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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? March is the most popular month to cruise between Panama and USA and there are 27 departures available from seven of the world's leading cruise lines.
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19 Cruises (27 Departures)
19 Cruises (27 Departures)
Departures
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Duration
11 Days
27 Days
Start & End Cities
Ship Size
Ship Features
Operators
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Price
$2,200pp
$47,998pp
Countries
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11 Day Spanish Lullaby with Oceania Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Miami
Operator: Oceania
Ship: Oceania Marina
Departure: 15 March 2028
Visits: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,999
Balcony
$4,799
Suite
$6,899
From (Per Person)
US$2,999
Save 2,999
Per Person
View Trip
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operator: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visits: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare
Inside
$2,894
Oceanview
$3,094
Balcony
$3,994
Suite
$6,194
From (Per Person)
US$2,894
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Santiago to Fort Lauderdale
Operator: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Visits: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$2,299
Oceanview
$2,499
Balcony
$4,119
Suite
$4,799
From (Per Person)
US$2,299
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (6)

20 Days (19 Nights) Santiago to Miami
Operator: Azamara
Ship: Azamara Journey
Departure: 10 March 2027
Visits: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Inside
-
Oceanview
$5,219
Balcony
-
Suite
-
From (Per Person)
US$5,219
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Miami
Operator: Oceania
Ship: Oceania Marina
Departure: 16 January 2028
Visits: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$3,099
Oceanview
$4,099
Balcony
$4,899
Suite
$6,899
From (Per Person)
US$3,099
Save 3,099
Per Person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Miami
Operator: Oceania
Ship: Oceania Marina
Departure: 15 March 2027
Visits: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$3,510
Oceanview
$4,500
Balcony
$4,815
Suite
$7,200
From (Per Person)
US$3,510
Save 4,288
Per Person
View Trip
12 Day Fuerte Amador (Panama City) to Fort Lauderdale with Crystal Cruises
New ReleaseCruise

12 Days (11 Nights) Panama City to Fort Lauderdale
Operator: Crystal
Ship: Crystal Serenity
Departure: 11 December 2027
Visits: Panama, Costa Rica, Honduras, Guatemala, Belize, Mexico, USA
Exclusive Savings
Oceanview
$4,798
Balcony
$6,026
Suite
$6,114
From (Per Person)
US$4,798
Save 1,002
Per Person
View Trip
12 Day Canal Gates To Leeward Light with Oceania Cruises
Cruise

12 Days (11 Nights) Panama City to Miami
Operator: Oceania
Ship: Oceania Sonata
Departure: 11 February 2029
Visits: Panama, Aruba, Grenada, Dominica, Saint Kitts and Nevis, Virgin Islands, USA
Your World Inclusions
Exclusive Savings
Balcony
$6,149
Suite
$8,399
From (Per Person)
US$6,149
Save 6,149
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Operator: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA
Suite
$5,735
From (Per Person)
US$5,735
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Panama City to Fort Lauderdale
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: Panama, Costa Rica, Belize, Mexico, USA
Exclusive Savings
Balcony
$3,799
Suite
$6,299
From (Per Person)
US$3,799
Save 150
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Operator: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA, Canada
Suite
$10,760
From (Per Person)
US$10,760
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
CruiseFlights Included

20 Days (19 Nights) Santiago to New York
Operator: Viking
Ships: Viking Octantis, Viking Polaris
Departures: Apr 2027 to Apr 2029
Visits: Chile, Peru, Panama, Jamaica, Bahamas, USA
Exclusive Savings
Balcony
$9,999
Suite
$16,499
From (Per Person)
US$9,999
Save 2,000
Per Person
View Trip
13 Day Panama Canal& Island Gems with Oceania Cruises
Cruise

13 Days (12 Nights) Panama City to Miami
Operator: Oceania
Ship: Oceania Vista
Departure: 19 January 2029
Visits: Panama, Costa Rica, Cayman Islands, Jamaica +4 more, Dominican Republic, Virgin Islands, Puerto Rico, USA
Your World Inclusions
Exclusive Savings
Balcony
$4,999
Suite
$8,599
From (Per Person)
US$4,999
Save 4,999
Per Person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visits: Panama, Colombia, Aruba, Curacao +7 more, Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,757
Suite
$17,089
From (Per Person)
US$16,757
Save 31,241
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visits: Panama, Colombia, Aruba, Curacao +4 more, Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,391
Suite
$7,771
From (Per Person)
US$7,391
Save 14,007
Per Person
View Trip
15 Day Fuerte Amador (Panama City) to New York with Crystal Cruises
New ReleaseCruise

15 Days (14 Nights) Panama City to New York
Operator: Crystal
Ship: Crystal Serenity
Departure: 20 August 2027
Visits: Panama, Colombia, Jamaica, Cayman Islands, USA
Exclusive Savings
Oceanview
$5,975
Balcony
$7,467
Suite
$7,642
From (Per Person)
US$5,975
Save 1,625
Per Person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Operator: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Visits: Panama, Colombia, Aruba, Curacao +6 more, Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Exclusive Savings
Balcony
$9,355
Suite
$9,877
From (Per Person)
US$9,355
Save 17,143
Per Person
View Trip
12 Day Crescent Beaches & Colorful Towns with Regent Seven Seas
Cruise

12 Days (11 Nights) Panama City to Miami
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 22 February 2027
Visits: Panama, Costa Rica, Honduras, Belize +5 more, Guatemala, Mexico, Cayman Islands, Jamaica, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,382
Suite
$11,619
From (Per Person)
US$11,382
Save 18,416
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
CruiseFlights Included

18 Days (17 Nights) Santiago to Fort Lauderdale
Operator: Viking
Ship: Viking Polaris
Departure: 22 March 2027
Visits: Chile, Peru, Ecuador, Panama, Mexico, USA
Balcony
$10,999
Suite
$16,999
From (Per Person)
US$10,999
Per Person
View Trip
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