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MSC Cruises from Rome

Start your journey from Rome with 61 unique MSC cruise itineraries to choose from. April is the most popular month to begin your cruise from Rome and MSC Cruises have 380 trips departing this season.
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Duration
3 Days
122 Days
Price
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61 Cruises (380 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2026 to Oct 2026
Visit: Italy, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$1,010
Oceanview
$1,150
Balcony
$1,310
Suite
$2,023
From
US$1,010
Save 50
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Sep 2026
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$740
Oceanview
$790
Balcony
$1,000
Suite
$1,780
From
US$740
Per Person
View Trip
12 Day Western Europe with MSC Cruises
Cruise

12 Days (11 Nights) Rome to London
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 May 2027
Visit: Italy, Spain, Portugal, France, England
Bonus Onboard Credit
Inside
$1,184
Oceanview
$1,434
Balcony
$1,714
Suite
$3,515
From
US$1,184
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2026 to Oct 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Inside
$707
Oceanview
$797
Balcony
$967
Suite
$1,767
From
US$707
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Bonus Onboard Credit
Inside
$1,033
Oceanview
$1,194
Balcony
$1,449
Suite
$2,348
From
US$1,033
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,454
Oceanview
$1,724
Balcony
$2,004
Suite
$3,199
From
US$1,454
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 08 April 2027
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$731
Oceanview
$881
Balcony
$1,131
Suite
$1,331
From
US$731
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain
Inside
-
Oceanview
-
Balcony
$536
Suite
-
From
US$536
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France, Spain
Inside
$289
Oceanview
$349
Balcony
$469
Suite
$859
From
US$289
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Rome to Doha
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus, Egypt, Oman, Qatar
Bonus Onboard Credit
Inside
$1,507
Oceanview
$1,967
Balcony
$2,380
Suite
$4,446
From
US$1,507
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Bridgetown
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Visit: Italy, Corsica, France, Spain (+4 more), Saint Martin, Saint Kitts and Nevis, Saint Vincent, Barbados
Bonus Onboard Credit
Inside
$1,264
Oceanview
$1,554
Balcony
$1,864
Suite
-
From
US$1,264
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2027 to Nov 2027
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$846
Oceanview
$956
Balcony
$1,056
Suite
$1,546
From
US$846
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$1,254
Oceanview
$1,464
Balcony
$1,584
Suite
$2,251
From
US$1,254
Per Person
View Trip
19 Day Mediterranean with MSC Cruises
Cruise

19 Days (18 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 03 November 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,318
Oceanview
$1,988
Balcony
$2,943
Suite
$3,651
From
US$1,318
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Feb 2026 to Mar 2028
Visit: Italy, Sicily, Malta, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$764
Oceanview
$834
Balcony
$1,013
Suite
$1,604
From
US$764
Save 52
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,487
Oceanview
$1,807
Balcony
$2,137
Suite
$3,398
From
US$1,487
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rome to La Romana
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France, Spain, Morocco (+4 more), Antigua and Barbuda, Saint Martin, Saint Kitts and Nevis, Dominican Republic
Bonus Onboard Credit
Inside
$1,146
Oceanview
$1,630
Balcony
$2,451
Suite
$3,961
From
US$1,146
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain, Malta, Greece
Bonus Onboard Credit
Inside
$959
Oceanview
$1,089
Balcony
$1,199
Suite
$1,709
From
US$959
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$989
Oceanview
$1,159
Balcony
$1,289
Suite
$1,769
From
US$989
Save 59
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France, Spain
Inside
$359
Oceanview
$411
Balcony
$758
Suite
$872
From
US$359
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

23 Days (22 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,775
Oceanview
$2,185
Balcony
$2,409
Suite
-
From
US$1,775
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 03 November 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,359
Oceanview
-
Balcony
-
Suite
-
From
US$1,359
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
$667
Oceanview
$775
Balcony
$874
Suite
$1,671
From
US$667
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
-
Oceanview
$1,114
Balcony
$1,249
Suite
$2,539
From
US$1,114
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$667
Oceanview
$727
Balcony
$777
Suite
$1,087
From
US$667
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Fort-de-France
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Visit: Italy, Corsica, France, Spain (+6 more), Saint Martin, Saint Kitts and Nevis, Saint Vincent, Barbados, Grenada, Martinique
Bonus Onboard Credit
Inside
$1,509
Oceanview
$1,859
Balcony
$2,169
Suite
$3,517
From
US$1,509
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Bonus Onboard Credit
Inside
$1,254
Oceanview
$1,373
Balcony
$1,724
Suite
$2,946
From
US$1,254
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$20,065
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Inside
$820
Oceanview
$920
Balcony
$1,100
Suite
-
From
US$820
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 27 October 2026
Visit: Italy, Sicily, Greece, Montenegro
Inside
$419
Oceanview
$489
Balcony
$599
Suite
$1,119
From
US$419
Per Person
View Trip
Results: 1-30 of 61

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