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Cruises From Santiago

Choose from 36 unique cruise itineraries starting in Santiago, and travelling to Buenos Aires, Cape Town, El Calafate, Fort Lauderdale, Guayaquil and more. November is the most popular month to join a cruise from Santiago and you can select from 77 departures available from eleven leading cruise lines.
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33 Days
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36 Cruises (77 Cruise Departures)
14 Day Patagonian Shores & Chilean Fjords with Viking Cruises
Cruise

14 Days (13 Nights) Santiago to Ushuaia
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2023 to Oct 2023
Countries Visited: Chile, Argentina
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$13,855
Suite
$21,775
Save 352
From 13,715
View Trip
20 Day White Continent Exploration with Regent Seven Seas
Cruise

20 Days (19 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 19 February 2024
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Upgrade Your HorizonEarly Booking Savings
Inside
-
Oceanview
-
Balcony
$22,060
Suite
$22,753
From 22,060
View Trip
25 Day Spirit of South America with Santiago and Galapagos Cruise with Globus
Tour+Cruise

25 Days Santiago to Guayaquil
Operated By: Globus
Departures: Apr 2023 to Nov 2024
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, Wildlife, Scenic / Sightseeing
Countries Visited: Chile, Brazil, Argentina, Peru (+2 more), Ecuador, Galapagos
Exclusive Savings
Save 264
From 15,427
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2023 to Mar 2025
Countries Visited: Chile, Falkland Islands, Uruguay, Argentina
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$7,915
Suite
$14,845
Save 192
From 7,835
View Trip
23 Day In-depth Antarctica & Patagonia Expedition (Northbound) with Hurtigruten
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Hurtigruten
Ship: MS Fram
Departures: Mar 2023 to Mar 2024
Countries Visited: Chile, Antarctica
Inside
$16,172
Oceanview
$18,093
Balcony
-
Suite
$24,299
From 16,172
View Trip
27 Day South American Majesty with Regent Seven Seas
Cruise

27 Days (26 Nights) Santiago to Rio de Janeiro
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 17 February 2023
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+1 more), Brazil
Upgrade Your HorizonEarly Booking Savings
Inside
-
Oceanview
-
Balcony
$28,127
Suite
$29,246
From 28,127
View Trip
15 Day Cape Horn & Strait of Magellan with Princess
Cruise

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departures: Feb 2023 to Feb 2024
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Inside
$2,693
Oceanview
$2,903
Balcony
$3,773
Suite
$4,565
From 2,693
View Trip
30 Day Best of South America with Amazon & Galapagos Cruises with APT
Tour+Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Departure: 30 September 2023
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, River Cruise, Scenic / Sightseeing
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Earlybird Offer
Save 1,336
From 38,059
View Trip
29 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour+Cruise

29 Days Santiago to Guayaquil
Operated By: APT
Departures: Apr 2024 to Sep 2024
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, River Cruise, Scenic / Sightseeing
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Earlybird Saving
Save 1,688
From 38,907
View Trip
19 Day Andes & South America with Princess
Cruise

19 Days (18 Nights) Santiago to Los Angeles
Cruise Line: Princess
Ship: Sapphire Princess
Departures: Mar 2023 to Mar 2024
Countries Visited: Chile, Peru, Ecuador, Costa Rica (+2 more), Mexico, USA
Inside
$2,271
Oceanview
$2,442
Balcony
$3,419
Suite
$4,855
From 2,271
View Trip
30 Day Unexplored Antarctica between Two Continents with Ponant
Cruise

30 Days (29 Nights) Santiago to Lyttelton
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 08 January 2024
Countries Visited: Chile, Argentina, Antarctica, New Zealand
Early Booking Bonus
Inside
-
Oceanview
-
Balcony
$66,935
Suite
$97,427
From 66,935
View Trip
13 Day Chilean Fjords & Cape Horn with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 24 November 2023
Countries Visited: Chile, Argentina
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$16,771
Suite
$23,058
Save 1,824
From 16,771
View Trip
26 Day Deserts & Wild Islands of Chile and Polynesia with Scenic
Tour+Cruise

26 Days Santiago to Papeete
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 06 March 2024
Countries Visited: Chile, Easter Island, Pitcairn Islands, Tahiti
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$26,197
Suite
$35,036
Save 4,113
From 26,197
View Trip
27 Day Patagonian Adventure with Antarctica, South Georgia with Scenic
Tour+Cruise

