MSC South America Cruises

Join MSC on one of 132 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 420 cruises departing between November 2026 and April 2028.
Filter Results
132 Cruises (420 Departures)
132 Cruises (420 Departures)
Departures
Show More...
Duration
2 Days
116 Days
Start & End Cities
Ship Name
Show More...
Price
$200pp
$37,819pp
Countries
Show More...
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Dec 2027
Visits: Brazil
Exclusive Savings
Inside
$2,538
Oceanview
$2,755
Balcony
$3,161
Suite
$10,104
From (Per Person)
A$2,538
Per Person
Cruise
 (1)

18 Days (17 Nights) Genoa to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visits: Italy, France, Spain, Portugal, Brazil
Exclusive Savings
Inside
$2,176
Oceanview
$2,641
Balcony
$3,255
Suite
$8,987
From (Per Person)
A$2,176
Per Person
Cruise
 (1)

23 Days (22 Nights) Cagliari to Buenos Aires
Operator: MSC Cruises
Departure: 11 November 2026
Visits: Sardinia, Sicily, Malta, Spain +5 more, Gibraltar, Morocco, Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,316
Suite
-
From (Per Person)
A$4,316
Per Person
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 09 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,401
Suite
$2,922
From (Per Person)
A$1,401
Per Person
Cruise
 (1)

6 Days (5 Nights) Rio de Janeiro to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 09 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,126
Suite
$2,651
From (Per Person)
A$1,126
Per Person
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Operator: MSC Cruises
Ship: MSC Divina
Departure: 26 January 2027
Visits: Brazil
Exclusive Savings
Inside
$765
Oceanview
$815
Balcony
$815
Suite
$1,023
From (Per Person)
A$765
Per Person
Cruise
 (1)

27 Days (26 Nights) Buenos Aires to Genoa
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 04 March 2027
Visits: Argentina, Brazil, Cape Verde, Portugal +4 more, Morocco, Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,500
Suite
-
From (Per Person)
A$4,500
Per Person
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2027 to Jan 2028
Visits: Brazil
Exclusive Savings
Inside
$1,332
Oceanview
$1,461
Balcony
$1,817
Suite
$2,269
From (Per Person)
A$1,332
Per Person
Cruise
 (1)

9 Days (8 Nights) Itajai to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 07 March 2027
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,912
Suite
$3,781
From (Per Person)
A$1,912
Per Person
Cruise
 (1)

25 Days (24 Nights) Itajai to Barcelona
Operator: MSC Cruises
Ship: MSC Musica
Departure: 05 March 2028
Visits: Brazil, Cape Verde, Spain, France, Italy
Exclusive Savings
Inside
$2,452
Oceanview
$3,115
Balcony
$4,273
Suite
$11,753
From (Per Person)
A$2,452
Per Person
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Operator: MSC Cruises
Departures: Nov 2026 to Dec 2027
Visits: Brazil
Exclusive Savings
Inside
$587
Oceanview
$607
Balcony
$676
Suite
$1,023
From (Per Person)
A$587
Per Person
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2028
Visits: Brazil
Exclusive Savings
Inside
$1,142
Oceanview
$1,201
Balcony
$1,330
Suite
$1,976
From (Per Person)
A$1,142
Per Person
Cruise
 (1)

4 Days (3 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 18 December 2026
Visits: Brazil
Exclusive Savings
Inside
$587
Oceanview
$656
Balcony
$666
Suite
$943
From (Per Person)
A$587
Per Person
Cruise
 (1)

10 Days (9 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Departure: 13 February 2027
Visits: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$2,028
Oceanview
-
Balcony
$2,602
Suite
$3,671
From (Per Person)
A$2,028
Per Person
Cruise
 (1)

19 Days (18 Nights) Rome to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visits: Italy, France, Spain, Brazil
Exclusive Savings
Inside
$2,612
Oceanview
$3,196
Balcony
$3,473
Suite
$5,503
From (Per Person)
A$2,612
Per Person
Cruise
 (1)

18 Days (17 Nights) Rome to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visits: Italy, France, Spain, Brazil
Exclusive Savings
Inside
$2,542
Oceanview
$2,859
Balcony
$3,265
Suite
$5,176
From (Per Person)
A$2,542
Per Person
Cruise
 (1)

8 Days (7 Nights) Santos to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2027
Visits: Brazil
Exclusive Savings
Inside
$1,765
Oceanview
$1,983
Balcony
$2,359
Suite
$3,302
From (Per Person)
A$1,765
Per Person
Cruise
 (1)

20 Days (19 Nights) Itajai to Valencia
Operator: MSC Cruises
Ship: MSC Musica
Departure: 05 March 2028
Visits: Brazil, Cape Verde, Spain
Exclusive Savings
Inside
$1,916
Oceanview
$2,431
Balcony
$3,351
Suite
$9,297
From (Per Person)
A$1,916
Per Person
Cruise
 (1)

20 Days (19 Nights) Rome to Buenos Aires
Operator: MSC Cruises
Departure: 16 November 2027
Visits: Italy, Spain, Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$3,107
Oceanview
$3,780
Balcony
$4,077
Suite
$6,216
From (Per Person)
A$3,107
Per Person
Cruise
 (1)

7 Days (6 Nights) Santos to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2026
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,061
From (Per Person)
A$3,061
Per Person
Cruise
 (1)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Operator: MSC Cruises
Departure: 08 March 2028
Visits: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,575
Oceanview
$1,783
Balcony
$2,179
Suite
$2,832
From (Per Person)
A$1,575
Per Person
Cruise
 (1)

2 Days (1 Nights) Itajai to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 14 March 2027
Visits: Brazil
Exclusive Savings
Inside
$325
Oceanview
$335
Balcony
$414
Suite
$489
From (Per Person)
A$325
Per Person
Cruise
 (1)

25 Days (24 Nights) Rome to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visits: Italy, Sicily, Spain, France, Portugal, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,613
Suite
$10,394
From (Per Person)
A$4,613
Per Person
Cruise
 (1)

23 Days (22 Nights) Itajai to Genoa
Operator: MSC Cruises
Ship: MSC Musica
Departure: 05 March 2028
Visits: Brazil, Cape Verde, Spain, France, Italy
Exclusive Savings
Inside
$2,226
Oceanview
$2,829
Balcony
$3,889
Suite
$10,773
From (Per Person)
A$2,226
Per Person
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 16 December 2027
Visits: Brazil
Exclusive Savings
Inside
$723
Oceanview
$802
Balcony
$1,050
Suite
$1,371
From (Per Person)
A$723
Per Person
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Dec 2027
Visits: Brazil
Exclusive Savings
Inside
$2,538
Oceanview
$2,646
Balcony
$3,062
Suite
$5,441
From (Per Person)
A$2,538
Per Person
Cruise
 (1)

8 Days (7 Nights) Santos to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2026
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
$1,191
Balcony
$1,260
Suite
$4,183
From (Per Person)
A$1,191
Per Person
Cruise
 (1)

22 Days (21 Nights) Palermo to Buenos Aires
Operator: MSC Cruises
Departure: 12 November 2026
Visits: Sicily, Malta, Spain, Gibraltar +4 more, Morocco, Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,285
From (Per Person)
A$6,285
Per Person
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departure: 29 December 2026
Visits: Brazil
Exclusive Savings
Inside
$2,478
Oceanview
-
Balcony
$3,042
Suite
$7,609
From (Per Person)
A$2,478
Per Person
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visits: Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,277
Suite
$1,757
From (Per Person)
A$1,277
Per Person
Results: 1-30 of 132

No trips found. Try adjusting the search filters.