Home > Cruises > South America Cruises > Chile > Cruises from Santiago

Cruises from Santiago

Choose from 44 unique expeditions and cruises starting in Santiago, and traveling to Bridgetown, Buenos Aires, Fort Lauderdale, Hamburg, Hobart and more. February is the most popular month to join a cruise from Santiago and you can select from 104 departures available from thirteen leading cruise lines.
Filter Results
Departures
Show More...
Duration
9 Days
37 Days
Countries Visited
End City
Ship Features
Operators
Show More...
Price
$1,900pp
$75,542pp
Countries
Show More...
Filter Results
44 Cruises (104 Cruise Departures)
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departures: Feb 2027 to Feb 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Inside
-
Oceanview
$13,795
Balcony
$15,085
Suite
-
From
US$13,795
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (7)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,099
Suite
$12,999
From
US$8,099
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$11,995
Suite
-
From
US$11,995
Per Person
View Trip
18 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 21 March 2028
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Book Early & Have It All Fare Option
Inside
$2,794
Oceanview
$3,094
Balcony
$3,794
Suite
$5,694
From
US$2,794
Per Person
View Trip
23 Day South America & Antarctica with Holland America
Cruise
 (3)

23 Days (22 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 January 2027
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Fare Saver
Inside
-
Oceanview
-
Balcony
$8,019
Suite
$12,969
From
US$8,019
Per Person
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Feb 2027 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,439
Oceanview
$2,689
Balcony
$3,839
Suite
$5,039
From
US$2,439
Per Person
View Trip
9 Day King George Island to Puerto Williams with Silversea
Cruise
 (1)

9 Days (8 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 December 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
$27,600
Suite
$42,000
From
US$27,600
Per Person
View Trip
16 Day South America & Antarctica with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departures: Jan 2028 to Mar 2028
Visit: Chile, Argentina, Antarctica, Falkland Islands, Uruguay
Inside
$3,069
Oceanview
$3,349
Balcony
$5,089
Suite
$5,589
From
US$3,069
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Inside
$2,459
Oceanview
$2,559
Balcony
$3,659
Suite
$4,759
From
US$2,459
Per Person
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (4)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Visit: Chile, Peru, Panama, Costa Rica, Colombia, Mexico, USA
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Inside
$4,989
Oceanview
$5,559
Balcony
$6,169
Suite
$10,019
From
US$4,989
Per Person
View Trip
10 Day Puerto Williams to King George Island with Silversea
Cruise
 (1)

10 Days (9 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Oct 2026 to Feb 2028
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$13,920
Balcony
$14,210
Suite
$25,600
From
US$13,920
Save 6,090
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Princess Standard
Inside
$1,977
Oceanview
-
Balcony
$2,933
Suite
$4,322
From
US$1,977
Per Person
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2026 to Nov 2028
Visit: Chile, Argentina
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Save 1,000
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,124
Oceanview
$2,324
Balcony
$3,124
Suite
$4,724
From
US$2,124
Per Person
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 December 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$16,920
Balcony
$18,900
Suite
$30,700
From
US$16,920
Save 1,880
Per Person
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 07 November 2026
Visit: Chile, Falkland Islands, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$23,130
Balcony
$26,100
Suite
$43,500
From
US$23,130
Save 2,570
Per Person
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse II, Scenic Eclipse I
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$41,715
Suite
$47,435
From
US$41,715
Per Person
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Jan 2027 to Feb 2029
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Inside
-
Oceanview
-
Balcony
$45,985
Suite
$49,230
From
US$45,985
Per Person
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ships: Seabourn Venture
Departures: Feb 2027 to Feb 2028
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$19,395
Suite
$21,995
From
US$19,395
Per Person
View Trip
16 Day Puerto Williams to Punta Arenas with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 18 January 2027
Visit: Chile, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
-
Suite
$39,900
From
US$39,900
Per Person
View Trip
12 Day Puerto Williams to Puerto Williams with Silversea
Cruise

12 Days (11 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 18 February 2028
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,520
Suite
$31,300
From
US$17,520
Save 4,380
Per Person
View Trip
25 Day Ultimate South America to the Caribbean Through the Panama Canal with Scenic
New ReleaseCruise

25 Days (24 Nights) Santiago to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia (+5 more), Panama, Curacao, Saint Vincent, Saint Lucia, Barbados
Inside
-
Oceanview
-
Balcony
$24,800
Suite
$30,200
From
US$24,800
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Apr 2027 to Apr 2029
Visit: Chile, Peru, Panama, Jamaica, Bahamas, USA
Flights Included
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,995
Suite
$16,495
From
US$10,995
Save 1,000
Per Person
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Cunard Fare
Value Fare
Inside
$5,429
Oceanview
$7,459
Balcony
$8,479
Suite
$20,219
From
US$5,429
Per Person
View Trip
13 Day Chairman’s Voyage: Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,258
Suite
$29,067
From
US$21,258
Save 2,517
Per Person
View Trip
11 Day Punta Arenas to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 02 February 2027
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$17,370
Balcony
$18,900
Suite
$30,300
From
US$17,370
Save 1,930
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,536
Suite
$11,962
From
US$8,536
Save 3,009
Per Person
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ships: Seabourn Venture
Departures: Feb 2027 to Feb 2028
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Inside
-
Oceanview
-
Balcony
$23,795
Suite
$26,395
From
US$23,795
Per Person
View Trip
31 Day Unexplored Western Antarctica Between Two Continents with Ponant
Cruise

31 Days (30 Nights) Santiago to Hobart
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 10 January 2028
Visit: Chile, Argentina, Antarctica, Australia
Inside
-
Oceanview
-
Balcony
$75,542
Suite
$79,143
From
US$75,542
Per Person
View Trip
16 Day Beyond the Antarctic Circle – In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2027
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$29,010
Suite
$30,830
From
US$29,010
Per Person
View Trip
Results: 1-30 of 44

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Adventure Cruises Luxury Cruises

Trip Lengths

1 Month 10 Day 2 Week 3 Week

Departure Months

October November December January February March April

Cities

Puerto Williams San Antonio Santiago Valparaiso

Routes

Buenos Aires to San Antonio Buenos Aires to Santiago San Antonio to Buenos Aires Santiago to Buenos Aires Santiago to Santiago

Country Routes

Argentina to Chile Chile to USA Chile to Argentina USA to Chile

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations