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Panama Cruises Starting In April 2027 and 2028

If you're looking at joining a cruise to Panama in April 2027 or 2028, we have 24 unique cruise itineraries and 86 departures available, operated by seven of the world's leading cruise lines departing in April.
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24 Cruises (86 Departures)
24 Cruises (86 Departures)
Departures
Duration
7 Days
26 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
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Price
$1,200pp
$39,400pp
Countries
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11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$10,789
Suite
$17,996
From (Per Person)
A$10,789
Save 433
Per Person
View Trip
12 Day Costa Rica & the Panama Canal with Aurora Expeditions
New ReleaseCruise

12 Days (11 Nights) San Jose to Panama City
Operator: Aurora Expeditions
Ships: Sylvia Earle, Douglas Mawson
Departures: Apr 2027 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
$24,346
Balcony
$24,448
Suite
$39,016
From (Per Person)
A$24,346
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Mar 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,354
Oceanview
$1,449
Balcony
$1,790
Suite
$2,411
From (Per Person)
A$1,354
Save 1,830
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,429
Oceanview
$1,529
Balcony
$2,079
Suite
$2,529
From (Per Person)
A$1,429
Save 926
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico
Exclusive Savings
Inside
$2,773
Oceanview
$3,159
Balcony
$4,030
Suite
$15,929
From (Per Person)
A$2,773
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,506
Oceanview
$1,603
Balcony
$2,113
Suite
$2,581
From (Per Person)
A$1,506
Save 1,254
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,458
Oceanview
$1,621
Balcony
$2,219
Suite
$2,789
From (Per Person)
A$1,458
Save 972
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Apr 2027 to Apr 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,342
Oceanview
$1,584
Balcony
$2,139
Suite
$2,691
From (Per Person)
A$1,342
Save 1,210
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,386
Oceanview
$1,502
Balcony
$2,050
Suite
$2,589
From (Per Person)
A$1,386
Save 1,156
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,334
Oceanview
$1,386
Balcony
$1,883
Suite
$2,532
From (Per Person)
A$1,334
Save 1,905
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 03 April 2027
Visits: USA, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$2,451
Oceanview
$2,714
Balcony
$3,338
Suite
$6,525
From (Per Person)
A$2,451
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

26 Days (25 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico, Canada
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,357
Suite
-
From (Per Person)
A$6,357
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 11 April 2027
Visits: Colombia, Aruba, Bonaire, Curacao, Panama
Exclusive Savings
Inside
$2,214
Oceanview
$2,419
Balcony
$3,130
Suite
$3,434
From (Per Person)
A$2,214
Save 1,209
Per Person
View Trip
16 Day World Cruise Segment - Panama Canal with Princess
Cruise
 (4)

16 Days (15 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Coral Princess
Departures: Jan 2028 to Apr 2028
Visits: USA, Colombia, Panama, El Salvador, Mexico
Exclusive Savings
Inside
$2,586
Oceanview
$2,824
Balcony
$3,260
Suite
$5,952
From (Per Person)
A$2,586
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ship: Island Princess
Departures: Mar 2027 to Apr 2027
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$2,355
Oceanview
$2,784
Balcony
$3,754
Suite
$6,166
From (Per Person)
A$2,355
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Operator: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$3,895
Oceanview
$4,598
Balcony
$5,904
Suite
$14,161
From (Per Person)
A$3,895
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 April 2028
Visits: Colombia, Bonaire, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,763
Oceanview
$1,862
Balcony
$2,537
Suite
$2,956
From (Per Person)
A$1,763
Save 994
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$3,050
Oceanview
$3,337
Balcony
$4,248
Suite
$13,533
From (Per Person)
A$3,050
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visits: Panama, Colombia, Aruba, Bonaire, Curacao
Exclusive Savings
Inside
$1,749
Oceanview
$1,831
Balcony
-
Suite
$3,199
From (Per Person)
A$1,749
Save 1,219
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ships: Emerald Princess, Island Princess, Sapphire Princess
Departures: Nov 2026 to Apr 2028
Visits: USA, Aruba, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,289
Oceanview
$2,437
Balcony
$3,507
Suite
$5,061
From (Per Person)
A$2,289
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (12)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Crown Princess
Departure: 04 April 2027
Visits: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,161
Oceanview
$2,368
Balcony
$4,032
Suite
$7,081
From (Per Person)
A$2,161
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 01 April 2028
Visits: Panama, Colombia, Bonaire, Aruba, Curacao
Exclusive Savings
Inside
$1,646
Oceanview
$1,785
Balcony
$2,390
Suite
$2,959
From (Per Person)
A$1,646
Save 924
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Operator: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA
Exclusive Savings
Suite
$9,663
From (Per Person)
A$9,663
Save 197
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Operator: Princess
Ship: Star Princess
Departure: 07 April 2028
Visits: USA, Turks and Caicos Islands, Aruba, Panama, Mexico
Sanctuary Collection
Exclusive Savings
Inside
$2,784
Oceanview
$2,913
Balcony
$3,824
Suite
$5,754
From (Per Person)
A$2,784
Per Person
View Trip
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