Home > Cruises > Europe Cruises > Western Europe Cruises > Cruises from Spain to Italy

Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 339 departures available from seventeen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
3 Days
29 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$200pp
$42,098pp
Countries
Show More...
Filter Results
168 Cruises (339 Cruise Departures)
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
Limited Time Offer
Inside
$2,407
Oceanview
$2,705
Balcony
$2,875
Suite
-
From
US$2,407
Per Person
View Trip
10 Day Under The Tuscan Sunset with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 17 June 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,499
Suite
$11,849
From
US$11,499
Save 11,499
Per Person
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+5 more), Italy, Greece, Montenegro, Croatia, Malta
Inside
-
Oceanview
$3,899
Balcony
$4,979
Suite
-
From
US$3,899
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 September 2026
Visit: Spain, Corsica, France, Italy
Princess Standard
Sanctuary Collection
Inside
$1,619
Oceanview
$2,039
Balcony
$2,614
Suite
$2,889
From
US$1,619
Per Person
View Trip
22 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy, Croatia
Inside
$3,899
Oceanview
$4,249
Balcony
$5,449
Suite
$11,649
From
US$3,899
Per Person
View Trip
13 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence, Rome & Venice with Azamara Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 March 2027
Visit: Spain, France, Italy, Sicily, Montenegro, Croatia
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Inside
$2,909
Oceanview
$3,319
Balcony
$4,209
Suite
$5,989
From
US$2,909
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 10 April 2027
Visit: Spain, France, Italy
Inside
$969
Oceanview
$1,149
Balcony
-
Suite
$1,749
From
US$969
Per Person
View Trip
8 Day Regal Retreat with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 June 2027
Visit: Spain, France, Monaco, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,799
Suite
$9,599
From
US$8,799
Save 8,799
Per Person
View Trip
23 Day Greek Isles With Amalfi Coast, Istanbul & Dubrovnik with Holland America
Cruise
 (3)

23 Days (22 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 April 2027
Visit: Spain, France, Italy, Sicily (+4 more), Greece, Turkey, Albania, Croatia
Book Early & Have It All Fare Option
Inside
$4,174
Oceanview
$4,654
Balcony
$5,954
Suite
$8,184
From
US$4,174
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Inside
$1,169
Oceanview
$1,619
Balcony
$1,669
Suite
$1,819
From
US$1,169
Per Person
View Trip
8 Day A Journey Through Sparkling Bays & Riviera Radiance with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Visit: Spain, Sardinia, France, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,450
From
US$4,450
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 25 April 2026
Visit: Spain, France, Corsica, Italy
Princess Standard
Princess Premier
Inside
$1,341
Oceanview
$1,856
Balcony
$1,910
Suite
$3,191
From
US$1,341
Per Person
View Trip
10 Day A Journey Along Spain’s Coast To The Italian Rivieras with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 24 January 2027
Visit: Spain, France, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,865
From
US$4,865
Per Person
View Trip
11 Day Riviera Yacht Harbors with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 25 April 2026
Visit: Spain, France, Monaco, Italy
Yours to Explore
Inside
-
Oceanview
-
Balcony
$13,699
Suite
$13,699
From
US$13,699
Per Person
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 18 April 2026
Visit: Spain, Italy
Inside
-
Oceanview
$225
Balcony
-
Suite
-
From
US$225
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: Aug 2026 to Sep 2026
Visit: Spain, France, Italy, Sicily
Inside
$879
Oceanview
$1,119
Balcony
$1,169
Suite
$1,549
From
US$879
Per Person
View Trip
8 Day Relaxation & Romance with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 01 April 2028
Visit: Spain, France, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,749
Suite
$5,299
From
US$3,749
Save 3,749
Per Person
View Trip
8 Day Culinary Towns & Villages with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 November 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,799
Suite
$8,799
From
US$7,799
Save 7,799
Per Person
View Trip
13 Day Mediterranean Nights with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 September 2026
Visit: Spain, France, Italy, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,149
Suite
$15,899
From
US$14,149
Save 14,149
Per Person
View Trip
28 Day Solar Eclipse Collectors' Voyage: Iberia & Italy with Holland America
Cruise
 (3)

28 Days (27 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 02 August 2026
Visit: Spain, Morocco, Portugal, Corsica (+4 more), Italy, Montenegro, Greece, Sicily
Fare Saver
Inside
$4,454
Oceanview
-
Balcony
-
Suite
-
From
US$4,454
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 24 October 2026
Visit: Spain, France, Italy
Inside
$329
Oceanview
$379
Balcony
$439
Suite
$1,329
From
US$329
Per Person
View Trip
21 Day Barcelona to Rome with Silversea
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 28 September 2026
Visit: Spain, France, Monaco, Corsica, Italy, Sicily
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$12,200
Suite
$24,100
From
US$12,200
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,279
Oceanview
$1,459
Balcony
$1,934
Suite
$2,109
From
US$1,279
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,199
Oceanview
$1,429
Balcony
$1,624
Suite
$1,879
From
US$1,199
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2026 to Jul 2026
Visit: Spain, France, Corsica, Italy
Princess Standard
Princess Premier
Sanctuary Collection
Inside
$1,399
Oceanview
$1,649
Balcony
$1,874
Suite
$2,665
From
US$1,399
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 21 June 2027
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$1,102
Oceanview
$1,443
Balcony
$1,685
Suite
$2,615
From
US$1,102
Save 558
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,279
Oceanview
$1,849
Balcony
$1,899
Suite
$1,979
From
US$1,279
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Amalfi & Venice with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 24 April 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Inside
$3,079
Oceanview
$3,579
Balcony
$4,549
Suite
$6,969
From
US$3,079
Per Person
View Trip
8 Day Mediterranean with Total Solar Eclipse with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Visit: Spain, Gibraltar, Italy
Princess Standard
Sanctuary Collection
Inside
$2,329
Oceanview
$2,959
Balcony
$3,684
Suite
$4,619
From
US$2,329
Per Person
View Trip
15 Day Spain, France, Italy, Croatia & Malta with Seabourn
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 25 September 2027
Visit: Spain, France, Corsica, Sardinia (+5 more), Italy, Sicily, Malta, Montenegro, Croatia
Yours to Explore
Inside
-
Oceanview
-
Balcony
$14,399
Suite
-
From
US$14,399
Per Person
View Trip
Results: 91-120 of 168

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Cape Verde England France Germany Gibraltar Guernsey Italy Malta Morocco Portugal Puerto Rico Senegal Spain USA

Cities

Cruises from Barcelona Cruises from Lanzarote Cruises from Las Palmas de Gran Canaria Cruises from Malaga Cruises from Santa Cruz de Tenerife Cruises from Valencia

Routes

Cruises from Barcelona to Trieste Cruises from Barcelona to Rome Cruises from Barcelona to Venice Cruises from Barcelona to Bologna

Country Routes

Cruises from Spain to Italy

Cruise Lines Exploring Europe

APT Europe Cruises Azamara Europe Cruises Celebrity Europe Cruises Cunard Europe Cruises Emerald Europe Cruises G Adventures Europe Cruises Intrepid Europe Cruises MSC Europe Cruises NCL Europe Cruises Oceania Europe Cruises Ponant Europe Cruises Princess Europe Cruises Regent Seven Seas Europe Cruises Royal Caribbean Europe Cruises Scenic Europe Cruises Silversea Europe Cruises Viking Europe Cruises Virgin Voyages Europe Cruises

Western Europe Tours

France Tours Morocco Tours Portugal Tours Provence Tours Spain & Portugal Tours Spain Tours Western Europe Tours

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations