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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 91 cruises visiting the coastal ports and cities of South America this season. March is the most popular month to begin your cruise and MSC have 323 cruises departing between January 2026 and April 2027.
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2 Days
122 Days
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91 Cruises (323 Cruise Departures)
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,239
Oceanview
$1,499
Balcony
$1,719
Suite
$5,765
From
US$1,239
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$942
Oceanview
$1,072
Balcony
$1,626
Suite
$1,914
From
US$942
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Exclusive Savings
Inside
$844
Oceanview
$894
Balcony
$1,014
Suite
$1,374
From
US$844
Save 56
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$1,798
Suite
$2,473
From
US$1,798
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 24 January 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$891
Oceanview
$941
Balcony
$1,271
Suite
$1,441
From
US$891
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$889
Oceanview
$959
Balcony
$1,089
Suite
$1,349
From
US$889
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2027
Visit: France, Spain, Gibraltar, Morocco (+20 more), Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Visit: Uruguay, Argentina, Brazil
Bonus Onboard Credit
Inside
$1,678
Oceanview
$1,955
Balcony
$2,258
Suite
$3,348
From
US$1,678
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Feb 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$841
Oceanview
$931
Balcony
$1,061
Suite
-
From
US$841
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Venice to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 15 November 2026
Visit: Italy, Spain, Morocco, Brazil
Bonus Onboard Credit
Inside
$1,461
Oceanview
$1,741
Balcony
$2,851
Suite
$3,501
From
US$1,461
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Jan 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Drinks, WiFi & Onboard Credit
Exclusive Savings
Inside
$884
Oceanview
$1,094
Balcony
$1,214
Suite
$1,804
From
US$884
Save 147
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Bonus Onboard Credit
Inside
$1,549
Oceanview
$1,999
Balcony
$2,169
Suite
$7,154
From
US$1,549
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Itajai to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 08 March 2027
Visit: Brazil, Uruguay, Argentina
Inside
$779
Oceanview
$989
Balcony
$1,069
Suite
-
From
US$779
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Jan 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Exclusive Savings
Inside
$1,250
Oceanview
$1,500
Balcony
$1,630
Suite
$2,240
From
US$1,250
Save 57
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Jan 2026 to Dec 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Buenos Aires to Bari
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 31 March 2027
Visit: Argentina, Brazil, Spain, Corsica, Italy, Greece
Bonus Onboard Credit
Inside
$1,731
Oceanview
$2,151
Balcony
$2,347
Suite
$3,598
From
US$1,731
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Cagliari to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 11 November 2026
Visit: Sardinia, Sicily, Malta, Spain (+5 more), Gibraltar, Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,954
Oceanview
$2,330
Balcony
$2,582
Suite
-
From
US$1,954
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departures: Jan 2026 to Jan 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,068
Oceanview
$1,314
Balcony
-
Suite
$2,100
From
US$1,068
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain, England
Bonus Onboard Credit
Inside
$1,424
Oceanview
-
Balcony
-
Suite
-
From
US$1,424
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$319
Oceanview
$379
Balcony
$579
Suite
$699
From
US$319
Per Person
View Trip
21 Day South America with MSC Cruises
Cruise
 (2)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Visit: Uruguay, Argentina, Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,569
Oceanview
-
Balcony
$2,029
Suite
$4,060
From
US$1,569
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia, MSC Virtuosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$363
Oceanview
$393
Balcony
$463
Suite
$703
From
US$363
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Venice
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 20 March 2027
Visit: Brazil, Cape Verde, Spain, Morocco, Malta, Croatia, Italy
Bonus Onboard Credit
Inside
$1,641
Oceanview
$1,921
Balcony
$3,026
Suite
$3,676
From
US$1,641
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Bonus Onboard Credit
Inside
$1,899
Oceanview
$2,159
Balcony
$2,415
Suite
$8,196
From
US$1,899
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,104
Oceanview
$1,144
Balcony
$1,224
Suite
$1,694
From
US$1,104
Per Person
View Trip
6 Day South America with MSC Cruises
Cruise

6 Days (5 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 21 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$779
Oceanview
$849
Balcony
$949
Suite
$1,179
From
US$779
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Malaga to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 22 November 2026
Visit: Spain, Morocco, Brazil
Bonus Onboard Credit
Inside
$1,058
Oceanview
$1,298
Balcony
-
Suite
-
From
US$1,058
Per Person
View Trip
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