Home > Cruises > Central America Cruises > Panama Cruises

Panama Cruises

Are you looking for a cruise to Panama? Choose from 86 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, Fort-de-France, London and more. January is the most popular month to cruise to Panama and we have over 209 departures available from seventeen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
7 Days
30 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$1,200pp
$39,155pp
Countries
Show More...
Filter Results
86 Cruises (209 Cruise Departures)
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$3,032
Oceanview
$3,319
Balcony
$4,230
Suite
$13,497
From
A$3,032
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Exclusive Deal
Exclusive Savings
Inside
$1,594
Oceanview
$1,791
Balcony
$2,445
Suite
$4,087
From
A$1,594
Save 912
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (11)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Crown Princess
Departure: 03 December 2026
Visit: USA, Mexico, Costa Rica, Panama, Curacao
Princess Standard
Exclusive Savings
Inside
$1,795
Oceanview
$2,203
Balcony
$2,983
Suite
$4,013
From
A$1,795
Per Person
View Trip
30 Day Panama Canal & Easter Island Explorer with Seabourn
Cruise
 (1)

30 Days (29 Nights) Miami to Valparaiso
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 07 January 2028
Visit: USA, Panama, Ecuador, Peru, Chile
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
$26,125
Balcony
$31,123
Suite
$54,937
From
A$26,125
Save 473
Per Person
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise
 (5)

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Viking Cruises
Ships: Viking Sky, Viking Vesta
Departures: Dec 2026 to Dec 2027
Visit: USA, Mexico, Colombia, Panama, Costa Rica
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,354
Suite
$17,684
From
A$9,354
Save 1,443
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (5)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$4,666
Oceanview
$5,214
Balcony
$6,400
Suite
$9,370
From
A$4,666
Save 73
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2027
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Exclusive Savings
Inside
$3,081
Oceanview
$3,116
Balcony
$3,560
Suite
$5,853
From
A$3,081
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Aug 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Exclusive Deal
Exclusive Savings
Inside
$1,619
Oceanview
$1,730
Balcony
$2,069
Suite
$3,791
From
A$1,619
Save 1,581
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 30 January 2027
Visit: Panama, Colombia, Curacao, Aruba, Bonaire
Exclusive Deal
Exclusive Savings
Inside
$1,955
Oceanview
$1,975
Balcony
$2,680
Suite
$4,775
From
A$1,955
Save 823
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Aug 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Deal
Exclusive Savings
Inside
$1,299
Oceanview
$1,312
Balcony
$1,912
Suite
$2,893
From
A$1,299
Save 1,234
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Exclusive Savings
Inside
$2,141
Oceanview
$2,313
Balcony
$2,701
Suite
$3,972
From
A$2,141
Per Person
View Trip
8 Day Southern Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 December 2026
Visit: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
Exclusive Savings
Inside
$2,037
Oceanview
$2,046
Balcony
$2,958
Suite
$4,900
From
A$2,037
Save 872
Per Person
View Trip
18 Day New York To Los Angeles with Cunard
Cruise
 (1)

18 Days (17 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador, Mexico
Exclusive Savings
Inside
$6,143
Oceanview
$7,232
Balcony
$9,212
Suite
-
From
A$6,143
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 10 April 2027
Visit: Panama, Colombia, Aruba, Bonaire, Curacao
Exclusive Deal
Exclusive Savings
Inside
$2,011
Oceanview
$2,165
Balcony
$3,219
Suite
$4,988
From
A$2,011
Save 848
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

26 Days (25 Nights) Miami to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 08 April 2027
Visit: USA, Colombia, Panama, Mexico, Canada
Exclusive Savings
Inside
-
Oceanview
$4,916
Balcony
$6,074
Suite
-
From
A$4,916
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 13 December 2027
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Exclusive Savings
Inside
$2,091
Oceanview
$2,368
Balcony
$3,338
Suite
$5,556
From
A$2,091
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Jan 2028
Visit: Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,854
Suite
$11,704
From
A$6,854
Save 217
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Emerald Princess, Island Princess, Sapphire Princess
Departures: Nov 2026 to Apr 2028
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Exclusive Savings
Inside
$2,091
Oceanview
$2,368
Balcony
$2,914
Suite
$3,972
From
A$2,091
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 18 March 2028
Visit: Panama, Colombia, Curacao, Aruba
Exclusive Deal
Exclusive Savings
Inside
$1,667
Oceanview
$1,864
Balcony
$2,531
Suite
$4,208
From
A$1,667
Save 690
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 12 December 2026
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Exclusive Savings
Inside
$2,230
Oceanview
$2,327
Balcony
$2,479
Suite
$3,131
From
A$2,230
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,060
From
A$8,060
Save 165
Per Person
View Trip
16 Day Panama Canal Holiday with Holland America
Cruise
 (4)

16 Days (15 Nights) San Diego to Miami
Cruise Line: Holland America
Ship: Zaandam
Departure: 18 December 2027
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Fare Saver
Exclusive Savings
Inside
$4,153
Oceanview
$4,608
Balcony
$7,677
Suite
$14,736
From
A$4,153
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visit: Panama, Costa Rica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,854
Suite
$11,704
From
A$6,854
Save 242
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Exclusive Deal
Exclusive Savings
Inside
$1,293
Oceanview
$1,414
Balcony
$2,635
Suite
$4,388
From
A$1,293
Save 719
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Nov 2026 to Apr 2028
Visit: Colombia, Aruba, Curacao, Panama
Exclusive Deal
Exclusive Savings
Inside
$1,614
Oceanview
$1,713
Balcony
$2,505
Suite
$4,218
From
A$1,614
Save 785
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 27 September 2027
Visit: USA, Mexico, Panama, Colombia
Exclusive Savings
Inside
$3,382
Oceanview
$3,669
Balcony
$4,610
Suite
$13,813
From
A$3,382
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: USA, Mexico, Belize, Costa Rica, Panama
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,022
Suite
$9,354
From
A$6,022
Save 1,379
Per Person
View Trip
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Cruise Line: Emerald Cruises
Ships: Emerald Azzurra
Departures: Feb 2028 to Feb 2029
Visit: Costa Rica, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$14,745
Balcony
-
Suite
$17,621
From
A$14,745
Save 4,233
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 13 February 2027
Visit: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
Exclusive Savings
Inside
$1,523
Oceanview
$1,576
Balcony
$2,549
Suite
$5,659
From
A$1,523
Save 633
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 11 April 2027
Visit: Colombia, Aruba, Bonaire, Curacao, Panama
Exclusive Deal
Exclusive Savings
Inside
$2,219
Oceanview
$2,393
Balcony
$3,265
Suite
$5,240
From
A$2,219
Save 957
Per Person
View Trip
Results: 31-60 of 86

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Trip Lengths

10 Day 2 Week 3 Week 7 Day

Departure Months

June July August September October November December January February March April

Cities

Colon Panama City Santiago

Routes

Colon to Colon Miami to Panama City Panama City to Miami

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2026. Global Journeys. You're viewing our site in Australian dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (ATIA). No. A11351.

Travel Industry Associations