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Central America Luxury Cruises

Explore the best luxury cruises to the Central America. Choose from 82 unique cruise itineraries from 7 leading cruise lines. December is the most popular month to join a luxury cruise to the Central America with 82 departures starting between May 2024 and April 2026.
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82 Cruises (82 Cruise Departures)
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 23 March 2025
Countries Visited: USA, Mexico, Guatemala, Belize (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,138
OCEANVIEW
$5,514
BALCONY
$7,732
SUITE
$10,266
Save 2,032
From 5,138
View Trip
8 Day Tropical Retreats with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 04 December 2024
Countries Visited: USA, Mexico, Belize, Honduras
Exclusive Deal
INSIDE
$2,784
OCEANVIEW
$2,933
BALCONY
$3,774
SUITE
$5,368
Save 2,016
From 2,784
View Trip
11 Day Western Caribbean Bliss with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Cartagena
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 03 December 2024
Countries Visited: USA, Mexico, Belize, Guatemala (+4 more), Honduras, Costa Rica, Panama, Colombia
Exclusive Deal
INSIDE
$3,578
OCEANVIEW
$3,885
BALCONY
$5,103
SUITE
$6,875
Save 2,022
From 3,578
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 08 February 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,465
OCEANVIEW
$5,999
BALCONY
$8,207
SUITE
$10,741
Save 2,035
From 5,465
View Trip
17 Day Beyond The Panama Canal with Oceania Cruises
Cruise
 (1)

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 23 December 2024
Countries Visited: USA, Bahamas, Colombia, Costa Rica (+3 more), Nicaragua, Guatemala, Mexico
Exclusive Deal
INSIDE
$6,866
OCEANVIEW
$7,559
BALCONY
$10,688
SUITE
$16,182
Save 2,044
From 6,866
View Trip
19 Day San Francisco To Miami with Cunard
Cruise
 (8)

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 28 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+2 more), Colombia, Aruba
INSIDE
$3,668
OCEANVIEW
$4,163
BALCONY
$5,005
SUITE
$10,895
From 3,668
View Trip
11 Day Maya Revelations with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Cartagena
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 01 March 2025
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Costa Rica, Panama, Colombia
Exclusive Deal
INSIDE
$5,257
OCEANVIEW
$5,792
BALCONY
$7,544
SUITE
$9,316
Save 2,033
From 5,257
View Trip
10 Day Panama City to Fort Lauderdale with Silversea
Cruise

10 Days (9 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 11 January 2025
Countries Visited: Aruba, Colombia, Panama, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$6,187
From 6,187
View Trip
17 Day Stars & Salsa with Regent Seven Seas
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 January 2026
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+3 more), Costa Rica, Colombia, Cayman Islands
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,952
SUITE
$15,982
Save 6,778
From 14,952
View Trip
8 Day Sun-drenched Islands with Regent Seven Seas
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 17 February 2025
Countries Visited: USA, Mexico, Honduras, Belize
Exclusive DealExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,445
BALCONY
$7,554
SUITE
$8,583
Save 3,405
From 6,445
View Trip
8 Day Rhythms Under The Sun with Regent Seven Seas
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 December 2024
Countries Visited: USA, Honduras, Belize, Mexico
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,355
SUITE
$5,449
Save 5,415
From 4,355
View Trip
9 Day Cartagena to Fort Lauderdale with Silversea
Cruise

9 Days (8 Nights) Cartagena to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Moon
Departure: 29 December 2024
Countries Visited: Belize, Colombia, Honduras, Mexico (+2 more), Panama, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$9,306
SUITE
-
From 9,306
View Trip
8 Day A Journey Traversing The Panama Canal with Explora Journeys
Cruise

