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MSC Cruises from Orlando

Start your journey from Orlando with 58 unique MSC cruise itineraries to choose from. January is the most popular month to begin your cruise from Orlando and MSC Cruises have 281 trips departing this season.
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15 Days
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58 Cruises (281 Cruise Departures)
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 January 2026
Countries Visited: USA, Turks and Caicos Islands, Bahamas
Escape To Sea
INSIDE
$399
OCEANVIEW
$476
BALCONY
$599
SUITE
$1,159
From (per person) 399
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Apr 2027
Countries Visited: USA, Bahamas, Dominican Republic
Escape To Sea
INSIDE
$485
OCEANVIEW
$585
BALCONY
$735
SUITE
$1,395
From (per person) 485
View Trip
7 Day Caribbean And Antilles with MSC Cruises
Cruise

7 Days (6 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 January 2026
Countries Visited: USA, Bahamas, Dominican Republic
Escape To Sea
INSIDE
$419
OCEANVIEW
$529
BALCONY
$649
SUITE
$1,299
From (per person) 419
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 January 2026
Countries Visited: USA, Bahamas
Escape To Sea
INSIDE
$288
OCEANVIEW
$352
BALCONY
$422
SUITE
$742
From (per person) 288
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 22 November 2026
Countries Visited: USA, Bahamas, Jamaica, Cayman Islands
Escape To Sea
INSIDE
$876
OCEANVIEW
$1,066
BALCONY
$1,286
SUITE
$2,026
From (per person) 876
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Jan 2026 to Jan 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic
Escape To Sea
INSIDE
$439
OCEANVIEW
$549
BALCONY
$709
SUITE
$1,469
From (per person) 439
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2026 to Oct 2026
Countries Visited: USA, Bahamas, Mexico
Escape To Sea
INSIDE
$778
OCEANVIEW
$958
BALCONY
$1,098
SUITE
$1,928
From (per person) 778
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2026 to Dec 2026
Countries Visited: USA, Bahamas, Jamaica, Cayman Islands
Escape To Sea
INSIDE
$620
OCEANVIEW
$730
BALCONY
$880
SUITE
$1,400
From (per person) 620
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Dominican Republic
Escape To Sea
INSIDE
$1,123
OCEANVIEW
$1,323
BALCONY
$1,643
SUITE
$4,431
From (per person) 1,123
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Apr 2027
Countries Visited: USA, Bahamas, Dominican Republic, Mexico
Escape To Sea
INSIDE
$1,028
OCEANVIEW
$1,228
BALCONY
$1,528
SUITE
$2,848
From (per person) 1,028
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Countries Visited: USA, Mexico, Belize, Bahamas
Escape To Sea
INSIDE
$699
OCEANVIEW
$809
BALCONY
$939
SUITE
$3,157
From (per person) 699
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Sep 2025
Countries Visited: USA, Bahamas
Escape To Sea
INSIDE
$332
OCEANVIEW
$392
BALCONY
$452
SUITE
$832
From (per person) 332
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 December 2025
Countries Visited: USA, Bahamas, Jamaica
Escape To Sea
INSIDE
$719
OCEANVIEW
$826
BALCONY
$996
SUITE
$1,893
From (per person) 719
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 18 December 2025
Countries Visited: USA, Bahamas, Jamaica
Escape To Sea
INSIDE
$1,199
OCEANVIEW
$1,399
BALCONY
$1,629
SUITE
$2,789
From (per person) 1,199
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: May 2026 to Oct 2026
Countries Visited: USA, Bahamas, Mexico
Escape To Sea
INSIDE
$788
OCEANVIEW
$978
BALCONY
$1,128
SUITE
$2,038
From (per person) 788
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Aug 2025 to Oct 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Escape To Sea
INSIDE
$1,097
OCEANVIEW
$905
BALCONY
$1,075
SUITE
$3,121
From (per person) 905
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 09 October 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Escape To Sea
INSIDE
$753
OCEANVIEW
$923
BALCONY
$1,073
SUITE
$2,580
From (per person) 753
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2026 to Oct 2026
Countries Visited: USA, Bahamas, Mexico
Escape To Sea
INSIDE
$522
OCEANVIEW
$642
BALCONY
$732
SUITE
$1,302
From (per person) 522
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Apr 2027
Countries Visited: USA, Bahamas, Mexico, Dominican Republic
Escape To Sea
INSIDE
$1,078
OCEANVIEW
$1,278
BALCONY
$1,578
SUITE
$2,898
From (per person) 1,078
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 23 November 2025
Countries Visited: USA, Puerto Rico, Bahamas
Escape To Sea
INSIDE
$618
OCEANVIEW
$725
BALCONY
$895
SUITE
$1,985
From (per person) 618
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 February 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+2 more), Cayman Islands, Jamaica
Escape To Sea
INSIDE
$1,134
OCEANVIEW
$1,414
BALCONY
$1,654
SUITE
$6,248
From (per person) 1,134
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 31 January 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic (+3 more), Mexico, Cayman Islands, Jamaica
Escape To Sea
INSIDE
$1,082
OCEANVIEW
$1,282
BALCONY
$1,602
SUITE
$3,762
From (per person) 1,082
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 09 January 2026
Countries Visited: USA, Mexico, Belize, Honduras
Escape To Sea
INSIDE
$498
OCEANVIEW
$605
BALCONY
$775
SUITE
$1,553
From (per person) 498
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 28 December 2025
Countries Visited: USA, Bahamas, Mexico
Escape To Sea
INSIDE
$1,023
OCEANVIEW
-
BALCONY
$1,163
SUITE
-
From (per person) 1,023
View Trip
5 Day Bahamas with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 01 February 2026
Countries Visited: USA, Bahamas
Escape To Sea
INSIDE
$302
OCEANVIEW
$382
BALCONY
$442
SUITE
$772
From (per person) 302
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Oct 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Escape To Sea
INSIDE
$777
OCEANVIEW
$612
BALCONY
$722
SUITE
$1,469
From (per person) 612
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 27 December 2026
Countries Visited: USA, Dominican Republic, Bahamas
Escape To Sea
INSIDE
$1,100
OCEANVIEW
$1,210
BALCONY
$1,360
SUITE
$1,880
From (per person) 1,100
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Countries Visited: USA, Mexico, Belize, Bahamas (+1 more), Dominican Republic
Escape To Sea
INSIDE
$1,330
OCEANVIEW
$1,510
BALCONY
$1,770
SUITE
$4,450
From (per person) 1,330
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 13 December 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Puerto Rico
Escape To Sea
INSIDE
$1,144
OCEANVIEW
$1,371
BALCONY
$1,701
SUITE
$4,284
From (per person) 1,144
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Sep 2025 to Sep 2025
Countries Visited: USA, Bahamas, Mexico
Escape To Sea
INSIDE
$784
OCEANVIEW
$878
BALCONY
$1,048
SUITE
$2,574
From (per person) 784
View Trip
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