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Cruises from Santiago

Choose from 41 unique expeditions and cruises starting in Santiago, and traveling to Bridgetown, Buenos Aires, Fort Lauderdale, Hobart, Lima and more. February is the most popular month to join a cruise from Santiago and you can select from 103 departures available from twelve leading cruise lines.
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41 Cruises (103 Departures)
41 Cruises (103 Departures)
Departures
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Duration
9 Days
33 Days
Countries Visited
End City
Ship Features
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Price
$2,000pp
$76,970pp
Countries
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33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Cruise Line: Holland America
Tour Operator: Travelmarvel
Departures: Feb 2027 to Feb 2028
Trip Styles: Coach, Cruise, Scenic
Visits: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Oceanview
$13,795
Balcony
$15,085
From (Per Person)
US$13,795
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visits: Chile, Argentina, Falkland Islands, Uruguay
Balcony
$8,999
Suite
$12,999
From (Per Person)
US$8,999
Per Person
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 December 2026
Visits: Chile, Antarctica
Exclusive Savings
Oceanview
$16,920
Balcony
$18,900
Suite
$30,700
From (Per Person)
US$16,920
Save 1,880
Per Person
View Trip
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visits: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Inside
$2,894
Oceanview
$3,094
Balcony
$3,894
Suite
$6,194
From (Per Person)
US$2,894
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Dec 2026 to Dec 2027
Visits: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,024
Oceanview
$2,224
Balcony
$3,024
Suite
$4,724
From (Per Person)
US$2,024
Per Person
View Trip
9 Day King George Island to Puerto Williams with Silversea
Cruise
 (1)

9 Days (8 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 December 2026
Visits: Chile, Antarctica
Oceanview
-
Balcony
$28,000
Suite
$34,100
From (Per Person)
US$28,000
Per Person
View Trip
9 Day Chile & Peru Cruise: Arica, Pisco & Lima with Azamara Cruises
Cruise
 (4)

9 Days (8 Nights) Santiago to Lima
Cruise Line: Azamara
Ship: Azamara Journey
Departure: 10 March 2027
Visits: Chile, Peru
Azamara Always Included
Inside
$2,119
Oceanview
$2,419
Balcony
$2,729
Suite
$4,669
From (Per Person)
US$2,119
Per Person
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Feb 2027 to Feb 2028
Visits: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,439
Oceanview
$2,689
Balcony
$3,839
Suite
$5,039
From (Per Person)
US$2,439
Per Person
View Trip
18 Day South Georgia & Falklands - From Punta Arenas to Montevideo  with HX Expeditions
Cruise
 (1)

18 Days (17 Nights) Santiago to Montevideo
Cruise Line: HX Expeditions
Ship: MS Fram
Departure: 12 March 2027
Visits: Chile, Argentina, Falkland Islands, South Georgia Island, Uruguay
Bonus Onboard Credit
Inside
-
Oceanview
$12,404
Suite
$16,416
From (Per Person)
US$12,404
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Dec 2027
Visits: Chile, Argentina, Falkland Islands, Uruguay
Inside
$2,202
Oceanview
-
Balcony
$2,455
Suite
$4,649
From (Per Person)
US$2,202
Per Person
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 07 November 2026
Visits: Chile, Falkland Islands, South Georgia Island, Antarctica
Oceanview
$25,700
Balcony
$29,000
Suite
$43,500
From (Per Person)
US$25,700
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Visits: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$2,459
Oceanview
$2,559
Balcony
$3,859
Suite
$4,759
From (Per Person)
US$2,459
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (4)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara
Ship: Azamara Journey
Departure: 10 March 2027
Visits: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Always Included
Inside
$5,629
Oceanview
$6,029
Balcony
$6,719
Suite
$11,089
From (Per Person)
US$5,629
Per Person
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with HX Expeditions
Cruise
 (1)

23 Days (22 Nights) Santiago to Santiago
Cruise Line: HX Expeditions
Ship: MS Fram
Departures: Nov 2026 to Feb 2028
Visits: Chile, Falkland Islands, South Georgia Island, Antarctica
Bonus Onboard Credit
Inside
-
Oceanview
$19,676
Suite
$24,451
From (Per Person)
US$19,676
Per Person
View Trip
10 Day Puerto Williams to King George Island with Silversea
Cruise
 (1)

