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Cruises from Santiago

Choose from 38 unique expeditions and cruises starting in Santiago, and traveling to Bridgetown, Buenos Aires, Cape Town, Fort Lauderdale, Guayaquil and more. February is the most popular month to join a cruise from Santiago and you can select from 77 departures available from fifteen leading cruise lines.
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9 Days
37 Days
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$102,955pp
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38 Cruises (77 Cruise Departures)
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2027 to Dec 2027
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$27,590
Suite
$29,290
From
US$27,590
Per Person
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama, Aruba, USA
Inside
$3,399
Oceanview
$4,699
Balcony
$5,299
Suite
$12,517
From
US$3,399
Per Person
View Trip
16 Day Beyond the Antarctic Circle – In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2027 to Dec 2027
Visit: Chile, Argentina, Antarctica
Inside
-
Oceanview
-
Balcony
$29,190
Suite
$31,010
From
US$29,190
Per Person
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 07 April 2027
Visit: Chile, Easter Island, Pitcairn Islands, French Polynesia
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,700
Suite
$20,865
From
US$14,700
Save 259
Per Person
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Nov 2026 to Dec 2027
Visit: Chile, South Georgia Island, Antarctica
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$14,625
Balcony
$18,225
Suite
$26,025
From
US$14,625
Save 4,875
Per Person
View Trip
24 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires with HX Expeditions
Cruise

24 Days (23 Nights) Santiago to Buenos Aires
Cruise Line: HX Expeditions
Ship: MS Fram
Departure: 20 March 2026
Visit: Chile, Antarctica, Falkland Islands, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$14,837
Balcony
-
Suite
$19,775
From
US$14,837
Save 6,485
Per Person
View Trip
13 Day Chairman’s Voyage: Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,529
Suite
$25,998
From
US$18,529
Save 22,461
Per Person
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse II, Scenic Eclipse I
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Antarctica
Early Booking Savings
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$38,983
Suite
$39,735
From
US$38,983
Save 23,622
Per Person
View Trip
Results: 31-38 of 38

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