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MSC Cruises from Santos

Start your journey from Santos with 30 unique MSC cruise itineraries to choose from. March is the most popular month to begin your cruise from Santos and MSC Cruises have 69 trips departing this season.
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30 Cruises (69 Departures)
30 Cruises (69 Departures)
Departures
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Duration
2 Days
25 Days
Price
$79pp
$10,551pp
Countries
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15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Santos to Lisbon
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 07 March 2027
Visits: Brazil, Cape Verde, Portugal
Inside
-
Oceanview
-
Balcony
$1,831
Suite
$3,005
From (Per Person)
US$1,831
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visits: Brazil
Inside
$536
Oceanview
$596
Balcony
$746
Suite
$1,077
From (Per Person)
US$536
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 05 December 2026
Visits: Brazil, Uruguay, Argentina
Inside
$1,039
Oceanview
$1,249
Balcony
$1,539
Suite
$2,259
From (Per Person)
US$1,039
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 05 February 2027
Visits: Brazil
Inside
$809
Oceanview
$929
Balcony
$1,049
Suite
$1,259
From (Per Person)
US$809
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ships: MSC Divina, MSC Meraviglia, MSC Musica
Departures: Nov 2026 to Mar 2028
Visits: Brazil
Inside
$415
Oceanview
$465
Balcony
$625
Suite
$855
From (Per Person)
US$415
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Santos to Itajai
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2026
Visits: Brazil
Inside
$799
Oceanview
$919
Balcony
$1,209
Suite
-
From (Per Person)
US$799
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ships: MSC Divina, MSC Meraviglia, MSC Musica
Departures: Feb 2027 to Apr 2028
Visits: Brazil
Inside
$465
Oceanview
$579
Balcony
$709
Suite
$929
From (Per Person)
US$465
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

23 Days (22 Nights) Santos to Marseille
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 07 March 2027
Visits: Brazil, Cape Verde, Portugal, Morocco, Spain, France
Inside
$1,734
Oceanview
$2,050
Balcony
$2,529
Suite
$4,459
From (Per Person)
US$1,734
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Rome
Operator: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visits: Brazil, Spain, France, Italy
Inside
-
Oceanview
$1,314
Balcony
$1,784
Suite
$4,934
From (Per Person)
US$1,314
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visits: Brazil
Inside
$526
Oceanview
$596
Balcony
$776
Suite
$1,077
From (Per Person)
US$526
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Santos to Marseille
Operator: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visits: Brazil, Spain, France
Inside
$990
Oceanview
$1,140
Balcony
$1,540
Suite
-
From (Per Person)
US$990
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Genoa
Operator: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visits: Brazil, Spain, France, Italy
Inside
$1,059
Oceanview
$1,189
Balcony
$1,529
Suite
-
From (Per Person)
US$1,059
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Operator: MSC Cruises
Ships: MSC Divina, MSC Musica, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visits: Brazil
Inside
$79
Oceanview
$119
Balcony
$189
Suite
$379
From (Per Person)
US$79
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

22 Days (21 Nights) Santos to Barcelona
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 07 March 2027
Visits: Brazil, Cape Verde, Portugal, Morocco, Spain
Inside
$1,636
Oceanview
$2,052
Balcony
$2,401
Suite
$4,294
From (Per Person)
US$1,636
Per Person
View Trip
3 Day South America with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Santos to Rio de Janeiro
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2026
Visits: Brazil
Inside
-
Oceanview
-
Balcony
$499
Suite
$509
From (Per Person)
US$499
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Santos to Barcelona
Operator: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visits: Brazil, Spain
Inside
-
Oceanview
$1,088
Balcony
$1,488
Suite
$5,068
From (Per Person)
US$1,088
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Santos to Salvador
Operator: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visits: Brazil
Inside
-
Oceanview
$505
Balcony
$552
Suite
$832
From (Per Person)
US$505
Per Person
View Trip
25 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

25 Days (24 Nights) Santos to Amalfi
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 07 March 2027
Visits: Brazil, Cape Verde, Portugal, Morocco, Spain, France, Italy
Inside
$1,992
Oceanview
$2,246
Balcony
$2,774
Suite
$5,245
From (Per Person)
US$1,992
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Santos to Genoa
Operator: MSC Cruises
Ship: MSC Seaview
Departure: 07 March 2027
Visits: Brazil, Cape Verde, Portugal, Morocco, Spain, France, Italy
Inside
$1,936
Oceanview
$2,160
Balcony
$2,668
Suite
$5,073
From (Per Person)
US$1,936
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

22 Days (21 Nights) Santos to Valencia
Operator: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visits: Brazil, Spain, France, Italy, Sicily
Inside
-
Oceanview
-
Balcony
$2,381
Suite
-
From (Per Person)
US$2,381
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Santos to Paranagua
Operator: MSC Cruises
Ship: MSC Musica
Departure: 20 December 2026
Visits: Brazil
Inside
-
Oceanview
-
Balcony
$1,009
Suite
$2,100
From (Per Person)
US$1,009
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

20 Days (19 Nights) Santos to Rome
Operator: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visits: Brazil, Spain, Morocco, Italy
Inside
$1,249
Oceanview
$1,679
Balcony
$1,989
Suite
$3,469
From (Per Person)
US$1,249
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Divina
Departure: 18 December 2026
Visits: Brazil
Inside
$419
Oceanview
$519
Balcony
$599
Suite
$889
From (Per Person)
US$419
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Barcelona
Operator: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visits: Brazil, Spain, Morocco
Inside
$1,230
Oceanview
$1,520
Balcony
$2,145
Suite
-
From (Per Person)
US$1,230
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Operator: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visits: Brazil, Spain, Morocco
Inside
$1,434
Oceanview
$1,704
Balcony
$1,954
Suite
$5,474
From (Per Person)
US$1,434
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Operator: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visits: Brazil
Inside
$677
Oceanview
-
Balcony
$941
Suite
$1,409
From (Per Person)
US$677
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Operator: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visits: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Inside
-
Oceanview
-
Balcony
-
Suite
$9,179
From (Per Person)
US$9,179
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Operator: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Dec 2027
Visits: Brazil
Inside
$1,549
Oceanview
$1,799
Balcony
$2,049
Suite
$4,309
From (Per Person)
US$1,549
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Amalfi
Operator: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visits: Brazil, Spain, Morocco, Tunisia, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$10,551
From (Per Person)
US$10,551
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Operator: MSC Cruises
Ships: MSC Meraviglia, MSC Seaview
Departures: Dec 2026 to Mar 2028
Visits: Brazil, Uruguay, Argentina
Inside
$829
Oceanview
$1,029
Balcony
$1,319
Suite
$1,839
From (Per Person)
US$829
Per Person
View Trip
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