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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 110 cruises visiting the coastal ports and cities of South America this season. March is the most popular month to begin your cruise and MSC have 352 cruises departing between December 2025 and April 2027.
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122 Days
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110 Cruises (352 Cruise Departures)
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 05 December 2026
Visit: Brazil
Inside
$439
Oceanview
$509
Balcony
$569
Suite
$909
From
US$439
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Drinks & WiFi Package
Inside
$185
Oceanview
$196
Balcony
$238
Suite
$406
From
US$185
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departures: Jan 2026 to Jan 2026
Visit: Brazil
Inside
$841
Oceanview
$981
Balcony
$1,449
Suite
$1,691
From
US$841
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England
Inside
$1,520
Oceanview
-
Balcony
$1,840
Suite
$3,166
From
US$1,520
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Inside
$843
Oceanview
$1,013
Balcony
$1,453
Suite
$1,723
From
US$843
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Dec 2025 to Mar 2026
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$1,801
Oceanview
$2,046
Balcony
$2,310
Suite
$3,348
From
US$1,801
Save 63
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Itajai to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 14 March 2027
Visit: Brazil
Inside
$721
Oceanview
$771
Balcony
$1,051
Suite
$1,201
From
US$721
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Inside
$1,549
Oceanview
$1,999
Balcony
$2,169
Suite
$7,154
From
US$1,549
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 24 January 2027
Visit: Brazil
Inside
$891
Oceanview
$941
Balcony
$1,271
Suite
$1,441
From
US$891
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 October 2026
Visit: Italy, France, Spain, Morocco, Brazil
Inside
$994
Oceanview
$1,154
Balcony
$1,594
Suite
-
From
US$994
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Inside
$889
Oceanview
$1,075
Balcony
$1,629
Suite
$1,917
From
US$889
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,104
Oceanview
$1,144
Balcony
$1,224
Suite
$1,694
From
US$1,104
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 17 January 2026
Visit: Brazil, Uruguay, Argentina
Inside
$1,170
Oceanview
$1,438
Balcony
$1,722
Suite
$2,330
From
US$1,170
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$2,014
Oceanview
$2,062
Balcony
$2,159
Suite
$2,644
From
US$2,014
Save 53
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
11 Day South America with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$3,188
Oceanview
-
Balcony
-
Suite
$5,468
From
US$3,188
Save 91
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2027
Visit: France, Spain, Gibraltar, Morocco (+20 more), Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
$73,949
From
US$16,622
Save 427
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Brugge
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England, France, Belgium
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,263
Suite
-
From
US$2,263
Save 54
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Dec 2025 to Mar 2027
Visit: Brazil
Inside
$700
Oceanview
$878
Balcony
$1,039
Suite
$1,399
From
US$700
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Malaga to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 22 November 2026
Visit: Spain, Morocco, Brazil
Inside
$1,058
Oceanview
$1,298
Balcony
-
Suite
-
From
US$1,058
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departures: Jan 2026 to Jan 2026
Visit: Brazil
Inside
$1,277
Oceanview
$1,112
Balcony
-
Suite
-
From
US$1,112
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 29 December 2026
Visit: Brazil
Inside
$1,594
Oceanview
$1,644
Balcony
$1,744
Suite
$2,066
From
US$1,594
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 21 December 2025
Visit: Brazil
Inside
$1,478
Oceanview
$1,642
Balcony
-
Suite
$2,539
From
US$1,478
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Jan 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,250
Oceanview
$1,500
Balcony
$1,630
Suite
$2,240
From
US$1,250
Save 53
Per Person
View Trip
21 Day South America with MSC Cruises
Cruise
 (2)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Visit: Uruguay, Argentina, Brazil, Spain, Morocco
Inside
$1,599
Oceanview
-
Balcony
$2,029
Suite
$4,060
From
US$1,599
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Jan 2026 to Dec 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 17 February 2026
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,952
Oceanview
$2,286
Balcony
$2,513
Suite
$3,424
From
US$1,952
Save 51
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visit: Brazil
Inside
$569
Oceanview
$649
Balcony
$739
Suite
$1,179
From
US$569
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$811
Oceanview
$861
Balcony
$1,191
Suite
$1,361
From
US$811
Per Person
View Trip
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