MSC South America Cruises

Join MSC on one of 132 cruises visiting the coastal ports and cities of South America this season. March is the most popular month to begin your cruise and MSC have 439 cruises departing between November 2026 and April 2028.
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132 Cruises (439 Departures)
132 Cruises (439 Departures)
Departures
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Duration
2 Days
116 Days
Start & End Cities
Ship Name
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Price
$79pp
$22,379pp
Countries
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Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visits: Brazil
Inside
$535
Oceanview
$595
Balcony
$746
Suite
$1,142
From (Per Person)
US$535
Per Person
Cruise
 (1)

20 Days (19 Nights) Santos to Rome
Operator: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visits: Brazil, Spain, Morocco, Italy
Inside
$1,419
Oceanview
$1,769
Balcony
$2,349
Suite
$3,469
From (Per Person)
US$1,419
Per Person
Cruise
 (1)

16 Days (15 Nights) Marseille to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visits: France, Spain, Brazil
Inside
$1,380
Oceanview
$1,580
Balcony
$1,850
Suite
$3,230
From (Per Person)
US$1,380
Per Person
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Departures: Nov 2026 to Mar 2028
Visits: Brazil
Inside
$415
Oceanview
$465
Balcony
$635
Suite
$855
From (Per Person)
US$415
Per Person
Cruise
 (1)

16 Days (15 Nights) Barcelona to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visits: Spain, Brazil
Inside
$1,380
Oceanview
$1,580
Balcony
$1,850
Suite
-
From (Per Person)
US$1,380
Per Person
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2028
Visits: Brazil
Inside
$771
Oceanview
$871
Balcony
$1,161
Suite
$1,501
From (Per Person)
US$771
Per Person
Cruise
 (1)

19 Days (18 Nights) Genoa to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visits: Italy, France, Spain, Portugal, Brazil
Inside
$1,412
Oceanview
$1,751
Balcony
$2,419
Suite
-
From (Per Person)
US$1,412
Per Person
Cruise
 (1)

2 Days (1 Nights) Itajai to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 14 March 2027
Visits: Brazil
Inside
$189
Oceanview
$209
Balcony
$269
Suite
$419
From (Per Person)
US$189
Per Person
Cruise
 (1)

23 Days (22 Nights) Santos to Marmaris
Operator: MSC Cruises
Ship: MSC Divina
Departure: 19 March 2028
Visits: Brazil, Spain, Morocco, Italy, Greece, Turkey
Inside
-
Oceanview
-
Balcony
$2,365
Suite
$6,945
From (Per Person)
US$2,365
Per Person
Cruise
 (1)

6 Days (5 Nights) Sao Paulo to Sao Paulo
Operator: MSC Cruises
Ship: MSC Divina
Departure: 21 December 2026
Visits: Brazil
Inside
$889
Oceanview
$959
Balcony
$1,089
Suite
$1,349
From (Per Person)
US$889
Per Person
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2027 to Jan 2028
Visits: Brazil
Inside
$809
Oceanview
$899
Balcony
$1,149
Suite
$2,469
From (Per Person)
US$809
Per Person
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visits: Italy, France, Spain, Brazil
Inside
$1,554
Oceanview
$1,844
Balcony
$2,064
Suite
$3,624
From (Per Person)
US$1,554
Per Person
Cruise
 (1)

20 Days (19 Nights) Itajai to Valencia
Operator: MSC Cruises
Ship: MSC Musica
Departure: 05 March 2028
Visits: Brazil, Cape Verde, Spain
Inside
$979
Oceanview
$1,349
Balcony
$1,999
Suite
$5,999
From (Per Person)
US$979
Per Person
Cruise
 (1)

18 Days (17 Nights) Rome to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visits: Italy, France, Spain, Brazil
Inside
$1,554
Oceanview
$1,764
Balcony
$2,064
Suite
$3,344
From (Per Person)
US$1,554
Per Person
Cruise
 (1)

