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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
8 Day A Journey Of Balearic Allure, Classic Culture & Italian Artistry with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora VI
Departures: Sep 2028 to Oct 2028
Visit: Spain, Tunisia, Sicily, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,982
From
A$6,982
Save 164
Per Person
View Trip
10 Day Seaside Splendor with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 November 2027
Visit: Spain, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,628
Suite
$7,878
From
A$4,628
Save 2,102
Per Person
View Trip
11 Day Iconic Italy & the French Riviera with Scenic
New ReleaseCruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 24 September 2028
Visit: Spain, France, Monaco, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,751
Suite
$22,279
From
A$18,751
Save 4,844
Per Person
View Trip
15 Day Mediterranean Odyssey: Spain, Italy and the French Riviera with Scenic
New ReleaseCruise

15 Days (14 Nights) Malaga to Rome
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 21 April 2027
Visit: Spain, France, Monaco, Italy, Corsica
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,602
Suite
$33,823
From
A$21,602
Save 6,393
Per Person
View Trip
8 Day Cultures & Cuisines with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,784
Suite
$14,000
From
A$13,784
Save 2,256
Per Person
View Trip
13 Day Southern Europe Sojourn with Oceania Cruises
Cruise

13 Days (12 Nights) Barcelona to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 25 June 2026
Visit: Spain, France, Monaco, Corsica (+5 more), Italy, Sicily, Greece, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,934
Suite
$23,261
From
A$8,546
Save 2,214
Per Person
View Trip
29 Day Hidden Gems Of France, Italy, Croatia & Slovenia with Seabourn
Cruise

29 Days (28 Nights) Barcelona to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 07 October 2028
Visit: Spain, France, Sardinia, Corsica (+8 more), Monaco, Italy, Sicily, Malta, Montenegro, Croatia, Greece, Slovenia
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$26,695
Suite
$41,689
From
A$26,695
Save 484
Per Person
View Trip
10 Day Western Mediterranean Quest with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 06 November 2028
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,887
Suite
$8,272
From
A$4,887
Save 2,133
Per Person
View Trip
15 Day Olive Trees & Lavender Fields with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 07 June 2028
Visit: Spain, France, Italy, Sicily, Malta, Montenegro, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,419
Suite
$25,957
From
A$24,419
Save 2,451
Per Person
View Trip
10 Day Mediterranean Masterpieces with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 02 June 2027
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,540
Suite
$9,993
From
A$6,540
Save 2,160
Per Person
View Trip
8 Day Best Of Italy & French Riviera with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 06 August 2027
Visit: Spain, France, Italy, Sicily
Exclusive Savings
Inside
$1,647
Oceanview
$2,060
Balcony
$2,371
Suite
$4,146
From
A$1,647
Save 854
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: May 2027 to Sep 2027
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,465
Oceanview
$2,076
Balcony
$2,349
Suite
$3,511
From
A$1,465
Save 861
Per Person
View Trip
12 Day Savoring The World with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 09 November 2028
Visit: Spain, Sardinia, Sicily, Tunisia, Malta, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,448
Suite
$17,693
From
A$15,448
Save 2,282
Per Person
View Trip
8 Day Relaxation & Romance with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 01 April 2028
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,514
Suite
$7,774
From
A$5,514
Save 2,136
Per Person
View Trip
11 Day Riviera Harbors & Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 09 October 2028
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,194
Suite
$10,230
From
A$7,194
Save 2,206
Per Person
View Trip
8 Day Barcelona to Rome with Silversea
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 07 September 2026
Visit: Spain, Sardinia, Tunisia, Sicily, Italy
Last Minute Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$7,497
Balcony
$8,575
Suite
$16,562
From
A$7,497
Save 153
Per Person
View Trip
15 Day A Holiday To Remember with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 20 December 2027
Visit: Spain, Morocco, Tunisia, Sicily, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,816
Suite
$10,512
From
A$7,816
Save 2,184
Per Person
View Trip
10 Day Islands & Empires with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Trieste
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 29 October 2027
Visit: Spain, Italy, Sicily, Malta, Greece, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,579
Suite
$8,052
From
A$4,579
Save 2,101
Per Person
View Trip
19 Day Italia In Full with Regent Seven Seas
Cruise

19 Days (18 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy (+5 more), Sicily, Sardinia, Montenegro, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$32,223
Suite
$34,154
From
A$32,223
Save 2,597
Per Person
View Trip
8 Day Fine Wines & Culinary Capitals with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 24 August 2028
Visit: Spain, France, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,098
Suite
$13,284
From
A$12,098
Save 2,222
Per Person
View Trip
Results: 181-200 of 200

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