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MSC Cruises from Orlando

Start your journey from Orlando with 43 unique MSC cruise itineraries to choose from. December is the most popular month to begin your cruise from Orlando and MSC Cruises have 349 trips departing this season.
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16 Days
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43 Cruises (349 Cruise Departures)
5 Day Caribbean & Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: May 2026 to Feb 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$251
Oceanview
$311
Balcony
$371
Suite
$782
From
US$251
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 14 March 2026
Visit: USA, Bahamas, Dominican Republic, Mexico, Cayman Islands, Jamaica
Bonus Onboard Credit
Inside
$1,196
Oceanview
$1,416
Balcony
$1,746
Suite
-
From
US$1,196
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 27 December 2026
Visit: USA, Dominican Republic, Bahamas
Bonus Onboard Credit
Inside
$1,119
Oceanview
$1,239
Balcony
$1,419
Suite
$2,285
From
US$1,119
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 21 November 2027
Visit: USA, Bahamas, Cayman Islands, Jamaica
Bonus Onboard Credit
Inside
$1,048
Oceanview
$1,178
Balcony
$1,428
Suite
$2,519
From
US$1,048
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 19 April 2026
Visit: USA, Bahamas, Mexico
Bonus Onboard Credit
Inside
$1,058
Oceanview
$1,248
Balcony
$1,408
Suite
$2,258
From
US$1,058
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 21 November 2027
Visit: USA, Bahamas, Cayman Islands, Jamaica
Bonus Onboard Credit
Inside
$711
Oceanview
$811
Balcony
$1,001
Suite
$1,731
From
US$711
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 December 2027
Visit: USA, Bahamas, Dominican Republic, Turks and Caicos Islands, Jamaica, Cayman Islands, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$2,179
Oceanview
$2,411
Balcony
$2,770
Suite
$4,361
From
US$2,179
Save 53
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 December 2027
Visit: USA, Bahamas, Dominican Republic, Turks and Caicos Islands
Bonus Onboard Credit
Inside
$1,318
Oceanview
$1,478
Balcony
$1,728
Suite
$2,898
From
US$1,318
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 December 2027
Visit: USA, Bahamas, Dominican Republic, Turks and Caicos Islands
Bonus Onboard Credit
Inside
$981
Oceanview
$1,111
Balcony
$1,301
Suite
$2,065
From
US$981
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Apr 2026 to Oct 2026
Visit: USA, Bahamas, Mexico
Bonus Onboard Credit
Inside
$439
Oceanview
$625
Balcony
$625
Suite
$1,319
From
US$439
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Feb 2026 to Oct 2027
Visit: USA, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$441
Oceanview
$551
Balcony
$691
Suite
$1,387
From
US$441
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 04 April 2026
Visit: USA, Mexico, Belize, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$1,282
Oceanview
$1,502
Balcony
$1,772
Suite
$4,371
From
US$1,282
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Jan 2027 to Feb 2027
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$303
Oceanview
$363
Balcony
$433
Suite
$783
From
US$303
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2027 to Apr 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$363
Oceanview
$403
Balcony
$473
Suite
$813
From
US$363
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2026 to Dec 2026
Visit: USA, Bahamas, Jamaica, Cayman Islands
Bonus Onboard Credit
Inside
$888
Oceanview
$1,048
Balcony
$1,248
Suite
$2,684
From
US$888
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visit: USA, Bahamas, Mexico, Dominican Republic
Bonus Onboard Credit
Inside
$1,122
Oceanview
$1,322
Balcony
$1,602
Suite
$2,877
From
US$1,122
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Feb 2026 to Apr 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$258
Oceanview
$328
Balcony
$328
Suite
$618
From
US$258
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Mar 2026 to Mar 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$490
Oceanview
$540
Balcony
$469
Suite
$832
From
US$469
Per Person
View Trip
16 Day Caribbean And Antilles with MSC Cruises
Cruise

16 Days (15 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 October 2027
Visit: USA, Bahamas, Mexico, Dominican Republic, Puerto Rico
Bonus Onboard Credit
Inside
$1,400
Oceanview
$1,600
Balcony
$1,970
Suite
$3,446
From
US$1,400
Per Person
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: May 2026 to Oct 2026
Visit: USA, Bahamas, Mexico
Bonus Onboard Credit
Inside
$838
Oceanview
$1,048
Balcony
$1,188
Suite
$2,093
From
US$838
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 20 December 2026
Visit: USA, Bahamas, Jamaica, Cayman Islands, Dominican Republic
Bonus Onboard Credit
Exclusive Savings
Inside
$2,101
Oceanview
$2,353
Balcony
$2,673
Suite
$3,566
From
US$2,101
Save 51
Per Person
View Trip
6 Day Caribbean And Antilles with MSC Cruises
Cruise

6 Days (5 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departure: 26 March 2026
Visit: USA, Bahamas, Turks and Caicos Islands
Bonus Onboard Credit
Inside
$579
Oceanview
$639
Balcony
$729
Suite
-
From
US$579
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Dec 2026 to Apr 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$251
Oceanview
$311
Balcony
$371
Suite
$721
From
US$251
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 21 March 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas, Dominican Republic
Bonus Onboard Credit
Inside
$1,196
Oceanview
$1,416
Balcony
$1,746
Suite
-
From
US$1,196
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 21 March 2026
Visit: USA, Mexico, Cayman Islands, Jamaica, Bahamas
Bonus Onboard Credit
Inside
$574
Oceanview
$684
Balcony
$844
Suite
$1,800
From
US$574
Per Person
View Trip
11 Day Caribbean And Antilles with MSC Cruises
Cruise

11 Days (10 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 30 December 2027
Visit: USA, Bahamas, Jamaica, Cayman Islands, Mexico
Bonus Onboard Credit
Inside
$1,536
Oceanview
$1,686
Balcony
$1,946
Suite
$3,021
From
US$1,536
Per Person
View Trip
5 Day Caribbean And Antilles with MSC Cruises
Cruise

5 Days (4 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seashore
Departures: Mar 2026 to Jan 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$252
Oceanview
$321
Balcony
$342
Suite
$722
From
US$252
Per Person
View Trip
4 Day Caribbean And Antilles with MSC Cruises
Cruise

4 Days (3 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 13 January 2028
Visit: USA, Bahamas
Bonus Onboard Credit
Inside
$363
Oceanview
$403
Balcony
$473
Suite
$813
From
US$363
Per Person
View Trip
15 Day Caribbean And Antilles with MSC Cruises
Cruise

15 Days (14 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Nov 2026 to Oct 2027
Visit: USA, Bahamas, Dominican Republic, Mexico
Bonus Onboard Credit
Exclusive Savings
Inside
$1,092
Oceanview
$1,272
Balcony
$1,582
Suite
$2,828
From
US$1,092
Save 59
Per Person
View Trip
8 Day Caribbean And Antilles with MSC Cruises
Cruise

8 Days (7 Nights) Orlando to Orlando
Cruise Line: MSC Cruises
Ship: MSC Seashore
Departures: Nov 2026 to Dec 2026
Visit: USA, Bahamas, Jamaica, Cayman Islands
Bonus Onboard Credit
Inside
$771
Oceanview
$911
Balcony
$1,101
Suite
$1,569
From
US$771
Per Person
View Trip
Results: 1-30 of 43

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