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Panama Cruises

Are you looking for a cruise to Panama? Choose from 94 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, London, Los Angeles and more. January is the most popular month to cruise to Panama and we have over 239 departures available from seventeen of the world's leading cruise lines.
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94 Cruises (239 Cruise Departures)
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Visit: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$803
Oceanview
$763
Balcony
$883
Suite
$1,598
From
US$1,207
Save 50
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$769
Oceanview
$888
Balcony
$1,198
Suite
$1,151
From
US$769
Save 1,320
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$898
Oceanview
$1,028
Balcony
$1,115
Suite
$1,300
From
US$898
Save 636
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$841
Oceanview
$951
Balcony
$1,228
Suite
$1,316
From
US$841
Save 1,317
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2026
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,027
Oceanview
$1,407
Balcony
$1,127
Suite
$1,812
From
US$1,027
Save 592
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$731
Oceanview
$745
Balcony
$1,020
Suite
$1,016
From
US$731
Save 758
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$868
Oceanview
$998
Balcony
$1,165
Suite
$1,310
From
US$868
Save 710
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 March 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$966
Oceanview
$1,097
Balcony
$1,556
Suite
$1,606
From
US$966
Save 538
Per Person
View Trip
8 Day Southern Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 December 2026
Visit: Panama, Colombia, Aruba, Bonaire
Bonus Onboard Credit
Exclusive Savings
Inside
$979
Oceanview
$1,009
Balcony
$1,591
Suite
$1,617
From
US$979
Save 575
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 13 February 2027
Visit: Panama, Colombia, Aruba, Bonaire
Bonus Onboard Credit
Exclusive Savings
Inside
$815
Oceanview
$935
Balcony
$1,348
Suite
$1,288
From
US$815
Save 468
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$107,982
From
US$107,982
Save 3,198
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 08 March 2026
Visit: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,234
Oceanview
$1,294
Balcony
$1,304
Suite
$1,449
From
US$1,234
Save 686
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 February 2026
Visit: Panama, Colombia, Bonaire, Aruba
Exclusive Savings
Inside
$1,323
Oceanview
-
Balcony
$1,524
Suite
-
From
US$1,323
Save 721
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 14 February 2027
Visit: Colombia, Aruba, Bonaire, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$856
Oceanview
$986
Balcony
$1,418
Suite
$1,363
From
US$856
Save 494
Per Person
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 20 December 2026
Visit: Colombia, Aruba, Bonaire, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,810
Oceanview
$1,820
Balcony
$1,943
Suite
$1,888
From
US$1,810
Save 896
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$842
Oceanview
$940
Balcony
$1,212
Suite
$1,207
From
US$842
Save 583
Per Person
View Trip
17 Day Panama Canal - Ocean To Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Orlando
Cruise Line: Princess
Ship: Star Princess
Departure: 10 October 2027
Visit: USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$1,429
Oceanview
$1,699
Balcony
$2,199
Suite
$3,199
From
US$1,429
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$861
Oceanview
$981
Balcony
$1,178
Suite
$1,233
From
US$861
Save 635
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Feb 2026 to Mar 2026
Visit: Colombia, Bonaire, Aruba, Panama
Exclusive Savings
Inside
$1,319
Oceanview
-
Balcony
$1,829
Suite
$1,929
From
US$1,319
Save 785
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 28 December 2026
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,329
Oceanview
$1,379
Balcony
$2,109
Suite
$2,949
From
US$1,329
Per Person
View Trip
21 Day Seattle to Miami with Silversea
Cruise
 (1)

21 Days (20 Nights) Seattle to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 11 May 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$16,870
From
US$16,870
Save 3,030
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 13 December 2027
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,399
Oceanview
$1,599
Balcony
$2,099
Suite
$3,499
From
US$1,399
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$5,215
Suite
$5,880
From
US$5,215
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,650
Oceanview
$1,869
Balcony
$3,009
Suite
$3,990
From
US$1,650
Per Person
View Trip
16 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

16 Days (15 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Coral Princess
Departure: 06 January 2027
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$2,052
Oceanview
$2,278
Balcony
$2,902
Suite
$4,482
From
US$2,052
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$973
Oceanview
$1,035
Balcony
$1,327
Suite
$1,517
From
US$973
Save 583
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: USA, Mexico, Belize, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
US$3,799
Per Person
View Trip
11 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

11 Days (10 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 14 November 2026
Visit: Panama, Bonaire, Aruba, Curacao, Trinidad and Tobago
Exclusive Savings
Inside
$927
Oceanview
$1,053
Balcony
$1,538
Suite
$1,558
From
US$927
Save 546
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Bonus Onboard Credit
Inside
$1,818
Oceanview
$2,038
Balcony
$2,487
Suite
$6,367
From
US$1,818
Per Person
View Trip
24 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

24 Days (23 Nights) Fort Lauderdale to Honolulu
Cruise Line: Princess
Ship: Coral Princess
Departure: 06 January 2027
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$3,260
Oceanview
$3,409
Balcony
$4,659
Suite
$6,978
From
US$3,260
Per Person
View Trip
Results: 31-60 of 94

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