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MSC Cruises from Orlando

Start your journey from Orlando with 47 unique MSC cruise itineraries to choose from. March and December are the most popular months to begin your cruise from Orlando and MSC Cruises have 363 trips departing this season.
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16 Days
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47 Cruises (363 Cruise Departures)
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 07 March 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$1,108
Oceanview
$1,328
Balcony
$1,658
Suite
$6,492
From
US$1,108
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Visit: USA, Mexico, Belize, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$1,272
Oceanview
$1,492
Balcony
$1,752
Suite
$4,351
From
US$1,272
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Dec 2026 to Apr 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$251
Oceanview
$311
Balcony
$371
Suite
$721
From
US$251
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: May 2026 to Oct 2026
Visit: USA, Bahamas, Mexico
Bonus Onboard Credit
Inside
$828
Oceanview
$1,018
Balcony
$1,168
Suite
$2,044
From
US$828
Per Person
View Trip
16 Day Caribbean And Antilles with MSC Cruises
Cruise

16 Days (15 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 October 2027
Visit: USA, Bahamas, Mexico, Dominican Republic, Puerto Rico
Bonus Onboard Credit
Inside
$1,346
Oceanview
$1,566
Balcony
$1,926
Suite
$3,403
From
US$1,346
Per Person
View Trip
9 Day Caribbean And Antilles with MSC Cruises
Cruise

9 Days (8 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2027
Visit: USA, Bahamas, Dominican Republic, Puerto Rico
Bonus Onboard Credit
Inside
$769
Oceanview
$889
Balcony
$1,069
Suite
$1,909
From
US$769
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 27 December 2026
Visit: USA, Dominican Republic, Bahamas
Bonus Onboard Credit
Inside
$1,428
Oceanview
$1,618
Balcony
$1,838
Suite
$2,985
From
US$1,428
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 December 2027
Visit: USA, Bahamas, Dominican Republic, Turks and Caicos Islands
Bonus Onboard Credit
Inside
$1,258
Oceanview
$1,438
Balcony
$1,678
Suite
$2,849
From
US$1,258
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 December 2027
Visit: USA, Bahamas, Dominican Republic, Turks and Caicos Islands
Bonus Onboard Credit
Inside
$967
Oceanview
$1,097
Balcony
$1,277
Suite
$2,042
From
US$967
Per Person
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 26 March 2026
Visit: USA, Bahamas, Turks and Caicos Islands
Bonus Onboard Credit
Inside
$535
Oceanview
$595
Balcony
$675
Suite
$962
From
US$535
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Jan 2026 to Jan 2026
Visit: USA, Bahamas, Puerto Rico, Dominican Republic
Bonus Onboard Credit
Inside
$429
Oceanview
$539
Balcony
$669
Suite
$3,080
From
US$429
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas
Bonus Onboard Credit
Inside
$568
Oceanview
$678
Balcony
$818
Suite
$1,632
From
US$568
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Visit: USA, Mexico, Belize, Bahamas
Bonus Onboard Credit
Inside
$579
Oceanview
$689
Balcony
$819
Suite
$1,571
From
US$579
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 19 April 2026
Visit: USA, Bahamas, Mexico
Bonus Onboard Credit
Inside
$1,038
Oceanview
$1,228
Balcony
$1,378
Suite
$2,228
From
US$1,038
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 December 2027
Visit: USA, Bahamas, Jamaica, Cayman Islands, Mexico
Bonus Onboard Credit
Inside
$1,227
Oceanview
$1,357
Balcony
$1,537
Suite
$2,294
From
US$1,227
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 March 2026
Visit: USA, Bahamas, Dominican Republic, Mexico, Belize
Bonus Onboard Credit
Inside
$1,192
Oceanview
$1,412
Balcony
$1,712
Suite
$3,711
From
US$1,192
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jan 2027 to Feb 2027
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$293
Oceanview
$353
Balcony
$413
Suite
$763
From
US$293
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$1,046
Oceanview
$1,266
Balcony
$1,596
Suite
$4,307
From
US$1,046
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Feb 2026 to Mar 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$229
Oceanview
$329
Balcony
$369
Suite
$792
From
US$229
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Oct 2027
Visit: USA, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$399
Oceanview
$489
Balcony
$619
Suite
$1,377
From
US$399
Per Person
View Trip
5 Day Caribbean & Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: May 2026 to Feb 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Free Balcony Upgrade
Inside
$251
Oceanview
$311
Balcony
$371
Suite
$782
From
US$251
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 January 2026
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
-
Suite
$948
From
US$948
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 22 November 2026
Visit: USA, Bahamas, Jamaica, Cayman Islands
Bonus Onboard Credit
Inside
$858
Oceanview
$1,028
Balcony
$1,228
Suite
$2,481
From
US$858
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jan 2026 to Mar 2026
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$199
Oceanview
$259
Balcony
$299
Suite
$752
From
US$199
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 14 March 2026
Visit: USA, Bahamas, Dominican Republic, Mexico, Cayman Islands, Jamaica
Bonus Onboard Credit
Inside
$1,176
Oceanview
$1,396
Balcony
$1,726
Suite
-
From
US$1,176
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 20 December 2026
Visit: USA, Bahamas, Jamaica, Cayman Islands, Dominican Republic
Bonus Onboard Credit
Exclusive Savings
Inside
$2,072
Oceanview
$2,324
Balcony
$2,634
Suite
$3,527
From
US$2,072
Save 50
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jan 2026 to Apr 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Free Balcony Upgrade
Inside
$219
Oceanview
$299
Balcony
$339
Suite
$618
From
US$219
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 December 2027
Visit: USA, Bahamas, Dominican Republic, Turks and Caicos Islands, Jamaica, Cayman Islands, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,130
Oceanview
$2,382
Balcony
$2,731
Suite
$4,322
From
US$2,130
Save 52
Per Person
View Trip
13 Day Caribbean And Antilles with MSC Cruises
Cruise

13 Days (12 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2027
Visit: USA, Bahamas, Dominican Republic, Puerto Rico
Bonus Onboard Credit
Inside
$1,033
Oceanview
$1,203
Balcony
$1,443
Suite
$2,641
From
US$1,033
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 13 January 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$349
Oceanview
$389
Balcony
$449
Suite
$789
From
US$349
Per Person
View Trip
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