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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 339 departures available from seventeen of the world's leading cruise lines.
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168 Cruises (339 Cruise Departures)
7 Day Mediterranean with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Barcelona to Trieste
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$395
Oceanview
$495
Balcony
$575
Suite
$965
From
US$395
Per Person
View Trip
11 Day Croissants & Cannoli with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 16 September 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,349
Balcony
$4,999
Suite
$7,199
From
US$2,999
Save 2,999
Per Person
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise
 (1)

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Mira, Viking Neptune, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Jul 2026 to Jul 2028
Visit: Spain, France, Monaco, Italy, Sicily, Croatia
Viking $999 Air Deal
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,898
Suite
$9,498
From
US$6,898
Save 2,000
Per Person
View Trip
11 Day Greek Isles & Malta Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ships: Celebrity Equinox
Departures: Apr 2026 to Oct 2027
Visit: Spain, Malta, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,326
Oceanview
$2,498
Balcony
$2,598
Suite
$5,122
From
US$2,326
Save 2,394
Per Person
View Trip
8 Day A Journey of Iconic Islands & Coastal Wonders with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Oct 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,700
From
US$4,700
Per Person
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (5)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Visit: Spain, France, Monaco, Italy, Sicily, Montenegro, Slovenia
Azamara Always Included
Inside
$3,239
Oceanview
$3,739
Balcony
$5,179
Suite
$10,839
From
US$3,239
Per Person
View Trip
10 Day Mediterranean Horizons with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 07 October 2027
Visit: Spain, France, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,599
Suite
$11,999
From
US$11,599
Save 11,599
Per Person
View Trip
8 Day Etruscan Waterways with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 21 April 2026
Visit: Spain, France, Italy, Corsica, Sardinia
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,849
Suite
-
From
US$3,849
Save 3,849
Per Person
View Trip
14 Day An Extended Journey Of Splendid Coastlines & Formula 1 Action with Explora Journeys
Cruise

14 Days (13 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 27 May 2026
Visit: Spain, France, Sardinia, Italy, Monaco
Ocean View in Monaco
3 Day Paddock Club Access
Inside
-
Oceanview
-
Balcony
-
Suite
$30,660
From
US$24,500
Per Person
View Trip
11 Day Fall In The Roman Empire with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 08 October 2027
Visit: Spain, France, Monaco, Italy
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,099
Oceanview
$4,399
Balcony
$4,899
Suite
$6,699
From
US$3,099
Save 3,099
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Barcelona to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$365
Oceanview
$495
Balcony
$625
Suite
$1,075
From
US$365
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 20 August 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
Bonus Onboard Credit
Inside
$2,019
Oceanview
$2,219
Balcony
$2,449
Suite
$5,529
From
US$2,019
Per Person
View Trip
11 Day Spain, Portugal & Morocco with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 18 September 2027
Visit: Spain, Morocco, Portugal, Sardinia, Italy
Exclusive Savings
Inside
$2,713
Oceanview
$3,154
Balcony
$3,424
Suite
$6,856
From
US$2,713
Save 1,602
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 June 2027
Visit: Spain, Corsica, Italy
Bonus Onboard Credit
Inside
$1,119
Oceanview
$1,319
Balcony
$1,369
Suite
$3,089
From
US$1,119
Per Person
View Trip
8 Day A Journey Through The Picturesque Mediterranean & Historic Beauty Of The Sparkling Riviera with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: Jun 2026 to Aug 2026
Visit: Spain, France, Italy, Sardinia, Corsica
Sky & Sea
Inside
-
Oceanview
-
Balcony
-
Suite
$5,625
From
US$5,625
Per Person
View Trip
15 Day Italy And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro, Croatia, Malta
Inside
$2,449
Oceanview
$2,699
Balcony
$2,959
Suite
$5,439
From
US$2,449
Per Person
View Trip
15 Day Italy, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Inside
$2,539
Oceanview
$2,719
Balcony
$2,879
Suite
$6,139
From
US$2,539
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 May 2026
Visit: Spain, Corsica, Sicily, Italy, Greece, Montenegro, Croatia
Inside
$2,709
Oceanview
$2,709
Balcony
-
Suite
$13,379
From
US$2,709
Per Person
View Trip
8 Day Spain, France & Italy Cruise: Barcelona, Nice & Portovenere with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 02 June 2028
Visit: Spain, France, Italy
Azamara Always Included
Inside
$2,049
Oceanview
$2,329
Balcony
$2,729
Suite
$4,129
From
US$2,049
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 04 June 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Inside
$2,799
Oceanview
$3,209
Balcony
$3,369
Suite
$4,959
From
US$2,799
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (7)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2026 to Apr 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Princess Premier
Sanctuary Collection
Inside
$1,279
Oceanview
$1,579
Balcony
$1,779
Suite
$1,929
From
US$1,279
Per Person
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (3)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jul 2026 to Jun 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Fare Saver
Book Early & Have It All Fare Option
Inside
$1,604
Oceanview
$1,704
Balcony
$2,254
Suite
$3,804
From
US$1,604
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Visit: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
Inside
$2,119
Oceanview
$2,209
Balcony
$2,629
Suite
$5,359
From
US$2,119
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Inside
$2,819
Oceanview
$3,289
Balcony
$3,769
Suite
$5,839
From
US$2,819
Per Person
View Trip
10 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Apr 2026 to Sep 2027
Visit: Spain, France, Italy, Sicily, Greece, Montenegro, Croatia
Inside
$1,349
Oceanview
$1,449
Balcony
$1,549
Suite
$1,919
From
US$1,349
Per Person
View Trip
13 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence & Venice with Azamara Cruises
Cruise
 (8)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 08 June 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia, Slovenia
Azamara Always Included
Inside
$5,329
Oceanview
$5,939
Balcony
$7,329
Suite
$10,609
From
US$5,329
Per Person
View Trip
8 Day Relaxing Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 06 August 2027
Visit: Spain, France, Italy, Corsica
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,449
Suite
$5,549
From
US$3,449
Save 3,449
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 20 September 2026
Visit: Spain, France, Italy, Sicily
Inside
$1,129
Oceanview
-
Balcony
$1,769
Suite
$1,999
From
US$1,129
Per Person
View Trip
8 Day Italy And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Bonus Onboard Credit
Inside
$1,519
Oceanview
$1,449
Balcony
$1,929
Suite
$2,889
From
US$1,449
Per Person
View Trip
15 Day Greek Isles: Mykonos & Naples with Holland America
Cruise
 (3)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2027 to Aug 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Book Early & Have It All Fare Option
Inside
$2,569
Oceanview
$2,919
Balcony
$3,489
Suite
$5,439
From
US$2,569
Per Person
View Trip
Results: 61-90 of 168

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