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MSC South America Cruises

MSC South America Cruises

Join MSC on one of 115 cruises visiting the coastal ports and cities of South America this season. March is the most popular month to begin your cruise and MSC have 370 cruises departing between November 2025 and April 2027.
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122 Days
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115 Cruises (370 Cruise Departures)
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 17 February 2026
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,937
Oceanview
$2,286
Balcony
$2,468
Suite
$3,424
From
US$1,937
Save 51
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 09 February 2027
Visit: Uruguay, Argentina, Brazil
Inside
$1,139
Oceanview
$1,459
Balcony
$1,619
Suite
$2,344
From
US$1,139
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Barcelona to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 20 November 2026
Visit: Spain, Morocco, Brazil
Inside
$1,229
Oceanview
$1,449
Balcony
$2,273
Suite
$2,787
From
US$1,229
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 07 December 2025
Visit: Brazil
Inside
$449
Oceanview
$563
Balcony
$664
Suite
$991
From
US$449
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Dec 2025 to Mar 2027
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$849
Oceanview
$1,129
Balcony
$1,269
Suite
$1,917
From
US$849
Save 61
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 16 December 2025
Visit: Brazil
Drinks + WiFi + Onboard Credit
Inside
$749
Oceanview
$868
Balcony
$974
Suite
$1,318
From
US$749
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Rio de Janeiro to Oslo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England (+4 more), France, Belgium, Denmark, Norway
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,739
From
US$8,739
Save 252
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$839
Oceanview
$889
Balcony
$1,219
Suite
$1,389
From
US$839
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 29 December 2026
Visit: Brazil
Inside
$1,619
Oceanview
$1,669
Balcony
$1,769
Suite
$2,091
From
US$1,619
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Rio de Janeiro to Hamburg
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England (+5 more), France, Belgium, Denmark, Norway, Germany
Inside
$2,039
Oceanview
$2,319
Balcony
$2,512
Suite
$4,229
From
US$2,039
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 26 December 2026
Visit: Uruguay, Argentina, Brazil
Inside
$1,629
Oceanview
$1,898
Balcony
$2,053
Suite
$2,820
From
US$1,629
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Florence to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 10 November 2026
Visit: Italy, Sardinia, Sicily, Malta (+6 more), Spain, Gibraltar, Morocco, Brazil, Uruguay, Argentina
Inside
$2,049
Oceanview
$2,463
Balcony
$2,706
Suite
$4,073
From
US$2,049
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco
Inside
$1,203
Oceanview
$1,463
Balcony
$1,683
Suite
$5,565
From
US$1,203
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Itajai to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 14 March 2027
Visit: Brazil
Inside
$749
Oceanview
$799
Balcony
$1,079
Suite
$1,229
From
US$749
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Visit: Brazil
Inside
$843
Oceanview
$1,013
Balcony
$1,453
Suite
$1,723
From
US$843
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 04 January 2026
Visit: Brazil
Inside
$762
Oceanview
$937
Balcony
-
Suite
$1,555
From
US$762
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Inside
$1,499
Oceanview
$1,949
Balcony
$2,119
Suite
$6,951
From
US$1,499
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Rio de Janeiro to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Inside
$1,685
Oceanview
$2,185
Balcony
$2,273
Suite
$7,647
From
US$1,685
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2027
Visit: France, Spain, Gibraltar, Morocco (+20 more), Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
$47,196
From
US$16,622
Save 427
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rio de Janeiro to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England
Inside
$1,390
Oceanview
$1,530
Balcony
$1,690
Suite
$3,021
From
US$1,390
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Inside
$1,859
Oceanview
$2,119
Balcony
$2,376
Suite
$7,992
From
US$1,859
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 16 December 2025
Visit: Brazil
Inside
$905
Oceanview
-
Balcony
$1,577
Suite
-
From
US$905
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,986
Oceanview
$2,034
Balcony
$2,131
Suite
$2,616
From
US$1,986
Save 53
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$17,766
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$17,766
Save 463
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 15 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Inside
$1,158
Oceanview
$1,438
Balcony
$1,748
Suite
$2,992
From
US$1,158
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 24 January 2027
Visit: Brazil
Inside
$919
Oceanview
$969
Balcony
$1,299
Suite
$1,469
From
US$919
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Inside
$499
Oceanview
$529
Balcony
$589
Suite
$879
From
US$499
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 29 December 2025
Visit: Brazil
Exclusive Savings
Inside
$2,875
Oceanview
$3,053
Balcony
-
Suite
-
From
US$2,875
Save 82
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Maceio to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$359
Oceanview
$429
Balcony
$489
Suite
$829
From
US$359
Per Person
View Trip
6 Day MSC Grand Voyages with MSC Cruises
Cruise

6 Days (5 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$889
Suite
-
From
US$889
Per Person
View Trip
Results: 1-30 of 115

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