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MSC South America Cruises

Join MSC on one of 102 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 284 cruises departing between February 2026 and January 2028.
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122 Days
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102 Cruises (284 Cruise Departures)
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Bonus Onboard Credit
Inside
$944
Oceanview
$1,104
Balcony
$1,384
Suite
-
From
US$944
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,834
Oceanview
$1,864
Balcony
$1,998
Suite
$2,399
From
US$1,834
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Buenos Aires to Rome
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 31 March 2027
Visit: Argentina, Brazil, Spain, Corsica, Italy
Bonus Onboard Credit
Inside
$1,487
Oceanview
$1,847
Balcony
$2,087
Suite
$3,437
From
US$1,487
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 18 November 2027
Visit: Spain, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,694
Oceanview
$2,073
Balcony
$2,219
Suite
$3,722
From
US$1,694
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 15 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Bonus Onboard Credit
Inside
$1,247
Oceanview
$1,527
Balcony
$1,847
Suite
$3,088
From
US$1,247
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,018
Oceanview
$1,188
Balcony
$1,478
Suite
-
From
US$1,018
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,375
From
US$475
Per Person
View Trip
6 Day South America with MSC Cruises
Cruise

6 Days (5 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 21 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$894
Oceanview
$952
Balcony
$1,078
Suite
$1,331
From
US$894
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 24 January 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$891
Oceanview
$941
Balcony
$1,271
Suite
$1,441
From
US$891
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
$2,303
Oceanview
$2,359
Balcony
$2,470
Suite
-
From
US$2,303
Save 62
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

20 Days (19 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 March 2026
Visit: Argentina, Brazil, Spain, Morocco
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,206
From
US$3,206
Save 83
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visit: Spain, Brazil
Bonus Onboard Credit
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$5,153
From
US$1,290
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Rio de Janeiro to Oslo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England (+4 more), France, Belgium, Denmark, Norway
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,461
From
US$4,461
Save 120
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Buenos Aires to Trieste
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 31 March 2027
Visit: Argentina, Brazil, Spain, Corsica, Italy, Greece
Bonus Onboard Credit
Inside
$1,844
Oceanview
$2,223
Balcony
$2,485
Suite
$3,824
From
US$1,844
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Bonus Onboard Credit
Inside
$1,949
Oceanview
$2,209
Balcony
$2,550
Suite
$8,438
From
US$1,949
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Feb 2026 to Mar 2026
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Inside
$1,680
Oceanview
$1,958
Balcony
$2,258
Suite
$3,199
From
US$1,680
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 27 December 2026
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Inside
$1,895
Oceanview
$2,114
Balcony
$2,284
Suite
$2,967
From
US$1,895
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 04 November 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,337
Oceanview
$2,007
Balcony
$2,971
Suite
$3,679
From
US$1,337
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Cagliari to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 11 November 2026
Visit: Sardinia, Sicily, Malta, Spain (+5 more), Gibraltar, Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$2,004
Oceanview
$2,379
Balcony
$2,641
Suite
-
From
US$2,004
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 29 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,529
Oceanview
$1,579
Balcony
$1,857
Suite
-
From
US$1,529
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,087
From
US$1,290
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia, MSC Virtuosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$423
Oceanview
$453
Balcony
$513
Suite
$842
From
US$423
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Feb 2026 to Mar 2026
Visit: Brazil
Bonus Onboard Credit
Exclusive Savings
Inside
$965
Oceanview
$1,075
Balcony
$1,629
Suite
$1,917
From
US$965
Save 55
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Florence to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 10 November 2026
Visit: Italy, Sardinia, Sicily, Malta (+6 more), Spain, Gibraltar, Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,803
Suite
$4,132
From
US$2,803
Save 66
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 05 January 2027
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Inside
$1,466
Oceanview
$1,741
Balcony
$1,917
Suite
$2,551
From
US$1,466
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,911
Oceanview
-
Balcony
$2,531
Suite
$4,122
From
US$1,911
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$961
Oceanview
$1,027
Balcony
$1,165
Suite
$1,579
From
US$961
Per Person
View Trip
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