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MSC South America Cruises

Join MSC on one of 86 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 196 cruises departing between November 2026 and January 2028.
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116 Days
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86 Cruises (196 Cruise Departures)
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 24 January 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,341
Suite
-
From
US$931
Per Person
View Trip
25 Day South America with MSC Cruises
Cruise
 (1)

25 Days (24 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal, Morocco, Spain
Inside
$2,169
Oceanview
$2,529
Balcony
$3,089
Suite
$4,899
From
US$2,169
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visit: Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
-
From
US$1,290
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Nov 2026 to Nov 2026
Visit: Brazil
Inside
$476
Oceanview
-
Balcony
$674
Suite
$1,119
From
US$476
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 11 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,409
Oceanview
$1,649
Balcony
$1,839
Suite
$2,369
From
US$1,409
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,269
Oceanview
$1,449
Balcony
$1,699
Suite
$2,229
From
US$1,269
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,170
From
US$1,290
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$931
Oceanview
$1,051
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$851
Oceanview
$971
Balcony
$1,251
Suite
-
From
US$851
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,454
Oceanview
$1,804
Balcony
$2,004
Suite
$3,564
From
US$1,454
Per Person
View Trip
26 Day South America with MSC Cruises
Cruise
 (1)

26 Days (25 Nights) Buenos Aires to Marseille
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal, Morocco, Spain, France
Inside
$2,220
Oceanview
$2,650
Balcony
$3,220
Suite
$5,150
From
US$2,220
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Inside
-
Oceanview
$2,139
Balcony
$2,959
Suite
-
From
US$2,139
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 06 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
$1,099
Oceanview
$1,229
Balcony
$1,509
Suite
$2,099
From
US$1,099
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Drinks & WiFi Package
Inside
$1,308
Oceanview
$1,488
Balcony
$1,758
Suite
$2,268
From
US$1,308
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$799
Oceanview
$949
Balcony
$1,251
Suite
-
From
US$799
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Inside
$1,041
Oceanview
$1,301
Balcony
$1,801
Suite
-
From
US$1,041
Per Person
View Trip
28 Day South America with MSC Cruises
Cruise
 (1)

28 Days (27 Nights) Buenos Aires to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal (+4 more), Morocco, Spain, France, Italy
Inside
-
Oceanview
-
Balcony
$3,469
Suite
$7,389
From
US$3,469
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Marseille to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 07 November 2027
Visit: France, Spain, Portugal, Brazil
Inside
$1,183
Oceanview
$1,433
Balcony
$2,063
Suite
-
From
US$1,183
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,487
Oceanview
$1,807
Balcony
$2,137
Suite
$3,487
From
US$1,487
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visit: Brazil
Inside
$99
Oceanview
$139
Balcony
$189
Suite
$379
From
US$99
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 28 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,599
Oceanview
$1,929
Balcony
$2,249
Suite
$7,069
From
US$1,599
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 07 January 2027
Visit: Argentina, Brazil, Uruguay
Inside
$1,448
Oceanview
$1,628
Balcony
$1,908
Suite
$2,408
From
US$1,448
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Genoa to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,369
Oceanview
$1,709
Balcony
$1,969
Suite
-
From
US$1,369
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 05 December 2026
Visit: Brazil, Uruguay, Argentina
Inside
$1,114
Oceanview
$1,314
Balcony
$1,524
Suite
$2,114
From
US$1,114
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 15 March 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Inside
-
Oceanview
-
Balcony
$1,670
Suite
-
From
US$1,670
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visit: Italy, France, Spain, Portugal, Brazil
Inside
$1,265
Oceanview
$1,585
Balcony
$2,195
Suite
-
From
US$1,265
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 10 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,469
Oceanview
$1,649
Balcony
$1,839
Suite
$2,369
From
US$1,469
Per Person
View Trip
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