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Panama Cruises

Are you looking for a cruise to Panama? Choose from 99 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, London, Los Angeles and more. January is the most popular month to cruise to Panama and we have over 246 departures available from fifteen of the world's leading cruise lines.
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99 Cruises (246 Cruise Departures)
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2026 to Feb 2026
Countries Visited: Costa Rica, Panama
Complimentary Hotel Night
From (per person) 8,990
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 26 February 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,070
SUITE
$9,270
From (per person) 6,070
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Champlain, Le Laperouse
Departures: Feb 2026 to Feb 2027
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$10,700
From (per person) 6,420
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (2)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 05 January 2027
Countries Visited: Costa Rica, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$11,280
SUITE
$16,560
From (per person) 11,280
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$7,980
SUITE
$9,180
Save (per person) 11,010
From (per person) 7,980
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,820
SUITE
$11,410
From (per person) 6,820
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$11,290
SUITE
$17,390
From (per person) 11,290
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departures: Dec 2026 to Mar 2027
Countries Visited: Costa Rica, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Apr 2026 to Apr 2027
Countries Visited: Panama, Colombia
Latest Offer
INSIDE
$106
OCEANVIEW
$136
BALCONY
$118
SUITE
$143
Save (per person) 156
From (per person) 106
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,640
SUITE
$10,430
From (per person) 6,640
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (2)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Azamara Circle Loyalty Quarterly Savings
INSIDE
$2,569
OCEANVIEW
$2,789
BALCONY
$3,149
SUITE
$4,659
From (per person) 2,569
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,970
SUITE
$11,770
Save (per person) 14,020
From (per person) 10,970
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$14,845
SUITE
$17,145
Save (per person) 17,945
From (per person) 14,845
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,120
SUITE
$8,130
From (per person) 5,120
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Apr 2027
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$829
OCEANVIEW
$859
BALCONY
$981
SUITE
$1,276
Save (per person) 725
From (per person) 829
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Dec 2025 to Feb 2027
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest Offer
INSIDE
$875
OCEANVIEW
$915
BALCONY
$1,037
SUITE
$1,362
Save (per person) 810
From (per person) 875
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Bonaire, Aruba, Panama
Latest OfferExclusive Solo Offer
INSIDE
$1,024
OCEANVIEW
$1,075
BALCONY
$1,224
SUITE
$1,493
Save (per person) 703
From (per person) 1,024
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Latest OfferExclusive Solo Offer
INSIDE
$1,090
OCEANVIEW
$1,068
BALCONY
$1,218
SUITE
$1,497
Save (per person) 699
From (per person) 1,068
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 04 October 2026
Countries Visited: USA, Mexico, Panama, Aruba
Exclusive DealSummer Swing Sale
INSIDE
$1,737
OCEANVIEW
$1,869
BALCONY
$3,309
SUITE
$6,269
From (per person) 1,737
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Countries Visited: USA, Aruba, Panama, Mexico
Exclusive DealSummer Swing Sale
INSIDE
$2,049
OCEANVIEW
$2,289
BALCONY
$3,345
SUITE
$4,689
From (per person) 2,049
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest Offer
INSIDE
$924
OCEANVIEW
$964
BALCONY
$1,086
SUITE
$1,431
Save (per person) 520
From (per person) 924
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$941
OCEANVIEW
$1,052
BALCONY
$1,140
SUITE
$1,430
Save (per person) 650
From (per person) 941
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Latest Offer
INSIDE
$937
OCEANVIEW
$977
BALCONY
$1,066
SUITE
$1,426
Save (per person) 554
From (per person) 937
View Trip
19 Day New York To San Francisco with Cunard
Cruise
 (3)

19 Days (18 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Memorial Day Sale
INSIDE
$3,509
OCEANVIEW
$5,359
BALCONY
$5,409
SUITE
-
From (per person) 3,509
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 21 December 2025
Countries Visited: Colombia, Curacao, Aruba, Panama
Latest OfferExclusive Solo Offer
INSIDE
$1,504
OCEANVIEW
$1,554
BALCONY
$1,634
SUITE
$1,854
Save (per person) 735
From (per person) 1,504
View Trip
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