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MSC Cruises from Rome

Start your journey from Rome with 58 unique MSC cruise itineraries to choose from. April and October are the most popular months to begin your cruise from Rome and MSC Cruises have 377 trips departing this season.
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Duration
3 Days
122 Days
Price
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58 Cruises (377 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2026 to Oct 2026
Visit: Italy, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$986
Oceanview
$1,126
Balcony
$1,310
Suite
$2,023
From
US$986
Save 50
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Inside
-
Oceanview
$1,004
Balcony
$1,454
Suite
-
From
US$1,004
Per Person
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France
Inside
-
Oceanview
-
Balcony
$259
Suite
-
From
US$259
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 15 November 2027
Visit: Italy, Spain
Bonus Onboard Credit
Inside
$549
Oceanview
$639
Balcony
$719
Suite
$1,149
From
US$549
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

23 Days (22 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,775
Oceanview
$2,185
Balcony
$2,409
Suite
-
From
US$1,775
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Apr 2027
Visit: Italy, Sicily, Malta, Spain, France
Bonus Onboard Credit
Inside
$1,104
Oceanview
$1,264
Balcony
$1,364
Suite
$2,037
From
US$1,104
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$1,254
Oceanview
$1,464
Balcony
$1,584
Suite
$2,251
From
US$1,254
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2027 to Nov 2027
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$787
Oceanview
$897
Balcony
$987
Suite
$1,477
From
US$787
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rome to Cagliari
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France, Spain, Sardinia
Inside
-
Oceanview
-
Balcony
$879
Suite
-
From
US$879
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
-
Oceanview
-
Balcony
$529
Suite
$1,259
From
US$529
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
$667
Oceanview
$793
Balcony
$874
Suite
$1,671
From
US$667
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
-
Oceanview
$1,132
Balcony
$1,249
Suite
$2,539
From
US$1,132
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departures: Dec 2026 to Dec 2027
Visit: Italy, France, Spain, Morocco
Bonus Onboard Credit
Exclusive Savings
Inside
$2,306
Oceanview
$2,500
Balcony
$1,492
Suite
$2,367
From
US$1,492
Save 63
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France, Spain
Inside
$289
Oceanview
$349
Balcony
$469
Suite
$859
From
US$289
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France
Inside
-
Oceanview
$311
Balcony
$460
Suite
$628
From
US$311
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Sep 2026
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$801
Oceanview
$800
Balcony
$1,020
Suite
$1,814
From
US$800
Per Person
View Trip
12 Day Western Europe with MSC Cruises
Cruise

12 Days (11 Nights) Rome to London
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 May 2027
Visit: Italy, Spain, Portugal, France, England
Bonus Onboard Credit
Inside
$1,184
Oceanview
$1,434
Balcony
$1,714
Suite
$3,515
From
US$1,184
Per Person
View Trip
13 Day MSC World Cruise with MSC Cruises
Cruise

13 Days (12 Nights) Rome to Berlin
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 May 2027
Visit: Italy, France, Spain, Germany
Bonus Onboard Credit
Inside
$1,319
Oceanview
$1,559
Balcony
$1,959
Suite
$3,336
From
US$1,319
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,839
Oceanview
$2,259
Balcony
$2,521
Suite
-
From
US$1,839
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

21 Days (20 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Bonus Onboard Credit
Inside
$1,679
Oceanview
$2,189
Balcony
$2,644
Suite
$4,923
From
US$1,679
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 16 November 2027
Visit: Italy, Spain, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,869
Oceanview
$2,265
Balcony
$2,469
Suite
$3,846
From
US$1,869
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Feb 2026 to Mar 2028
Visit: Italy, Sicily, Malta, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$764
Oceanview
$792
Balcony
$882
Suite
$1,604
From
US$764
Save 52
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain
Bonus Onboard Credit
Inside
$424
Oceanview
$514
Balcony
$577
Suite
$1,087
From
US$424
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$989
Oceanview
$1,159
Balcony
$1,289
Suite
$1,769
From
US$989
Save 56
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Rome to Doha
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus, Egypt, Oman, Qatar
Bonus Onboard Credit
Inside
$1,507
Oceanview
$1,967
Balcony
$2,380
Suite
$4,446
From
US$1,507
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Bridgetown
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Visit: Italy, Corsica, France, Spain (+4 more), Saint Martin, Saint Kitts and Nevis, Saint Vincent, Barbados
Bonus Onboard Credit
Inside
$1,264
Oceanview
$1,554
Balcony
$1,864
Suite
-
From
US$1,264
Per Person
View Trip
36 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

36 Days (35 Nights) Rome to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,646
Oceanview
$3,040
Balcony
$3,717
Suite
-
From
US$2,646
Save 53
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 23 April 2027
Visit: Italy, Greece, Turkey
Inside
$624
Oceanview
$734
Balcony
$854
Suite
-
From
US$624
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$667
Oceanview
$727
Balcony
$777
Suite
$1,087
From
US$667
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2026 to Oct 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Inside
$698
Oceanview
$768
Balcony
$948
Suite
$1,748
From
US$698
Per Person
View Trip
Results: 1-30 of 58

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