Home > Cruises > Central America Cruises > Panama > Cruises From Colon

Cruises From Colon

Choose from 30 unique cruises starting in Colon, and traveling to Cancun, Cartagena, Fort-de-France, Los Angeles and Puntarenas. December and January are the most popular months to join a cruise from Colon and you can select from 87 departures available from three leading cruise lines.
Filter Results
Departures
Show More...
Duration
2 Days
13 Days
End City
Ship Features
Operators
Price
$100pp
$9,010pp
Countries
Show More...
Filter Results
30 Cruises (87 Cruise Departures)
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,640
Suite
$9,550
From
US$5,640
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Visit: Panama, Colombia, Bonaire, Aruba
Latest Offer
Exclusive Savings
Inside
$797
Oceanview
$833
Balcony
$974
Suite
$1,375
From
US$1,103
Save 634
Per Person
View Trip
11 Day A Tropical Odyssey in Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Cancun
Cruise Line: Ponant
Ship: Le Champlain
Departure: 03 December 2025
Visit: Panama, Costa Rica, Colombia, Honduras, Guatemala, Belize, Mexico
Inside
-
Oceanview
-
Balcony
$8,710
Suite
$16,910
From
US$8,710
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Oct 2025 to Jan 2027
Visit: Panama, Colombia, Curacao, Aruba
Latest Offer
Exclusive Savings
Inside
$797
Oceanview
$907
Balcony
$1,032
Suite
$1,341
From
US$797
Save 786
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Visit: Panama, Colombia, Aruba, Bonaire
Latest Offer
Exclusive Savings
Inside
$1,022
Oceanview
$1,068
Balcony
$1,199
Suite
$1,637
From
US$1,698
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 26 February 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,640
Suite
$9,550
From
US$5,640
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visit: Panama, Colombia, Aruba, Bonaire, Curacao
Latest Offer
Exclusive Savings
Inside
$908
Oceanview
$1,037
Balcony
$1,477
Suite
$1,532
From
US$908
Save 501
Per Person
View Trip
11 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (2)

11 Days (10 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 12 March 2027
Visit: Panama, Colombia, Holland, Saint Vincent, Saint Lucia, Guadeloupe, Martinique
Inside
-
Oceanview
-
Balcony
$6,760
Suite
$10,670
From
US$6,760
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,810
Suite
$9,850
From
US$5,810
Per Person
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Visit: Panama, Costa Rica, Guatemala, Mexico, USA
Exclusive Savings
Inside
$1,850
Oceanview
$2,075
Balcony
$3,025
Suite
$4,250
From
US$1,850
Save 5,548
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 05 September 2026
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Latest Offer
Exclusive Savings
Inside
$738
Oceanview
$817
Balcony
$1,207
Suite
$1,242
From
US$738
Save 428
Per Person
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Visit: Panama, Colombia, Curacao, Aruba
Latest Offer
Exclusive Savings
Inside
$1,409
Oceanview
$1,460
Balcony
$1,510
Suite
-
From
US$1,409
Save 729
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$8,050
Suite
$13,630
From
US$8,050
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$6,120
Suite
$10,790
From
US$6,120
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Visit: Panama, Colombia, Bonaire, Aruba
Latest Offer
Exclusive Savings
Inside
$1,144
Oceanview
$1,055
Balcony
$1,104
Suite
$1,418
From
US$1,055
Save 570
Per Person
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Visit: Panama, Colombia
Multiple Deals Available
Inside
$134
Oceanview
$169
Balcony
$175
Suite
$273
From
US$169
Save 138
Per Person
View Trip
8 Day Southern Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 December 2026
Visit: Panama, Colombia, Aruba, Bonaire
Latest Offer
Exclusive Savings
Inside
$922
Oceanview
$1,052
Balcony
$1,502
Suite
$1,567
From
US$922
Save 515
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Mar 2027 to Mar 2027
Visit: Panama, Colombia, Curacao, Bonaire, Aruba
Latest Offer
Exclusive Savings
Inside
$884
Oceanview
$1,005
Balcony
$1,434
Suite
$1,489
From
US$884
Save 514
Per Person
View Trip
11 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

11 Days (10 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 14 November 2026
Visit: Panama, Bonaire, Aruba, Curacao, Trinidad and Tobago
Latest Offer
Exclusive Savings
Inside
$1,117
Oceanview
$1,276
Balcony
$1,796
Suite
$1,891
From
US$1,117
Save 591
Per Person
View Trip
11 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Bellot
Departure: 08 April 2027
Visit: Panama, Colombia, Holland, Saint Lucia, Guadeloupe, Martinique
Inside
-
Oceanview
-
Balcony
$6,360
Suite
$10,010
From
US$6,360
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Visit: Panama, Colombia, Aruba, Curacao
Latest Offer
Exclusive Savings
Inside
$962
Oceanview
$963
Balcony
$1,012
Suite
$2,187
From
US$962
Save 535
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 30 January 2027
Visit: Panama, Colombia, Curacao, Aruba, Bonaire
Latest Offer
Exclusive Savings
Inside
$809
Oceanview
$919
Balcony
$1,308
Suite
$1,353
From
US$809
Save 458
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Dec 2025 to Feb 2027
Visit: Panama, Colombia, Aruba, Bonaire
Latest Offer
Exclusive Savings
Inside
$773
Oceanview
$883
Balcony
$1,026
Suite
$1,308
From
US$773
Save 591
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Visit: Panama, Colombia, Bonaire, Curacao
Latest Offer
Exclusive Savings
Inside
$958
Oceanview
$883
Balcony
$1,058
Suite
$1,283
From
US$958
Save 535
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Visit: Panama, Colombia, Aruba, Curacao
Latest Offer
Exclusive Savings
Inside
$829
Oceanview
$928
Balcony
$996
Suite
$1,287
From
US$887
Save 682
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Visit: Panama, Colombia, Aruba, Curacao
Latest Offer
Exclusive Savings
Inside
$828
Oceanview
$927
Balcony
$995
Suite
$1,379
From
US$1,127
Save 600
Per Person
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 16 January 2026
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Guadeloupe, Martinique
Inside
-
Oceanview
-
Balcony
$8,480
Suite
$13,470
From
US$8,480
Per Person
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Visit: Panama, Costa Rica, Mexico, USA
Latest Offer
Exclusive Savings
Inside
$1,035
Oceanview
$1,275
Balcony
$1,857
Suite
-
From
US$1,035
Save 430
Per Person
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Latest Offer
Exclusive Savings
Inside
$1,274
Oceanview
$1,354
Balcony
$1,373
Suite
$2,148
From
US$1,274
Save 664
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Oct 2025 to Apr 2027
Visit: Panama, Colombia, Aruba, Curacao
Latest Offer
Exclusive Savings
Inside
$726
Oceanview
$826
Balcony
$1,096
Suite
$1,230
From
US$726
Save 880
Per Person
View Trip
Results: 30 results

No results found. Try amending the search filters.




Cruises found! Scroll up to view.

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Departure Months

October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 May 2026 June 2026 July 2026 August 2026 September 2026 October 2026 November 2026 December 2026 January 2027 February 2027 March 2027 April 2027

Cities

Colon Panama City Santiago

Routes

Colon to Colon Miami to Panama City Panama City to Miami

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2025. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations