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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 310 departures available from seventeen of the world's leading cruise lines.
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152 Cruises (310 Cruise Departures)
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 September 2027
Visit: Spain, France, Italy, Corsica
Princess Standard
Sanctuary Collection
Inside
$1,144
Oceanview
$1,494
Balcony
$1,689
Suite
$2,069
From
US$1,144
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 May 2026
Visit: Spain, France, Italy, Corsica, Sicily
Inside
$2,639
Oceanview
$2,969
Balcony
$3,779
Suite
$5,866
From
US$2,639
Per Person
View Trip
8 Day Elegant Shores with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 10 April 2026
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,582
Suite
$7,219
From
US$6,582
Save 11,216
Per Person
View Trip
8 Day Relaxing Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 06 August 2027
Visit: Spain, France, Italy, Corsica
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,271
Suite
$5,017
From
US$3,271
Save 3,427
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,672
Oceanview
$4,293
Balcony
$4,924
Suite
$7,669
From
US$3,672
Save 87
Per Person
View Trip
11 Day Spain, Portugal & France Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 24 July 2027
Visit: Spain, Gibraltar, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,187
Oceanview
$2,506
Balcony
$2,636
Suite
$8,967
From
US$2,589
Save 853
Per Person
View Trip
13 Day Dalmatian Diversion with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 03 October 2027
Visit: Spain, France, Monaco, Italy, Corsica, Montenegro, Croatia
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
$3,231
Oceanview
$3,571
Balcony
$5,656
Suite
$8,275
From
US$3,231
Save 3,367
Per Person
View Trip
22 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy, Croatia
Inside
$3,899
Oceanview
$4,249
Balcony
$5,449
Suite
$11,543
From
US$3,899
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Inside
$3,199
Oceanview
$2,849
Balcony
$4,979
Suite
-
From
US$2,849
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,339
Oceanview
$1,887
Balcony
$1,887
Suite
$2,071
From
US$1,339
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 28 September 2026
Visit: Spain, France, Monaco, Italy
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$6,720
Balcony
$7,280
Suite
$6,960
From
US$6,720
Save 1,680
Per Person
View Trip
12 Day Best Of The Mediterranean Cruise: Monte Carlo, Florence & Dubrovnik with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 29 September 2027
Visit: Spain, France, Monaco, Italy, Montenegro, Croatia
Azamara Always Included
Exclusive Savings
Inside
$3,480
Oceanview
$3,868
Balcony
$4,761
Suite
$7,157
From
US$3,480
Save 79
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 17 October 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
$1,149
Oceanview
-
Balcony
$1,589
Suite
$1,857
From
US$1,149
Per Person
View Trip
8 Day Etruscan Waterways with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 21 April 2026
Visit: Spain, France, Italy, Corsica, Sardinia
Your World Inclusions
Exclusive Savings
Inside
$2,735
Oceanview
-
Balcony
$3,657
Suite
-
From
US$2,735
Save 2,863
Per Person
View Trip
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
With Love From the World
Inside
$1,881
Oceanview
$2,151
Balcony
$2,331
Suite
$5,535
From
US$1,881
Per Person
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 15 August 2026
Visit: Spain, Sicily, Greece, Turkey, Italy
Exclusive Savings
Inside
$2,019
Oceanview
$2,209
Balcony
$2,602
Suite
$5,432
From
US$2,373
Save 758
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (3)

4 Days (3 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 27 February 2026
Visit: Spain, France, Italy
Inside
-
Oceanview
-
Balcony
$489
Suite
-
From
US$489
Per Person
View Trip
15 Day Southern Mediterranean Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 07 December 2026
Visit: Spain, France, Italy, Sicily, Tunisia, Malta
Exclusive Savings
Inside
-
Oceanview
$6,200
Balcony
$7,082
Suite
$8,013
From
US$6,200
Save 13,398
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Valencia to Bari
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 24 October 2026
Visit: Spain, Italy, Sicily, Greece, Montenegro
Bonus Onboard Credit
Inside
$845
Oceanview
$965
Balcony
$1,075
Suite
$1,853
From
US$845
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Inside
$2,399
Oceanview
$2,699
Balcony
$2,909
Suite
$6,164
From
US$2,399
Per Person
View Trip
8 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 13 April 2026
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
-
Balcony
$995
Suite
-
From
US$995
Per Person
View Trip
9 Day Canary Islands with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 04 April 2027
Visit: Spain, Morocco, Italy
Bonus Onboard Credit
Inside
$811
Oceanview
$971
Balcony
$1,061
Suite
$1,651
From
US$811
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 05 May 2026
Visit: Spain, Tunisia, Sicily, Italy
Inside
$619
Oceanview
-
Balcony
-
Suite
-
From
US$619
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Barcelona to Trieste
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$641
Oceanview
$741
Balcony
$821
Suite
$1,271
From
US$641
Per Person
View Trip
8 Day Costa Brave & Italy with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 29 October 2026
Visit: Spain, France, Corsica, Italy, Sardinia
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$1,960
Balcony
$2,658
Suite
$3,667
From
US$1,960
Save 2,938
Per Person
View Trip
13 Day Total Eclipse of the (Med) with Virgin Voyages
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 10 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
With Love From the World
Inside
$3,228
Oceanview
$3,468
Balcony
$3,588
Suite
$7,188
From
US$3,228
Per Person
View Trip
15 Day Italy, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Inside
$2,489
Oceanview
$2,719
Balcony
$2,979
Suite
$6,184
From
US$2,489
Per Person
View Trip
8 Day Mediterranean with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 01 March 2026
Visit: Spain, Gibraltar, France, Italy
Princess Standard
Inside
$1,170
Oceanview
$1,350
Balcony
-
Suite
$2,450
From
US$1,170
Per Person
View Trip
8 Day Malta, Croatia And Montenegro with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy
Inside
$949
Oceanview
$1,049
Balcony
$1,199
Suite
$2,979
From
US$949
Per Person
View Trip
8 Day Cultures & Cuisines with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 15 July 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,071
Suite
$7,365
From
US$7,071
Save 12,327
Per Person
View Trip
Results: 61-90 of 152

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