per Person
View Trip
8 Day Italy, France & Croatia Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 02 July 2027
Visit: Spain, Corsica, Italy, Sicily, Croatia
Exclusive Savings
Inside
$1,623
Oceanview
$2,004
Balcony
$2,282
Suite
$4,118
From
A$1,623
Save 817
Per Person
View Trip
11 Day Highlights of Spain, Morocco & Italy with Emerald Cruises
Cruise

11 Days (10 Nights) Tenerife to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Kaia
Departure: 20 April 2028
Visit: Spain, Morocco, Corsica, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$12,276
Balcony
-
Suite
$16,196
From
A$12,276
Save 3,219
Per Person
View Trip
Results: 121-150 of 200

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