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MSC Cruises from Orlando

Start your journey from Orlando with 49 unique MSC cruise itineraries to choose from. January is the most popular month to begin your cruise from Orlando and MSC Cruises have 333 trips departing this season.
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49 Cruises (333 Cruise Departures)
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 07 March 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas
Free Balcony Upgrade
Inside
$512
Oceanview
$692
Balcony
$702
Suite
$1,979
From
US$512
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visit: USA, Bahamas, Mexico, Dominican Republic
Inside
$1,152
Oceanview
$1,352
Balcony
$1,622
Suite
$2,896
From
US$1,152
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jan 2026 to Mar 2026
Visit: USA, Bahamas
Free Balcony Upgrade
Inside
$219
Oceanview
$299
Balcony
$359
Suite
$752
From
US$219
Per Person
View Trip
10 Day Caribbean And Antilles with MSC Cruises
Cruise

10 Days (9 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 16 January 2026
Visit: USA, Turks and Caicos Islands, Bahamas
Inside
-
Oceanview
-
Balcony
$979
Suite
-
From
US$979
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2026 to Oct 2026
Visit: USA, Bahamas, Mexico
Free Balcony Upgrade
Inside
$559
Oceanview
$679
Balcony
$769
Suite
$1,339
From
US$559
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Dec 2026 to Oct 2027
Visit: USA, Bahamas
Inside
$273
Oceanview
$333
Balcony
$413
Suite
$693
From
US$273
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visit: USA, Bahamas, Dominican Republic, Mexico
Exclusive Savings
Inside
$1,102
Oceanview
$1,302
Balcony
$1,602
Suite
$2,848
From
US$1,102
Save 59
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 21 December 2025
Visit: USA, Bahamas, Jamaica
Inside
$669
Oceanview
$779
Balcony
$919
Suite
$1,878
From
US$669
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 13 December 2025
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas, Puerto Rico
Inside
$1,212
Oceanview
$1,412
Balcony
$1,692
Suite
$7,339
From
US$1,212
Per Person
View Trip
13 Day Caribbean And Antilles with MSC Cruises
Cruise

13 Days (12 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 09 January 2026
Visit: USA, Mexico, Belize, Honduras, Turks and Caicos Islands, Bahamas
Inside
-
Oceanview
-
Balcony
$1,438
Suite
$3,121
From
US$1,438
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 31 January 2026
Visit: USA, Bahamas, Puerto Rico, Dominican Republic, Mexico, Cayman Islands, Jamaica
Inside
$1,090
Oceanview
$1,290
Balcony
$1,610
Suite
$3,672
From
US$1,090
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 20 December 2025
Visit: USA, Bahamas, Puerto Rico
Inside
$569
Oceanview
$679
Balcony
$849
Suite
$3,644
From
US$569
Per Person
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 28 December 2025
Visit: USA, Bahamas, Mexico
Inside
$939
Oceanview
$1,019
Balcony
$1,109
Suite
-
From
US$939
Per Person
View Trip
7 Day Caribbean And Antilles with MSC Cruises
Cruise

7 Days (6 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 January 2026
Visit: USA, Bahamas, Dominican Republic
Inside
$299
Oceanview
$409
Balcony
$529
Suite
$1,299
From
US$299
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas
Free Balcony Upgrade
Inside
$349
Oceanview
$469
Balcony
$629
Suite
$1,630
From
US$349
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Jan 2026 to Mar 2026
Visit: USA, Bahamas
Free Balcony Upgrade
Inside
$207
Oceanview
$277
Balcony
$337
Suite
$772
From
US$207
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 19 April 2026
Visit: USA, Bahamas, Mexico
Inside
$1,068
Oceanview
$1,258
Balcony
$1,408
Suite
$2,258
From
US$1,068
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 09 January 2026
Visit: USA, Mexico, Belize, Honduras
Inside
$406
Oceanview
$516
Balcony
$686
Suite
$1,569
From
US$406
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 24 January 2026
Visit: USA, Bahamas, Puerto Rico, Dominican Republic
Inside
$914
Oceanview
$1,064
Balcony
$1,394
Suite
$6,062
From
US$914
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Mar 2026
Visit: USA, Bahamas, Dominican Republic, Mexico, Cayman Islands, Jamaica
Inside
$1,066
Oceanview
$1,186
Balcony
$1,516
Suite
$4,589
From
US$1,066
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Visit: USA, Mexico, Belize, Bahamas
Inside
$631
Oceanview
$741
Balcony
$871
Suite
$2,570
From
US$631
Per Person
View Trip
5 Day Caribbean & Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: May 2026 to Nov 2026
Visit: USA, Bahamas
Free Balcony Upgrade
Inside
$292
Oceanview
$332
Balcony
$382
Suite
$692
From
US$292
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Visit: USA, Mexico, Belize, Bahamas, Dominican Republic
Inside
$1,332
Oceanview
$1,552
Balcony
$1,812
Suite
$4,410
From
US$1,332
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 23 November 2025
Visit: USA, Puerto Rico, Bahamas
Inside
$409
Oceanview
$519
Balcony
$689
Suite
$1,946
From
US$409
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 18 December 2025
Visit: USA, Bahamas, Jamaica
Inside
$1,148
Oceanview
$1,308
Balcony
$1,538
Suite
$2,267
From
US$1,148
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2025 to Oct 2027
Visit: USA, Bahamas, Dominican Republic
Free Balcony Upgrade
Inside
$279
Oceanview
$389
Balcony
$559
Suite
$1,481
From
US$279
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas, Dominican Republic
Inside
$1,046
Oceanview
$1,266
Balcony
$1,596
Suite
$4,307
From
US$1,046
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2026 to Oct 2026
Visit: USA, Bahamas, Mexico
Inside
$838
Oceanview
$1,018
Balcony
$1,158
Suite
$1,937
From
US$838
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 February 2026
Visit: USA, Bahamas, Dominican Republic, Mexico, Cayman Islands, Jamaica
Inside
$1,128
Oceanview
$1,278
Balcony
$1,608
Suite
$6,114
From
US$1,128
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Mar 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas, Dominican Republic
Inside
$1,088
Oceanview
$1,308
Balcony
$1,638
Suite
$6,356
From
US$1,088
Per Person
View Trip
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