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MSC Cruises from Orlando

Start your journey from Orlando with 32 unique MSC cruise itineraries to choose from. December is the most popular month to begin your cruise from Orlando and MSC Cruises have 334 trips departing this season.
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32 Cruises (334 Departures)
32 Cruises (334 Departures)
Departures
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Duration
4 Days
16 Days
Price
$200pp
$2,250pp
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11 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 November 2027
Visits: USA, Bahamas, Cayman Islands, Jamaica
Inside
$1,046
Oceanview
$1,176
Balcony
$1,426
Suite
$2,486
From (Per Person)
US$1,046
Per Person
View Trip
9 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2027
Visits: USA, Bahamas, Dominican Republic, Puerto Rico
Inside
$798
Oceanview
$918
Balcony
$1,108
Suite
$1,948
From (Per Person)
US$798
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 05 March 2028
Visits: USA, Bahamas
Inside
$500
Oceanview
$570
Balcony
$640
Suite
$1,050
From (Per Person)
US$500
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 21 November 2027
Visits: USA, Bahamas, Cayman Islands, Jamaica
Inside
$1,053
Oceanview
$1,203
Balcony
$1,463
Suite
$2,603
From (Per Person)
US$1,053
Per Person
View Trip
13 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

13 Days (12 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2027
Visits: USA, Bahamas, Dominican Republic, Puerto Rico
Inside
$1,103
Oceanview
$1,273
Balcony
$1,533
Suite
$2,783
From (Per Person)
US$1,103
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visits: USA, Bahamas, Mexico
Inside
$389
Oceanview
$509
Balcony
$679
Suite
$1,521
From (Per Person)
US$389
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 December 2027
Visits: USA, Bahamas, Dominican Republic, Turks and Caicos Islands, Jamaica, Cayman Islands, Mexico
Inside
$2,250
Oceanview
$2,490
Balcony
$2,870
Suite
$4,510
From (Per Person)
US$2,250
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visits: USA, Bahamas, Dominican Republic
Inside
$421
Oceanview
$541
Balcony
$687
Suite
$1,481
From (Per Person)
US$421
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 December 2027
Visits: USA, Bahamas, Dominican Republic, Turks and Caicos Islands
Inside
$1,323
Oceanview
$1,503
Balcony
$1,763
Suite
$2,993
From (Per Person)
US$1,323
Per Person
View Trip
5 Day Caribbean & Antilles with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jul 2026 to Sep 2028
Visits: USA, Bahamas
Inside
$269
Oceanview
$312
Balcony
$399
Suite
$892
From (Per Person)
US$269
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visits: USA, Bahamas, Mexico, Dominican Republic
Inside
$820
Oceanview
$1,060
Balcony
$1,440
Suite
$2,990
From (Per Person)
US$820
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 21 November 2027
Visits: USA, Bahamas, Cayman Islands, Jamaica
Inside
$721
Oceanview
$821
Balcony
$1,011
Suite
$1,741
From (Per Person)
US$721
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Nov 2026 to Jan 2028
Visits: USA, Bahamas
Inside
$256
Oceanview
$322
Balcony
$346
Suite
$722
From (Per Person)
US$256
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 December 2027
Visits: USA, Bahamas, Jamaica, Cayman Islands, Mexico
Inside
$1,566
Oceanview
$1,726
Balcony
$1,976
Suite
$3,126
From (Per Person)
US$1,566
Per Person
View Trip
16 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 October 2027
Visits: USA, Bahamas, Mexico, Dominican Republic, Puerto Rico
Inside
$1,419
Oceanview
$1,619
Balcony
$1,999
Suite
$3,569
From (Per Person)
US$1,419
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2027 to Sep 2028
Visits: USA, Bahamas
Inside
$323
Oceanview
$383
Balcony
$443
Suite
$773
From (Per Person)
US$323
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Dec 2026 to Apr 2028
Visits: USA, Bahamas
Inside
$293
Oceanview
$363
Balcony
$373
Suite
$763
From (Per Person)
US$293
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visits: USA, Bahamas, Dominican Republic, Mexico
Inside
$820
Oceanview
$1,060
Balcony
$1,470
Suite
$3,020
From (Per Person)
US$820
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jul 2026 to May 2028
Visits: USA, Bahamas
Inside
$258
Oceanview
$308
Balcony
$358
Suite
$648
From (Per Person)
US$258
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 December 2027
Visits: USA, Bahamas, Dominican Republic, Turks and Caicos Islands
Inside
$991
Oceanview
$1,121
Balcony
$1,311
Suite
$2,131
From (Per Person)
US$991
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 December 2027
Visits: USA, Bahamas, Jamaica, Cayman Islands, Mexico
Inside
$1,251
Oceanview
$1,381
Balcony
$1,571
Suite
$2,391
From (Per Person)
US$1,251
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 13 January 2028
Visits: USA, Bahamas
Inside
$383
Oceanview
$433
Balcony
$493
Suite
$823
From (Per Person)
US$383
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 27 December 2026
Visits: USA, Dominican Republic, Bahamas
Inside
$1,247
Oceanview
$1,447
Balcony
$1,687
Suite
$3,257
From (Per Person)
US$1,247
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 20 December 2026
Visits: USA, Bahamas, Jamaica, Cayman Islands, Dominican Republic
Inside
$1,846
Oceanview
$2,086
Balcony
$2,446
Suite
-
From (Per Person)
US$1,846
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2026 to Oct 2026
Visits: USA, Bahamas, Mexico
Inside
$418
Oceanview
$568
Balcony
$638
Suite
$1,411
From (Per Person)
US$418
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2026 to Dec 2026
Visits: USA, Bahamas, Jamaica, Cayman Islands
Inside
$769
Oceanview
$889
Balcony
$1,069
Suite
$1,559
From (Per Person)
US$769
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 27 December 2026
Visits: USA, Dominican Republic, Bahamas
Inside
$989
Oceanview
$1,109
Balcony
$1,289
Suite
$2,309
From (Per Person)
US$989
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2026 to Dec 2026
Visits: USA, Bahamas, Jamaica, Cayman Islands
Inside
$971
Oceanview
$1,141
Balcony
$1,381
Suite
-
From (Per Person)
US$971
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 22 November 2026
Visits: USA, Bahamas, Jamaica, Cayman Islands
Inside
$996
Oceanview
$1,206
Balcony
$1,426
Suite
$2,786
From (Per Person)
US$996
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Aug 2026 to Oct 2026
Visits: USA, Bahamas, Mexico
Inside
$681
Oceanview
$851
Balcony
$1,001
Suite
$2,523
From (Per Person)
US$681
Per Person
View Trip
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