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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? December and February are the most popular months to cruise between Panama and USA and there are 28 departures available from eight of the world's leading cruise lines.
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10 Days
37 Days
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$1,500pp
$16,995pp
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24 Cruises (28 Cruise Departures)
Cruise
 (1)

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$1,923
OCEANVIEW
$2,012
BALCONY
$3,428
SUITE
-
From (per person) 1,923
Cruise
 (3)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Bonus SavingsExclusive Deal
INSIDE
$4,984
OCEANVIEW
-
BALCONY
-
SUITE
-
Save (per person) 2,586
From (per person) 4,984
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Bonus SavingsExclusive Deal
INSIDE
$4,314
OCEANVIEW
$4,778
BALCONY
$6,854
SUITE
$9,135
Save (per person) 2,506
From (per person) 4,314
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$5,308
OCEANVIEW
$6,664
BALCONY
$7,882
SUITE
$16,594
From (per person) 5,308
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Dec 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,795
Save (per person) 1,068
From (per person) 6,561
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Earlybird Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$9,008
SUITE
$16,314
From (per person) 9,008
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Bonus SavingsExclusive Deal
INSIDE
$4,981
OCEANVIEW
$5,578
BALCONY
$8,127
SUITE
$11,414
Save (per person) 2,589
From (per person) 4,981
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
More At Sea Offer
INSIDE
$2,719
OCEANVIEW
$2,872
BALCONY
$4,907
SUITE
$5,472
From (per person) 2,719
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Aruba, USA
Exclusive Deal
INSIDE
$6,738
OCEANVIEW
$9,906
BALCONY
$10,896
SUITE
$19,806
From (per person) 6,738
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,641
OCEANVIEW
$5,086
BALCONY
$7,462
SUITE
$10,293
Save (per person) 2,029
From (per person) 4,641
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$9,317
OCEANVIEW
$13,871
BALCONY
$14,861
SUITE
$28,226
From (per person) 9,317
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Exclusive Deal
INSIDE
$10,407
OCEANVIEW
$14,862
BALCONY
$16,248
SUITE
$31,494
From (per person) 10,407
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Exclusive Deal
INSIDE
$7,237
OCEANVIEW
$8,722
BALCONY
$11,395
SUITE
$25,552
From (per person) 7,237
Cruise

14 Days (13 Nights) Panama City to New York
Cruise Line: Norwegian Cruise Line
Departure: 22 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+5 more), Saint Lucia, Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
More At Sea Offer
INSIDE
$5,015
OCEANVIEW
$5,779
BALCONY
$7,691
SUITE
$8,839
From (per person) 5,015
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
More At Sea OfferExclusive Solo Offer
INSIDE
$3,525
OCEANVIEW
$3,985
BALCONY
$5,285
SUITE
$5,667
From (per person) 3,525
Cruise

12 Days (11 Nights) Panama City to Galveston
Cruise Line: Norwegian Cruise Line
Departure: 26 January 2026
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
More At Sea Offer
INSIDE
$3,817
OCEANVIEW
$4,352
BALCONY
$5,729
SUITE
$6,234
From (per person) 3,817
Cruise

11 Days (10 Nights) Panama City to Tampa
Cruise Line: Norwegian Cruise Line
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
More At Sea Offer
INSIDE
$2,066
OCEANVIEW
$2,220
BALCONY
$3,673
SUITE
$4,132
From (per person) 2,066
Cruise

10 Days (9 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
More At Sea Offer
INSIDE
$1,588
OCEANVIEW
$1,619
BALCONY
$1,802
SUITE
$16,009
From (per person) 1,588
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Silversea
Departure: 24 December 2024
Countries Visited: Panama, Costa Rica, Mexico, USA
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$10,791
SUITE
$22,572
From (per person) 10,791
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,064
SUITE
$10,658
Save (per person) 6,286
From (per person) 10,064
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Departure: 16 February 2026
Countries Visited: Panama, Colombia, Aruba, Saint Lucia (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
More At Sea OfferExclusive Solo Offer
INSIDE
$3,781
OCEANVIEW
$4,317
BALCONY
$5,816
SUITE
$6,198
From (per person) 3,781
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,675
SUITE
$22,535
Save (per person) 1,160
From (per person) 15,675
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$4,483
OCEANVIEW
$4,938
BALCONY
$7,314
SUITE
$10,145
Save (per person) 2,027
From (per person) 4,483
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$5,252
OCEANVIEW
$6,192
BALCONY
$8,321
SUITE
$18,439
From (per person) 5,252
Results: 24 results

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