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MSC Cruises from Santos

Start your journey from Santos with 26 unique MSC cruise itineraries to choose from. April is the most popular month to begin your cruise from Santos and MSC Cruises have 47 trips departing this season.
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24 Days
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26 Cruises (47 Cruise Departures)
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,375
From
US$475
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar
Bonus Onboard Credit
Inside
$1,259
Oceanview
$1,439
Balcony
$1,859
Suite
$3,815
From
US$1,259
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Bonus Onboard Credit
Inside
$1,949
Oceanview
$2,209
Balcony
$2,550
Suite
$8,438
From
US$1,949
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

22 Days (21 Nights) Santos to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy, Sicily
Bonus Onboard Credit
Inside
$1,501
Oceanview
$1,711
Balcony
$2,230
Suite
-
From
US$1,501
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,857
Oceanview
$1,864
Balcony
$1,998
Suite
$13,207
From
US$1,857
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France
Bonus Onboard Credit
Inside
$927
Oceanview
$1,071
Balcony
$1,475
Suite
-
From
US$927
Per Person
View Trip
6 Day MSC Grand Voyages with MSC Cruises
Cruise

6 Days (5 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$654
Suite
-
From
US$654
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,320
Oceanview
$1,368
Balcony
$1,464
Suite
-
From
US$1,320
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Genoa
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy
Bonus Onboard Credit
Inside
$1,004
Oceanview
$1,168
Balcony
$1,561
Suite
-
From
US$1,004
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain
Bonus Onboard Credit
Inside
$888
Oceanview
$1,028
Balcony
$1,428
Suite
-
From
US$888
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
-
From
US$475
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy
Bonus Onboard Credit
Inside
$1,077
Oceanview
$1,231
Balcony
$1,674
Suite
-
From
US$1,077
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,394
Oceanview
$1,664
Balcony
$1,894
Suite
$5,265
From
US$1,394
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
$2,303
Oceanview
$2,359
Balcony
$2,470
Suite
-
From
US$2,303
Save 62
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,465
From
US$475
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 11 April 2026
Visit: Brazil, Spain, Gibraltar, France, Italy
Grand Voyages Sale
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,193
Suite
$3,242
From
US$2,193
Save 54
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Bonus Onboard Credit
Inside
$1,709
Oceanview
$2,049
Balcony
$2,188
Suite
$7,397
From
US$1,709
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$1,937
Suite
-
From
US$1,937
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Bonus Onboard Credit
Inside
$1,379
Oceanview
$1,609
Balcony
$1,939
Suite
$3,274
From
US$1,379
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Drinks & WiFi Package
Inside
$133
Oceanview
$196
Balcony
$238
Suite
$406
From
US$133
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visit: Brazil
Inside
$677
Oceanview
$773
Balcony
$893
Suite
$1,409
From
US$677
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$909
Oceanview
$979
Balcony
$1,119
Suite
$1,379
From
US$909
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to London
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain, England
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,083
Suite
-
From
US$2,083
Save 51
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 22 February 2026
Visit: Brazil, Argentina, Uruguay
Bonus Onboard Credit
Inside
$1,034
Oceanview
$1,259
Balcony
$1,470
Suite
$2,061
From
US$1,034
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy
Bonus Onboard Credit
Inside
$1,681
Oceanview
$2,031
Balcony
$2,269
Suite
-
From
US$1,681
Per Person
View Trip
Results: 26 results

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