Home > Cruises > Europe Cruises > Western Europe Cruises > Cruises from Spain to Italy

Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 339 departures available from seventeen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
3 Days
29 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$200pp
$42,098pp
Countries
Show More...
Filter Results
168 Cruises (339 Cruise Departures)
8 Day Canary Islands with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 05 April 2027
Visit: Spain, Morocco, Italy
Inside
$627
Oceanview
$787
Balcony
$907
Suite
-
From
US$627
Per Person
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,049
Oceanview
$3,299
Balcony
$4,299
Suite
$5,199
From
US$3,049
Save 3,049
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 September 2027
Visit: Spain, France, Italy, Corsica
Princess Standard
Sanctuary Collection
Inside
$1,189
Oceanview
$1,589
Balcony
$1,864
Suite
$2,089
From
US$1,189
Per Person
View Trip
8 Day Yachting Havens with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 May 2026
Visit: Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$2,549
Balcony
-
Suite
$9,699
From
US$2,549
Save 2,549
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 17 October 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
$1,149
Oceanview
-
Balcony
$1,589
Suite
$1,909
From
US$1,149
Per Person
View Trip
15 Day Iberia Celebration with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Bilbao to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 August 2026
Visit: Spain, Portugal, France, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,185
Oceanview
$3,395
Balcony
$5,250
Suite
$6,755
From
US$3,185
Save 5,913
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 May 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$919
Oceanview
$919
Balcony
$1,199
Suite
$3,079
From
US$919
Per Person
View Trip
13 Day Southern Europe Sojourn with Oceania Cruises
Cruise

13 Days (12 Nights) Barcelona to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 25 June 2026
Visit: Spain, France, Monaco, Corsica (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,332
Suite
-
From
US$6,332
Save 8,566
Per Person
View Trip
27 Day Ramblas To Renaissance with Oceania Cruises
Cruise
 (1)

27 Days (26 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 December 2026
Visit: Spain, Gibraltar, Morocco, Portugal, France, Italy, Corsica
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$8,099
Balcony
$12,549
Suite
$17,449
From
US$8,099
Save 8,099
Per Person
View Trip
8 Day Costa Brave & Italy with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 October 2026
Visit: Spain, France, Corsica, Italy, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$1,760
Oceanview
$2,080
Balcony
$2,880
Suite
$3,760
From
US$1,760
Save 2,638
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Inside
$2,399
Oceanview
$2,699
Balcony
$2,859
Suite
$6,119
From
US$2,399
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 02 August 2027
Visit: Spain, France, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,077
Oceanview
$1,427
Balcony
$1,669
Suite
$2,439
From
US$1,077
Save 541
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: May 2027 to Sep 2027
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,070
Oceanview
$1,490
Balcony
$1,685
Suite
$2,183
From
US$1,070
Save 545
Per Person
View Trip
12 Day Epicurean Spotlight On Wine with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 18 September 2026
Visit: Spain, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,699
Suite
$14,199
From
US$12,699
Save 12,699
Per Person
View Trip
12 Day Picturesque Panoramas with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 August 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,699
Suite
$13,699
From
US$12,699
Save 12,699
Per Person
View Trip
11 Day Italian Celebration with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,299
Suite
$14,499
From
US$13,299
Save 13,299
Per Person
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Barcelona to Florence
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 10 May 2026
Visit: Spain, France, Italy
Drinks & WiFi Package
Inside
-
Oceanview
-
Balcony
-
Suite
$859
From
US$859
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Barcelona to Livorno
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 05 May 2026
Visit: Spain, Tunisia, Sicily, Italy
Drinks & WiFi Package
Inside
-
Oceanview
-
Balcony
-
Suite
$2,819
From
US$2,819
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 05 May 2026
Visit: Spain, Tunisia, Sicily, Italy
Inside
$419
Oceanview
-
Balcony
-
Suite
-
From
US$419
Per Person
View Trip
12 Day Idyllic Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 07 July 2028
Visit: Spain, Corsica, Italy, Sardinia
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,424
Suite
$17,985
From
US$15,424
Save 2,321
Per Person
View Trip
12 Day Best Of Italy, France & Spain with Celebrity Cruises
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 24 May 2027
Visit: Spain, Corsica, France, Italy, Sicily
Exclusive Savings
Inside
$2,304
Oceanview
$2,350
Balcony
$2,822
Suite
$8,530
From
US$2,304
Save 1,333
Per Person
View Trip
11 Day Extravagant Ionian Journey with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 02 September 2026
Visit: Spain, Italy, Malta, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
$10,999
Balcony
-
Suite
$13,549
From
US$10,999
Save 10,999
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 28 September 2026
Visit: Spain, France, Monaco, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$7,500
Balcony
$7,900
Suite
$7,700
From
US$7,500
Save 2,500
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 08 December 2026
Visit: Spain, Morocco, Italy
Inside
$719
Oceanview
$839
Balcony
$1,039
Suite
$1,699
From
US$719
Per Person
View Trip
10 Day Ramblas & The Rivieras with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 September 2026
Visit: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,349
Suite
$8,199
From
US$6,349
Save 6,349
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 19 May 2026
Visit: Spain, France, Monaco, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,900
Suite
-
From
US$8,900
Save 2,500
Per Person
View Trip
11 Day Springtime Sunshine with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 05 April 2028
Visit: Spain, Sardinia, Corsica, France, Monaco, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,299
Suite
$6,899
From
US$4,299
Save 4,299
Per Person
View Trip
11 Day A Journey Of Unique Architecture Seamlessely Blending Culture & Scenic Beauty with Explora Journeys
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 03 May 2026
Visit: Spain, Morocco, Colombia, France, Monaco, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$7,050
From
US$7,050
Per Person
View Trip
10 Day Islands & Empires with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 29 October 2027
Visit: Spain, Italy, Sicily, Malta, Greece, Montenegro, Croatia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,399
Suite
$5,999
From
US$3,399
Save 3,399
Per Person
View Trip
12 Day Cultures of the Mediterranean Barcelona to Civitavecchia with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2027 to Sep 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$8,622
Balcony
-
Suite
$11,691
From
US$8,622
Save 1,928
Per Person
View Trip
Results: 121-150 of 168

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Cape Verde England France Germany Gibraltar Guernsey Italy Malta Morocco Portugal Puerto Rico Senegal Spain USA

Cities

Cruises from Barcelona Cruises from Lanzarote Cruises from Las Palmas de Gran Canaria Cruises from Malaga Cruises from Santa Cruz de Tenerife Cruises from Valencia

Routes

Cruises from Barcelona to Trieste Cruises from Barcelona to Rome Cruises from Barcelona to Venice Cruises from Barcelona to Bologna

Country Routes

Cruises from Spain to Italy

Cruise Lines Exploring Europe

APT Europe Cruises Azamara Europe Cruises Celebrity Europe Cruises Cunard Europe Cruises Emerald Europe Cruises G Adventures Europe Cruises Intrepid Europe Cruises MSC Europe Cruises NCL Europe Cruises Oceania Europe Cruises Ponant Europe Cruises Princess Europe Cruises Regent Seven Seas Europe Cruises Royal Caribbean Europe Cruises Scenic Europe Cruises Silversea Europe Cruises Viking Europe Cruises Virgin Voyages Europe Cruises

Western Europe Tours

France Tours Morocco Tours Portugal Tours Provence Tours Spain & Portugal Tours Spain Tours Western Europe Tours

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations