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MSC Cruises from Orlando

Start your journey from Orlando with 51 unique MSC cruise itineraries to choose from. December and February are the most popular months to begin your cruise from Orlando and MSC Cruises have 232 trips departing this season.
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15 Days
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51 Cruises (232 Cruise Departures)
12 Day Caribbean And Antilles with MSC Cruises
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Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2024 to May 2025
Countries Visited: USA, Bahamas, Mexico
Early Booking OfferSave And Sail Offer
INSIDE
$1,594
OCEANVIEW
$1,866
BALCONY
$2,273
SUITE
$3,398
From 1,594
View Trip
12 Day Caribbean And Antilles with MSC Cruises
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Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Aug 2024 to Oct 2024
Countries Visited: USA, Bahamas, Mexico
Last Minute OfferEarly Booking with Easy Plus Drinks
INSIDE
$1,335
OCEANVIEW
$1,665
BALCONY
$2,111
SUITE
$3,023
From 1,335
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Dec 2024 to Feb 2025
Countries Visited: USA, Bahamas, Mexico
Save And Sail Offer
INSIDE
$1,332
OCEANVIEW
$1,526
BALCONY
$1,788
SUITE
$2,526
From 1,332
View Trip
12 Day Caribbean And Antilles with MSC Cruises
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Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Save And Sail Offer
INSIDE
$2,069
OCEANVIEW
$2,341
BALCONY
$2,748
SUITE
$3,874
From 2,069
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 December 2025
Countries Visited: USA, Bahamas, Jamaica
Early Booking Offer
INSIDE
$1,469
OCEANVIEW
$1,663
BALCONY
$1,916
SUITE
$2,614
From 1,469
View Trip
15 Day Caribbean And Antilles with MSC Cruises
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Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+2 more), Cayman Islands, Jamaica
Early Booking Offer
INSIDE
$2,266
OCEANVIEW
$2,557
BALCONY
$3,042
SUITE
$5,991
From 2,266
View Trip
12 Day Caribbean And Antilles with MSC Cruises
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Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Oct 2025
Countries Visited: USA, Bahamas, Mexico
Early Booking Offer
INSIDE
$2,320
OCEANVIEW
$2,592
BALCONY
$2,922
SUITE
$4,833
From 2,320
View Trip
9 Day Caribbean And Antilles with MSC Cruises
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Cruise

9 Days (8 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 27 December 2025
Countries Visited: USA, Bahamas, Mexico, Cayman Islands (+1 more), Jamaica
Early Booking Offer
INSIDE
$2,086
OCEANVIEW
$2,251
BALCONY
$2,425
SUITE
$3,570
From 2,086
View Trip
6 Day Caribbean And Antilles with MSC Cruises
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Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 28 December 2025
Countries Visited: USA, Bahamas, Mexico
Early Booking Offer
INSIDE
$1,237
OCEANVIEW
$1,373
BALCONY
$1,508
SUITE
$2,013
From 1,237
View Trip
15 Day Caribbean And Antilles with MSC Cruises
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Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Dominican Republic
Early Booking Offer
INSIDE
$2,266
OCEANVIEW
$2,557
BALCONY
$3,042
SUITE
$6,941
From 2,266
View Trip
11 Day Caribbean And Antilles with MSC Cruises
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Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Jul 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Early Booking Offer
INSIDE
$2,743
OCEANVIEW
$2,986
BALCONY
$3,277
SUITE
$5,013
From 2,743
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+1 more), Bahamas
Early Booking Offer
INSIDE
$1,101
OCEANVIEW
$1,246
BALCONY
$1,489
SUITE
$2,488
From 1,101
View Trip
12 Day Caribbean And Antilles with MSC Cruises
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Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 03 August 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Early Booking Offer
INSIDE
$2,844
OCEANVIEW
$3,116
BALCONY
$3,446
SUITE
$5,357
From 2,844
View Trip
5 Day Caribbean & Antilles with MSC Cruises
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Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Aug 2024 to Oct 2024
Countries Visited: USA, Bahamas
Last Minute OfferEarly Booking with Easy Plus Drinks
INSIDE
$639
OCEANVIEW
$736
BALCONY
$901
SUITE
$1,241
From 639
View Trip
4 Day Caribbean And Antilles with MSC Cruises
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Cruise

