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MSC Cruises from Rome

Start your journey from Rome with 57 unique MSC cruise itineraries to choose from. October is the most popular month to begin your cruise from Rome and MSC Cruises have 403 trips departing this season.
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3 Days
122 Days
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57 Cruises (403 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2026 to Oct 2026
Visit: Italy, Spain, France
Inside
$921
Oceanview
$1,091
Balcony
$1,241
Suite
$1,927
From
US$921
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rome to Cagliari
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Oct 2026
Visit: Italy, France, Spain, Sardinia
Inside
$599
Oceanview
$639
Balcony
$869
Suite
-
From
US$599
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 28 November 2025
Visit: Italy, Spain, Morocco, Brazil
Inside
-
Oceanview
$1,543
Balcony
-
Suite
-
From
US$1,543
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Apr 2027
Visit: Italy, Sicily, Malta, Spain, France
Inside
$834
Oceanview
$1,217
Balcony
$1,307
Suite
$1,972
From
US$834
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 October 2026
Visit: Italy, France, Spain, Morocco, Brazil
Inside
$831
Oceanview
$971
Balcony
$1,351
Suite
-
From
US$831
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 October 2026
Visit: Italy, France, Spain, Morocco, Brazil
Inside
$1,035
Oceanview
$1,195
Balcony
$1,635
Suite
-
From
US$1,035
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2027 to Nov 2027
Visit: Italy, France, Spain
Inside
$754
Oceanview
$884
Balcony
$984
Suite
$1,814
From
US$754
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
$369
Oceanview
$459
Balcony
$529
Suite
$819
From
US$369
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Kusadasi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Apr 2027
Visit: Italy, Greece, Turkey
Inside
$289
Oceanview
$369
Balcony
$419
Suite
$1,099
From
US$289
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 October 2026
Visit: Italy, France, Spain, Morocco, Brazil
Inside
$963
Oceanview
$1,113
Balcony
$1,523
Suite
-
From
US$963
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Fort-de-France
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Visit: Italy, Corsica, France, Spain (+7 more), Saint Martin, Saint Kitts and Nevis, Dominica, Barbados, Grenada, Saint Vincent, Martinique
Inside
$1,414
Oceanview
$1,673
Balcony
$2,105
Suite
$3,400
From
US$1,414
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Visit: Italy, France
Inside
$168
Oceanview
$191
Balcony
$291
Suite
$571
From
US$168
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain
Inside
$521
Oceanview
$621
Balcony
$711
Suite
$1,131
From
US$521
Per Person
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Poesia
Departures: Apr 2026 to Oct 2026
Visit: Italy, France
Inside
$110
Oceanview
$167
Balcony
$224
Suite
$579
From
US$110
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain, Malta, Greece
Inside
$1,014
Oceanview
$1,110
Balcony
$1,222
Suite
$1,718
From
US$1,014
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 09 November 2026
Visit: Italy, Malta, Greece, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Inside
$1,559
Oceanview
$1,769
Balcony
$2,069
Suite
-
From
US$1,559
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Visit: Italy, Spain, France
Inside
$674
Oceanview
$735
Balcony
$770
Suite
$1,083
From
US$674
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Inside
$940
Oceanview
$1,140
Balcony
$1,360
Suite
$2,243
From
US$940
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 10 November 2025
Visit: Italy, France, Spain
Inside
$370
Oceanview
$445
Balcony
$605
Suite
$1,115
From
US$370
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Inside
-
Oceanview
$919
Balcony
$1,229
Suite
-
From
US$919
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

19 Days (18 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 November 2025
Visit: Italy, Spain, Morocco, Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,972
From
US$5,972
Save 168
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Oct 2027
Visit: Italy, Greece, Turkey
Inside
$938
Oceanview
$1,108
Balcony
$1,248
Suite
$1,708
From
US$938
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Visit: Italy, Spain, France
Inside
$1,197
Oceanview
$1,407
Balcony
$1,517
Suite
$2,186
From
US$1,197
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2026 to Oct 2026
Visit: Italy, France, Spain
Inside
$794
Oceanview
$914
Balcony
$1,044
Suite
$1,824
From
US$794
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Bridgetown
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 15 November 2026
Visit: Italy, Corsica, France, Spain (+4 more), Saint Martin, Saint Kitts and Nevis, Dominica, Barbados
Inside
$1,209
Oceanview
$1,500
Balcony
$1,792
Suite
-
From
US$1,209
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$730
Oceanview
$850
Balcony
$956
Suite
$1,661
From
US$730
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 10 November 2025
Visit: Italy, France, Spain
Inside
$358
Oceanview
$498
Balcony
$718
Suite
$1,308
From
US$358
Per Person
View Trip
12 Day Western Europe with MSC Cruises
Cruise

12 Days (11 Nights) Rome to London
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 May 2027
Visit: Italy, Spain, Portugal, France, England
Inside
$1,247
Oceanview
$1,507
Balcony
$1,767
Suite
$3,566
From
US$1,247
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 10 November 2025
Visit: Italy, France, Spain
Inside
$942
Oceanview
$1,162
Balcony
$1,522
Suite
$2,483
From
US$942
Per Person
View Trip
36 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

36 Days (35 Nights) Rome to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
-
Oceanview
$3,557
Balcony
$4,680
Suite
-
From
US$3,557
Save 82
Per Person
View Trip
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