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MSC South America Cruises

Join MSC on one of 89 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 202 cruises departing between November 2026 and January 2028.
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116 Days
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89 Cruises (202 Cruise Departures)
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Exclusive Savings
Inside
-
Oceanview
$3,577
Balcony
$4,755
Suite
-
From
A$3,577
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visit: Brazil
Exclusive Savings
Inside
$252
Oceanview
$301
Balcony
$380
Suite
$668
From
A$252
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 05 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,793
Oceanview
$2,070
Balcony
$2,367
Suite
$2,257
From
A$1,793
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Nov 2026
Visit: Brazil
Exclusive Savings
Inside
$776
Oceanview
-
Balcony
$1,182
Suite
$1,360
From
A$776
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,458
Oceanview
$1,706
Balcony
$1,963
Suite
$2,085
From
A$1,458
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 28 October 2027
Visit: Italy, France, Spain, Brazil
Exclusive Savings
Inside
$2,663
Oceanview
$3,158
Balcony
$3,633
Suite
$10,965
From
A$2,663
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Exclusive Savings
Inside
$1,389
Oceanview
$1,577
Balcony
$1,845
Suite
-
From
A$1,389
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Exclusive Savings
Inside
$1,800
Oceanview
$2,176
Balcony
$2,889
Suite
-
From
A$1,800
Per Person
View Trip
28 Day South America with MSC Cruises
Cruise
 (1)

28 Days (27 Nights) Buenos Aires to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal (+4 more), Morocco, Spain, France, Italy
Exclusive Savings
Inside
$4,308
Oceanview
$4,971
Balcony
$5,842
Suite
$8,812
From
A$4,308
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rio de Janeiro to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 15 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Exclusive Savings
Inside
$2,349
Oceanview
$2,725
Balcony
$3,151
Suite
$5,210
From
A$2,349
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,311
Suite
-
From
A$1,311
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visit: Spain, Brazil
Exclusive Savings
Inside
$2,135
Oceanview
$2,511
Balcony
$2,858
Suite
-
From
A$2,135
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Exclusive Savings
Inside
$1,488
Oceanview
$1,587
Balcony
$1,736
Suite
-
From
A$1,488
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

26 Days (25 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 22 October 2027
Visit: Italy, Greece, Turkey, France, Spain, Brazil
Exclusive Savings
Inside
-
Oceanview
$4,603
Balcony
-
Suite
$8,246
From
A$4,603
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Exclusive Savings
Inside
$861
Oceanview
$960
Balcony
$1,119
Suite
-
From
A$861
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 24 January 2027
Visit: Brazil
Exclusive Savings
Inside
$1,488
Oceanview
$1,676
Balcony
$2,023
Suite
-
From
A$1,488
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 10 January 2027
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,686
Oceanview
$1,934
Balcony
$2,191
Suite
$2,382
From
A$1,686
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,409
Oceanview
$1,656
Balcony
$2,013
Suite
$2,716
From
A$1,409
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Exclusive Savings
Inside
$861
Oceanview
$960
Balcony
$1,168
Suite
-
From
A$861
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 23 January 2027
Visit: Brazil
Exclusive Savings
Inside
$1,488
Oceanview
$1,647
Balcony
$2,023
Suite
-
From
A$1,488
Per Person
View Trip
26 Day South America with MSC Cruises
Cruise
 (1)

26 Days (25 Nights) Buenos Aires to Marseille
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal, Morocco, Spain, France
Exclusive Savings
Inside
$3,986
Oceanview
$4,610
Balcony
$5,422
Suite
$8,194
From
A$3,986
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visit: Italy, France, Spain, Portugal, Brazil
Exclusive Savings
Inside
$2,192
Oceanview
$2,647
Balcony
$3,518
Suite
-
From
A$2,192
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Genoa to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2027
Visit: Italy, France, Spain, Brazil
Exclusive Savings
Inside
$2,272
Oceanview
$2,787
Balcony
$3,153
Suite
$8,466
From
A$2,272
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Exclusive Savings
Inside
$2,135
Oceanview
$2,511
Balcony
$2,858
Suite
$4,927
From
A$2,135
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 15 March 2027
Visit: Brazil
Exclusive Savings
Inside
$861
Oceanview
$960
Balcony
$1,119
Suite
-
From
A$861
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Exclusive Savings
Inside
-
Oceanview
$2,020
Balcony
$2,683
Suite
-
From
A$2,020
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Exclusive Savings
Inside
$861
Oceanview
$960
Balcony
$1,188
Suite
-
From
A$861
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Exclusive Savings
Inside
$1,389
Oceanview
$1,548
Balcony
$1,924
Suite
-
From
A$1,389
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 06 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,694
Oceanview
$1,981
Balcony
$2,367
Suite
$3,169
From
A$1,694
Per Person
View Trip
25 Day South America with MSC Cruises
Cruise
 (1)

25 Days (24 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visit: Argentina, Brazil, Cape Verde, Portugal, Morocco, Spain
Exclusive Savings
Inside
$3,890
Oceanview
$4,395
Balcony
$5,197
Suite
$7,791
From
A$3,890
Per Person
View Trip
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