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Cruises From Santiago

Choose from 27 unique cruise itineraries starting in Santiago, and travelling to Buenos Aires, Cape Town, El Calafate, Fort Lauderdale, Guayaquil and more. January and February are the most popular months to join a cruise from Santiago and you can select from 67 departures available from ten leading cruise lines.
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11 Days
32 Days
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27 Cruises (67 Cruise Departures)
14 Day Patagonian Shores & Chilean Fjords with Viking Cruises
Cruise

14 Days (13 Nights) Santiago to Ushuaia
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2023 to Nov 2024
Countries Visited: Chile, Argentina
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$13,855
Suite
$20,785
Save 352
From 13,715
View Trip
19 Day Isles Of Wonder with Regent Seven Seas
Cruise

19 Days (18 Nights) Santiago to Papeete
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 16 February 2025
Countries Visited: Chile, Easter Island, French Polynesia
Early Booking Savings
Inside
-
Oceanview
-
Balcony
$21,656
Suite
$22,913
From 21,656
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (2)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2023 to Mar 2025
Countries Visited: Chile, Falkland Islands, Uruguay, Argentina
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$7,915
Suite
$14,845
Save 212
From 7,835
View Trip
23 Day In-depth Antarctica & Patagonia Expedition (Northbound) with Hurtigruten
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Hurtigruten
Ship: MS Fram
Departures: Mar 2024 to Mar 2025
Countries Visited: Chile, Antarctica
Inside
$15,811
Oceanview
$18,618
Balcony
-
Suite
$24,651
From 15,811
View Trip
15 Day Cape Horn & Strait of Magellan with Princess
Cruise

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 19 February 2024
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Inside
$2,420
Oceanview
$2,483
Balcony
$3,291
Suite
$4,182
From 2,420
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise

13 Days (12 Nights) Santiago to Ushuaia
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 08 November 2024
Countries Visited: Chile, Argentina
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$13,855
Suite
$19,795
Save 280
From 13,715
View Trip
25 Day Spirit of South America with Santiago and Galapagos Cruise with Globus
Tour+Cruise

25 Days Santiago to Guayaquil
Operated By: Globus
Departures: Sep 2023 to Nov 2024
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, Wildlife, Scenic / Sightseeing
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Savings
Save 279
From 15,427
View Trip
30 Day Best of South America with Amazon & Galapagos Cruises with APT
Tour+Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Departure: 30 September 2023
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, River Cruise, Scenic / Sightseeing
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Limited Time Sale
Save 841
From 38,554
View Trip
29 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour+Cruise

29 Days Santiago to Guayaquil
Operated By: APT
Departures: May 2024 to Sep 2024
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, River Cruise, Scenic / Sightseeing
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Earlybird Saving + Early Payment Discount
Save 1,688
From 33,707
View Trip
19 Day Andes & South America with Princess
Cruise

19 Days (18 Nights) Santiago to Los Angeles
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 18 March 2024
Countries Visited: Chile, Peru, Ecuador, Costa Rica (+2 more), Mexico, USA
Inside
$2,146
Oceanview
$2,299
Balcony
$3,008
Suite
$4,156
From 2,146
View Trip
30 Day Unexplored Antarctica between Two Continents with Ponant
Cruise

30 Days (29 Nights) Santiago to Lyttelton
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 08 January 2024
Countries Visited: Chile, Argentina, Antarctica, New Zealand
Early Booking Bonus
Inside
-
Oceanview
-
Balcony
$66,935
Suite
$97,427
From 66,935
View Trip
13 Day Chilean Fjords & Cape Horn with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 24 November 2023
Countries Visited: Chile, Argentina
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$15,122
Suite
$23,058
Save 3,473
From 15,122
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 31 October 2023
Countries Visited: Chile, Falkland Islands, Antarctica
Door-to-Door Economy Class Included
Inside
-
Oceanview
-
Balcony
-
Suite
$31,581
From 31,581
View Trip
27 Day Patagonian Adventure with Antarctica, South Georgia with Scenic
Tour+Cruise

27 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 27 January 2024
Countries Visited: Chile, Argentina, Brazil, Falkland Islands (+2 more), South Georgia Island, Antarctica
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$49,536
Suite
-
Save 8,194
From 49,536
View Trip
17 Day Edge Of The World Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 01 February 2026
Countries Visited: Chile, Argentina, Uruguay
Early Booking Savings
Inside
-
Oceanview
-
Balcony
$23,050
Suite
$24,584
From 23,050
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2024 to Mar 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$15,340
Suite
$22,765
Save 320
From 15,185
View Trip
20 Day White Continent Exploration with Regent Seven Seas
Cruise

20 Days (19 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 19 February 2024
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Special DiscountEarly Booking Savings
Inside
-
Oceanview
-
Balcony
$21,110
Suite
$23,476
From 21,110
View Trip
26 Day Ultimate Chilean Fjords & Weddell Sea with Scenic
Cruise

26 Days (25 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 24 November 2023
Countries Visited: Chile, Antarctica, Argentina
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$39,472
Suite
$51,748
Save 9,483
From 39,472
View Trip
22 Day Puerto Williams to Walvis Bay with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 02 March 2024
Countries Visited: Chile, Falkland Islands, Namibia, South Africa
Door-to-Door Economy Class Included
Inside
-
Oceanview
-
Balcony
$26,532
Suite
-
From 26,532
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Inside
$7,237
Oceanview
$8,524
Balcony
$11,098
Suite
$25,552
From 7,237
View Trip
11 Day Puerto Williams to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Dec 2024 to Feb 2025
Countries Visited: Chile, Antarctica
Door-to-Door Economy Class IncludedPort-to-Port Only
Inside
-
Oceanview
$14,503
Balcony
$16,978
Suite
$28,116
From 14,503
View Trip
20 Day Chilean Fjords & Argentinean Patagonia with Scenic
Tour+Cruise

20 Days Santiago to El Calafate
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 24 November 2023
Countries Visited: Chile, Argentina
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$27,183
Suite
$35,119
Save 3,607
From 27,183
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with Hurtigruten
Cruise

23 Days (22 Nights) Santiago to Santiago
Cruise Line: Hurtigruten
Ship: MS Fram
Departures: Nov 2023 to Feb 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Inside
$17,708
Oceanview
$20,716
Balcony
-
Suite
$27,182
From 17,708
View Trip
27 Day Antarctica, South Georgia & Torres del Paine - Cruise & Land Journey with Scenic
Tour+Cruise

27 Days Santiago to Montevideo
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 16 February 2024
Countries Visited: Chile, Argentina, Antarctica, South Georgia Island (+2 more), Falkland Islands, Uruguay
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$49,100
Suite
$58,580
Save 8,330
From 49,100
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Inside
$4,658
Oceanview
$5,450
Balcony
$7,232
Suite
$16,340
From 4,658
View Trip
17 Day Antarctica & Cape Horn with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departures: Dec 2023 to Jan 2024
Countries Visited: Chile, Argentina, Antarctica, Falkland Islands (+1 more), Uruguay
Inside
$2,691
Oceanview
$2,772
Balcony
$4,691
Suite
$5,978
From 2,691
View Trip
16 Day In The Wake Of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Nov 2023 to Dec 2023
Countries Visited: Chile, Argentina, Antarctica
Early Booking Bonus
Inside
-
Oceanview
-
Balcony
$33,472
Suite
$51,104
From 33,472
View Trip
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