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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? March is the most popular month to cruise between Panama and USA and there are 21 departures available from nine of the world's leading cruise lines.
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11 Days
37 Days
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$19,498pp
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18 Cruises (21 Cruise Departures)
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$2,724
OCEANVIEW
$3,024
BALCONY
$3,724
SUITE
$5,224
From (per person) 2,724
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Exclusive Deal
INSIDE
$6,939
OCEANVIEW
$9,739
BALCONY
$10,839
SUITE
$22,439
From (per person) 6,939
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$7,649
SUITE
$8,049
Save (per person) 11,849
From (per person) 7,649
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,995
SUITE
$14,995
From (per person) 9,995
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Latest OfferExclusive Solo Offer
INSIDE
$1,186
OCEANVIEW
$1,485
BALCONY
$1,888
SUITE
$2,803
Save (per person) 464
From (per person) 1,186
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$3,299
SUITE
$5,499
Save (per person) 200
From (per person) 3,299
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (2)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$2,289
OCEANVIEW
$2,559
BALCONY
$2,919
SUITE
$4,699
From (per person) 2,289
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Fleetwide SaleExclusive Deal
INSIDE
$3,299
OCEANVIEW
$3,599
BALCONY
$5,199
SUITE
$7,199
Save (per person) 3,299
From (per person) 3,299
View Trip
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Fleetwide SaleExclusive Deal
INSIDE
$3,299
OCEANVIEW
$3,599
BALCONY
$5,199
SUITE
$7,299
Save (per person) 3,299
From (per person) 3,299
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$6,109
OCEANVIEW
$6,799
BALCONY
$8,729
SUITE
$13,159
From (per person) 6,109
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Countries Visited: Panama, El Salvador, Guatemala, Mexico (+1 more), USA
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$7,865
From (per person) 6,420
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Fleetwide SaleExclusive Deal
INSIDE
$2,590
OCEANVIEW
$2,905
BALCONY
$4,235
SUITE
$5,950
Save (per person) 4,808
From (per person) 2,590
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$6,359
OCEANVIEW
$9,059
BALCONY
$10,059
SUITE
$20,159
From (per person) 6,359
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$5,599
SUITE
$7,999
From (per person) 5,599
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Memorial Day SaleExclusive Deal
INSIDE
$3,299
OCEANVIEW
$3,699
BALCONY
$5,199
SUITE
$7,499
Save (per person) 3,299
From (per person) 3,299
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$3,999
BALCONY
$4,699
SUITE
$6,899
Save (per person) 3,199
From (per person) 3,199
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Aruba, USA
Exclusive Deal
INSIDE
$4,709
OCEANVIEW
$6,709
BALCONY
$7,409
SUITE
$14,309
From (per person) 4,709
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Jamaica, Bahamas, USA
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$3,999
BALCONY
$4,699
SUITE
$6,899
Save (per person) 3,199
From (per person) 3,199
View Trip
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