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MSC Cruises from Santos

Start your journey from Santos with 30 unique MSC cruise itineraries to choose from. December and April are the most popular months to begin your cruise from Santos and MSC Cruises have 64 trips departing this season.
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30 Cruises (64 Cruise Departures)
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France
Bonus Onboard Credit
Inside
$950
Oceanview
$1,100
Balcony
$1,510
Suite
-
From
US$950
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visit: Brazil
Inside
$569
Oceanview
$649
Balcony
$739
Suite
$1,179
From
US$569
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Bonus Onboard Credit
Inside
$1,949
Oceanview
$2,209
Balcony
$2,473
Suite
$8,438
From
US$1,949
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain
Bonus Onboard Credit
Inside
$888
Oceanview
$1,028
Balcony
$1,428
Suite
-
From
US$888
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Jan 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$889
Oceanview
$959
Balcony
$1,089
Suite
$1,349
From
US$889
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,104
Oceanview
$1,144
Balcony
$1,224
Suite
-
From
US$1,104
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

22 Days (21 Nights) Santos to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy, Sicily
Bonus Onboard Credit
Inside
$1,501
Oceanview
$1,711
Balcony
$2,230
Suite
-
From
US$1,501
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 22 February 2026
Visit: Brazil, Argentina, Uruguay
Bonus Onboard Credit
Inside
$1,034
Oceanview
$1,259
Balcony
$1,470
Suite
$2,061
From
US$1,034
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Venice
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 20 March 2027
Visit: Brazil, Cape Verde, Spain, Morocco, Malta, Croatia, Italy
Bonus Onboard Credit
Inside
$1,591
Oceanview
$1,871
Balcony
$3,045
Suite
$3,734
From
US$1,591
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Itajai
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$811
Oceanview
$861
Balcony
$1,191
Suite
$1,361
From
US$811
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 11 April 2026
Visit: Brazil, Spain, Gibraltar, France, Italy
Grand Voyages Sale
Inside
-
Oceanview
-
Balcony
$1,719
Suite
$2,990
From
US$1,719
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,375
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,465
From
US$475
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 11 April 2026
Visit: Brazil, Spain, Gibraltar, France
Bonus Onboard Credit
Inside
-
Oceanview
$1,620
Balcony
$2,010
Suite
$2,963
From
US$1,620
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
$2,014
Oceanview
$2,062
Balcony
$2,159
Suite
-
From
US$2,014
Save 53
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$329
Oceanview
$389
Balcony
$579
Suite
$699
From
US$329
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,619
Oceanview
$1,669
Balcony
$1,789
Suite
$11,489
From
US$1,619
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Santos to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$679
Oceanview
$809
Balcony
$1,189
Suite
$1,439
From
US$679
Per Person
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Santos to Palermo
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily
Bonus Onboard Credit
Inside
$1,709
Oceanview
$2,049
Balcony
$2,188
Suite
$7,397
From
US$1,709
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy
Bonus Onboard Credit
Inside
$1,104
Oceanview
$1,264
Balcony
$1,714
Suite
-
From
US$1,104
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar
Bonus Onboard Credit
Inside
$1,259
Oceanview
$1,439
Balcony
$1,709
Suite
$3,815
From
US$1,259
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Santos to Genoa
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 01 April 2027
Visit: Brazil, Spain, France, Italy
Bonus Onboard Credit
Inside
$1,029
Oceanview
$1,199
Balcony
$1,599
Suite
-
From
US$1,029
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Bonus Onboard Credit
Inside
$1,379
Oceanview
$1,609
Balcony
$1,939
Suite
$3,274
From
US$1,379
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Jan 2026 to Dec 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Santos to Rome
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 15 March 2026
Visit: Brazil, Cape Verde, Spain, Morocco, Italy
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,226
Suite
-
From
US$2,226
Save 54
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Drinks & WiFi Package
Inside
$133
Oceanview
$196
Balcony
$238
Suite
$406
From
US$133
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Bonus Onboard Credit
Inside
$1,394
Oceanview
$1,664
Balcony
$1,894
Suite
$5,265
From
US$1,394
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy
Bonus Onboard Credit
Inside
$1,791
Oceanview
$2,031
Balcony
$2,337
Suite
$7,750
From
US$1,791
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain
Bonus Onboard Credit
Inside
-
Oceanview
-
Balcony
$1,888
Suite
$3,414
From
US$1,888
Per Person
View Trip
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