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MSC South America Cruises

Join MSC on one of 95 cruises visiting the coastal ports and cities of South America this season. January is the most popular month to begin your cruise and MSC have 197 cruises departing between March 2026 and January 2028.
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122 Days
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95 Cruises (197 Cruise Departures)
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$851
Oceanview
$1,001
Balcony
$1,251
Suite
-
From
US$851
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Genoa to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,429
Oceanview
$1,709
Balcony
$1,969
Suite
$5,484
From
US$1,429
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 16 November 2027
Visit: Spain, Brazil
Inside
$1,607
Oceanview
$1,847
Balcony
$2,187
Suite
$5,736
From
US$1,607
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$525
Oceanview
$605
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$2,159
Oceanview
$2,343
Balcony
$2,557
Suite
-
From
US$2,159
Save 58
Per Person
View Trip
21 Day South America with MSC Cruises
Cruise
 (2)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Visit: Uruguay, Argentina, Brazil, Spain, Morocco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,060
From
US$4,060
Save 109
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: Dec 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Inside
$1,249
Oceanview
$1,557
Balcony
$1,689
Suite
$2,274
From
US$1,249
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 24 January 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Itajai to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 08 March 2027
Visit: Brazil, Uruguay, Argentina
Inside
$891
Oceanview
$1,110
Balcony
$1,225
Suite
-
From
US$891
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Buenos Aires to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 11 March 2027
Visit: Argentina, Brazil
Inside
$289
Oceanview
$379
Balcony
$439
Suite
$719
From
US$289
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica (+2 more), MSC Preziosa, MSC Virtuosa
Departures: Apr 2026 to Apr 2027
Visit: Brazil
Drinks & WiFi Package
Inside
$79
Oceanview
$119
Balcony
$179
Suite
$379
From
US$79
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Inside
$1,659
Oceanview
$2,139
Balcony
$2,890
Suite
-
From
US$1,659
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$851
Oceanview
$1,001
Balcony
$1,251
Suite
-
From
US$851
Per Person
View Trip
6 Day MSC Grand Voyages with MSC Cruises
Cruise

6 Days (5 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Inside
-
Oceanview
-
Balcony
-
Suite
$1,106
From
US$1,106
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 29 December 2026
Visit: Brazil
Exclusive Savings
Inside
-
Oceanview
$1,839
Balcony
$1,973
Suite
$2,374
From
US$1,839
Save 51
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Virtuosa
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Drinks & WiFi Package
Inside
$393
Oceanview
$463
Balcony
$583
Suite
$1,053
From
US$393
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$525
Oceanview
$605
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visit: Italy, France, Spain, Portugal, Brazil
Inside
$1,245
Oceanview
$1,585
Balcony
$2,142
Suite
-
From
US$1,245
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Feb 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,001
Oceanview
$1,070
Balcony
$1,220
Suite
-
From
US$1,001
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 05 December 2026
Visit: Brazil
Inside
$521
Oceanview
$605
Balcony
$689
Suite
$1,085
From
US$521
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2027
Visit: France, Spain, Gibraltar, Morocco (+20 more), Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Nov 2026 to Nov 2026
Visit: Brazil
Inside
$469
Oceanview
$549
Balcony
$659
Suite
$949
From
US$469
Per Person
View Trip
116 Day MSC World Cruise with MSC Cruises
Cruise

116 Days (115 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2028
Visit: France, Spain, Turks and Caicos Islands, Bahamas (+24 more), Mexico, Costa Rica, Panama, Ecuador, Peru, Chile, French Polynesia, Tonga, New Caledonia, New Zealand, Australia, Indonesia, Vietnam, Thailand, Cambodia, Singapore, Malaysia, Sri Lanka, India, United Arab Emirates, Oman, Jordan, Egypt, Italy
Exclusive Savings
Inside
$18,267
Oceanview
$21,041
Balcony
$29,567
Suite
$72,847
From
US$18,267
Save 482
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rio de Janeiro to Paris
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England, France
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,059
Suite
$6,720
From
US$2,059
Save 50
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 13 November 2027
Visit: Italy, France, Spain, Brazil
Drinks & WiFi Package
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,955
From
US$7,955
Save 228
Per Person
View Trip
13 Day MSC Grand Voyages with MSC Cruises
Cruise

13 Days (12 Nights) Santos to Funchal
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$2,714
From
US$2,714
Save 74
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Inside
$1,739
Oceanview
$2,049
Balcony
$2,188
Suite
$7,397
From
US$1,739
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,087
From
US$1,290
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Cagliari to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 11 November 2026
Visit: Sardinia, Sicily, Malta, Spain (+5 more), Gibraltar, Morocco, Brazil, Uruguay, Argentina
Inside
$2,004
Oceanview
$2,379
Balcony
$2,641
Suite
-
From
US$2,004
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$393
Oceanview
$463
Balcony
$583
Suite
$948
From
US$393
Per Person
View Trip
Results: 1-30 of 95

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