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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 121 cruises visiting the coastal ports and cities of South America this season. March is the most popular month to begin your cruise and MSC have 390 cruises departing between November 2025 and April 2027.
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2 Days
122 Days
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121 Cruises (390 Cruise Departures)
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 09 December 2026
Visit: Brazil
Inside
$749
Oceanview
$799
Balcony
$1,079
Suite
$1,229
From
US$749
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 25 December 2025
Visit: Brazil
Exclusive Savings
Inside
-
Oceanview
$2,124
Balcony
-
Suite
-
From
US$2,124
Save 60
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Venice to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 15 November 2026
Visit: Italy, Spain, Morocco, Brazil
Inside
$1,479
Oceanview
$1,759
Balcony
$2,772
Suite
$3,422
From
US$1,479
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Inside
$1,499
Oceanview
$1,949
Balcony
$2,119
Suite
$6,951
From
US$1,499
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Inside
$499
Oceanview
$529
Balcony
$589
Suite
$879
From
US$499
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Inside
$69
Oceanview
$129
Balcony
$169
Suite
$329
From
US$69
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Jan 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,219
Oceanview
$1,469
Balcony
$1,599
Suite
$2,209
From
US$1,219
Save 53
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Rio de Janeiro to Venice
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 21 March 2027
Visit: Brazil, Cape Verde, Spain, Morocco, Malta, Croatia, Italy
Inside
$1,559
Oceanview
$1,829
Balcony
$2,809
Suite
$3,410
From
US$1,559
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 04 January 2026
Visit: Brazil
Inside
$699
Oceanview
$866
Balcony
-
Suite
$1,454
From
US$699
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 21 January 2026
Visit: Argentina, Uruguay, Brazil
Inside
$1,306
Oceanview
-
Balcony
$1,810
Suite
$2,245
From
US$1,306
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,119
Oceanview
$1,159
Balcony
$1,259
Suite
$1,709
From
US$1,119
Per Person
View Trip
11 Day South America with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 26 December 2025
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$3,327
Oceanview
$3,762
Balcony
$4,041
Suite
$5,206
From
US$3,327
Save 96
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$499
Oceanview
$529
Balcony
$599
Suite
$879
From
US$499
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa
Departures: Nov 2025 to Mar 2027
Visit: Brazil
Exclusive Savings
Inside
$389
Oceanview
$419
Balcony
$479
Suite
$729
From
US$389
Save 69
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 15 November 2026
Visit: Spain, Gibraltar, Morocco, Brazil, Uruguay, Argentina
Inside
$1,549
Oceanview
$1,909
Balcony
$2,119
Suite
$3,166
From
US$1,549
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 26 December 2025
Visit: Brazil
Exclusive Savings
Inside
$2,231
Oceanview
$2,435
Balcony
$2,533
Suite
$7,240
From
US$2,231
Save 63
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 29 December 2025
Visit: Brazil
Exclusive Savings
Inside
$2,740
Oceanview
$2,910
Balcony
$3,478
Suite
-
From
US$2,740
Save 78
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departures: Jan 2026 to Jan 2026
Visit: Brazil
Inside
$780
Oceanview
$981
Balcony
$1,421
Suite
$1,691
From
US$780
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Rio de Janeiro to Copenhagen
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England, France, Belgium, Denmark
Inside
$1,762
Oceanview
-
Balcony
$2,203
Suite
$3,814
From
US$1,762
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$289
Oceanview
$379
Balcony
$579
Suite
$699
From
US$289
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 24 January 2027
Visit: Brazil
Inside
$919
Oceanview
$969
Balcony
$1,299
Suite
$1,469
From
US$919
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Nov 2025 to Mar 2027
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$849
Oceanview
$1,129
Balcony
$1,269
Suite
$1,917
From
US$849
Save 61
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

19 Days (18 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 November 2025
Visit: Italy, Spain, Morocco, Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,972
From
US$5,972
Save 168
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Nov 2025 to Mar 2027
Visit: Brazil
Inside
$599
Oceanview
$701
Balcony
$839
Suite
$1,127
From
US$599
Per Person
View Trip
11 Day South America with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$3,188
Oceanview
$3,588
Balcony
$3,989
Suite
$5,468
From
US$3,188
Save 91
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Dec 2025 to Mar 2027
Visit: Brazil
Inside
$869
Oceanview
$919
Balcony
$1,039
Suite
$1,399
From
US$869
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Buenos Aires to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 11 March 2027
Visit: Argentina, Brazil
Inside
$259
Oceanview
$379
Balcony
$439
Suite
$719
From
US$259
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 23 December 2025
Visit: Brazil
Inside
$853
Oceanview
$1,033
Balcony
$1,189
Suite
$1,681
From
US$853
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Inside
$1,879
Oceanview
$2,248
Balcony
$2,491
Suite
$4,082
From
US$1,879
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Inside
$847
Oceanview
$1,024
Balcony
$1,552
Suite
$1,825
From
US$847
Per Person
View Trip
Results: 1-30 of 121

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