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Central America Luxury Cruises

Explore the best luxury cruises to Central America. Choose from 104 unique cruise itineraries with 264 past traveler reviews from 10 leading cruise lines. January is the most popular month to join a luxury cruise to Central America with 115 departures starting between April 2026 and April 2028.
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181 Days
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104 Cruises (115 Cruise Departures)
17 Day Ultimate Panama Canal Transit with Regent Seven Seas
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 24 January 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama, Colombia, Cayman Islands
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,699
Suite
$17,699
From
US$16,699
Save 16,699
Per Person
View Trip
18 Day Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia with Azamara Cruises
Cruise
 (5)

18 Days (17 Nights) San Diego to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 24 May 2027
Visit: USA, Mexico, Guatemala, El Salvador, Costa Rica, Panama, Colombia
Azamara Always Included
Inside
$6,129
Oceanview
$6,609
Balcony
$7,499
Suite
$12,339
From
US$6,129
Per Person
View Trip
36 Day Miami To Sydney with Cunard
Cruise

36 Days (35 Nights) Miami to Sydney
Cruise Line: Cunard
Ship: Queen Anne
Departure: 23 January 2028
Visit: USA, Colombia, Panama, Guatemala, Mexico, Fiji, Australia
Inside
$6,799
Oceanview
$8,499
Balcony
$10,499
Suite
$20,599
From
US$6,799
Per Person
View Trip
17 Day Panama Canal & Pacific Gems with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 29 December 2026
Visit: USA, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,899
Suite
$16,499
From
US$15,899
Save 15,899
Per Person
View Trip
16 Day Treasures Of Two Oceans with Oceania Cruises
Cruise

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 06 January 2027
Visit: USA, Cayman Islands, Colombia, Panama, Guatemala, Mexico
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,299
Suite
$9,360
From
US$6,299
Save 6,299
Per Person
View Trip
27 Day Los Angeles To Southampton with Cunard
Cruise
 (13)

27 Days (26 Nights) Los Angeles to London
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba, Portugal, England
Inside
$4,879
Oceanview
$5,679
Balcony
$7,179
Suite
$16,879
From
US$4,879
Per Person
View Trip
27 Day Southampton To Los Angeles with Cunard
Cruise
 (1)

27 Days (26 Nights) London to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 January 2027
Visit: England, USA, Aruba, Panama, El Salvador, Mexico
Bonus Onboard Credit
Inside
$3,049
Oceanview
$4,349
Balcony
$5,429
Suite
$13,899
From
US$3,049
Per Person
View Trip
30 Day Hamburg To Los Angeles with Cunard
Cruise

30 Days (29 Nights) Hamburg to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 09 January 2028
Visit: Germany, England, Portugal, USA (+4 more), Colombia, Panama, Guatemala, Mexico
Inside
$6,329
Oceanview
$8,429
Balcony
$9,329
Suite
$18,429
From
US$6,329
Per Person
View Trip
28 Day Southampton To Los Angeles with Cunard
Cruise

28 Days (27 Nights) London to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 11 January 2028
Visit: England, Portugal, USA, Colombia, Panama, Guatemala, Mexico
Inside
$5,389
Oceanview
$6,689
Balcony
$8,089
Suite
$15,789
From
US$5,389
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,399
Suite
$13,849
From
US$13,399
Save 13,399
Per Person
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Visit: Panama, Colombia, Costa Rica, Honduras, Mexico, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$7,049
Balcony
-
Suite
-
From
US$7,049
Save 7,049
Per Person
View Trip
19 Day Discover the Secrets of Panama and Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) San Jose to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama, Colombia, Aruba (+5 more), Curacao, Bonaire, Grenada, Saint Vincent, Barbados
Inside
-
Oceanview
$19,240
Balcony
-
Suite
-
From
US$19,240
Per Person
View Trip
19 Day Discover the Secrets of Panama and Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) Bridgetown to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 13 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+5 more), Curacao, Aruba, Colombia, Panama, Costa Rica
Inside
-
Oceanview
$19,390
Balcony
-
Suite
-
From
US$19,390
Per Person
View Trip
30 Day Holiday Harbors & Hollywood with Oceania Cruises
Cruise

