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MSC Cruises from Rome

Start your journey from Rome with 40 unique MSC cruise itineraries to choose from. April is the most popular month to begin your cruise from Rome and MSC Cruises have 435 trips departing this season.
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21 Days
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40 Cruises (435 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: Jul 2025 to Oct 2026
Countries Visited: Italy, Spain, France
Escape To SeaDrinks and Wi-Fi Included
INSIDE
$951
OCEANVIEW
$1,121
BALCONY
$1,241
SUITE
$1,953
From (per person) 951
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Nov 2025 to Apr 2027
Countries Visited: Italy, Spain, France
Escape To Sea
INSIDE
$414
OCEANVIEW
$514
BALCONY
$604
SUITE
$1,244
From (per person) 414
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Countries Visited: Italy, Spain, France
Escape To Sea
INSIDE
$634
OCEANVIEW
$694
BALCONY
$764
SUITE
$1,074
From (per person) 634
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Nov 2025 to Apr 2027
Countries Visited: Italy, Sicily, Malta, Spain (+1 more), France
Escape To SeaDrinks and Wi-Fi Included
INSIDE
$707
OCEANVIEW
$813
BALCONY
$925
SUITE
$1,625
From (per person) 707
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Jun 2025 to Nov 2025
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea
INSIDE
$780
OCEANVIEW
$950
BALCONY
$1,130
SUITE
$1,870
From (per person) 780
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

20 Days (19 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 09 November 2026
Countries Visited: Italy, Malta, Greece, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Escape To Sea
INSIDE
$1,499
OCEANVIEW
$1,769
BALCONY
$2,069
SUITE
-
From (per person) 1,499
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Countries Visited: Italy, Spain
Escape To Sea
INSIDE
$521
OCEANVIEW
$611
BALCONY
$691
SUITE
$1,081
From (per person) 521
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 28 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil
Escape To Sea
INSIDE
$1,213
OCEANVIEW
$1,543
BALCONY
$2,005
SUITE
$2,665
From (per person) 1,213
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rome to La Romana
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+4 more), Antigua and Barbuda, Saint Martin, Saint Kitts and Nevis, Dominican Republic
Escape To Sea
INSIDE
$1,189
OCEANVIEW
$1,429
BALCONY
$2,349
SUITE
$3,929
From (per person) 1,189
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ship: MSC World Asia
Departure: 12 April 2027
Countries Visited: Italy, Sicily, Malta, Spain (+1 more), France
Escape To Sea
INSIDE
$1,057
OCEANVIEW
$1,207
BALCONY
$1,277
SUITE
$1,967
From (per person) 1,057
View Trip
9 Day Mediterranean with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Countries Visited: Italy, Spain, Malta, Greece
Escape To Sea
INSIDE
$1,014
OCEANVIEW
$1,110
BALCONY
$1,222
SUITE
$1,718
From (per person) 1,014
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2027 to Nov 2027
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
$759
OCEANVIEW
$889
BALCONY
$989
SUITE
$1,819
From (per person) 759
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Countries Visited: Italy, Sicily, Spain, France
Escape To Sea
INSIDE
$956
OCEANVIEW
$1,146
BALCONY
$1,276
SUITE
$1,756
From (per person) 956
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Countries Visited: Italy, Spain, Portugal
Escape To Sea
INSIDE
$1,020
OCEANVIEW
$1,184
BALCONY
$1,331
SUITE
$2,557
From (per person) 1,020
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 28 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil
Escape To Sea
INSIDE
-
OCEANVIEW
$1,253
BALCONY
$1,627
SUITE
$2,166
From (per person) 1,253
View Trip
6 Day Canary Islands with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rome to Lanzarote
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Countries Visited: Italy, Spain
One Way Cruise Offer
INSIDE
$419
OCEANVIEW
$529
BALCONY
$619
SUITE
$1,689
From (per person) 419
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Fort-de-France
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Countries Visited: Italy, Corsica, France, Spain (+7 more), Saint Martin, Saint Kitts and Nevis, Dominica, Barbados, Grenada, Saint Vincent, Martinique
Escape To Sea
INSIDE
$1,309
OCEANVIEW
$1,669
BALCONY
$2,009
SUITE
$3,399
From (per person) 1,309
View Trip
11 Day Mediterranean with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 10 November 2025
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
$1,078
OCEANVIEW
$1,258
BALCONY
$1,458
SUITE
-
From (per person) 1,078
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Countries Visited: Italy, Spain, Portugal
Escape To Sea
INSIDE
$730
OCEANVIEW
$850
BALCONY
$956
SUITE
$1,661
From (per person) 730
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Countries Visited: Italy, Spain, Portugal, Puerto Rico (+1 more), USA
Escape To Sea
INSIDE
$1,215
OCEANVIEW
$1,485
BALCONY
$1,655
SUITE
$5,855
From (per person) 1,215
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Jul 2025 to Oct 2026
Countries Visited: Italy, Greece, Turkey
Mutiple Deals Available
INSIDE
$987
OCEANVIEW
$1,147
BALCONY
$1,297
SUITE
$1,757
From (per person) 987
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 19 August 2025
Countries Visited: Italy, France, Spain
Escape To SeaDrinks and Wi-Fi Included
INSIDE
$1,343
OCEANVIEW
-
BALCONY
$1,623
SUITE
$2,185
From (per person) 1,343
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 09 November 2025
Countries Visited: Italy, Sicily, Spain, France
One Way Cruise Offer
INSIDE
$508
OCEANVIEW
$618
BALCONY
$768
SUITE
$1,348
From (per person) 508
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Countries Visited: Italy, Spain, France
Escape To Sea
INSIDE
$1,209
OCEANVIEW
$1,419
BALCONY
$1,529
SUITE
$2,259
From (per person) 1,209
View Trip
13 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

13 Days (12 Nights) Rome to Hamburg
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 20 April 2026
Countries Visited: Italy, Spain, Portugal, France (+2 more), England, Germany
Escape To Sea
INSIDE
$1,014
OCEANVIEW
$1,184
BALCONY
$1,344
SUITE
$2,544
From (per person) 1,014
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Oct 2026
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea
INSIDE
$771
OCEANVIEW
$861
BALCONY
$1,031
SUITE
-
From (per person) 771
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2027 to Nov 2027
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea
INSIDE
$787
OCEANVIEW
$897
BALCONY
$987
SUITE
$1,477
From (per person) 787
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Countries Visited: Italy, France, Spain
One Way Cruise Offer
INSIDE
$479
OCEANVIEW
$559
BALCONY
$679
SUITE
$1,099
From (per person) 479
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: Jul 2025 to Oct 2026
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
$768
OCEANVIEW
$924
BALCONY
$1,024
SUITE
$1,517
From (per person) 768
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise

3 Days (2 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: Sep 2025 to Sep 2025
Countries Visited: Italy, France
One Way Cruise Offer
INSIDE
$129
OCEANVIEW
$185
BALCONY
$249
SUITE
-
From (per person) 129
View Trip
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