10 Days (9 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Oct 2026 to Feb 2028
Visits: Chile, Antarctica
Oceanview
$12,900
Balcony
$15,250
Suite
$25,600
From (Per Person)
US$12,900
Per Person
View Trip
16 Day South America & Antarctica with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departures: Jan 2028 to Mar 2028
Visits: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Inside
$3,069
Oceanview
$3,349
Balcony
$5,089
Suite
$5,839
From (Per Person)
US$3,069
Per Person
View Trip
24 Day Antarctica & Falklands - From Punta Arenas to Buenos Aires with HX Expeditions
Cruise
 (1)

24 Days (23 Nights) Santiago to Buenos Aires
Cruise Line: HX Expeditions
Ship: MS Fram
Departure: 18 March 2028
Visits: Chile, Antarctica, Falkland Islands, Argentina
Bonus Onboard Credit
Inside
-
Oceanview
$18,005
Suite
$23,926
From (Per Person)
US$18,005
Per Person
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
CruiseFlights Included

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2026 to Nov 2028
Visits: Chile, Argentina
Exclusive Savings
Balcony
$9,999
Suite
$14,999
From (Per Person)
US$9,999
Save 1,000
Per Person
View Trip
13 Day Chairman’s Voyage: Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visits: Chile, Argentina
Balcony
$24,615
Suite
$31,995
From (Per Person)
US$24,615
Per Person
View Trip
24 Day Ultimate Chilean Fjords & Antarctica’s Weddell Sea with Scenic
New ReleaseCruise

24 Days (23 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visits: Chile, Argentina, Antarctica
Balcony
$52,145
Suite
-
From (Per Person)
US$52,145
Per Person
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 07 April 2027
Visits: Chile, Easter Island, Pitcairn Islands, French Polynesia
Balcony
$18,098
Suite
$24,998
From (Per Person)
US$18,098
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visits: Chile, Peru, Ecuador, Colombia, Panama
Exclusive Savings
Balcony
$8,536
Suite
$11,962
From (Per Person)
US$8,536
Save 3,009
Per Person
View Trip
16 Day Beyond the Antarctic Circle – In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2027
Visits: Chile, Argentina, Antarctica
Balcony
$31,690
Suite
$32,520
From (Per Person)
US$31,690
Per Person
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Cruise Line: Seabourn
Tour Operator: APT
Ships: Seabourn Venture
Departures: Feb 2027 to Feb 2028
Trip Styles: Cruise, Scenic
Visits: Chile, Argentina, Antarctica, Brazil
Balcony
$23,795
Suite
$26,395
From (Per Person)
US$23,795
Per Person
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2027 to Dec 2027
Visits: Chile, Argentina, Antarctica
Balcony
$27,430
Suite
$29,130
From (Per Person)
US$27,430
Per Person
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Nov 2026 to Nov 2028
Visits: Chile, Argentina
Exclusive Savings
Balcony
$17,148
Suite
$25,734
From (Per Person)
US$17,148
Save 3,247
Per Person
View Trip
23 Day Patagonian Adventure and the Weddell Sea - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

23 Days Santiago to Buenos Aires
Tour Operator: Scenic
Ship: Scenic Eclipse I
Departure: 26 November 2026
Trip Styles: Coach, Cruise, Scenic
Visits: Chile, Argentina, Antarctica
Balcony
$41,310
Suite
$51,810
From (Per Person)
US$41,310
Per Person
View Trip
31 Day Unexplored Western Antarctica Between Two Continents with Ponant
Cruise

31 Days (30 Nights) Santiago to Hobart
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 10 January 2028
Visits: Chile, Argentina, Antarctica, Australia
Balcony
$76,970
Suite
$79,140
From (Per Person)
US$76,970
Per Person
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Nov 2026 to Feb 2029
Visits: Chile, South Georgia Island, Antarctica
Exclusive Savings
Oceanview
$19,120
Balcony
$19,880
Suite
$33,800
From (Per Person)
US$19,120
Save 8,520
Per Person
View Trip
16 Day Puerto Williams to Punta Arenas with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 18 January 2027
Visits: Chile, South Georgia Island, Antarctica
Oceanview
$23,900
Balcony
$29,900
Suite
$52,900
From (Per Person)
US$23,900
Per Person
View Trip
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