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Cruises From Colon

Choose from 29 unique cruises starting in Colon, and traveling to Cancun, Cartagena, Fort-de-France, Los Angeles and Puntarenas. January is the most popular month to join a cruise from Colon and you can select from 93 departures available from three leading cruise lines.
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29 Cruises (93 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Latest Offer
INSIDE
$1,111
OCEANVIEW
$1,141
BALCONY
$1,190
SUITE
$1,380
Save (per person) 600
From (per person) 1,111
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departure: 05 September 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Latest Offer
INSIDE
$896
OCEANVIEW
$946
BALCONY
$1,060
SUITE
$1,414
Save (per person) 498
From (per person) 896
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 26 February 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$864
OCEANVIEW
$895
BALCONY
$964
SUITE
$1,114
Save (per person) 492
From (per person) 864
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$5,810
SUITE
$9,850
From (per person) 5,810
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,050
SUITE
$13,630
From (per person) 8,050
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Apr 2027
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$804
OCEANVIEW
$834
BALCONY
$956
SUITE
$1,251
Save (per person) 717
From (per person) 804
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,640
SUITE
$9,550
From (per person) 5,640
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Dec 2025 to Feb 2027
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest Offer
INSIDE
$850
OCEANVIEW
$890
BALCONY
$1,012
SUITE
$1,337
Save (per person) 867
From (per person) 850
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 16 January 2026
Countries Visited: Panama, Colombia, Curacao, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
INSIDE
-
OCEANVIEW
-
BALCONY
$8,040
SUITE
$12,740
From (per person) 8,040
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest Offer
INSIDE
$899
OCEANVIEW
$939
BALCONY
$1,061
SUITE
$1,406
Save (per person) 545
From (per person) 899
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Latest Offer
INSIDE
$912
OCEANVIEW
$952
BALCONY
$1,041
SUITE
$1,401
Save (per person) 592
From (per person) 912
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Latest OfferExclusive Solo Offer
INSIDE
$1,112
OCEANVIEW
$1,382
BALCONY
$1,775
SUITE
-
Save (per person) 464
From (per person) 1,112
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$916
OCEANVIEW
$1,027
BALCONY
$1,116
SUITE
$1,424
Save (per person) 591
From (per person) 916
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Jan 2027
Countries Visited: Panama, Colombia, Curacao, Aruba
Latest Offer
INSIDE
$884
OCEANVIEW
$924
BALCONY
$1,047
SUITE
$1,381
Save (per person) 729
From (per person) 884
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Latest Offer
INSIDE
$1,261
OCEANVIEW
$1,262
BALCONY
$1,361
SUITE
$3,461
Save (per person) 664
From (per person) 1,261
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,730
SUITE
$10,160
From (per person) 6,730
View Trip
11 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (2)

11 Days (10 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 12 March 2027
Countries Visited: Panama, Colombia, Holland, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,360
SUITE
$10,010
From (per person) 6,360
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departure: 10 April 2027
Countries Visited: Panama, Colombia, Aruba, Bonaire (+1 more), Curacao
Latest Offer
INSIDE
$1,007
OCEANVIEW
$1,048
BALCONY
$1,190
SUITE
$1,575
Save (per person) 545
From (per person) 1,007
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departures: Mar 2027 to Mar 2027
Countries Visited: Panama, Colombia, Curacao, Bonaire (+1 more), Aruba
Latest Offer
INSIDE
$966
OCEANVIEW
$1,006
BALCONY
$1,138
SUITE
$1,504
Save (per person) 580
From (per person) 966
View Trip
11 Day A Tropical Odyssey in Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Cancun
Cruise Line: Ponant
Ship: Le Champlain
Departure: 03 December 2025
Countries Visited: Panama, Costa Rica, Colombia, Honduras (+3 more), Guatemala, Belize, Mexico
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$9,950
SUITE
$13,260
From (per person) 9,950
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$930
OCEANVIEW
$1,035
BALCONY
$1,064
SUITE
$1,264
Save (per person) 579
From (per person) 930
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departure: 30 January 2027
Countries Visited: Panama, Colombia, Curacao, Aruba (+1 more), Bonaire
Latest Offer
INSIDE
$896
OCEANVIEW
$936
BALCONY
$1,059
SUITE
$1,393
Save (per person) 498
From (per person) 896
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest Offer
INSIDE
$1,211
OCEANVIEW
$1,262
BALCONY
$1,412
SUITE
$1,801
Save (per person) 643
From (per person) 1,211
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Latest Offer
INSIDE
$1,325
OCEANVIEW
$1,356
BALCONY
$1,405
SUITE
$1,675
Save (per person) 685
From (per person) 1,325
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$11,290
SUITE
$17,390
From (per person) 11,290
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Fleetwide SaleExclusive Deal
INSIDE
$2,220
OCEANVIEW
$2,490
BALCONY
$3,630
SUITE
$5,100
Save (per person) 5,178
From (per person) 2,220
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Latest Offer
INSIDE
$860
OCEANVIEW
$891
BALCONY
$960
SUITE
$1,260
Save (per person) 535
From (per person) 860
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Apr 2026 to Apr 2027
Countries Visited: Panama, Colombia
Latest Offer
INSIDE
$113
OCEANVIEW
$123
BALCONY
$116
SUITE
$159
Save (per person) 121
From (per person) 113
View Trip
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