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MSC Cruises from Rome

Start your journey from Rome with 57 unique MSC cruise itineraries to choose from. October is the most popular month to begin your cruise from Rome and MSC Cruises have 369 trips departing this season.
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3 Days
122 Days
Price
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57 Cruises (369 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: May 2026 to Oct 2026
Visit: Italy, Spain, France
Inside
$962
Oceanview
$1,115
Balcony
$1,305
Suite
$2,057
From
US$962
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 08 April 2027
Visit: Italy, Spain, France
Inside
$731
Oceanview
$881
Balcony
$1,131
Suite
$1,331
From
US$731
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,144
Oceanview
$1,324
Balcony
$1,564
Suite
$2,683
From
US$1,144
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Inside
$1,144
Oceanview
$1,373
Balcony
$1,704
Suite
$2,946
From
US$1,144
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

21 Days (20 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus (+4 more), Egypt, Oman, Qatar, United Arab Emirates
Inside
$1,679
Oceanview
$2,189
Balcony
$2,644
Suite
$4,923
From
US$1,679
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Kusadasi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Apr 2027
Visit: Italy, Greece, Turkey
Inside
$249
Oceanview
$359
Balcony
$419
Suite
$1,099
From
US$249
Per Person
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France
Inside
-
Oceanview
$189
Balcony
$289
Suite
-
From
US$189
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France, Spain
Inside
-
Oceanview
$349
Balcony
$509
Suite
$859
From
US$349
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain, Malta, Greece
Inside
$712
Oceanview
$842
Balcony
$952
Suite
$1,462
From
US$712
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departures: Nov 2027 to Dec 2027
Visit: Italy, France, Spain, Morocco
Inside
$1,029
Oceanview
$1,229
Balcony
$1,409
Suite
$2,403
From
US$1,029
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Visit: Italy, Spain, France
Inside
$514
Oceanview
$594
Balcony
$664
Suite
$894
From
US$514
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

19 Days (18 Nights) Rome to Doha
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 21 November 2027
Visit: Italy, Greece, Turkey, Cyprus, Egypt, Oman, Qatar
Inside
$1,667
Oceanview
$1,967
Balcony
$2,380
Suite
$4,446
From
US$1,667
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Apr 2026 to Apr 2027
Visit: Italy, Sicily, Malta, Spain, France
Inside
$1,104
Oceanview
$1,264
Balcony
$1,364
Suite
$2,037
From
US$1,104
Per Person
View Trip
12 Day Western Europe with MSC Cruises
Cruise

12 Days (11 Nights) Rome to London
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 May 2027
Visit: Italy, Spain, Portugal, France, England
Inside
$1,184
Oceanview
$1,434
Balcony
$1,714
Suite
$3,515
From
US$1,184
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rome to La Romana
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France, Spain, Morocco (+4 more), Antigua and Barbuda, Saint Martin, Saint Kitts and Nevis, Dominican Republic
Inside
$1,146
Oceanview
$1,630
Balcony
$2,451
Suite
$3,961
From
US$1,146
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Inside
$1,160
Oceanview
$1,369
Balcony
$1,674
Suite
$2,832
From
US$1,160
Per Person
View Trip
11 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Lanzarote
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$783
Oceanview
$908
Balcony
$1,120
Suite
$3,577
From
US$783
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$761
Oceanview
$940
Balcony
$1,146
Suite
$2,539
From
US$761
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 25 December 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,202
Oceanview
$2,367
Balcony
$2,561
Suite
$6,079
From
US$2,202
Save 60
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Italy, Sicily, Spain, France
Exclusive Savings
Inside
$1,019
Oceanview
$1,149
Balcony
$1,300
Suite
$1,769
From
US$1,019
Save 56
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
$339
Oceanview
$429
Balcony
$519
Suite
$1,259
From
US$339
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France
Inside
-
Oceanview
-
Balcony
$460
Suite
$628
From
US$460
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain
Inside
$379
Oceanview
$479
Balcony
$559
Suite
$849
From
US$379
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Sep 2026
Visit: Italy, France, Spain, Sardinia
Inside
$861
Oceanview
$850
Balcony
$1,080
Suite
$1,811
From
US$850
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 15 November 2027
Visit: Italy, Spain
Inside
$549
Oceanview
$639
Balcony
$719
Suite
$1,149
From
US$549
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Inside
$996
Oceanview
$1,267
Balcony
$1,505
Suite
$6,545
From
US$996
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Rome to Bari
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 27 October 2026
Visit: Italy, Sicily, Greece, Montenegro
Inside
-
Oceanview
$539
Balcony
$689
Suite
$1,119
From
US$539
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Inside
$1,487
Oceanview
$1,807
Balcony
$2,137
Suite
$3,398
From
US$1,487
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
Exclusive Savings
Inside
$16,622
Oceanview
$19,493
Balcony
$28,272
Suite
-
From
US$16,622
Save 427
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Mar 2026 to Mar 2028
Visit: Italy, Sicily, Malta, Spain, France
Exclusive Savings
Inside
$836
Oceanview
$996
Balcony
$1,096
Suite
$1,826
From
US$836
Save 52
Per Person
View Trip
Results: 1-30 of 57

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