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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? March is the most popular month to cruise between Panama and USA and there are 25 departures available from seven of the world's leading cruise lines.
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37 Days
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19 Cruises (25 Cruise Departures)
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Inside
$2,794
Oceanview
$3,094
Balcony
$3,794
Suite
$5,694
From
US$2,794
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$12,295
Suite
-
From
US$12,295
Per Person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$3,199
Oceanview
$3,999
Balcony
$4,699
Suite
$6,499
From
US$3,199
Save 3,199
Per Person
View Trip
11 Day Spanish Lullaby with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2028
Visit: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,999
Balcony
$4,799
Suite
$6,899
From
US$2,999
Save 2,999
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (3)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Visit: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Inside
$4,989
Oceanview
$5,559
Balcony
$6,169
Suite
$10,019
From
US$4,989
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$2,299
Oceanview
$2,399
Balcony
$3,399
Suite
$4,599
From
US$2,299
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: Panama, Costa Rica, Belize, Mexico, USA
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$4,099
Suite
$6,799
From
US$4,099
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 16 January 2028
Visit: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,099
Oceanview
$4,099
Balcony
$4,899
Suite
$6,899
From
US$3,099
Save 3,099
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: Panama, Costa Rica, Honduras, Belize, Mexico, USA
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,099
Suite
$6,499
From
US$4,099
Save 150
Per Person
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$4,449
Balcony
$5,099
Suite
$10,399
From
US$4,449
Save 4,449
Per Person
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama, Aruba, USA
Bonus Onboard Credit
Inside
$2,999
Oceanview
$4,499
Balcony
$5,099
Suite
$11,329
From
US$2,999
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,599
Suite
$11,999
From
US$11,599
Save 11,599
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
Inside
-
Oceanview
-
Balcony
-
Suite
$7,280
From
US$7,280
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Bonus Onboard Credit
Value Fare
Inside
$5,209
Oceanview
$7,269
Balcony
$8,109
Suite
$18,109
From
US$5,209
Per Person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+7 more), Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,899
Suite
$24,749
From
US$23,899
Save 23,899
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Apr 2027 to Apr 2029
Visit: Chile, Peru, Panama, Jamaica, Bahamas, USA
Flights Included
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,295
Suite
$16,495
From
US$11,295
Save 900
Per Person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Visit: Panama, Colombia, Aruba, Curacao (+6 more), Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,199
Suite
$12,599
From
US$12,199
Save 12,199
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA, Canada
Inside
-
Oceanview
-
Balcony
-
Suite
$11,840
From
US$11,840
Per Person
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Bonus Onboard Credit
Value Fare
Inside
$5,929
Oceanview
$8,189
Balcony
$9,319
Suite
$20,069
From
US$5,929
Per Person
View Trip
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