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MSC Cruises from Rome

Start your journey from Rome with 54 unique MSC cruise itineraries to choose from. October is the most popular month to begin your cruise from Rome and MSC Cruises have 353 trips departing this season.
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Duration
4 Days
122 Days
Price
$200pp
$19,709pp
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54 Cruises (353 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2026 to Oct 2026
Visit: Italy, Spain, France
Inside
$903
Oceanview
$1,115
Balcony
$1,305
Suite
$2,045
From
US$903
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 19 April 2026
Visit: Italy, Spain, France
Inside
-
Oceanview
-
Balcony
$758
Suite
-
From
US$758
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$888
Oceanview
$1,131
Balcony
$1,346
Suite
-
From
US$888
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain, Malta, Greece
Inside
$527
Oceanview
$657
Balcony
$767
Suite
$1,277
From
US$527
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 25 December 2026
Visit: Italy, France, Spain
Inside
$2,262
Oceanview
$2,432
Balcony
$2,632
Suite
$6,259
From
US$2,262
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Sep 2026
Visit: Italy, France, Spain, Sardinia
Inside
$1,071
Oceanview
$934
Balcony
$947
Suite
$1,887
From
US$934
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Inside
$1,220
Oceanview
$1,419
Balcony
$1,704
Suite
$2,905
From
US$1,220
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
$339
Oceanview
$429
Balcony
$519
Suite
$1,259
From
US$339
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 27 October 2026
Visit: Italy, Sicily, Greece, Montenegro
Inside
-
Oceanview
-
Balcony
$649
Suite
$1,119
From
US$649
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$952
Oceanview
$1,267
Balcony
$1,505
Suite
$6,734
From
US$952
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 07 May 2027
Visit: Italy, France, Spain, Morocco, Gibraltar
Inside
$1,642
Oceanview
$1,842
Balcony
$2,512
Suite
$2,732
From
US$1,642
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

21 Days (20 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Inside
$1,849
Oceanview
$2,189
Balcony
$2,709
Suite
$5,059
From
US$1,849
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departures: Nov 2027 to Dec 2027
Visit: Italy, France, Spain, Morocco
Inside
$1,029
Oceanview
$1,229
Balcony
$1,409
Suite
$2,469
From
US$1,029
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,487
Oceanview
$1,807
Balcony
$2,137
Suite
$3,487
From
US$1,487
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2026 to Oct 2026
Visit: Italy, France, Spain
Inside
$763
Oceanview
$838
Balcony
$1,078
Suite
$1,778
From
US$763
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain
Inside
$379
Oceanview
$479
Balcony
$559
Suite
$849
From
US$379
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rome to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Apr 2027
Visit: Italy, Greece, Turkey
Drinks & WiFi Package
Inside
$624
Oceanview
$712
Balcony
$852
Suite
$1,680
From
US$624
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Berlin
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 14 May 2026
Visit: Italy, France, Spain, Germany
Inside
-
Oceanview
$1,590
Balcony
$2,110
Suite
-
From
US$1,590
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 15 November 2027
Visit: Italy, Spain
Inside
$549
Oceanview
$639
Balcony
$719
Suite
$1,149
From
US$549
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Italy, Sicily, Spain, France
Inside
$761
Oceanview
$861
Balcony
$1,041
Suite
-
From
US$761
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$761
Oceanview
$940
Balcony
$1,173
Suite
$2,349
From
US$761
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Inside
$1,083
Oceanview
$1,244
Balcony
$1,449
Suite
$2,408
From
US$1,083
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Rome to Doha
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus, Egypt, Oman, Qatar
Inside
$1,667
Oceanview
$1,967
Balcony
$2,437
Suite
$4,567
From
US$1,667
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Lirica, MSC Sinfonia
Departures: Nov 2026 to Mar 2028
Visit: Italy, Spain, France
Inside
$580
Oceanview
$716
Balcony
$1,036
Suite
$1,316
From
US$580
Per Person
View Trip
116 Day MSC World Cruise with MSC Cruises
Cruise

116 Days (115 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2028
Visit: Italy, France, Spain, Turks and Caicos Islands (+24 more), Bahamas, Mexico, Costa Rica, Panama, Ecuador, Peru, Chile, French Polynesia, Tonga, New Caledonia, New Zealand, Australia, Indonesia, Vietnam, Thailand, Cambodia, Singapore, Malaysia, Sri Lanka, India, United Arab Emirates, Oman, Jordan, Egypt
Inside
$19,709
Oceanview
$21,609
Balcony
$30,399
Suite
-
From
US$19,709
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Inside
$1,659
Oceanview
$2,139
Balcony
$2,959
Suite
-
From
US$1,659
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 14 October 2027
Visit: Italy, France, Sardinia
Inside
$632
Oceanview
$712
Balcony
$980
Suite
$1,068
From
US$632
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

23 Days (22 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Inside
$1,605
Oceanview
$2,045
Balcony
$2,835
Suite
-
From
US$1,605
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,454
Oceanview
$1,724
Balcony
$2,004
Suite
$3,284
From
US$1,454
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Visit: Italy, Spain, France
Inside
$1,254
Oceanview
$1,464
Balcony
$1,584
Suite
$2,314
From
US$1,254
Per Person
View Trip
Results: 1-30 of 54

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