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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 363 departures available from eighteen of the world's leading cruise lines.
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200 Cruises (363 Cruise Departures)
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 23 June 2028
Visit: Spain, Corsica, Italy, Malta, Montenegro, Croatia
Exclusive Savings
Inside
$4,261
Oceanview
$4,756
Balcony
$5,399
Suite
$10,399
From
A$4,261
Per Person
View Trip
12 Day Mediterranean with Greek Isles & Italy with Princess
Cruise
 (2)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departures: Jun 2028 to Sep 2028
Visit: Spain, France, Corsica, Italy (+4 more), Malta, Montenegro, Greece, Sicily
Princess Standard
Exclusive Savings
Inside
$2,199
Oceanview
$2,643
Balcony
$2,485
Suite
$3,461
From
A$2,199
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Just Cruise Fare
Exclusive Savings
Inside
$2,242
Oceanview
-
Balcony
$3,328
Suite
$3,269
From
A$2,242
Per Person
View Trip
8 Day Italy And Adriatic with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro
Exclusive Savings
Inside
$2,080
Oceanview
$2,229
Balcony
$2,724
Suite
$5,031
From
A$2,080
Per Person
View Trip
11 Day Greek Isles & Malta Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2027 to Oct 2027
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,188
Oceanview
$2,747
Balcony
$3,059
Suite
$7,038
From
A$2,188
Save 1,658
Per Person
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (3)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jul 2026 to Jun 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Fare Saver
Exclusive Savings
Inside
$3,995
Oceanview
$3,272
Balcony
$4,658
Suite
$5,599
From
A$3,272
Per Person
View Trip
8 Day Malta, Croatia And Montenegro with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy
First Come, First Served Offer
Exclusive Savings
Inside
$2,209
Oceanview
$2,447
Balcony
$2,585
Suite
$5,169
From
A$2,209
Per Person
View Trip
9 Day France & Italy Cruise: Marseille, Nice, & Florence with Azamara Cruises
Cruise
 (5)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 21 April 2028
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$2,699
Oceanview
$2,924
Balcony
$3,581
Suite
$5,022
From
A$2,699
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 17 October 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$1,488
Oceanview
$1,963
Balcony
$2,359
Suite
$2,597
From
A$1,488
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Exclusive Savings
Inside
$4,560
Oceanview
$5,197
Balcony
$6,001
Suite
$9,382
From
A$4,560
Save 69
Per Person
View Trip
27 Day Ramblas To Renaissance with Oceania Cruises
Cruise
 (1)

27 Days (26 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 December 2026
Visit: Spain, Gibraltar, Morocco, Portugal, France, Italy, Corsica
Your World Inclusions
Exclusive Savings
Inside
$10,919
Oceanview
$11,482
Balcony
$17,738
Suite
$24,625
From
A$10,919
Save 2,231
Per Person
View Trip
10 Day Spring In Southern Europe with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 26 April 2027
Visit: Spain, Sardinia, Sicily, Greece, Italy, Croatia
Your World Inclusions
Exclusive Savings
Inside
$3,010
Oceanview
$3,445
Balcony
$4,803
Suite
$6,533
From
A$3,010
Save 2,820
Per Person
View Trip
8 Day Barcelona to Civitavecchia (Rome) with Silversea
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 14 November 2027
Visit: Spain, France, Italy
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,468
Suite
$11,858
From
A$5,468
Save 3,832
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: Aug 2026 to Sep 2026
Visit: Spain, France, Italy, Sicily
Just Cruise Fare
Exclusive Savings
Inside
$1,675
Oceanview
$2,018
Balcony
$2,166
Suite
$2,420
From
A$1,675
Per Person
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Feb 2027 to Jul 2028
Visit: Spain, France, Monaco, Italy, Sicily, Croatia
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,314
Suite
$16,900
From
A$11,314
Save 1,553
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 20 September 2026
Visit: Spain, France, Italy, Sicily
Just Cruise Fare
Exclusive Savings
Inside
$1,899
Oceanview
$2,718
Balcony
$2,762
Suite
$2,836
From
A$1,899
Per Person
View Trip
11 Day Radiant Rivieras with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 November 2026
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,522
Suite
$5,814
From
A$4,522
Save 5,178
Per Person
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,566
Oceanview
$4,213
Balcony
$7,457
Suite
$6,173
From
A$3,566
Per Person
View Trip
15 Day Mediterranean And Croatia with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 15 September 2028
Visit: Spain, France, Corsica, Italy, Malta, Croatia
Exclusive Savings
Inside
$4,261
Oceanview
$4,756
Balcony
$5,597
Suite
$10,894
From
A$4,261
Per Person
View Trip
15 Day Greek Isles: Mykonos & Naples with Holland America
Cruise
 (3)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2027 to Aug 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Fare Saver
Exclusive Savings
Inside
$3,847
Oceanview
$4,431
Balcony
$5,193
Suite
$8,371
From
A$3,847
Per Person
View Trip
9 Day Canary Islands with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 04 April 2027
Visit: Spain, Morocco, Italy
Exclusive Savings
Inside
$1,463
Oceanview
$1,741
Balcony
$1,721
Suite
$2,632
From
A$1,463
Per Person
View Trip
11 Day Canary Islands with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Las Palmas de Gran Canaria to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 02 April 2027
Visit: Spain, Morocco, Italy
Exclusive Savings
Inside
$1,668
Oceanview
$1,916
Balcony
$2,163
Suite
$3,599
From
A$1,668
Per Person
View Trip
11 Day Fall In The Roman Empire with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 08 October 2027
Visit: Spain, France, Monaco, Italy
Your World Inclusions
Exclusive Savings
Inside
$4,425
Oceanview
$5,977
Balcony
$6,656
Suite
$9,081
From
A$4,425
Save 2,095
Per Person
View Trip
8 Day Spain, France & Italy Cruise: Barcelona, Nice & Portovenere with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 02 June 2028
Visit: Spain, France, Italy
Azamara Always Included
Exclusive Savings
Inside
$2,829
Oceanview
$3,211
Balcony
$3,760
Suite
$5,661
From
A$2,829
Per Person
View Trip
11 Day Mediterranean Moments: Spain to Italy with Emerald Cruises
New ReleaseCruise
 (3)

11 Days (10 Nights) Malaga to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 21 April 2028
Visit: Spain, Tunisia, Sicily, Italy
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$11,446
Balcony
-
Suite
$15,121
From
A$11,446
Save 3,199
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Exclusive Savings
Inside
$1,882
Oceanview
$2,031
Balcony
$2,427
Suite
-
From
A$1,882
Per Person
View Trip
8 Day Italy & Croatia Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 08 May 2027
Visit: Spain, Italy, Croatia
Exclusive Savings
Inside
$1,484
Oceanview
$1,555
Balcony
$2,135
Suite
$3,739
From
A$1,484
Save 793
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily, Italy
Exclusive Savings
Inside
$1,783
Oceanview
$1,912
Balcony
$2,358
Suite
-
From
A$1,783
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 04 August 2028
Visit: Spain, France, Corsica, Italy, Malta, Montenegro, Croatia
Exclusive Savings
Inside
$4,261
Oceanview
$4,756
Balcony
$5,201
Suite
$10,399
From
A$4,261
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 20 August 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
First Come, First Served Offer
Exclusive Savings
Inside
$3,875
Oceanview
$4,380
Balcony
$4,716
Suite
$10,627
From
A$3,875
Per Person
View Trip
Results: 61-90 of 200

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