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MSC Cruises from Rome

Start your journey from Rome with 30 unique MSC cruise itineraries to choose from. April is the most popular month to begin your cruise from Rome and MSC Cruises have 322 trips departing this season.
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4 Days
21 Days
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30 Cruises (322 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: May 2025 to Oct 2026
Countries Visited: Italy, Spain, France
Escape To SeaDrinks and Wi-Fi Included
INSIDE
$793
OCEANVIEW
$963
BALCONY
$1,221
SUITE
$1,686
From (per person) 793
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 09 November 2025
Countries Visited: Italy, Sicily, Spain, France
One Way Cruise Offer
INSIDE
$498
OCEANVIEW
$618
BALCONY
$768
SUITE
$1,348
From (per person) 498
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Fort-de-France
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Countries Visited: Italy, Corsica, France, Spain (+7 more), Saint Martin, Saint Kitts and Nevis, Dominica, Barbados, Grenada, Saint Vincent, Martinique
Escape To Sea
INSIDE
$1,309
OCEANVIEW
$1,669
BALCONY
$2,009
SUITE
$3,399
From (per person) 1,309
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Countries Visited: Italy, Spain, France
Escape To Sea
INSIDE
$634
OCEANVIEW
$694
BALCONY
$764
SUITE
$1,074
From (per person) 634
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Countries Visited: Italy, Sicily, Spain, France
Escape To SeaDrinks and Wi-Fi Included
INSIDE
$956
OCEANVIEW
$1,096
BALCONY
$1,236
SUITE
$1,706
From (per person) 956
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: May 2025 to Nov 2025
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea
INSIDE
$779
OCEANVIEW
$921
BALCONY
$1,087
SUITE
$1,815
From (per person) 779
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Countries Visited: Italy, Spain
Escape To Sea
INSIDE
$549
OCEANVIEW
$639
BALCONY
$719
SUITE
$1,109
From (per person) 549
View Trip
13 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

13 Days (12 Nights) Rome to Hamburg
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 20 April 2026
Countries Visited: Italy, Spain, Portugal, France (+2 more), England, Germany
Escape To Sea
INSIDE
$1,014
OCEANVIEW
$1,184
BALCONY
$1,344
SUITE
$2,544
From (per person) 1,014
View Trip
11 Day Mediterranean with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 10 November 2025
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
$1,088
OCEANVIEW
$1,268
BALCONY
$1,468
SUITE
-
From (per person) 1,088
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 28 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil
Escape To Sea
INSIDE
$1,113
OCEANVIEW
$1,333
BALCONY
$1,833
SUITE
$2,433
From (per person) 1,113
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

20 Days (19 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 09 November 2026
Countries Visited: Italy, Malta, Greece, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Escape To Sea
INSIDE
$1,499
OCEANVIEW
$1,769
BALCONY
$2,069
SUITE
-
From (per person) 1,499
View Trip
21 Day Transatlantic with MSC Cruises
Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 17 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Escape To Sea
INSIDE
-
OCEANVIEW
$1,739
BALCONY
$2,299
SUITE
$3,729
From (per person) 1,739
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Nov 2025 to Apr 2027
Countries Visited: Italy, Spain, France
Escape To Sea
INSIDE
$429
OCEANVIEW
$519
BALCONY
$609
SUITE
$1,249
From (per person) 429
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil (+2 more), Uruguay, Argentina
Escape To Sea
INSIDE
$1,367
OCEANVIEW
$1,477
BALCONY
$1,707
SUITE
$3,237
From (per person) 1,367
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Countries Visited: Italy, France, Spain
One Way Cruise Offer
INSIDE
$479
OCEANVIEW
$559
BALCONY
$679
SUITE
$1,099
From (per person) 479
View Trip
9 Day Mediterranean with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Countries Visited: Italy, Spain, Malta, Greece
Escape To Sea
INSIDE
$1,014
OCEANVIEW
$1,110
BALCONY
$1,222
SUITE
$1,718
From (per person) 1,014
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Oct 2026
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea
INSIDE
$811
OCEANVIEW
$911
BALCONY
$1,071
SUITE
-
From (per person) 811
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Nov 2025 to Apr 2026
Countries Visited: Italy, Sicily, Malta, Spain (+1 more), France
Escape To Sea
INSIDE
$672
OCEANVIEW
$796
BALCONY
$861
SUITE
$1,581
From (per person) 672
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departures: Dec 2025 to Dec 2025
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
$1,134
OCEANVIEW
$1,264
BALCONY
$1,414
SUITE
$2,344
From (per person) 1,134
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Kusadasi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 24 April 2026
Countries Visited: Italy, Greece, Turkey
One Way Cruise Offer
INSIDE
$299
OCEANVIEW
-
BALCONY
$459
SUITE
$1,109
From (per person) 299
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Sicily, Spain, France
Escape To Sea
INSIDE
$801
OCEANVIEW
$971
BALCONY
$1,155
SUITE
$1,865
From (per person) 801
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Escape To Sea
INSIDE
$1,121
OCEANVIEW
-
BALCONY
-
SUITE
-
From (per person) 1,121
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 24 April 2026
Countries Visited: Italy, Greece, Turkey
Escape To Sea
INSIDE
$1,010
OCEANVIEW
$1,156
BALCONY
$1,268
SUITE
$1,637
From (per person) 1,010
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 19 August 2025
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
-
OCEANVIEW
-
BALCONY
$1,340
SUITE
$1,902
From (per person) 1,340
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 10 October 2025
Countries Visited: Italy, Greece, Turkey
Escape To Sea
INSIDE
-
OCEANVIEW
$1,149
BALCONY
$1,349
SUITE
$1,909
From (per person) 1,149
View Trip
14 Day Western Europe with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Copenhagen
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 02 May 2026
Countries Visited: Italy, France, Spain, Morocco (+1 more), Denmark
Escape To Sea
INSIDE
$1,299
OCEANVIEW
$1,579
BALCONY
$1,949
SUITE
-
From (per person) 1,299
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: May 2025 to Oct 2026
Countries Visited: Italy, Greece, Turkey
Escape To Sea
INSIDE
$822
OCEANVIEW
$992
BALCONY
$1,098
SUITE
$1,709
From (per person) 822
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 28 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil
Escape To Sea
INSIDE
$919
OCEANVIEW
$1,039
BALCONY
$1,489
SUITE
$1,979
From (per person) 919
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Countries Visited: Italy, France
Escape To Sea
INSIDE
$256
OCEANVIEW
$306
BALCONY
$366
SUITE
$676
From (per person) 256
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: May 2025 to Oct 2026
Countries Visited: Italy, France, Spain
Escape To Sea
INSIDE
$696
OCEANVIEW
$924
BALCONY
$976
SUITE
$1,373
From (per person) 696
View Trip
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