Panama Cruises

Are you looking for a cruise to Panama? Choose from 97 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, London, Los Angeles and more. January is the most popular month to cruise to Panama and we have over 242 departures available from fifteen of the world's leading cruise lines.
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30 Days
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97 Cruises (242 Cruise Departures)
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Departures: Feb 2026 to Feb 2027
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$10,700
From (per person) 6,420
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$11,280
SUITE
$16,560
From (per person) 11,280
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,820
SUITE
$11,410
From (per person) 6,820
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,640
SUITE
$10,430
From (per person) 6,640
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2026 to Feb 2026
Countries Visited: Costa Rica, Panama
Complimentary Hotel Night
From (per person) 8,990
Cruise
 (2)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 05 January 2027
Countries Visited: Costa Rica, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 26 February 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$11,280
SUITE
$16,560
From (per person) 11,280
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$7,980
SUITE
$9,180
Save (per person) 11,010
From (per person) 7,980
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Departures: Apr 2026 to Apr 2027
Countries Visited: Panama, Colombia
Latest OfferBonus Onboard Credit
INSIDE
$156
OCEANVIEW
$186
BALCONY
$205
SUITE
$306
From (per person) 181
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,070
SUITE
$9,270
From (per person) 6,070
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departures: Dec 2026 to Jan 2027
Countries Visited: Costa Rica, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Departures: Nov 2026 to Jan 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Azamara Circle Loyalty Quarterly Savings
INSIDE
$2,839
OCEANVIEW
$3,129
BALCONY
$3,589
SUITE
$5,649
From (per person) 2,839
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,120
SUITE
$8,130
From (per person) 5,120
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$6,400
SUITE
$12,200
From (per person) 6,400
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$14,845
SUITE
$17,145
Save (per person) 17,945
From (per person) 14,845
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,970
SUITE
$11,770
Save (per person) 14,020
From (per person) 10,970
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Latest OfferBonus Onboard Credit
INSIDE
$1,024
OCEANVIEW
$1,065
BALCONY
$1,191
SUITE
$1,826
From (per person) 1,376
Cruise
 (3)

16 Days (15 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Adventure Awaits Sale
INSIDE
$3,389
OCEANVIEW
$4,869
BALCONY
$5,359
SUITE
-
From (per person) 3,389
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Bonaire, Aruba, Panama
Latest OfferBonus Onboard Credit
INSIDE
$1,111
OCEANVIEW
$1,162
BALCONY
$1,349
SUITE
$1,893
From (per person) 1,501
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest OfferBonus Onboard Credit
INSIDE
$1,029
OCEANVIEW
$1,139
BALCONY
$1,266
SUITE
$1,849
From (per person) 1,380
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Latest OfferBonus Onboard Credit
INSIDE
$1,126
OCEANVIEW
$1,166
BALCONY
$1,353
SUITE
$1,926
From (per person) 1,520
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Departures: Dec 2025 to Feb 2027
Countries Visited: Colombia, Aruba, Bonaire, Panama
Latest OfferBonus Onboard Credit
INSIDE
$1,031
OCEANVIEW
$1,081
BALCONY
$1,241
SUITE
$1,853
From (per person) 1,383
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest OfferBonus Onboard Credit
INSIDE
$1,324
OCEANVIEW
$1,375
BALCONY
$1,562
SUITE
$2,226
From (per person) 1,804
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Departure: 19 April 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Latest OfferBonus Onboard Credit
INSIDE
$1,157
OCEANVIEW
$1,258
BALCONY
$1,495
SUITE
$2,345
From (per person) 1,573
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Departures: Oct 2025 to Apr 2027
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest OfferBonus Onboard Credit
INSIDE
$916
OCEANVIEW
$946
BALCONY
$1,106
SUITE
$1,676
From (per person) 1,217
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
2 for 1 Fares + Fly Free Premium Economy
INSIDE
-
OCEANVIEW
-
BALCONY
$24,605
SUITE
-
Save (per person) 24,625
From (per person) 24,605
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