25 Days (24 Nights) Itajai to Barcelona
Operator: MSC Cruises
Ship: MSC Musica
Departure: 05 March 2028
Visits: Brazil, Cape Verde, Spain, France, Italy
Inside
$1,249
Oceanview
$1,719
Balcony
$2,539
Suite
$7,569
From (Per Person)
US$1,249
Per Person
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 09 March 2027
Visits: Brazil
Inside
-
Oceanview
-
Balcony
$899
Suite
-
From (Per Person)
US$899
Per Person
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 27 January 2028
Visits: Brazil
Inside
$519
Oceanview
$619
Balcony
$729
Suite
$949
From (Per Person)
US$519
Per Person
Cruise
 (1)

16 Days (15 Nights) Santos to Valencia
Operator: MSC Cruises
Ship: MSC Divina
Departure: 19 March 2028
Visits: Brazil, Spain, Morocco
Inside
$977
Oceanview
-
Balcony
$1,637
Suite
$4,737
From (Per Person)
US$977
Per Person
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 02 December 2026
Visits: Brazil
Inside
$529
Oceanview
$619
Balcony
$729
Suite
$969
From (Per Person)
US$529
Per Person
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2028
Visits: Brazil
Inside
$771
Oceanview
$871
Balcony
$1,099
Suite
$1,501
From (Per Person)
US$771
Per Person
Cruise
 (1)

19 Days (18 Nights) Rome to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visits: Italy, France, Spain, Brazil
Inside
$1,587
Oceanview
$1,977
Balcony
$2,197
Suite
$3,547
From (Per Person)
US$1,587
Per Person
Cruise
 (1)

3 Days (2 Nights) Santos to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2026
Visits: Brazil
Inside
-
Oceanview
$279
Balcony
$349
Suite
$509
From (Per Person)
US$279
Per Person
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departure: 23 January 2027
Visits: Brazil
Inside
$956
Oceanview
$1,076
Balcony
$1,376
Suite
$2,146
From (Per Person)
US$956
Per Person
Cruise
 (1)

4 Days (3 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 18 December 2026
Visits: Brazil
Inside
$419
Oceanview
$519
Balcony
$599
Suite
$889
From (Per Person)
US$419
Per Person
Cruise
 (1)

8 Days (7 Nights) Santos to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2027
Visits: Brazil
Inside
$1,099
Oceanview
$1,259
Balcony
$1,519
Suite
$2,149
From (Per Person)
US$1,099
Per Person
Cruise
 (1)

20 Days (19 Nights) Santos to Rome
Operator: MSC Cruises
Ship: MSC Divina
Departure: 19 March 2028
Visits: Brazil, Spain, Morocco, Italy
Inside
$1,259
Oceanview
$1,769
Balcony
$2,109
Suite
$3,449
From (Per Person)
US$1,259
Per Person
Cruise
 (1)

9 Days (8 Nights) Itajai to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 07 March 2027
Visits: Brazil
Inside
-
Oceanview
-
Balcony
$1,289
Suite
$2,594
From (Per Person)
US$1,289
Per Person
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Departures: Feb 2027 to Apr 2028
Visits: Brazil
Inside
$465
Oceanview
$579
Balcony
$709
Suite
$929
From (Per Person)
US$465
Per Person
Cruise
 (1)

7 Days (6 Nights) Itajai to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 03 January 2028
Visits: Brazil
Inside
$809
Oceanview
$899
Balcony
$1,149
Suite
$1,449
From (Per Person)
US$809
Per Person
Cruise
 (1)

9 Days (8 Nights) Itajai to Itajai
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 06 December 2026
Visits: Brazil, Uruguay, Argentina
Inside
$1,029
Oceanview
$1,239
Balcony
$1,559
Suite
$2,119
From (Per Person)
US$1,029
Per Person
Results: 1-30 of 132

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