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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 116 cruises visiting the coastal ports and cities of South America this season. December and March are the most popular months to begin your cruise and MSC have 324 cruises departing between January 2026 and January 2028.
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122 Days
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116 Cruises (324 Cruise Departures)
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Jan 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Drinks & WiFi Package
Inside
$908
Oceanview
$998
Balcony
$1,108
Suite
$1,388
From
US$908
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Bonus Onboard Credit
Inside
$1,709
Oceanview
$2,049
Balcony
$2,188
Suite
$7,397
From
US$1,709
Per Person
View Trip
28 Day South America with MSC Cruises
Cruise

28 Days (27 Nights) Itajai to Venice
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 14 March 2027
Visit: Brazil, Cape Verde, Spain, Morocco, Malta, Croatia, Italy
Bonus Onboard Credit
Inside
$2,199
Oceanview
$2,369
Balcony
$3,901
Suite
$4,765
From
US$2,199
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$811
Oceanview
$861
Balcony
$1,191
Suite
$1,361
From
US$811
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Rio de Janeiro to Copenhagen
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England, France, Belgium, Denmark
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,895
From
US$3,895
Save 104
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Venice to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 15 November 2026
Visit: Italy, Spain, Morocco, Brazil
Bonus Onboard Credit
Inside
$1,398
Oceanview
$1,749
Balcony
$2,809
Suite
$4,280
From
US$1,398
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,465
From
US$475
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Buenos Aires to Bari
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 31 March 2027
Visit: Argentina, Brazil, Spain, Corsica, Italy, Greece
Bonus Onboard Credit
Inside
$1,751
Oceanview
$2,171
Balcony
$2,376
Suite
$3,656
From
US$1,751
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Feb 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$861
Oceanview
$931
Balcony
$1,061
Suite
-
From
US$861
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$843
Oceanview
$1,013
Balcony
$1,453
Suite
$1,773
From
US$843
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
$2,014
Oceanview
$2,062
Balcony
$2,159
Suite
-
From
US$2,014
Save 53
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 28 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,599
Oceanview
$1,929
Balcony
$2,197
Suite
$6,252
From
US$1,599
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Buenos Aires to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 11 March 2027
Visit: Argentina, Brazil
Inside
$259
Oceanview
$379
Balcony
$439
Suite
$719
From
US$259
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,375
From
US$475
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 16 November 2027
Visit: Spain, Brazil
Bonus Onboard Credit
Inside
$1,607
Oceanview
$1,847
Balcony
$2,127
Suite
$5,736
From
US$1,607
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Seaview, MSC Virtuosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$700
Oceanview
$878
Balcony
$1,039
Suite
$1,399
From
US$700
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,289
Oceanview
$1,549
Balcony
$1,779
Suite
$6,008
From
US$1,289
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,104
Oceanview
$1,144
Balcony
$1,224
Suite
-
From
US$1,104
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
116 Day MSC World Cruise with MSC Cruises
Cruise

116 Days (115 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2028
Visit: Italy, France, Spain, Turks and Caicos Islands (+24 more), Bahamas, Mexico, Costa Rica, Panama, Ecuador, Peru, Chile, French Polynesia, Tonga, New Caledonia, New Zealand, Australia, Indonesia, Vietnam, Thailand, Cambodia, Singapore, Malaysia, Sri Lanka, India, United Arab Emirates, Oman, Jordan, Egypt
Exclusive Savings
Inside
$18,267
Oceanview
$21,041
Balcony
$27,152
Suite
$69,386
From
US$18,267
Save 482
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$329
Oceanview
$389
Balcony
$579
Suite
$699
From
US$329
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,087
From
US$1,290
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

20 Days (19 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 March 2026
Visit: Argentina, Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$1,959
Suite
$3,206
From
US$1,959
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 21 January 2026
Visit: Argentina, Uruguay, Brazil
Bonus Onboard Credit
Inside
-
Oceanview
$1,596
Balcony
$1,810
Suite
$2,245
From
US$1,596
Per Person
View Trip
6 Day South America with MSC Cruises
Cruise

6 Days (5 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 21 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$799
Oceanview
$849
Balcony
$959
Suite
$1,179
From
US$799
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 09 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$721
Oceanview
$771
Balcony
$1,051
Suite
$1,201
From
US$721
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 29 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,594
Oceanview
$1,644
Balcony
$1,764
Suite
$2,066
From
US$1,594
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 17 February 2026
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Inside
$1,879
Oceanview
$2,148
Balcony
$2,468
Suite
$3,424
From
US$1,879
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$889
Oceanview
$1,075
Balcony
$1,629
Suite
$1,917
From
US$889
Per Person
View Trip
Results: 1-30 of 116

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