8 Days (7 Nights) Panama City to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 24 May 2024
Countries Visited: Panama, Colombia, USA
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,593
SUITE
$6,519
From 5,593
View Trip
8 Day Tropical Retreats with Oceania Cruises
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 02 March 2025
Countries Visited: USA, Mexico, Belize, Honduras
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,684
SUITE
$7,189
Save 2,036
From 4,684
View Trip
8 Day Mayan Magic with Regent Seven Seas
Cruise

8 Days (7 Nights) Miami to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 06 December 2024
Countries Visited: USA, Mexico, Belize, Honduras
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$7,403
Save 3,417
From 7,403
View Trip
19 Day Los Angeles to Fort Lauderdale with Silversea
Cruise

19 Days (18 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$14,058
BALCONY
$15,345
SUITE
$24,948
From 14,058
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
View Trip
10 Day Panama Canal Voyage with Azamara Cruises
Cruise

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$2,943
OCEANVIEW
$3,043
BALCONY
$3,820
SUITE
$5,372
From 2,943
View Trip
22 Day Seattle To Miami with Cunard
Cruise
 (8)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 25 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+2 more), Colombia, Aruba
INSIDE
$4,659
OCEANVIEW
$5,253
BALCONY
$6,144
SUITE
$13,668
From 4,659
View Trip
18 Day Panama Canal Holiday Voyage with Azamara Cruises
Cruise
 (1)

18 Days (17 Nights) Miami to San Diego
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 December 2024
Countries Visited: USA, Colombia, Costa Rica, Guatemala (+1 more), Mexico
INSIDE
$4,645
OCEANVIEW
$5,384
BALCONY
$7,339
SUITE
$11,247
From 4,645
View Trip
19 Day Fort Lauderdale to Los Angeles with Silversea
Cruise

19 Days (18 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 17 December 2024
Countries Visited: Colombia, Costa Rica, Mexico, Panama (+1 more), USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$10,989
BALCONY
$14,652
SUITE
$31,383
From 10,989
View Trip
22 Day Crossing Horizons with Regent Seven Seas
Cruise

22 Days (21 Nights) Miami to Honolulu
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 11 January 2026
Countries Visited: USA, Colombia, Costa Rica, Nicaragua (+2 more), Guatemala, Mexico
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$24,119
SUITE
$26,040
Save 8,511
From 24,119
View Trip
19 Day Fort Lauderdale to Los Angeles with Silversea
Cruise

19 Days (18 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Silversea
Ship: Silver Moon
Departure: 01 April 2025
Countries Visited: Colombia, Costa Rica, Guatemala, Mexico (+2 more), Panama, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$13,662
BALCONY
$15,147
SUITE
$26,334
From 13,662
View Trip
13 Day A Journey Of Pacific Pleasures And The Panama Canal with Explora Journeys
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 12 May 2024
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+1 more), Panama
The Total Luxury OfferExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,554
SUITE
$9,217
From 7,554
View Trip
14 Day San Francisco (California) to Cartagena with Silversea
Cruise

14 Days (13 Nights) San Francisco to Cartagena
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 26 May 2024
Countries Visited: Colombia, Costa Rica, Mexico, Panama (+1 more), USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$7,474
BALCONY
$9,751
SUITE
-
From 7,474
View Trip
12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,138
BALCONY
$7,326
SUITE
-
From 6,138
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,979
OCEANVIEW
$6,514
BALCONY
$9,414
SUITE
$13,117
Save 2,041
From 5,979
View Trip
17 Day Tropical Holiday with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 13 December 2024
Countries Visited: USA, Cayman Islands, Colombia, Costa Rica (+3 more), Nicaragua, Guatemala, Mexico
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,396
SUITE
$16,278
Save 3,934
From 15,396
View Trip
19 Day West Coast Wonders with Regent Seven Seas
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 06 June 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+3 more), Costa Rica, Colombia, Cayman Islands
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$19,825
SUITE
$21,745
Save 5,775
From 19,825
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,977
OCEANVIEW
$6,511
BALCONY
$9,412
SUITE
$13,115
Save 2,043
From 5,977
View Trip
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