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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 58 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 162 cruises departing between October 2025 and April 2026.
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25 Days
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$7,070pp
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58 Cruises (162 Cruise Departures)
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) London to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 07 October 2025
Countries Visited: England, France, Spain, Portugal (+1 more), Brazil
Grand Voyages Sale
INSIDE
$1,632
OCEANVIEW
$1,892
BALCONY
$2,057
SUITE
$4,027
From (per person) 1,632
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 26 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$1,693
OCEANVIEW
$1,965
BALCONY
$2,175
SUITE
$2,603
From (per person) 1,693
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departures: Nov 2025 to Dec 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$538
OCEANVIEW
$648
BALCONY
$738
SUITE
$1,028
From (per person) 538
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 16 February 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$1,573
OCEANVIEW
$1,890
BALCONY
$2,097
SUITE
$3,119
From (per person) 1,573
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 16 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$908
OCEANVIEW
-
BALCONY
$1,211
SUITE
$2,102
From (per person) 908
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Salvador to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 11 December 2025
Countries Visited: Brazil
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$489
SUITE
$599
From (per person) 489
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2025 to Mar 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$823
OCEANVIEW
$983
BALCONY
$1,163
SUITE
$2,073
From (per person) 823
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Dec 2025 to Dec 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$584
OCEANVIEW
$692
BALCONY
$896
SUITE
$952
From (per person) 584
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 08 November 2025
Countries Visited: Spain, Morocco, Brazil, Uruguay (+1 more), Argentina
Escape To Sea
INSIDE
$1,194
OCEANVIEW
$1,408
BALCONY
$1,675
SUITE
$2,809
From (per person) 1,194
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Countries Visited: Uruguay, Argentina, Brazil, Spain (+1 more), Morocco
Escape To Sea
INSIDE
$1,971
OCEANVIEW
$2,151
BALCONY
$2,451
SUITE
$4,503
From (per person) 1,971
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Nov 2025 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,285
OCEANVIEW
$1,559
BALCONY
$1,821
SUITE
$2,631
From (per person) 1,285
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Paris to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 08 October 2025
Countries Visited: France, Spain, Portugal, Brazil
Grand Voyages Sale
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$7,070
From (per person) 7,070
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 17 February 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,670
OCEANVIEW
-
BALCONY
$2,165
SUITE
$2,948
From (per person) 1,670
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 20 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$890
OCEANVIEW
$1,060
BALCONY
$1,500
SUITE
$1,770
From (per person) 890
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departures: Jan 2026 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$707
OCEANVIEW
$857
BALCONY
$997
SUITE
$1,467
From (per person) 707
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Funchal to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 13 October 2025
Countries Visited: Portugal, Spain, Brazil
Escape To Sea
INSIDE
$1,165
OCEANVIEW
-
BALCONY
$1,750
SUITE
-
From (per person) 1,165
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Santos to Oslo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+4 more), France, Belgium, Denmark, Norway
Escape To Sea
INSIDE
$1,725
OCEANVIEW
$2,200
BALCONY
$2,298
SUITE
-
From (per person) 1,725
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 March 2026
Countries Visited: Argentina, Brazil, Spain, Morocco
Escape To Sea
INSIDE
-
OCEANVIEW
-
BALCONY
$1,659
SUITE
$2,929
From (per person) 1,659
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Paris to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 08 October 2025
Countries Visited: France, Spain, Portugal, Brazil
Grand Voyages Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$2,074
SUITE
$6,771
From (per person) 2,074
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Copenhagen
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+3 more), France, Belgium, Denmark
Escape To Sea
INSIDE
$1,571
OCEANVIEW
$1,844
BALCONY
$2,117
SUITE
$3,650
From (per person) 1,571
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rio de Janeiro to Paris
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+1 more), France
Grand Voyages Sale
INSIDE
$1,261
OCEANVIEW
$1,408
BALCONY
$1,618
SUITE
$4,054
From (per person) 1,261
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,579
OCEANVIEW
$1,852
BALCONY
$2,126
SUITE
$2,948
From (per person) 1,579
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 13 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$761
OCEANVIEW
$911
BALCONY
$1,101
SUITE
$1,531
From (per person) 761
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 29 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$1,956
OCEANVIEW
-
BALCONY
$2,586
SUITE
-
From (per person) 1,956
View Trip
6 Day MSC Grand Voyages with MSC Cruises
Cruise

6 Days (5 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 21 October 2025
Countries Visited: Brazil
One Way Cruise Offer
INSIDE
$470
OCEANVIEW
-
BALCONY
$679
SUITE
$1,131
From (per person) 470
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 29 March 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$650
OCEANVIEW
$755
BALCONY
$854
SUITE
$1,095
From (per person) 650
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Nov 2025 to Mar 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$1,513
OCEANVIEW
$1,764
BALCONY
$1,686
SUITE
$2,473
From (per person) 1,513
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England
Escape To Sea
INSIDE
$1,245
OCEANVIEW
$1,445
BALCONY
$1,645
SUITE
$3,085
From (per person) 1,245
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 26 December 2025
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$2,735
OCEANVIEW
$3,079
BALCONY
$3,423
SUITE
$4,469
From (per person) 2,735
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$1,435
OCEANVIEW
$1,752
BALCONY
$1,959
SUITE
$2,981
From (per person) 1,435
View Trip
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