30 Days (29 Nights) Miami to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 06 December 2027
Visit: USA, Aruba, Curacao, Bonaire (+11 more), Grenada, Barbados, Saint Lucia, Guadeloupe, Virgin Islands, Cayman Islands, Colombia, Panama, Costa Rica, Guatemala, Mexico
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,249
Suite
$19,899
From
US$14,249
Save 14,249
Per Person
View Trip
11 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (2)

11 Days (10 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 12 March 2027
Visit: Panama, Colombia, Bonaire, Saint Vincent, Saint Lucia, Guadeloupe, Martinique
Inside
-
Oceanview
-
Balcony
$6,760
Suite
$11,330
From
US$6,760
Per Person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,099
Oceanview
$4,099
Balcony
$4,599
Suite
$6,499
From
US$3,099
Save 3,099
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
-
Balcony
-
Suite
$7,105
From
US$7,105
Per Person
View Trip
26 Day Epic Caribbean Escape: Barbados to Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

26 Days (25 Nights) Bridgetown to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 06 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+5 more), Curacao, Aruba, Colombia, Panama, Costa Rica
Inside
-
Oceanview
$26,035
Balcony
-
Suite
-
From
US$26,035
Per Person
View Trip
16 Day Antilles To Andes with Oceania Cruises
Cruise
 (1)

16 Days (15 Nights) Miami to Lima
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 19 December 2026
Visit: USA, Curacao, Aruba, Colombia, Panama, Ecuador, Peru
Your World Inclusions
Exclusive Savings
Inside
$3,225
Oceanview
$3,375
Balcony
$4,762
Suite
$7,237
From
US$3,225
Save 5,373
Per Person
View Trip
19 Day Discover Barbados, Panama & Costa Rica with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) Bridgetown to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 06 January 2028
Visit: Barbados, Saint Vincent, Grenada, Bonaire (+4 more), Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
$18,940
Balcony
-
Suite
-
From
US$18,940
Per Person
View Trip
21 Day Treasures Of The Tropics with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba (+7 more), Curacao, Colombia, Panama, Costa Rica, Honduras, Guatemala, Mexico
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$5,699
Oceanview
$7,599
Balcony
$9,149
Suite
$13,149
From
US$5,699
Save 5,699
Per Person
View Trip
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,391
Suite
$13,618
From
US$11,391
Save 1,039
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,999
Balcony
$4,275
Suite
$5,850
From
US$2,999
Save 3,149
Per Person
View Trip
21 Day Panama Canal & Caribbean with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 January 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,299
Oceanview
-
Balcony
$9,499
Suite
$12,849
From
US$6,299
Save 6,299
Per Person
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (1)

13 Days (12 Nights) Fort-de-France to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departure: 26 October 2026
Visit: Martinique, Guadeloupe, Saint Lucia, Saint Vincent, Bonaire, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$7,550
Suite
$11,910
From
US$7,550
Per Person
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,249
Oceanview
$4,349
Balcony
$4,849
Suite
$6,699
From
US$3,249
Save 3,249
Per Person
View Trip
22 Day Seattle To Miami with Cunard
Cruise
 (13)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama, Curacao, Aruba
Bonus Onboard Credit
Inside
$2,049
Oceanview
$2,149
Balcony
$3,299
Suite
$12,699
From
US$2,049
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
Inside
-
Oceanview
-
Balcony
-
Suite
$5,215
From
US$5,215
Per Person
View Trip
21 Day Panama Canal Navigator with Oceania Cruises
Cruise
 (3)

21 Days (20 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2027
Visit: USA, Mexico, Belize, Guatemala (+8 more), Honduras, Costa Rica, Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,199
Oceanview
$7,699
Balcony
$8,899
Suite
$12,349
From
US$6,199
Save 6,199
Per Person
View Trip
34 Day Seattle To Miami with Cunard
Cruise
 (13)

34 Days (33 Nights) Seattle to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2026
Visit: USA, Mexico, Guatemala, Panama (+8 more), Curacao, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Saint Martin, Virgin Islands
Bonus Onboard Credit
Inside
$3,118
Oceanview
$3,451
Balcony
$4,813
Suite
$12,477
From
US$3,118
Per Person
View Trip
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