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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 313 departures available from seventeen of the world's leading cruise lines.
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153 Cruises (313 Cruise Departures)
8 Day Cultures & Cuisines with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,071
Suite
$7,365
From
US$7,071
Save 12,327
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Amalfi & Venice with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 24 April 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$3,327
Oceanview
$3,860
Balcony
$4,908
Suite
$7,517
From
US$3,327
Save 72
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Inside
$2,869
Oceanview
$2,699
Balcony
$3,169
Suite
$6,123
From
US$2,699
Per Person
View Trip
9 Day Italy Intensive Cruise: Portofino, Florence & Porto Santo Stefano with Azamara Cruises
Cruise
 (3)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 09 April 2026
Visit: Spain, France, Italy
Azamara Always Included
Inside
$1,889
Oceanview
$2,259
Balcony
-
Suite
-
From
US$1,889
Per Person
View Trip
11 Day Croissants & Cannoli with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia, Sicily
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$2,937
Oceanview
$3,180
Balcony
$4,877
Suite
$7,011
From
US$2,937
Save 3,061
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Apr 2026 to Sep 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Exclusive Savings
Inside
$2,151
Oceanview
$2,684
Balcony
$3,412
Suite
$4,178
From
US$2,151
Save 129
Per Person
View Trip
10 Day Italian Interlude with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 24 March 2028
Visit: Spain, Sardinia, Sicily, Greece, Croatia, Italy
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$2,545
Oceanview
$2,788
Balcony
$4,291
Suite
$6,134
From
US$2,545
Save 2,653
Per Person
View Trip
8 Day Italy And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Inside
$1,589
Oceanview
$1,439
Balcony
$1,549
Suite
$3,079
From
US$1,439
Per Person
View Trip
12 Day Around Italy's Boot: Italy, Dalmatia & Venice with Holland America
Cruise
 (2)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 September 2026
Visit: Spain, France, Italy, Sicily, Greece, Croatia, Montenegro
Fare Saver
Exclusive Savings
Inside
$3,234
Oceanview
$3,332
Balcony
$5,351
Suite
-
From
US$3,234
Save 55
Per Person
View Trip
11 Day Charmed Rivieras with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 21 April 2026
Visit: Spain, France, Corsica, Sardinia, Italy
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,996
Oceanview
$3,127
Balcony
-
Suite
$10,988
From
US$2,996
Save 3,802
Per Person
View Trip
23 Day Greek Isles With Amalfi Coast, Istanbul & Dubrovnik with Holland America
Cruise
 (2)

23 Days (22 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 April 2027
Visit: Spain, France, Italy, Sicily (+4 more), Greece, Turkey, Albania, Croatia
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,007
Oceanview
$4,468
Balcony
$5,604
Suite
$7,917
From
US$4,007
Per Person
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (2)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 11 April 2026
Visit: Spain, France, Italy
Inside
$119
Oceanview
$179
Balcony
$249
Suite
$799
From
US$119
Per Person
View Trip
12 Day Best Of Italy, France & Spain with Celebrity Cruises
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 24 May 2027
Visit: Spain, Corsica, France, Italy, Sicily
Exclusive Savings
Inside
$2,104
Oceanview
$2,260
Balcony
$2,481
Suite
$7,072
From
US$2,104
Save 1,173
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (4)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Exclusive Savings
Inside
$4,807
Oceanview
$5,311
Balcony
-
Suite
-
From
US$4,807
Save 122
Per Person
View Trip
10 Day Toast To Toulon with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 31 August 2027
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,642
Suite
$9,034
From
US$8,642
Save 13,956
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2027
Visit: Spain, France, Italy, Sicily
Inside
$999
Oceanview
$1,649
Balcony
$1,519
Suite
$1,769
From
US$999
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,174
Oceanview
$1,324
Balcony
$1,549
Suite
$1,819
From
US$1,174
Per Person
View Trip
13 Day French & Italian Treasures with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 30 September 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily, Malta
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,344
Oceanview
$3,713
Balcony
$5,924
Suite
$7,951
From
US$3,344
Save 3,854
Per Person
View Trip
11 Day Highlights of Spain, Morocco & Italy with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Santa Cruz de Tenerife to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 08 April 2026
Visit: Spain, Morocco, Corsica, Italy
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,658
From
US$9,658
Save 12,232
Per Person
View Trip
16 Day Barcelona to Civitavecchia with Silversea
Cruise

16 Days (15 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 25 July 2026
Visit: Spain, Corsica, France, Monaco, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$7,500
Suite
$11,800
From
US$7,500
Per Person
View Trip
9 Day Italy, France & Spain Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 16 April 2026
Visit: Spain, France, Italy, Sicily
Inside
$1,395
Oceanview
$1,565
Balcony
$1,615
Suite
$14,296
From
US$1,395
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Inside
$1,189
Oceanview
-
Balcony
$1,679
Suite
$1,828
From
US$1,189
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 03 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,301
Oceanview
$1,521
Balcony
$2,210
Suite
$3,700
From
US$1,301
Save 648
Per Person
View Trip
13 Day Portsmouth To Venice Grand Voyage with Azamara Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 March 2027
Visit: Spain, France, Italy, Sicily, Montenegro, Croatia
Azamara Always Included
Exclusive Savings
Inside
$3,804
Oceanview
$4,367
Balcony
$5,560
Suite
$7,966
From
US$3,804
Save 85
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: May 2026 to Sep 2026
Visit: Spain, France, Corsica, Italy, Sicily
Exclusive Savings
Inside
$1,281
Oceanview
$1,381
Balcony
$1,804
Suite
$3,171
From
US$1,281
Save 708
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 June 2027
Visit: Spain, Corsica, Italy, Malta, Montenegro, Croatia
Inside
$2,069
Oceanview
$2,409
Balcony
$2,799
Suite
$5,916
From
US$2,069
Per Person
View Trip
15 Day Italy And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro, Croatia, Malta
Inside
$2,399
Oceanview
$2,659
Balcony
$2,919
Suite
$6,223
From
US$2,399
Per Person
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (5)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+10 more), Viking Libra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Jul 2028
Visit: Spain, France, Monaco, Italy
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,699
Suite
$3,499
From
US$2,699
Save 950
Per Person
View Trip
8 Day Barcelona to Civitavecchia (Rome) with Silversea
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 November 2027
Visit: Spain, France, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,380
Suite
$5,480
From
US$4,380
Save 2,920
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 10 April 2027
Visit: Spain, France, Italy
Bonus Onboard Credit
Inside
$949
Oceanview
$1,129
Balcony
-
Suite
$1,719
From
US$949
Per Person
View Trip
Results: 91-120 of 153

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