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Panama Cruises

Are you looking for a cruise to Panama? Choose from 91 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, Fort-de-France, Guayaquil and more. January is the most popular month to cruise to Panama and we have over 208 departures available from eighteen of the world's leading cruise lines.
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91 Cruises (208 Departures)
91 Cruises (208 Departures)
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7 Days
30 Days
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$900pp
$29,650pp
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8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Operator: Emerald Cruises
Ships: Emerald Azzurra
Departures: Jan 2028 to Jan 2029
Visits: Panama, Costa Rica
Exclusive Savings
Oceanview
$5,460
Suite
$7,035
From (Per Person)
US$5,460
Save 1,668
Per Person
View Trip
13 Day Costa Rica, Panama from the Atlantic to the Pacific via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Operator: Emerald Cruises
Ship: Emerald Azzurra
Departure: 31 January 2029
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
$10,847
Suite
$13,421
From (Per Person)
US$10,847
Save 1,998
Per Person
View Trip
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Operator: Emerald Cruises
Ships: Emerald Azzurra
Departures: Feb 2028 to Feb 2029
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
$10,551
Suite
$13,026
From (Per Person)
US$10,551
Save 1,996
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Puntarenas to Colon
Operator: Ponant
Ship: Le Laperouse
Departure: 19 February 2027
Visits: Costa Rica, Panama
Balcony
$8,610
Suite
$14,350
From (Per Person)
US$8,610
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visits: Costa Rica, Panama
Balcony
$8,140
Suite
$13,490
From (Per Person)
US$8,140
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Mar 2027
Visits: Costa Rica, Panama
Balcony
$5,890
Suite
$9,800
From (Per Person)
US$5,890
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visits: Panama, Costa Rica
Balcony
$8,140
Suite
$13,490
From (Per Person)
US$8,140
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visits: Panama, Costa Rica
Balcony
$6,050
Suite
$10,070
From (Per Person)
US$6,050
Per Person
View Trip
8 Day Coastal Adventures: Costa Rica & Panama with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) San Jose to Panama City
Operator: Emerald Cruises
Ships: Emerald Azzurra
Departures: Feb 2028 to Feb 2029
Visits: Costa Rica, Panama
Exclusive Savings
Oceanview
$5,310
Suite
$6,885
From (Per Person)
US$5,310
Save 1,668
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ship: Le Bougainville
Departure: 23 February 2028
Visits: Costa Rica, Panama
Balcony
$10,140
Suite
$17,020
From (Per Person)
US$10,140
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Operator: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visits: Panama, Costa Rica
Balcony
$7,620
Suite
$11,600
From (Per Person)
US$7,620
Per Person
View Trip
12 Day Costa Rica & the Panama Canal with Aurora Expeditions
New ReleaseCruise

12 Days (11 Nights) San Jose to Panama City
Operator: Aurora Expeditions
Ship: Sylvia Earle
Departure: 09 April 2027
Visits: Costa Rica, Panama
Oceanview
-
Balcony
$16,195
Suite
$23,795
From (Per Person)
US$16,195
Per Person
View Trip
10 Day Panama and Costa Rica: Crossing the Canal with Aurora Expeditions
New ReleaseCruise

10 Days (9 Nights) Panama City to San Jose
Operator: Aurora Expeditions
Ship: Douglas Mawson
Departure: 04 October 2027
Visits: Panama, Costa Rica
Oceanview
$11,795
Balcony
$12,495
Suite
$18,795
From (Per Person)
US$11,795
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Operator: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visits: Panama, Peru
Oceanview
$6,600
Balcony
$7,110
Suite
$13,160
From (Per Person)
US$6,600
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Eastbound with Tauck
Tour + Cruise

12 Days Puntarenas to Panama City
Operator: Tauck
Cruise Line: Ponant
Ship: Le Lapérouse
Departure: 03 February 2027
Trip Styles: Coach, Cruise, Scenic
Visits: Costa Rica, Panama
From (Per Person)
US$9,290
Per Person
View Trip
7 Day Callao (Lima) to Fuerte Amador with Crystal Cruises
Cruise

7 Days (6 Nights) Lima to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 05 December 2027
Visits: Peru, Ecuador, Panama
Exclusive Savings
Oceanview
$3,196
Balcony
$3,810
Suite
$3,898
From (Per Person)
US$3,196
Save 404
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Operator: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visits: Bahamas, Colombia, Panama
Exclusive Savings
Balcony
$11,891
Suite
$13,241
From (Per Person)
US$11,891
Save 1,104
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Aug 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$930
Oceanview
$1,026
Balcony
$1,341
Suite
$1,401
From (Per Person)
US$930
Save 1,404
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$992
Oceanview
$1,162
Balcony
$1,447
Suite
$1,677
From (Per Person)
US$992
Save 704
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Jan 2027
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,208
Oceanview
$1,243
Balcony
$1,940
Suite
$3,907
From (Per Person)
US$1,208
Save 685
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Mar 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,139
Oceanview
$1,269
Balcony
$1,796
Suite
$2,236
From (Per Person)
US$1,139
Save 485
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Jan 2027
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,256
Oceanview
$1,457
Balcony
$1,908
Suite
$2,170
From (Per Person)
US$1,256
Save 773
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 23 January 2027
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,398
Oceanview
$1,552
Balcony
-
Suite
-
From (Per Person)
US$1,398
Save 711
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,001
Oceanview
$1,111
Balcony
$1,549
Suite
$1,939
From (Per Person)
US$1,001
Save 456
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Operator: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visits: USA, Colombia, Panama, Mexico
Inside
$1,377
Oceanview
$1,617
Balcony
$2,197
Suite
$10,547
From (Per Person)
US$1,377
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 08 January 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,103
Oceanview
$1,243
Balcony
$1,591
Suite
$2,011
From (Per Person)
US$1,103
Save 426
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 09 January 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,120
Oceanview
$1,201
Balcony
$1,678
Suite
$2,088
From (Per Person)
US$1,120
Save 443
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 24 January 2027
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,424
Oceanview
$1,435
Balcony
$2,144
Suite
$2,249
From (Per Person)
US$1,424
Save 730
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (6)

11 Days (10 Nights) Panama City to Valparaiso
Operator: Azamara
Ship: Azamara Quest
Departure: 14 January 2028
Visits: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$4,369
Oceanview
$5,129
Balcony
$6,298
Suite
$9,252
From (Per Person)
US$4,369
Save 230
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,056
Oceanview
$1,169
Balcony
$1,706
Suite
$2,086
From (Per Person)
US$1,056
Save 485
Per Person
View Trip
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