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Aug 2024 to Apr 2026
Countries Visited: USA, Bahamas
Mutiple Deals Available
INSIDE
$505
OCEANVIEW
$608
BALCONY
$685
SUITE
$1,000
From 505
View Trip
11 Day Caribbean And Antilles with MSC Cruises
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Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 18 December 2025
Countries Visited: USA, Bahamas, Jamaica
Early Booking Offer
INSIDE
$1,997
OCEANVIEW
$2,288
BALCONY
$2,637
SUITE
$3,655
From 1,997
View Trip
15 Day Caribbean And Antilles with MSC Cruises
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Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Dominican Republic
Early Booking Offer
INSIDE
$2,198
OCEANVIEW
$2,489
BALCONY
$2,974
SUITE
$6,873
From 2,198
View Trip
12 Day Caribbean And Antilles with MSC Cruises
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Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2025 to Aug 2025
Countries Visited: USA, Bahamas, Mexico
Early Booking Offer
INSIDE
$2,563
OCEANVIEW
$2,835
BALCONY
$3,164
SUITE
$5,075
From 2,563
View Trip
5 Day Caribbean And Antilles with MSC Cruises
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Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jul 2025 to Apr 2026
Countries Visited: USA, Bahamas
Early Booking Offer
INSIDE
$553
OCEANVIEW
$650
BALCONY
$747
SUITE
$1,183
From 553
View Trip
5 Day Caribbean And Antilles with MSC Cruises
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Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Dec 2024 to Apr 2026
Countries Visited: USA, Bahamas
Early Booking OfferSave And Sail Offer
INSIDE
$572
OCEANVIEW
$679
BALCONY
$776
SUITE
$1,203
From 572
View Trip
11 Day Caribbean And Antilles with MSC Cruises
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Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 13 February 2025
Countries Visited: USA, Bahamas, Mexico
Save And Sail Offer
INSIDE
$1,794
OCEANVIEW
$2,046
BALCONY
$2,425
SUITE
$3,463
From 1,794
View Trip
5 Day Caribbean And Antilles with MSC Cruises
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Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2024 to Jun 2025
Countries Visited: USA, Bahamas
Early Booking OfferSave And Sail Offer
INSIDE
$693
OCEANVIEW
$800
BALCONY
$945
SUITE
$1,333
From 693
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Save Map View
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 February 2025
Countries Visited: USA, Bahamas, Mexico
Save And Sail Offer
INSIDE
$1,992
OCEANVIEW
$2,263
BALCONY
$2,671
SUITE
$3,796
From 1,992
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Apr 2026
Countries Visited: USA, Bahamas, Dominican Republic
Early Booking Offer
INSIDE
$1,101
OCEANVIEW
$1,246
BALCONY
$1,489
SUITE
$2,488
From 1,101
View Trip
15 Day Caribbean And Antilles with MSC Cruises
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Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 March 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+1 more), Belize
Early Booking Offer
INSIDE
$2,421
OCEANVIEW
$2,712
BALCONY
$3,197
SUITE
$6,146
From 2,421
View Trip
11 Day Caribbean And Antilles with MSC Cruises
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Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 13 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Save And Sail Offer
INSIDE
$1,872
OCEANVIEW
$2,124
BALCONY
$2,502
SUITE
$3,540
From 1,872
View Trip
11 Day Caribbean And Antilles with MSC Cruises
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Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Aug 2024 to Oct 2025
Countries Visited: USA, Bahamas, Mexico
Mutiple Deals Available
INSIDE
$1,348
OCEANVIEW
$1,600
BALCONY
$1,978
SUITE
$3,016
From 1,348
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Aug 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Early Booking Offer
INSIDE
$1,887
OCEANVIEW
$2,051
BALCONY
$2,265
SUITE
$2,973
From 1,887
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 20 December 2025
Countries Visited: USA, Bahamas, Puerto Rico
Early Booking Offer
INSIDE
$1,469
OCEANVIEW
$1,615
BALCONY
$1,857
SUITE
$2,857
From 1,469
View Trip
8 Day Caribbean And Antilles with MSC Cruises
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Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+1 more), Bahamas
Early Booking Offer
INSIDE
$1,169
OCEANVIEW
$1,314
BALCONY
$1,557
SUITE
$2,556
From 1,169
View Trip
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