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MSC Cruises from Rome

Start your journey from Rome with 60 unique MSC cruise itineraries to choose from. April and October are the most popular months to begin your cruise from Rome and MSC Cruises have 347 trips departing this season.
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Duration
3 Days
122 Days
Price
$100pp
$19,709pp
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60 Cruises (347 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2026 to Oct 2026
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$942
Oceanview
$1,122
Balcony
$1,260
Suite
$1,975
From
US$942
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal, Saint Martin, Bahamas, USA
Inside
-
Oceanview
-
Balcony
$1,454
Suite
-
From
US$1,454
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (3)

7 Days (6 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 09 February 2026
Visit: Italy, Sicily, Malta, Spain, France
Inside
-
Oceanview
-
Balcony
$879
Suite
-
From
US$879
Per Person
View Trip
19 Day Mediterranean with MSC Cruises
Cruise

19 Days (18 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 03 November 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,289
Oceanview
$1,959
Balcony
$2,914
Suite
$3,622
From
US$1,289
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Jan 2026 to Apr 2027
Visit: Italy, Sicily, Malta, Spain, France
Bonus Onboard Credit
Inside
$637
Oceanview
$976
Balcony
$791
Suite
$1,370
From
US$637
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Bonus Onboard Credit
Inside
$1,251
Oceanview
$1,515
Balcony
$1,830
Suite
$3,033
From
US$1,251
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Inside
$979
Oceanview
$1,139
Balcony
$1,269
Suite
$1,749
From
US$979
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France, Spain
Inside
$299
Oceanview
$359
Balcony
$469
Suite
$859
From
US$299
Per Person
View Trip
36 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

36 Days (35 Nights) Rome to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$3,121
Oceanview
$3,587
Balcony
$4,363
Suite
-
From
US$3,121
Save 68
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Berlin
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 14 May 2026
Visit: Italy, France, Spain, Germany
Bonus Onboard Credit
Inside
-
Oceanview
$1,590
Balcony
$1,980
Suite
-
From
US$1,590
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
$369
Oceanview
-
Balcony
$529
Suite
$1,259
From
US$369
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Apr 2027 to Oct 2027
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$1,234
Oceanview
$1,444
Balcony
$1,554
Suite
$2,221
From
US$1,234
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 03 November 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,359
Oceanview
-
Balcony
-
Suite
-
From
US$1,359
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Kusadasi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Apr 2027
Visit: Italy, Greece, Turkey
Inside
$269
Oceanview
$339
Balcony
$409
Suite
$1,099
From
US$269
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Sep 2026
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$777
Oceanview
$887
Balcony
$1,057
Suite
-
From
US$777
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,094
Oceanview
$1,324
Balcony
$1,564
Suite
$2,683
From
US$1,094
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Sinfonia
Departures: Jan 2026 to Apr 2027
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$557
Oceanview
$636
Balcony
$821
Suite
$1,276
From
US$557
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 27 October 2026
Visit: Italy, Sicily, Greece, Montenegro
Inside
$379
Oceanview
$489
Balcony
$599
Suite
$1,119
From
US$379
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2026 to Oct 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Inside
$752
Oceanview
$834
Balcony
$944
Suite
$1,774
From
US$752
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Apr 2027
Visit: Italy, Sicily, Malta, Spain, France
Bonus Onboard Credit
Inside
$1,084
Oceanview
$1,244
Balcony
$1,334
Suite
$2,008
From
US$1,084
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
$946
Oceanview
$1,108
Balcony
$1,225
Suite
$2,516
From
US$946
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,454
Oceanview
$1,724
Balcony
$2,004
Suite
$3,199
From
US$1,454
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 15 November 2027
Visit: Italy, Spain
Bonus Onboard Credit
Inside
$569
Oceanview
$659
Balcony
$719
Suite
$1,169
From
US$569
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 09 November 2026
Visit: Italy, Malta, Greece, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,187
Suite
-
From
US$2,187
Save 52
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain
Bonus Onboard Credit
Inside
$448
Oceanview
$538
Balcony
$619
Suite
$1,111
From
US$448
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Inside
$800
Oceanview
$900
Balcony
$1,070
Suite
-
From
US$800
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

21 Days (20 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Bonus Onboard Credit
Inside
$1,679
Oceanview
$2,189
Balcony
$2,644
Suite
$4,923
From
US$1,679
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 22 October 2027
Visit: Italy, Greece, Turkey, France, Spain, Brazil
Bonus Onboard Credit
Inside
$2,169
Oceanview
$2,464
Balcony
$2,882
Suite
$4,705
From
US$2,169
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$667
Oceanview
$727
Balcony
$767
Suite
$1,077
From
US$667
Per Person
View Trip
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