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MSC Cruises from Palermo

Start your journey from Palermo with 10 unique MSC cruise itineraries to choose from. October is the most popular month to begin your cruise from Palermo and MSC Cruises have 195 trips departing this season.
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8 Days
27 Days
Price
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10 Cruises (195 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Sicily, Spain, France, Italy
Bonus Onboard Credit
Inside
$800
Oceanview
$900
Balcony
$1,070
Suite
-
From
US$800
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Palermo to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 12 November 2026
Visit: Sicily, Malta, Spain, Gibraltar (+4 more), Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,911
Oceanview
$2,318
Balcony
$2,531
Suite
$4,122
From
US$1,911
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Palermo to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 12 November 2027
Visit: Sicily, Italy, France, Spain, Brazil
Drinks, WiFi & Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,379
From
US$8,379
Save 240
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Apr 2027 to Oct 2027
Visit: Sicily, Malta, Spain, France, Italy
Bonus Onboard Credit
Inside
$1,020
Oceanview
$1,160
Balcony
$1,290
Suite
$1,800
From
US$1,020
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: May 2026 to Nov 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Bonus Onboard Credit
Inside
$865
Oceanview
$975
Balcony
$1,065
Suite
$1,675
From
US$865
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Sicily, Spain, France, Italy
Bonus Onboard Credit
Inside
$927
Oceanview
$1,057
Balcony
$1,187
Suite
$1,667
From
US$927
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Meraviglia, MSC Virtuosa
Departures: May 2026 to Nov 2027
Visit: Sicily, Italy, France, Spain, Tunisia
Bonus Onboard Credit
Inside
$912
Oceanview
$1,022
Balcony
$1,182
Suite
$2,208
From
US$912
Per Person
View Trip
27 Day Mediterranean with MSC Cruises
Cruise

27 Days (26 Nights) Palermo to Miami
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 16 October 2026
Visit: Sicily, Italy, France, Spain (+4 more), Gibraltar, Morocco, Portugal, USA
Bonus Onboard Credit
Inside
$2,109
Oceanview
$2,436
Balcony
$2,785
Suite
$7,082
From
US$2,109
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ships: MSC Euribia, MSC Splendida
Departures: Feb 2026 to Mar 2027
Visit: Sicily, Tunisia, Spain, France, Italy
Bonus Onboard Credit
Inside
$625
Oceanview
$856
Balcony
$793
Suite
$1,403
From
US$625
Per Person
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Palermo to Palermo
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 29 April 2026
Visit: Sicily, Malta, Spain, France, Italy, Sardinia
Bonus Onboard Credit
Inside
$1,039
Oceanview
$1,179
Balcony
$1,239
Suite
$1,819
From
US$1,039
Per Person
View Trip
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