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Cruises from Santiago

Choose from 35 unique expeditions and cruises starting in Santiago, and traveling to Buenos Aires, Fort Lauderdale, Hamburg, Hobart, Lima and more. February is the most popular month to join a cruise from Santiago and you can select from 75 departures available from twelve leading cruise lines.
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37 Days
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35 Cruises (75 Cruise Departures)
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Inside
-
Oceanview
$13,795
Balcony
$15,085
Suite
-
From
US$13,795
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (7)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,099
Suite
$12,999
From
US$8,099
Per Person
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 December 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,900
Suite
$27,600
From
US$18,900
Save 1,500
Per Person
View Trip
16 Day South America & Antarctica with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departures: Jan 2028 to Mar 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Inside
$2,929
Oceanview
$3,289
Balcony
$4,729
Suite
$4,989
From
US$2,929
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$12,495
Suite
$16,995
From
US$12,495
Per Person
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2027 to Dec 2027
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$27,770
Suite
$29,470
From
US$27,770
Per Person
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse II, Scenic Eclipse I
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$57,655
Suite
$74,155
From
US$57,655
Per Person
View Trip
10 Day Puerto Williams to King George Island with Silversea
Cruise
 (1)

10 Days (9 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Oct 2026 to Feb 2028
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$12,900
Balcony
$14,700
Suite
$23,500
From
US$12,900
Save 3,500
Per Person
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Inside
-
Oceanview
-
Balcony
$23,795
Suite
$26,395
From
US$23,795
Per Person
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 07 November 2026
Visit: Chile, Falkland Islands, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$23,100
Balcony
$26,100
Suite
$43,500
From
US$23,100
Save 3,500
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Princess Standard
Inside
$2,102
Oceanview
-
Balcony
$2,370
Suite
$3,002
From
US$2,102
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,976
Suite
$13,462
From
US$10,976
Save 1,674
Per Person
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Feb 2027 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,299
Oceanview
$2,499
Balcony
$3,719
Suite
$4,299
From
US$2,299
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$2,299
Oceanview
$2,399
Balcony
$3,399
Suite
$4,899
From
US$2,299
Per Person
View Trip
9 Day King George Island to Puerto Williams with Silversea
Cruise
 (1)

9 Days (8 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 December 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,500
Suite
$30,600
From
US$24,500
Save 3,500
Per Person
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama, Aruba, USA
Bonus Onboard Credit
Inside
$3,399
Oceanview
$4,699
Balcony
$5,299
Suite
$12,529
From
US$3,399
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (3)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Visit: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Inside
$6,529
Oceanview
$7,339
Balcony
$7,879
Suite
$13,089
From
US$6,529
Per Person
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$19,395
Suite
$21,995
From
US$19,395
Per Person
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2026 to Oct 2028
Visit: Chile, Argentina
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Save 1,000
Per Person
View Trip
23 Day South America & Antarctica with Holland America
Cruise
 (3)

23 Days (22 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 January 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Fare Saver
Inside
$4,899
Oceanview
-
Balcony
$7,599
Suite
$12,799
From
US$4,899
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Bonus Onboard Credit
Inside
$5,209
Oceanview
$7,349
Balcony
$8,109
Suite
$18,109
From
US$5,209
Per Person
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Jan 2027 to Feb 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$48,313
Suite
$55,887
From
US$48,313
Save 3,726
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,284
Oceanview
$2,484
Balcony
$3,384
Suite
$4,599
From
US$2,284
Per Person
View Trip
31 Day Unexplored Western Antarctica Between Two Continents with Ponant
Cruise

31 Days (30 Nights) Santiago to Hobart
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 10 January 2028
Visit: Chile, Argentina, Antarctica, Australia
Inside
-
Oceanview
-
Balcony
$74,470
Suite
$79,520
From
US$74,470
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Apr 2027 to Apr 2028
Visit: Chile, Peru, Panama, Jamaica, Bahamas
Flights Included
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,995
Suite
$16,495
From
US$10,995
Save 1,000
Per Person
View Trip
23 Day Patagonian Adventure and the Weddell Sea - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

23 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 26 November 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$40,969
Suite
$47,335
From
US$40,969
Save 3,631
Per Person
View Trip
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Inside
$2,804
Oceanview
$3,104
Balcony
$3,804
Suite
$5,304
From
US$2,804
Per Person
View Trip
12 Day Puerto Williams to Puerto Williams with Silversea
Cruise

12 Days (11 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 18 February 2028
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$13,600
Balcony
$16,500
Suite
$27,200
From
US$13,600
Save 3,500
Per Person
View Trip
16 Day Beyond the Antarctic Circle – In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2027 to Dec 2027
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$29,190
Suite
$31,010
From
US$29,190
Per Person
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Nov 2026 to Dec 2027
Visit: Chile, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$19,400
Balcony
$22,700
Suite
$30,800
From
US$19,400
Save 2,500
Per Person
View Trip
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