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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
11 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 18 September 2027
Visit: Spain, Morocco, Portugal, Sardinia, Italy
Exclusive Savings
Inside
$2,806
Oceanview
$3,181
Balcony
$3,483
Suite
$9,479
From
A$2,806
Save 1,841
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
First Come, First Served Offer
Exclusive Savings
Inside
$4,192
Oceanview
$4,796
Balcony
$4,855
Suite
$9,785
From
A$4,192
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 25 August 2028
Visit: Spain, France, Italy, Malta, Croatia
Exclusive Savings
Inside
$4,261
Oceanview
$4,756
Balcony
$5,201
Suite
$10,399
From
A$4,261
Per Person
View Trip
11 Day Spain, Portugal & France Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 24 July 2027
Visit: Spain, Gibraltar, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,466
Oceanview
$2,670
Balcony
$2,718
Suite
$7,334
From
A$2,466
Save 1,633
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Sep 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Just Cruise Fare
Exclusive Savings
Inside
$4,236
Oceanview
$4,727
Balcony
$5,561
Suite
$7,273
From
A$4,236
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 24 October 2026
Visit: Spain, France, Italy
Drinks Package
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$2,211
From
A$2,211
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 September 2026
Visit: Spain, Corsica, France, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,924
Oceanview
$2,379
Balcony
$3,673
Suite
$3,834
From
A$1,924
Per Person
View Trip
15 Day Italy, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
First Come, First Served Offer
Exclusive Savings
Inside
$4,231
Oceanview
$4,607
Balcony
$4,726
Suite
$9,409
From
A$4,231
Per Person
View Trip
19 Day An Extended Journey From A Riviera New Year To The Mediterranean’s Deep Soul with Explora Journeys
Cruise
 (1)

19 Days (18 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 28 December 2026
Visit: Spain, France, Italy, Sicily, Malta, Tunisia
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$16,317
From
A$16,317
Save 333
Per Person
View Trip
8 Day French Riviera & Tuscan Seas with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 August 2028
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
$3,398
Oceanview
$4,281
Balcony
$5,086
Suite
$6,919
From
A$3,398
Save 2,092
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Amalfi
Cruise Line: Princess
Ship: Sun Princess
Departure: 01 October 2028
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,628
Oceanview
$1,816
Balcony
$2,484
Suite
$2,742
From
A$1,628
Per Person
View Trip
23 Day Greek Isles With Amalfi Coast, Istanbul & Dubrovnik with Holland America
Cruise
 (3)

23 Days (22 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 April 2027
Visit: Spain, France, Italy, Sicily (+4 more), Greece, Turkey, Albania, Croatia
Fare Saver
Exclusive Savings
Inside
$6,256
Oceanview
$6,979
Balcony
$8,761
Suite
$12,384
From
A$6,256
Per Person
View Trip
10 Day Romantic Locales & Canals with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 21 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Your World Inclusions
Exclusive Savings
Inside
$3,064
Oceanview
$3,335
Balcony
$4,794
Suite
$6,579
From
A$3,064
Save 2,836
Per Person
View Trip
9 Day A Journey Through Catalan Creativity, Riviera Allure & Italian Elegance with Explora Journeys
Cruise
 (1)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2028 to Aug 2028
Visit: Spain, Sardinia, Italy, Monaco, France
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,120
From
A$7,120
Save 155
Per Person
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 06 October 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Exclusive Savings
Inside
$4,021
Oceanview
$4,428
Balcony
$5,873
Suite
$9,802
From
A$4,021
Save 2,089
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 10 September 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
First Come, First Served Offer
Exclusive Savings
Inside
$4,192
Oceanview
$4,518
Balcony
$4,815
Suite
$10,349
From
A$4,192
Per Person
View Trip
9 Day France, Monaco & Italy Cruise: Cannes, Monte Carlo & Portofino with Azamara Cruises
Cruise
 (4)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 September 2028
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,048
Oceanview
$3,303
Balcony
$4,067
Suite
$5,743
From
A$3,048
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 23 June 2028
Visit: Spain, Corsica, Italy
Exclusive Savings
Inside
$2,130
Oceanview
$2,526
Balcony
$2,674
Suite
$5,941
From
A$2,130
Per Person
View Trip
22 Day The Best of the Mediterranean with Princess
Cruise
 (2)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 06 June 2028
Visit: Spain, France, Corsica, Italy (+6 more), Malta, Montenegro, Greece, Sicily, Sardinia, Croatia
Princess Standard
Exclusive Savings
Inside
$3,763
Oceanview
$4,514
Balcony
$4,242
Suite
$5,797
From
A$3,763
Per Person
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 15 August 2026
Visit: Spain, Sicily, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,310
Oceanview
$2,459
Balcony
$2,528
Suite
$9,345
From
A$2,310
Save 1,571
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 03 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,819
Oceanview
$2,765
Balcony
$2,290
Suite
$3,579
From
A$1,819
Save 977
Per Person
View Trip
11 Day Croissants & Cannoli with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Exclusive Savings
Inside
$4,097
Oceanview
$4,572
Balcony
$7,007
Suite
$9,781
From
A$4,097
Save 2,083
Per Person
View Trip
11 Day Extravagant Ionian Journey with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 02 September 2026
Visit: Spain, Italy, Malta, Croatia, Slovenia
Exclusive Savings
Inside
-
Oceanview
$16,782
Balcony
-
Suite
$18,664
From
A$16,782
Save 2,308
Per Person
View Trip
15 Day Maritime Memories In The Med with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 January 2028
Visit: Spain, Morocco, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,828
Suite
$11,940
From
A$6,828
Save 2,152
Per Person
View Trip
15 Day Spain, France, Italy, Croatia & Malta with Seabourn
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 25 September 2027
Visit: Spain, France, Corsica, Sardinia (+5 more), Italy, Sicily, Malta, Montenegro, Croatia
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,761
Suite
-
From
A$16,761
Save 323
Per Person
View Trip
13 Day The Rivieras; A Mediterranean Masterpiece with Aurora Expeditions
New ReleaseCruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Aurora Expeditions
Ship: Douglas Mawson
Departure: 30 June 2026
Visit: Spain, France, Italy, Corsica
Inside
-
Oceanview
$20,095
Balcony
$21,295
Suite
$33,895
From
A$20,095
Per Person
View Trip
13 Day Mediterranean Nights with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 28 September 2026
Visit: Spain, France, Italy, Malta
Exquisite Escapes
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,836
Suite
$11,325
From
A$10,836
Save 12,374
Per Person
View Trip
11 Day Italian Celebration with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 May 2027
Visit: Spain, France, Monaco, Italy, Sicily, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,211
Suite
$22,122
From
A$20,211
Save 2,379
Per Person
View Trip
10 Day Under The Tuscan Sunset with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 17 June 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,797
Suite
$16,993
From
A$16,797
Save 2,313
Per Person
View Trip
8 Day Spellbinding Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 16 April 2027
Visit: Spain, France, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,758
Suite
$7,387
From
A$4,758
Save 2,112
Per Person
View Trip
Results: 91-120 of 200

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