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Panama Cruises Starting In April 2027 and 2028

If you're looking at joining a cruise to Panama in April 2027 or 2028, we have 24 unique cruise itineraries and 109 departures available, operated by seven of the world's leading cruise lines departing in April.
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24 Cruises (109 Departures)
24 Cruises (109 Departures)
Departures
Duration
7 Days
26 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
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Price
$1,300pp
$47,840pp
Countries
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11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$10,440
Suite
$17,366
From (Per Person)
A$10,440
Save 460
Per Person
View Trip
12 Day Costa Rica & the Panama Canal with Aurora Expeditions
New ReleaseCruise

12 Days (11 Nights) San Jose to Panama City
Operator: Aurora Expeditions
Ship: Sylvia Earle
Departure: 09 April 2027
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
-
Balcony
$24,448
Suite
$35,833
From (Per Person)
A$24,448
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,460
Oceanview
$1,621
Balcony
$2,289
Suite
$2,578
From (Per Person)
A$1,460
Save 971
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,466
Oceanview
$1,623
Balcony
$2,197
Suite
$2,578
From (Per Person)
A$1,466
Save 1,173
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,388
Oceanview
$1,644
Balcony
$2,258
Suite
$2,672
From (Per Person)
A$1,388
Save 1,198
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,391
Oceanview
$1,547
Balcony
$2,081
Suite
$2,474
From (Per Person)
A$1,391
Save 1,269
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Aug 2026 to Mar 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,464
Oceanview
$1,621
Balcony
$2,164
Suite
$2,529
From (Per Person)
A$1,464
Save 1,647
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,389
Oceanview
$1,545
Balcony
$1,996
Suite
$2,296
From (Per Person)
A$1,416
Save 1,150
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico
Exclusive Savings
Inside
$2,308
Oceanview
$2,961
Balcony
$3,832
Suite
$15,523
From (Per Person)
A$2,308
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,389
Oceanview
$1,545
Balcony
$2,079
Suite
$2,371
From (Per Person)
A$1,389
Save 926
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 03 April 2027
Visits: USA, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$2,640
Oceanview
$3,497
Balcony
$4,150
Suite
$7,615
From (Per Person)
A$2,640
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (12)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Crown Princess
Departure: 04 April 2027
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,062
Oceanview
$2,262
Balcony
$3,705
Suite
$6,180
From (Per Person)
A$2,062
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

26 Days (25 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico, Canada
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,317
Suite
-
From (Per Person)
A$6,317
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Operator: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$3,677
Oceanview
$4,350
Balcony
$5,578
Suite
$11,785
From (Per Person)
A$3,677
Per Person
View Trip
16 Day World Cruise Segment - Panama Canal with Princess
Cruise
 (4)

16 Days (15 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Coral Princess
Departures: Jan 2028 to Apr 2028
Visits: USA, Colombia, Panama, El Salvador, Mexico
Exclusive Savings
Inside
$2,818
Oceanview
$3,057
Balcony
$3,532
Suite
$6,432
From (Per Person)
A$2,818
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 April 2028
Visits: Colombia, Bonaire, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,657
Oceanview
$1,861
Balcony
$2,537
Suite
$2,880
From (Per Person)
A$1,657
Save 944
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visits: Panama, Colombia, Bonaire, Aruba, Curacao
Exclusive Savings
Inside
$1,581
Oceanview
$1,772
Balcony
$2,388
Suite
$2,872
From (Per Person)
A$1,927
Save 548
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visits: Panama, Colombia, Aruba, Bonaire, Curacao
Exclusive Savings
Inside
$2,263
Oceanview
$2,677
Balcony
$3,223
Suite
$3,422
From (Per Person)
A$2,263
Save 1,220
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 11 April 2027
Visits: Colombia, Aruba, Bonaire, Curacao, Panama
Exclusive Savings
Inside
$2,419
Oceanview
$2,628
Balcony
$3,003
Suite
$3,391
From (Per Person)
A$2,419
Save 1,304
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$2,484
Oceanview
$2,512
Balcony
$3,704
Suite
$4,995
From (Per Person)
A$2,484
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$3,050
Oceanview
$3,337
Balcony
$4,248
Suite
$13,533
From (Per Person)
A$3,050
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ships: Emerald Princess, Island Princess, Sapphire Princess
Departures: Nov 2026 to Apr 2028
Visits: USA, Aruba, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,275
Oceanview
$2,498
Balcony
$3,465
Suite
$5,641
From (Per Person)
A$2,275
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Operator: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA
Exclusive Savings
Suite
$10,177
From (Per Person)
A$10,177
Save 208
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 07 April 2028
Visits: USA, Turks and Caicos Islands, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$3,017
Oceanview
$3,729
Balcony
$4,551
Suite
$6,155
From (Per Person)
A$3,017
Per Person
View Trip
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