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MSC Cruises from Orlando

Start your journey from Orlando with 47 unique MSC cruise itineraries to choose from. December and February are the most popular months to begin your cruise from Orlando and MSC Cruises have 226 trips departing this season.
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47 Cruises (226 Cruise Departures)
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 23 November 2025
Countries Visited: USA, Puerto Rico, Bahamas
Exclusive Deal
INSIDE
$1,771
OCEANVIEW
$2,177
BALCONY
$2,632
SUITE
$4,048
From (per person) 1,771
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Dominican Republic
Exclusive Deal
INSIDE
$2,326
OCEANVIEW
$2,722
BALCONY
$3,316
SUITE
$7,563
From (per person) 2,326
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 31 January 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic (+3 more), Mexico, Cayman Islands, Jamaica
Exclusive Deal
INSIDE
$2,177
OCEANVIEW
$2,573
BALCONY
$3,167
SUITE
$10,029
From (per person) 2,177
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jan 2025 to Oct 2025
Countries Visited: USA, Bahamas, Mexico
Exclusive DealSave And Sail Offer
INSIDE
$1,563
OCEANVIEW
$1,821
BALCONY
$2,147
SUITE
$3,672
From (per person) 1,563
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+2 more), Bahamas, Dominican Republic
Exclusive Deal
INSIDE
$2,256
OCEANVIEW
$2,652
BALCONY
$3,246
SUITE
$7,493
From (per person) 2,256
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2025 to Aug 2025
Countries Visited: USA, Bahamas, Mexico
Exclusive Deal
INSIDE
$2,385
OCEANVIEW
$2,642
BALCONY
$3,028
SUITE
$5,048
From (per person) 2,385
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 28 December 2025
Countries Visited: USA, Bahamas, Mexico
Exclusive Deal
INSIDE
$1,255
OCEANVIEW
$1,443
BALCONY
$1,562
SUITE
$2,245
From (per person) 1,255
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Mar 2025 to May 2025
Countries Visited: USA, Bahamas, Mexico
Mutiple Deals Available
INSIDE
$1,982
OCEANVIEW
$2,131
BALCONY
$2,527
SUITE
$3,810
From (per person) 1,982
View Trip
9 Day Caribbean And Antilles with MSC Cruises
Cruise

9 Days (8 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 27 December 2025
Countries Visited: USA, Bahamas, Mexico, Cayman Islands (+1 more), Jamaica
Exclusive Deal
INSIDE
$2,167
OCEANVIEW
$2,434
BALCONY
$2,711
SUITE
$4,127
From (per person) 2,167
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 November 2025
Countries Visited: USA, Bahamas, Mexico, Honduras
Exclusive Deal
INSIDE
$1,084
OCEANVIEW
$1,302
BALCONY
$1,638
SUITE
$2,698
From (per person) 1,084
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Last Minute DealSave And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$1,767
SUITE
$2,588
From (per person) 1,767
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 23 November 2025
Countries Visited: USA, Puerto Rico, Bahamas
Exclusive Deal
INSIDE
$1,183
OCEANVIEW
$1,450
BALCONY
$1,787
SUITE
$2,846
From (per person) 1,183
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 24 January 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic
Exclusive Deal
INSIDE
$2,098
OCEANVIEW
$2,494
BALCONY
$3,088
SUITE
$7,335
From (per person) 2,098
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 06 July 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Exclusive Deal
INSIDE
$3,058
OCEANVIEW
$3,335
BALCONY
$3,820
SUITE
$9,518
From (per person) 3,058
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Oct 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Exclusive Deal
INSIDE
$1,421
OCEANVIEW
$1,589
BALCONY
$1,856
SUITE
$2,678
From (per person) 1,421
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jan 2026 to Apr 2026
Countries Visited: USA, Bahamas
Early Booking OfferExclusive Deal
INSIDE
$558
OCEANVIEW
$707
BALCONY
$816
SUITE
$1,301
From (per person) 558
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 March 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+1 more), Belize
Exclusive Deal
INSIDE
$2,484
OCEANVIEW
$2,880
BALCONY
$3,474
SUITE
$6,751
From (per person) 2,484
View Trip
7 Day Caribbean And Antilles with MSC Cruises
Cruise

7 Days (6 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 January 2026
Countries Visited: USA, Bahamas, Dominican Republic
Exclusive Deal
INSIDE
$952
OCEANVIEW
$1,130
BALCONY
$1,358
SUITE
$2,338
From (per person) 952
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+1 more), Bahamas
Exclusive Deal
INSIDE
$1,163
OCEANVIEW
$1,411
BALCONY
$1,757
SUITE
$3,024
From (per person) 1,163
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 13 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Save And Sail Offer
INSIDE
$1,791
OCEANVIEW
$2,048
BALCONY
$2,395
SUITE
$3,603
From (per person) 1,791
View Trip
13 Day Caribbean And Antilles with MSC Cruises
Cruise

13 Days (12 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 December 2025
Countries Visited: USA, Bahamas, Jamaica, Mexico
Exclusive Deal
INSIDE
$2,774
OCEANVIEW
$3,210
BALCONY
$3,705
SUITE
$6,031
From (per person) 2,774
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2025 to Sep 2025
Countries Visited: USA, Bahamas
Exclusive Deal
INSIDE
$746
OCEANVIEW
$845
BALCONY
$994
SUITE
$1,459
From (per person) 746
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jul 2025 to Oct 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Exclusive Deal
INSIDE
$1,985
OCEANVIEW
$2,233
BALCONY
$2,678
SUITE
$4,401
From (per person) 1,985
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 25 May 2025
Countries Visited: USA, Bahamas, Mexico
Exclusive Deal
INSIDE
$2,731
OCEANVIEW
$3,008
BALCONY
$3,493
SUITE
$5,394
From (per person) 2,731
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 February 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+2 more), Cayman Islands, Jamaica
Exclusive Deal
INSIDE
$2,326
OCEANVIEW
$2,722
BALCONY
$3,316
SUITE
$6,593
From (per person) 2,326
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Countries Visited: USA, Bahamas, Dominican Republic, Mexico (+2 more), Cayman Islands, Jamaica
Exclusive Deal
INSIDE
$2,326
OCEANVIEW
$2,722
BALCONY
$3,316
SUITE
$6,593
From (per person) 2,326
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Apr 2026
Countries Visited: USA, Bahamas, Dominican Republic
Early Booking OfferExclusive Deal
INSIDE
$1,114
OCEANVIEW
$1,381
BALCONY
$1,609
SUITE
$2,658
From (per person) 1,114
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Jan 2026 to Jan 2026
Countries Visited: USA, Bahamas, Puerto Rico, Dominican Republic
Exclusive Deal
INSIDE
$1,084
OCEANVIEW
$1,331
BALCONY
$1,678
SUITE
$2,945
From (per person) 1,084
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 March 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Save And Sail Offer
INSIDE
$1,982
OCEANVIEW
$2,250
BALCONY
$2,646
SUITE
$3,943
From (per person) 1,982
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Aug 2025 to Oct 2025
Countries Visited: USA, Bahamas, Honduras, Mexico
Exclusive Deal
INSIDE
$2,137
OCEANVIEW
$2,414
BALCONY
$2,899
SUITE
$5,196
From (per person) 2,137
View Trip
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