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Central America Luxury Cruises

Explore the best luxury cruises to Central America. Choose from 106 unique cruise itineraries from 10 leading cruise lines. January is the most popular month to join a luxury cruise to Central America with 113 departures starting between February 2026 and April 2028.
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181 Days
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106 Cruises (113 Cruise Departures)
17 Day Panama Canal & Pacific Gems with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 December 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,432
Suite
$12,922
From
US$12,432
Save 18,066
Per Person
View Trip
21 Day Miami To Seattle with Cunard
Cruise
 (13)

21 Days (20 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Inside
$1,499
Oceanview
$1,699
Balcony
$1,999
Suite
$5,699
From
US$1,499
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,595
Suite
$9,281
From
US$8,595
Save 14,903
Per Person
View Trip
36 Day Miami To Sydney with Cunard
Cruise

36 Days (35 Nights) Miami to Sydney
Cruise Line: Cunard
Ship: Queen Anne
Departure: 23 January 2028
Visit: USA, Colombia, Panama, Guatemala, Mexico, Fiji, Australia
Exclusive Savings
Inside
$6,749
Oceanview
$8,432
Balcony
$10,412
Suite
$20,411
From
US$6,749
Per Person
View Trip
27 Day Los Angeles To Southampton with Cunard
Cruise
 (13)

27 Days (26 Nights) Los Angeles to London
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba, Portugal, England
Inside
$4,879
Oceanview
$5,679
Balcony
$7,121
Suite
$16,724
From
US$4,879
Per Person
View Trip
27 Day Southampton To Los Angeles with Cunard
Cruise
 (1)

27 Days (26 Nights) London to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 January 2027
Visit: England, USA, Aruba, Panama, El Salvador, Mexico
Inside
$2,899
Oceanview
$4,119
Balcony
$4,699
Suite
$13,923
From
US$2,899
Per Person
View Trip
30 Day Hamburg To Los Angeles with Cunard
Cruise

30 Days (29 Nights) Hamburg to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 09 January 2028
Visit: Germany, England, Portugal, USA (+4 more), Colombia, Panama, Guatemala, Mexico
Inside
$6,329
Oceanview
$8,361
Balcony
$9,252
Suite
$18,261
From
US$6,329
Per Person
View Trip
28 Day Southampton To Los Angeles with Cunard
Cruise

28 Days (27 Nights) London to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 11 January 2028
Visit: England, Portugal, USA, Colombia, Panama, Guatemala, Mexico
Inside
$5,389
Oceanview
$6,637
Balcony
$8,023
Suite
$15,646
From
US$5,389
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,637
Suite
$10,274
From
US$9,637
Save 16,161
Per Person
View Trip
12 Day Panama Canal & Southern Caribbean Cruise: Cartagena, Aruba & Curacao with Azamara Cruises
Cruise
 (4)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Visit: Panama, Colombia, Aruba, Curacao, Bonaire, Dominican Republic, USA
Azamara Always Included
Exclusive Savings
Inside
$2,635
Oceanview
-
Balcony
-
Suite
$8,202
From
US$2,635
Save 54
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,726
Balcony
$4,405
Suite
$6,345
From
US$2,999
Save 2,999
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$6,780
Suite
$7,870
From
US$6,780
Per Person
View Trip
21 Day Panama Canal Navigator with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$6,046
Oceanview
$7,307
Balcony
$8,616
Suite
$12,060
From
US$6,046
Save 6,252
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$5,215
Suite
$5,880
From
US$5,215
Per Person
View Trip
26 Day Epic Caribbean Escape: Costa Rica to Barbados with Emerald Cruises
New ReleaseCruise
 (3)

26 Days (25 Nights) San Jose to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama, Colombia, Aruba (+5 more), Curacao, Bonaire, Saint Vincent, Grenada, Barbados
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$24,094
Balcony
-
Suite
$30,156
From
US$24,094
Save 25,376
Per Person
View Trip
12 Day Pristine Islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Bridgetown to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 20 October 2027
Visit: Barbados, Saint Lucia, Saint Vincent, Curacao, Colombia, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,324
Suite
$12,051
From
US$11,324
Save 14,966
Per Person
View Trip
22 Day Seattle To Miami with Cunard
Cruise
 (13)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama, Curacao, Aruba
Inside
$1,589
Oceanview
$1,899
Balcony
$2,100
Suite
$5,999
From
US$1,589
Per Person
View Trip
21 Day Panama Canal & Caribbean with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 January 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$5,850
Oceanview
$7,208
Balcony
$8,663
Suite
$12,107
From
US$5,850
Save 6,048
Per Person
View Trip
21 Day Treasures Of The Tropics with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba (+7 more), Curacao, Colombia, Panama, Costa Rica, Honduras, Guatemala, Mexico
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$5,605
Oceanview
$7,448
Balcony
$8,952
Suite
$12,832
From
US$5,605
Save 5,793
Per Person
View Trip
30 Day Holiday Harbors & Hollywood with Oceania Cruises
Cruise

30 Days (29 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 06 December 2027
Visit: USA, Aruba, Curacao, Bonaire (+11 more), Grenada, Barbados, Saint Lucia, Guadeloupe, Virgin Islands, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,336
Suite
$19,380
From
US$14,336
Save 15,062
Per Person
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,948
Oceanview
$3,821
Balcony
$4,597
Suite
$6,343
From
US$2,948
Save 3,050
Per Person
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,450
Oceanview
$2,590
Balcony
-
Suite
-
From
US$2,450
Save 4,548
Per Person
View Trip
26 Day Epic Caribbean Escape: Barbados to Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

26 Days (25 Nights) Bridgetown to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 06 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+5 more), Curacao, Aruba, Colombia, Panama, Costa Rica
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$24,098
Balcony
-
Suite
$30,161
From
US$24,098
Save 25,372
Per Person
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,980
Oceanview
$2,160
Balcony
$3,120
Suite
$4,236
From
US$1,980
Save 4,618
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,480
Suite
$14,215
From
US$13,480
Save 20,318
Per Person
View Trip
16 Day Antilles To Andes with Oceania Cruises
Cruise
 (1)

16 Days (15 Nights) Miami to Lima
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 19 December 2026
Visit: USA, Curacao, Aruba, Colombia, Panama, Ecuador, Peru
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$3,600
Oceanview
$3,765
Balcony
$5,166
Suite
$7,310
From
US$3,600
Save 4,998
Per Person
View Trip
21 Day Panama Canal Connoisseur with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Tampa to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$6,579
Oceanview
$6,918
Balcony
-
Suite
-
From
US$6,579
Save 6,819
Per Person
View Trip
19 Day Discover the Secrets of Panama and Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) San Jose to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama, Colombia, Aruba (+5 more), Curacao, Bonaire, Grenada, Saint Vincent, Barbados
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$18,264
Balcony
-
Suite
$22,629
From
US$18,264
Save 19,216
Per Person
View Trip
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,140
Suite
$12,002
From
US$9,140
Save 16,750
Per Person
View Trip
10 Day Cartagena to Bridgetown with Silversea
Cruise

10 Days (9 Nights) Cartagena to Bridgetown
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 03 February 2026
Visit: Colombia, Aruba, Bonaire, Curacao, Saint Lucia, Saint Vincent, Barbados
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$5,120
Balcony
$5,680
Suite
-
From
US$5,120
Save 1,280
Per Person
View Trip
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