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MSC South America Cruises

Join MSC on one of 85 cruises visiting the coastal ports and cities of South America this season. January is the most popular month to begin your cruise and MSC have 177 cruises departing between November 2026 and January 2028.
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122 Days
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85 Cruises (177 Cruise Departures)
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Jan 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,018
Oceanview
$1,098
Balcony
$1,248
Suite
$1,547
From
US$1,018
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Inside
-
Oceanview
$1,310
Balcony
$1,670
Suite
-
From
US$1,310
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visit: Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
-
From
US$1,290
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$981
Oceanview
$1,027
Balcony
$1,165
Suite
$1,579
From
US$981
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 15 March 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Venice to Santos
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 02 November 2027
Visit: Italy, Sicily, Spain, Brazil
Inside
$1,379
Oceanview
$1,889
Balcony
$3,259
Suite
$4,059
From
US$1,379
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Inside
$1,394
Oceanview
$1,664
Balcony
$1,894
Suite
$5,414
From
US$1,394
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 14 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
$1,526
Suite
$3,554
From
US$1,526
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Genoa to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,369
Oceanview
$1,709
Balcony
$1,969
Suite
$5,639
From
US$1,369
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 28 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,599
Oceanview
$1,929
Balcony
$2,249
Suite
$7,069
From
US$1,599
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Feb 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,001
Oceanview
$1,070
Balcony
$1,220
Suite
-
From
US$1,001
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 23 January 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$525
Oceanview
$605
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Marseille to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 07 November 2027
Visit: France, Spain, Portugal, Brazil
Inside
$1,183
Oceanview
$1,433
Balcony
$2,063
Suite
-
From
US$1,183
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 10 February 2027
Visit: Argentina, Brazil, Uruguay
Inside
$1,529
Oceanview
$1,881
Balcony
$2,024
Suite
$2,761
From
US$1,529
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 24 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
-
Oceanview
-
Balcony
$1,454
Suite
-
From
US$1,454
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 16 November 2027
Visit: Italy, Spain, Brazil, Uruguay, Argentina
Inside
$1,869
Oceanview
$2,319
Balcony
$2,529
Suite
$3,949
From
US$1,869
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,214
Oceanview
$1,344
Balcony
$1,654
Suite
-
From
US$1,214
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

26 Days (25 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 22 October 2027
Visit: Italy, Greece, Turkey, France, Spain, Brazil
Inside
$2,290
Oceanview
$2,850
Balcony
$3,320
Suite
$4,860
From
US$2,290
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$851
Oceanview
$1,001
Balcony
$1,251
Suite
-
From
US$851
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Palermo to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 12 November 2027
Visit: Sicily, Italy, France, Spain, Brazil
Drinks & WiFi Package
Inside
-
Oceanview
-
Balcony
-
Suite
$8,575
From
US$8,575
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Virtuosa
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Drinks & WiFi Package
Inside
$393
Oceanview
$463
Balcony
$583
Suite
$1,053
From
US$393
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 18 November 2027
Visit: Spain, Brazil, Uruguay, Argentina
Inside
$2,824
Oceanview
$3,584
Balcony
$3,924
Suite
$6,874
From
US$2,824
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Inside
-
Oceanview
$20,009
Balcony
$29,059
Suite
-
From
US$20,009
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2027
Visit: France, Spain, Gibraltar, Morocco (+20 more), Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy
Inside
$17,049
Oceanview
$20,009
Balcony
$29,059
Suite
-
From
US$17,049
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
$2,217
Oceanview
$2,407
Balcony
$2,627
Suite
-
From
US$2,217
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 January 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
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