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MSC South America Cruises

Join MSC on one of 90 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 202 cruises departing between November 2026 and January 2028.
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116 Days
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90 Cruises (202 Cruise Departures)
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visit: Italy, France, Spain, Portugal, Brazil
Inside
$1,265
Oceanview
$1,585
Balcony
$2,195
Suite
-
From
US$1,265
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Inside
$1,041
Oceanview
$1,301
Balcony
$1,801
Suite
-
From
US$1,041
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 02 December 2026
Visit: Brazil
Inside
$559
Oceanview
$619
Balcony
$719
Suite
$959
From
US$559
Per Person
View Trip
28 Day South America with MSC Cruises
Cruise
 (1)

28 Days (27 Nights) Buenos Aires to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal (+4 more), Morocco, Spain, France, Italy
Inside
$2,399
Oceanview
$2,859
Balcony
$3,469
Suite
$5,539
From
US$2,399
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 28 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,599
Oceanview
$1,929
Balcony
$2,249
Suite
$7,069
From
US$1,599
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Nov 2026 to Nov 2026
Visit: Brazil
Inside
$508
Oceanview
$558
Balcony
$756
Suite
$1,119
From
US$508
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 15 March 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$931
Oceanview
$1,051
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$525
Oceanview
$605
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Inside
-
Oceanview
$1,200
Balcony
$1,670
Suite
-
From
US$1,200
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 10 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,069
Oceanview
$1,249
Balcony
$1,439
Suite
$1,549
From
US$1,069
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visit: Brazil
Inside
$79
Oceanview
$119
Balcony
$189
Suite
$379
From
US$79
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Santos to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$732
Suite
$832
From
US$732
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,454
Oceanview
$1,804
Balcony
$2,004
Suite
$3,564
From
US$1,454
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$765
Suite
-
From
US$525
Per Person
View Trip
26 Day South America with MSC Cruises
Cruise
 (1)

26 Days (25 Nights) Buenos Aires to Marseille
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal, Morocco, Spain, France
Inside
$2,189
Oceanview
$2,619
Balcony
$3,189
Suite
$5,119
From
US$2,189
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

26 Days (25 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 22 October 2027
Visit: Italy, Greece, Turkey, France, Spain, Brazil
Inside
$2,200
Oceanview
$2,850
Balcony
$3,060
Suite
$5,280
From
US$2,200
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$690
Suite
-
From
US$690
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Inside
-
Oceanview
$2,139
Balcony
$2,959
Suite
-
From
US$2,139
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 24 January 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Inside
$908
Oceanview
$1,088
Balcony
$1,348
Suite
$1,868
From
US$908
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 January 2027
Visit: Brazil
Inside
$951
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$951
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 07 January 2027
Visit: Argentina, Brazil, Uruguay
Inside
$1,048
Oceanview
$1,228
Balcony
$1,508
Suite
$2,008
From
US$1,048
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Brazil, Uruguay, Argentina
Inside
$869
Oceanview
$1,049
Balcony
$1,299
Suite
$1,329
From
US$869
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 11 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,009
Oceanview
$1,189
Balcony
$1,439
Suite
$1,549
From
US$1,009
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$453
Oceanview
$463
Balcony
$593
Suite
$948
From
US$453
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Brazil, Uruguay, Argentina
Inside
$899
Oceanview
$1,079
Balcony
$1,269
Suite
$1,329
From
US$899
Per Person
View Trip
25 Day South America with MSC Cruises
Cruise
 (1)

25 Days (24 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal, Morocco, Spain
Inside
$2,049
Oceanview
$2,529
Balcony
$3,089
Suite
$4,899
From
US$2,049
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,170
From
US$1,290
Per Person
View Trip
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