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Panama Cruises Starting In April 2027 and 2028

If you're looking at joining a cruise to Panama in April 2027 or 2028, we have 24 unique cruise itineraries and 97 departures available, operated by seven of the world's leading cruise lines departing in April.
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24 Cruises (97 Departures)
24 Cruises (97 Departures)
Departures
Duration
7 Days
26 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
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Price
$1,300pp
$47,840pp
Countries
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11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$10,789
Suite
$17,996
From (Per Person)
A$10,789
Save 460
Per Person
View Trip
12 Day Costa Rica & the Panama Canal with Aurora Expeditions
New ReleaseCruise

12 Days (11 Nights) San Jose to Panama City
Operator: Aurora Expeditions
Ship: Douglas Mawson
Departure: 15 April 2028
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
$23,529
Balcony
$24,948
Suite
$37,708
From (Per Person)
A$23,529
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,478
Oceanview
$1,621
Balcony
$2,289
Suite
$2,761
From (Per Person)
A$1,478
Save 971
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico
Exclusive Savings
Inside
$2,773
Oceanview
$3,060
Balcony
$3,961
Suite
$15,929
From (Per Person)
A$2,773
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,429
Oceanview
$1,592
Balcony
$2,134
Suite
$2,445
From (Per Person)
A$1,429
Save 926
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Oct 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,416
Oceanview
$1,430
Balcony
$2,091
Suite
$2,487
From (Per Person)
A$1,416
Save 1,836
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,521
Oceanview
$1,623
Balcony
$2,197
Suite
$2,652
From (Per Person)
A$1,521
Save 1,088
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,431
Oceanview
$1,502
Balcony
$2,136
Suite
$2,548
From (Per Person)
A$1,431
Save 1,273
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,388
Oceanview
$1,644
Balcony
$2,007
Suite
$2,241
From (Per Person)
A$1,388
Save 1,199
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Oct 2026 to Mar 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,486
Oceanview
$1,621
Balcony
$2,195
Suite
$2,603
From (Per Person)
A$1,486
Save 1,461
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 03 April 2027
Visits: USA, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$2,515
Oceanview
$3,372
Balcony
$4,026
Suite
$7,491
From (Per Person)
A$2,515
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 April 2028
Visits: Colombia, Bonaire, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,657
Oceanview
$1,861
Balcony
$2,537
Suite
$2,955
From (Per Person)
A$1,657
Save 944
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ships: Emerald Princess, Island Princess, Sapphire Princess
Departures: Nov 2026 to Apr 2028
Visits: USA, Aruba, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,116
Oceanview
$2,363
Balcony
$3,306
Suite
$5,482
From (Per Person)
A$2,116
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Operator: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$3,672
Oceanview
$4,345
Balcony
$5,573
Suite
$11,780
From (Per Person)
A$3,672
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visits: Panama, Colombia, Aruba, Bonaire, Curacao
Exclusive Savings
Inside
$1,972
Oceanview
$2,325
Balcony
$3,223
Suite
$3,565
From (Per Person)
A$1,972
Save 1,085
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

26 Days (25 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico, Canada
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,574
Suite
-
From (Per Person)
A$6,574
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 11 April 2027
Visits: Colombia, Aruba, Bonaire, Curacao, Panama
Exclusive Savings
Inside
$2,423
Oceanview
$2,565
Balcony
$3,003
Suite
$3,519
From (Per Person)
A$2,423
Save 1,306
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (12)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Crown Princess
Departure: 04 April 2027
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$1,948
Oceanview
$2,086
Balcony
$3,542
Suite
$6,086
From (Per Person)
A$1,948
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$3,050
Oceanview
$3,337
Balcony
$4,248
Suite
$13,533
From (Per Person)
A$3,050
Per Person
View Trip
16 Day World Cruise Segment - Panama Canal with Princess
Cruise
 (4)

16 Days (15 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Coral Princess
Departures: Jan 2028 to Apr 2028
Visits: USA, Colombia, Panama, El Salvador, Mexico
Exclusive Savings
Inside
$2,676
Oceanview
$2,908
Balcony
$3,380
Suite
$6,250
From (Per Person)
A$2,676
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$2,350
Oceanview
$2,377
Balcony
$3,569
Suite
$4,859
From (Per Person)
A$2,350
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 01 April 2028
Visits: Panama, Colombia, Bonaire, Aruba, Curacao
Exclusive Savings
Inside
$1,581
Oceanview
$1,772
Balcony
$2,388
Suite
$2,946
From (Per Person)
A$1,581
Save 894
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 07 April 2028
Visits: USA, Turks and Caicos Islands, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$2,829
Oceanview
$3,542
Balcony
$4,294
Suite
$5,967
From (Per Person)
A$2,829
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Operator: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA
Exclusive Savings
Suite
$9,075
From (Per Person)
A$9,075
Save 185
Per Person
View Trip
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