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Cruises From Santiago

Choose from 46 unique expeditions and cruises starting in Santiago, and travelling to Barcelona, Buenos Aires, Cape Town, Fort Lauderdale, Guayaquil and more. February is the most popular month to join a cruise from Santiago and you can select from 136 departures available from thirteen leading cruise lines.
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7 Days
64 Days
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46 Cruises (136 Cruise Departures)
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 20 February 2026
Trip Styles: Coach, Group, Cruise, Scenic
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+2 more), Brazil, Peru
Exclusive Deal
Save (per person) 1,546
From (per person) 17,649
View Trip
16 Day Cape Horn & Strait of Magellan with Princess
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 19 December 2024
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$5,281
SUITE
$6,073
From (per person) 5,281
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (3)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Nov 2024 to Feb 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$19,595
Save (per person) 1,123
From (per person) 9,895
View Trip
23 Day Patagonian Adventure and the Weddell Sea - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

23 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 26 November 2026
Trip Styles: Coach, Group, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$53,336
SUITE
$65,404
Save (per person) 7,039
From (per person) 53,336
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departures: Feb 2025 to Jan 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$23,809
Save (per person) 1,491
From (per person) 23,809
View Trip
7 Day King George Island to King George Island with Silversea
Cruise

7 Days (6 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Jan 2026 to Feb 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$19,750
BALCONY
$25,591
SUITE
$45,391
Save (per person) 1,492
From (per person) 19,750
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Santiago
Ship: MS Fram
Departures: Nov 2024 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Flights Included
INSIDE
-
OCEANVIEW
$27,699
BALCONY
-
SUITE
$34,404
Save (per person) 1,170
From (per person) 27,699
View Trip
24 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires with HX Hurtigruten Expeditions
Cruise

24 Days (23 Nights) Santiago to Buenos Aires
Ship: MS Fram
Departure: 20 March 2026
Countries Visited: Chile, Antarctica, Falkland Islands, Argentina
Exclusive Savings
INSIDE
-
OCEANVIEW
$50,080
BALCONY
-
SUITE
$62,536
From (per person) 50,080
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2026
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$18,615
SUITE
$26,455
Save (per person) 380
From (per person) 18,615
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Oct 2024 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$25,443
BALCONY
$25,839
SUITE
$32,323
Save (per person) 1,655
From (per person) 25,443
View Trip
16 Day In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2025 to Jan 2026
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$35,900
SUITE
$37,449
Save (per person) 752
From (per person) 35,900
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 19 December 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$37,968
SUITE
$39,614
Save (per person) 752
From (per person) 37,968
View Trip
23 Day Puerto Williams to Valparaiso with Silversea
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,987
BALCONY
$30,244
SUITE
$46,381
Save (per person) 1,513
From (per person) 25,987
View Trip
23 Day In-depth Antarctica & Patagonia Expedition (Northbound) with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Ship: MS Fram
Departure: 15 March 2025
Countries Visited: Chile, Antarctica
Flights Included
INSIDE
$43,215
OCEANVIEW
$51,147
BALCONY
-
SUITE
$63,675
From (per person) 43,215
View Trip
16 Day Puerto Williams to King George Island with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 December 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$28,066
BALCONY
$32,323
SUITE
$50,044
Save (per person) 1,534
From (per person) 28,066
View Trip
23 Day Puerto Williams to Valparaiso with Silversea
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Countries Visited: Chile, Argentina, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$23,809
BALCONY
$28,165
SUITE
$48,361
Save (per person) 1,491
From (per person) 23,809
View Trip
19 Day Isles Of Wonder with Regent Seven Seas
Cruise

19 Days (18 Nights) Santiago to Papeete
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 16 February 2025
Countries Visited: Chile, Easter Island, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$20,260
SUITE
$22,478
Save (per person) 8,040
From (per person) 20,260
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,996
OCEANVIEW
$3,904
BALCONY
$5,610
SUITE
$7,243
From (per person) 3,904
View Trip
31 Day Chilean Fjords, Glaciers & Antarctic Wildlife Explorer with Scenic
Cruise

31 Days (30 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina, Falkland Islands, South Georgia Island (+1 more), Antarctica
Earlybird Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$47,335
SUITE
$69,836
Save (per person) 22,445
From (per person) 47,335
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 March 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,582
BALCONY
$18,265
SUITE
$32,323
Save (per person) 1,418
From (per person) 16,582
View Trip
20 Day Ushuaia & The White Continent with Regent Seven Seas
Cruise

20 Days (19 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 February 2025
Countries Visited: Chile, Argentina, Antarctica, Falkland Islands (+1 more), Uruguay
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$20,864
SUITE
$22,785
Save (per person) 8,036
From (per person) 20,864
View Trip
17 Day Edge Of The World Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 01 February 2026
Countries Visited: Chile, Argentina, Uruguay
Single Supplement SpecialExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$18,496
SUITE
$20,120
Save (per person) 7,264
From (per person) 18,496
View Trip
22 Day Puerto Williams to Cape Town with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 16 March 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,285
BALCONY
$16,879
SUITE
$25,096
Save (per person) 1,415
From (per person) 16,285
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Eclipse II
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Group, Cruise, Scenic
Countries Visited: Chile, Antarctica, Argentina
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$51,628
SUITE
$61,588
Save (per person) 5,533
From (per person) 51,628
View Trip
64 Day Patagonia To Iberia Mosiac with Oceania Cruises
Cruise

64 Days (63 Nights) Santiago to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 March 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+8 more), Brazil, Cape Verde, Senegal, Spain, Portugal, Morocco, Gibraltar, France
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$34,173
SUITE
-
Save (per person) 2,267
From (per person) 34,173
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Feb 2026 to Jan 2027
Trip Styles: Coach, Group, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$61,103
SUITE
$72,013
Save (per person) 5,638
From (per person) 61,103
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Group, Cruise, Scenic
Countries Visited: Chile, Argentina, Brazil
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$28,537
SUITE
$38,457
Save (per person) 6,788
From (per person) 28,537
View Trip
30 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour + Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Ship: Delfin III
Departures: Apr 2025 to Sep 2025
Trip Styles: Coach, Group, Cruise, River Cruise, Island Hopping, Scenic
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Exclusive DealFlash Sale
Save (per person) 3,093
From (per person) 39,302
View Trip
41 Day Puerto Williams to Cape Town with Silversea
Cruise

41 Days (40 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 22 February 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica (+2 more), Saint Helena, South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$47,223
SUITE
$71,973
From (per person) 47,223
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$38,631
SUITE
$40,288
Save (per person) 796
From (per person) 38,631
View Trip
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