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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 57 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 161 cruises departing between October 2025 and April 2026.
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25 Days
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$2,855pp
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57 Cruises (161 Cruise Departures)
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,579
OCEANVIEW
$1,852
BALCONY
$2,126
SUITE
$2,948
From (per person) 1,579
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Nov 2025 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,285
OCEANVIEW
$1,559
BALCONY
$1,821
SUITE
$2,631
From (per person) 1,285
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 March 2026
Countries Visited: Argentina, Brazil, Spain, Morocco
Escape To Sea
INSIDE
-
OCEANVIEW
-
BALCONY
$1,659
SUITE
$2,929
From (per person) 1,659
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 17 January 2026
Countries Visited: Brazil, Uruguay, Argentina
Escape To Sea
INSIDE
$833
OCEANVIEW
$1,023
BALCONY
$1,223
SUITE
$1,783
From (per person) 833
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2025 to Mar 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$823
OCEANVIEW
$983
BALCONY
$1,163
SUITE
$2,073
From (per person) 823
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Hamburg to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 05 October 2025
Countries Visited: Germany, England, France, Spain (+2 more), Portugal, Brazil
Escape To Sea
INSIDE
-
OCEANVIEW
-
BALCONY
$2,329
SUITE
$3,309
From (per person) 2,329
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Hamburg to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 05 October 2025
Countries Visited: Germany, England, France, Spain (+2 more), Portugal, Brazil
Escape To Sea
INSIDE
-
OCEANVIEW
-
BALCONY
$2,403
SUITE
$3,473
From (per person) 2,403
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 13 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$761
OCEANVIEW
$911
BALCONY
$1,101
SUITE
$1,531
From (per person) 761
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Nov 2025 to Apr 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$649
OCEANVIEW
$819
BALCONY
$1,049
SUITE
$1,529
From (per person) 649
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$1,435
OCEANVIEW
$1,752
BALCONY
$1,959
SUITE
$2,981
From (per person) 1,435
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) London to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 07 October 2025
Countries Visited: England, France, Spain, Portugal (+1 more), Brazil
Escape To Sea
INSIDE
$1,459
OCEANVIEW
$1,719
BALCONY
$1,859
SUITE
$3,429
From (per person) 1,459
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$2,855
OCEANVIEW
$3,228
BALCONY
$3,468
SUITE
$4,694
From (per person) 2,855
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Nov 2025 to Mar 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$1,134
OCEANVIEW
$1,764
BALCONY
$1,686
SUITE
$2,473
From (per person) 1,134
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 16 February 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$1,573
OCEANVIEW
$1,904
BALCONY
$2,097
SUITE
$3,119
From (per person) 1,573
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain
Escape To Sea
INSIDE
$1,111
OCEANVIEW
$1,221
BALCONY
$1,391
SUITE
$2,361
From (per person) 1,111
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Countries Visited: Uruguay, Argentina, Brazil, Spain (+1 more), Morocco
Escape To Sea
INSIDE
$1,971
OCEANVIEW
$2,151
BALCONY
$2,451
SUITE
$4,503
From (per person) 1,971
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) London to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 07 October 2025
Countries Visited: England, France, Spain, Portugal (+1 more), Brazil
Escape To Sea
INSIDE
$1,407
OCEANVIEW
-
BALCONY
$2,047
SUITE
$3,247
From (per person) 1,407
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Dec 2025 to Dec 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$584
OCEANVIEW
$692
BALCONY
$896
SUITE
$952
From (per person) 584
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Salvador to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 11 December 2025
Countries Visited: Brazil
One Way Cruise Offer
INSIDE
-
OCEANVIEW
$349
BALCONY
$489
SUITE
$599
From (per person) 349
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Santos to Paris
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+1 more), France
Escape To Sea
INSIDE
$1,313
OCEANVIEW
$1,565
BALCONY
$1,807
SUITE
$3,413
From (per person) 1,313
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departures: Oct 2025 to Nov 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$372
OCEANVIEW
$462
BALCONY
$542
SUITE
$802
From (per person) 372
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 29 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$1,956
OCEANVIEW
-
BALCONY
$2,714
SUITE
-
From (per person) 1,956
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 26 December 2025
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$2,735
OCEANVIEW
$3,079
BALCONY
$3,423
SUITE
$4,469
From (per person) 2,735
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 21 January 2026
Countries Visited: Argentina, Uruguay, Brazil
Escape To Sea
INSIDE
$1,100
OCEANVIEW
$1,276
BALCONY
$1,485
SUITE
$1,925
From (per person) 1,100
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Rio de Janeiro to Hamburg
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+5 more), France, Belgium, Denmark, Norway, Germany
Escape To Sea
INSIDE
$1,729
OCEANVIEW
$1,929
BALCONY
$2,229
SUITE
$3,809
From (per person) 1,729
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 29 March 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$650
OCEANVIEW
$755
BALCONY
$854
SUITE
$1,095
From (per person) 650
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 08 November 2025
Countries Visited: Spain, Morocco, Brazil, Uruguay (+1 more), Argentina
Escape To Sea
INSIDE
$1,279
OCEANVIEW
-
BALCONY
$1,611
SUITE
$2,809
From (per person) 1,279
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departures: Nov 2025 to Dec 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$538
OCEANVIEW
$648
BALCONY
$738
SUITE
$1,028
From (per person) 538
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Paris to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 08 October 2025
Countries Visited: France, Spain, Portugal, Brazil
Escape To Sea
INSIDE
$1,367
OCEANVIEW
-
BALCONY
$2,117
SUITE
$6,309
From (per person) 1,367
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Funchal to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 13 October 2025
Countries Visited: Portugal, Spain, Brazil
Escape To Sea
INSIDE
$1,216
OCEANVIEW
-
BALCONY
$1,750
SUITE
-
From (per person) 1,216
View Trip
Results: 1-30 of 57

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