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Cruises From Santiago

Choose from 51 unique expeditions and cruises starting in Santiago, and traveling to Broome, Buenos Aires, Cape Town, Darwin, Fort Lauderdale and more. February is the most popular month to join a cruise from Santiago and you can select from 129 departures available from twelve leading cruise lines.
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7 Days
58 Days
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51 Cruises (129 Cruise Departures)
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (4)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 22 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Bonus Instant Savings
INSIDE
$3,089
OCEANVIEW
-
BALCONY
$3,864
SUITE
$4,969
From (per person) 3,089
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Eclipse II
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Antarctica, Argentina
2 for 1 Fares + Fly Free Premium Economy2 for 1 Cruise Fares
INSIDE
-
OCEANVIEW
-
BALCONY
$37,525
SUITE
$45,873
Save (per person) 22,507
From (per person) 37,525
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$6,599
OCEANVIEW
$7,369
BALCONY
$9,509
SUITE
$14,379
From (per person) 6,599
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$6,359
OCEANVIEW
$9,059
BALCONY
$10,059
SUITE
$20,159
From (per person) 6,359
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 30 January 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
2 for 1 Fares + Fly Free Premium Economy2 for 1 Cruise Fares
INSIDE
-
OCEANVIEW
-
BALCONY
$46,863
SUITE
$52,638
Save (per person) 22,507
From (per person) 46,863
View Trip
58 Day Remote Islands Of The Pacific & Kimberley Expedition with Seabourn
Cruise

58 Days (57 Nights) Santiago to Broome
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+8 more), Cook Islands, Samoa, Tonga, Fiji, Vanuatu, Papua New Guinea, Indonesia, Australia
Exclusive DealBonus Onboard Credit
INSIDE
-
OCEANVIEW
-
BALCONY
$52,799
SUITE
$75,199
From (per person) 52,799
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 07 November 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,200
BALCONY
$28,500
SUITE
$42,900
From (per person) 25,200
View Trip
34 Day Puerto Williams to Walvis Bay with Silversea
Cruise

34 Days (33 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 March 2026
Countries Visited: Chile, Antarctica, Falkland Islands, South Georgia Island (+3 more), Saint Helena, Namibia, South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$30,300
SUITE
$42,500
From (per person) 30,300
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,314
OCEANVIEW
$2,564
BALCONY
$3,564
SUITE
$4,664
From (per person) 2,314
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
$32,410
SUITE
$34,420
From (per person) 32,410
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,995
SUITE
$14,995
From (per person) 9,995
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$2,724
OCEANVIEW
$3,024
BALCONY
$3,724
SUITE
$5,224
From (per person) 2,724
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,364
OCEANVIEW
$2,614
BALCONY
$3,564
SUITE
$4,564
From (per person) 2,364
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Countries Visited: Chile, Peru, Ecuador, Colombia (+1 more), Panama
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$11,235
SUITE
$15,285
Save (per person) 12,755
From (per person) 11,235
View Trip
31 Day Chilean Fjords, Glaciers & Antarctic Wildlife Explorer with Scenic
Cruise

31 Days (30 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina, Falkland Islands, South Georgia Island (+1 more), Antarctica
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$50,271
SUITE
$65,271
Save (per person) 48,544
From (per person) 50,271
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 24 January 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$25,700
From (per person) 25,700
View Trip
32 Day Across Oceanic Cultures: Chilean Coast To Fiji with Seabourn
Cruise

32 Days (31 Nights) Santiago to Lautoka
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+4 more), Cook Islands, Samoa, Tonga, Fiji
Exclusive DealBonus Onboard Credit
INSIDE
-
OCEANVIEW
-
BALCONY
$26,599
SUITE
$37,799
From (per person) 26,599
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$19,103
SUITE
$25,403
Save (per person) 19,287
From (per person) 19,103
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to New York
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2027
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
FLY FREE With VikingViking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,995
SUITE
$15,995
Save (per person) 2,500
From (per person) 9,995
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,799
SUITE
$11,999
From (per person) 7,799
View Trip
22 Day Puerto Williams to Cape Town with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Saint Helena (+1 more), South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,700
BALCONY
$17,700
SUITE
$23,900
From (per person) 16,700
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: Chile, Argentina
FLY FREE With VikingViking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,295
SUITE
$12,995
Save (per person) 2,000
From (per person) 8,295
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
INSIDE
$7,694
OCEANVIEW
$9,294
BALCONY
$18,694
SUITE
$33,344
From (per person) 7,694
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Bonus Instant Savings
INSIDE
$2,409
OCEANVIEW
$3,659
BALCONY
$3,759
SUITE
$5,209
From (per person) 2,409
View Trip
31 Day Unexplored Antarctica Between Two Continents with Ponant
Cruise

31 Days (30 Nights) Santiago to Hobart
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 17 January 2026
Countries Visited: Chile, Argentina, Antarctica, Australia
INSIDE
-
OCEANVIEW
-
BALCONY
$69,000
SUITE
-
From (per person) 69,000
View Trip
42 Day Puerto Williams to Mahe with Silversea
Cruise

42 Days (41 Nights) Santiago to Mahe
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Saint Helena (+4 more), South Africa, Mozambique, Tanzania, Seychelles
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$23,900
BALCONY
$27,600
SUITE
$52,900
From (per person) 23,900
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Nov 2025 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$24,100
BALCONY
$25,800
SUITE
$35,400
From (per person) 24,100
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 19 December 2025
Countries Visited: Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$40,110
From (per person) 40,110
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Santiago
Ship: MS Fram
Departures: Nov 2025 to Jan 2027
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Anniversary Offers
INSIDE
-
OCEANVIEW
$19,907
BALCONY
-
SUITE
$23,546
Save (per person) 12,299
From (per person) 19,907
View Trip
7 Day King George Island to King George Island with Silversea
Cruise

7 Days (6 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departures: Oct 2025 to Feb 2027
Countries Visited: Chile, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$11,550
From (per person) 11,550
View Trip
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