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Cruises from Santiago

Choose from 41 unique expeditions and cruises starting in Santiago, and traveling to Bridgetown, Buenos Aires, Cape Town, Fort Lauderdale, Hamburg and more. February is the most popular month to join a cruise from Santiago and you can select from 85 departures available from twelve leading cruise lines.
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9 Days
43 Days
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41 Cruises (85 Cruise Departures)
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Exclusive Savings
Inside
-
Oceanview
$13,572
Balcony
$14,836
Suite
-
From
US$13,572
Save 223
Per Person
View Trip
22 Day Puerto Williams to Cape Town with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Visit: Chile, Falkland Islands, South Georgia Island, Saint Helena, South Africa
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
$16,900
Suite
$23,500
From
US$16,900
Per Person
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 24 January 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,430
Suite
-
From
US$20,430
Save 2,270
Per Person
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Visit: Chile, Easter Island, Pitcairn Islands, French Polynesia
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,533
Suite
$15,615
From
US$12,533
Save 216
Per Person
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Mar 2026 to Dec 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,200
Suite
$19,500
From
US$13,200
Save 8,800
Per Person
View Trip
10 Day Puerto Williams to King George Island with Silversea
Cruise
 (1)

10 Days (9 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Oct 2026 to Feb 2028
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$10,320
Balcony
$12,880
Suite
$20,980
From
US$10,320
Save 6,880
Per Person
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,045
Suite
$21,593
From
US$19,045
Save 350
Per Person
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Brazil
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,268
Suite
$26,439
From
US$22,268
Save 22,887
Per Person
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2026 to Oct 2028
Visit: Chile, Argentina
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Save 500
Per Person
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Inside
$5,929
Oceanview
$8,128
Balcony
$9,247
Suite
$20,038
From
US$5,929
Per Person
View Trip
25 Day Ultimate South America to the Caribbean Through the Panama Canal with Scenic
New ReleaseCruise

25 Days (24 Nights) Santiago to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia (+5 more), Panama, Curacao, Saint Vincent, Saint Lucia, Barbados
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$54,300
Suite
$73,991
From
US$54,300
Save 1,580
Per Person
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Feb 2026 to Dec 2027
Visit: Chile, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$15,600
Balcony
$19,440
Suite
$26,340
From
US$15,600
Save 4,680
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Inside
$5,209
Oceanview
$7,216
Balcony
$8,048
Suite
$18,096
From
US$5,209
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Visit: Chile, Peru, Ecuador, Panama, Mexico, USA
Flights Included
Inside
-
Oceanview
-
Balcony
$10,995
Suite
$16,995
From
US$10,995
Per Person
View Trip
24 Day Ultimate Chilean Fjords & Antarctica’s Weddell Sea with Scenic
New ReleaseCruise

24 Days (23 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina, Antarctica
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$84,842
Suite
$112,390
From
US$84,842
Save 2,438
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,224
Oceanview
$2,324
Balcony
$3,224
Suite
$4,452
From
US$2,224
Per Person
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Visit: Chile, Argentina
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,686
Suite
$19,857
From
US$15,686
Save 22,704
Per Person
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 06 February 2027
Trip Styles: Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,373
Suite
$25,921
From
US$23,373
Save 422
Per Person
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Visit: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
Advantage Fare
Exclusive Savings
Inside
$7,583
Oceanview
$9,151
Balcony
$18,363
Suite
-
From
US$7,583
Per Person
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Feb 2026 to Jan 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica, Brazil
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$43,528
Suite
$48,330
From
US$43,528
Save 24,088
Per Person
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Eclipse II
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Antarctica, Argentina
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$35,103
Suite
$39,735
From
US$35,103
Save 27,502
Per Person
View Trip
23 Day Patagonian Adventure and the Weddell Sea - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

23 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 26 November 2026
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Fly Free Business Class
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$42,053
Suite
$48,029
From
US$42,053
Save 26,882
Per Person
View Trip
12 Day Puerto Williams to Puerto Williams with Silversea
Cruise

12 Days (11 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 18 February 2028
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$13,120
Balcony
$16,000
Suite
$26,540
From
US$13,120
Save 3,280
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Chile, Peru, Ecuador, Panama, Cayman Islands, USA
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,259
Oceanview
$2,359
Balcony
$3,259
Suite
$4,986
From
US$2,259
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (7)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departure: 22 December 2026
Visit: Chile, Argentina, Falkland Islands, Uruguay
Princess Standard
Inside
$2,182
Oceanview
-
Balcony
$2,796
Suite
$3,452
From
US$2,182
Per Person
View Trip
9 Day King George Island to Puerto Williams with Silversea
Cruise
 (1)

9 Days (8 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 04 December 2026
Visit: Chile, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,390
Suite
$20,420
From
US$12,390
Save 5,310
Per Person
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departures: Feb 2027 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,089
Oceanview
$2,289
Balcony
$3,189
Suite
$4,221
From
US$2,089
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (6)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$7,599
Suite
$12,999
From
US$7,599
Per Person
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise
 (1)

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departure: 07 November 2026
Visit: Chile, Falkland Islands, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$21,680
Balcony
$24,480
Suite
$35,420
From
US$21,680
Save 5,420
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,293
Suite
$12,640
From
US$9,293
Save 16,897
Per Person
View Trip
Results: 1-30 of 41

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