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MSC Cruises from Palermo

Start your journey from Palermo with 11 unique MSC cruise itineraries to choose from. October is the most popular month to begin your cruise from Palermo and MSC Cruises have 225 trips departing this season.
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5 Days
27 Days
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11 Cruises (225 Cruise Departures)
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Palermo to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 12 November 2027
Visit: Sicily, Italy, France, Spain, Brazil
Drinks & WiFi Package
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,335
From
US$8,335
Save 240
Per Person
View Trip
27 Day Mediterranean with MSC Cruises
Cruise

27 Days (26 Nights) Palermo to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain (+4 more), Gibraltar, Morocco, Portugal, USA
Inside
$2,242
Oceanview
-
Balcony
-
Suite
-
From
US$2,242
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Sicily, Spain, France, Italy
Inside
$1,000
Oceanview
$1,110
Balcony
$1,240
Suite
$1,690
From
US$1,000
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Inside
$2,021
Oceanview
$2,279
Balcony
$2,531
Suite
$4,122
From
US$2,021
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Palermo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain
Inside
-
Oceanview
-
Balcony
$559
Suite
-
From
US$559
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: May 2026 to Nov 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
$825
Oceanview
$1,078
Balcony
$1,045
Suite
$1,675
From
US$825
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Jan 2028
Visit: Sicily, Malta, Spain, France, Italy
Inside
$791
Oceanview
$951
Balcony
$1,081
Suite
$1,601
From
US$791
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 29 April 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Inside
-
Oceanview
-
Balcony
$1,499
Suite
$1,819
From
US$1,499
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Sicily, Spain, France, Italy
Inside
$820
Oceanview
$920
Balcony
$1,100
Suite
-
From
US$820
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Euribia, MSC Splendida
Departures: Mar 2026 to Mar 2028
Visit: Sicily, Tunisia, Spain, France, Italy
Inside
$721
Oceanview
$946
Balcony
$916
Suite
$1,526
From
US$721
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Meraviglia, MSC Virtuosa
Departures: May 2026 to Nov 2027
Visit: Sicily, Italy, France, Spain, Tunisia
Inside
$796
Oceanview
$966
Balcony
$1,126
Suite
$2,314
From
US$796
Per Person
View Trip
Results: 11 results

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