27 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 27 January 2024
Countries Visited: Chile, Argentina, Brazil, Falkland Islands (+2 more), South Georgia Island, Antarctica
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$49,536
Suite
$89,666
Save 8,194
From 49,536
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departures: Mar 2023 to Mar 2024
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Earlybird Saving
Inside
-
Oceanview
-
Balcony
$15,835
Suite
$23,755
Save 320
From 15,675
View Trip
17 Day Cape Horn Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Departure: 17 February 2023
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Early Booking Savings
Inside
-
Oceanview
-
Balcony
$12,510
Suite
$13,549
From 12,510
View Trip
18 Day Antarctica & Patagonia Expedition (Southbound) with Hurtigruten
Cruise

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Hurtigruten
Ship: MS Fridtjof Nansen
Departure: 27 October 2023
Countries Visited: Chile, Antarctica, Argentina
Inside
-
Oceanview
$14,241
Balcony
$17,353
Suite
$21,140
From 14,241
View Trip
19 Day In The Footsteps of Shackleton and The Endurance with Ponant
Cruise

19 Days (18 Nights) Santiago to Montevideo
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 11 March 2023
Countries Visited: Chile, Argentina, Antarctica, South Georgia Island (+1 more), Uruguay
Early Booking Bonus
Inside
-
Oceanview
-
Balcony
$35,881
Suite
$52,513
From 35,881
View Trip
26 Day Ultimate Chilean Fjords & Weddell Sea with Scenic
Cruise

26 Days (25 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 24 November 2023
Countries Visited: Chile, Antarctica, Argentina
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$35,216
Suite
$51,748
Save 8,364
From 35,216
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour+Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departures: Nov 2023 to Feb 2024
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, Scenic / Sightseeing
Countries Visited: Chile, Argentina, Uruguay, Falkland Islands (+2 more), Brazil, Peru
Earlybird Saving
Save 1,511
From 13,886
View Trip
20 Day Wild Atacama & the Chliean Fjords with Scenic
Tour+Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 17 November 2023
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, Scenic / Sightseeing
Countries Visited: Chile, Argentina
Earlybird Saving + Early Payment Discount
Save 3,575
From 24,015
View Trip
22 Day Puerto Williams to Walvis Bay with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 02 March 2024
Countries Visited: Chile, Falkland Islands, Namibia, South Africa
Door-To-Door All⁠ ⁠Inclusive
Inside
-
Oceanview
-
Balcony
$25,641
Suite
-
From 25,641
View Trip
14 Day South America Passage with Holland America
Cruise

14 Days (13 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 February 2023
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Have It All Offer
Inside
$2,861
Oceanview
$3,000
Balcony
$4,376
Suite
$7,128
From 2,861
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 02 November 2023
Countries Visited: Chile, Antarctica, Argentina
Early Booking Bonus
Inside
-
Oceanview
-
Balcony
$38,699
Suite
$56,865
From 38,699
View Trip
11 Day Puerto Williams to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Dec 2024 to Feb 2025
Countries Visited: Chile, Antarctica
Port-To-Port All⁠ ⁠Inclusive
Inside
-
Oceanview
$15,196
Balcony
$17,176
Suite
$25,839
From 15,196
View Trip
19 Day Isles Of Wonder with Regent Seven Seas
Cruise

19 Days (18 Nights) Santiago to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 16 February 2025
Countries Visited: Chile, French Polynesia
Early Booking Savings
Inside
-
Oceanview
-
Balcony
$20,141
Suite
$23,210
From 20,141
View Trip
20 Day Chilean Fjords & Argentinean Patagonia with Scenic
Tour+Cruise

20 Days Santiago to El Calafate
Operated By: Scenic
Ship: Scenic Eclipse II
Departure: 24 November 2023
Countries Visited: Chile, Argentina
Earlybird Saving + Early Payment Discount
Inside
-
Oceanview
-
Balcony
$27,183
Suite
$35,119
Save 3,607
From 27,183
View Trip
15 Day South American Adventure with Silversea
Cruise

15 Days (14 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Explorer
Departure: 04 March 2023
Countries Visited: Argentina, Chile
Door-To-Door All⁠ ⁠Inclusive
Inside
-
Oceanview
$16,236
Balcony
$22,770
Suite
-
From 16,236
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 16 November 2023
Countries Visited: Chile, Argentina, Antarctica
Early Booking Bonus
Inside
-
Oceanview
-
Balcony
$32,719
Suite
$48,272
From 32,719
View Trip
28 Day South America Inca Journey with Galapagos Cruise with APT
Tour+Cruise

28 Days Santiago to Guayaquil
Operated By: APT
Departure: 02 October 2023
Trip Styles: Fully Guided, Locally Guided, Coach, Cruise, Scenic / Sightseeing, Andean Explorer
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Earlybird Offer
Save 1,331
From 37,064
View Trip
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