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MSC Cruises from Rome

Start your journey from Rome with 61 unique MSC cruise itineraries to choose from. April is the most popular month to begin your cruise from Rome and MSC Cruises have 380 trips departing this season.
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3 Days
122 Days
Price
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61 Cruises (380 Cruise Departures)
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Kusadasi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 23 April 2027
Visit: Italy, Greece, Turkey
Inside
$299
Oceanview
$369
Balcony
$439
Suite
$1,099
From
US$299
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,454
Oceanview
$1,724
Balcony
$2,004
Suite
$3,199
From
US$1,454
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 28 October 2026
Visit: Italy, Spain, Portugal, Puerto Rico, USA
Bonus Onboard Credit
Inside
$1,109
Oceanview
$1,339
Balcony
$1,568
Suite
-
From
US$1,109
Per Person
View Trip
13 Day MSC World Cruise with MSC Cruises
Cruise

13 Days (12 Nights) Rome to Berlin
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 May 2027
Visit: Italy, France, Spain, Germany
Bonus Onboard Credit
Inside
$1,319
Oceanview
$1,559
Balcony
$1,959
Suite
$3,336
From
US$1,319
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2027 to Nov 2027
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$846
Oceanview
$956
Balcony
$1,056
Suite
$1,546
From
US$846
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC World Asia, MSC World Europa
Departures: Feb 2026 to Mar 2028
Visit: Italy, Sicily, Malta, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$764
Oceanview
$834
Balcony
$1,013
Suite
$1,604
From
US$764
Save 52
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Sep 2026
Visit: Italy, France, Spain, Sardinia
Bonus Onboard Credit
Inside
$740
Oceanview
$790
Balcony
$1,000
Suite
$1,780
From
US$740
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
-
Oceanview
-
Balcony
$529
Suite
$1,259
From
US$529
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 25 December 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$2,202
Oceanview
$2,367
Balcony
$2,561
Suite
$3,667
From
US$2,202
Save 60
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2027 to Oct 2027
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Inside
$820
Oceanview
$920
Balcony
$1,100
Suite
-
From
US$820
Per Person
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Funchal
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
$667
Oceanview
$775
Balcony
$874
Suite
$1,671
From
US$667
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France, Spain
Inside
$359
Oceanview
$411
Balcony
$758
Suite
$872
From
US$359
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Apr 2026 to Oct 2027
Visit: Italy, Greece, Turkey
Bonus Onboard Credit
Inside
$699
Oceanview
$869
Balcony
$1,006
Suite
$1,397
From
US$699
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Visit: Italy, Sicily, Spain, France
Bonus Onboard Credit
Exclusive Savings
Inside
$989
Oceanview
$1,159
Balcony
$1,289
Suite
$1,769
From
US$989
Save 59
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 20 April 2026
Visit: Italy, France, Spain
Inside
$289
Oceanview
$349
Balcony
$469
Suite
$859
From
US$289
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France
Inside
-
Oceanview
$311
Balcony
$460
Suite
$628
From
US$311
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,487
Oceanview
$1,807
Balcony
$2,137
Suite
$3,398
From
US$1,487
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Berlin
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 14 May 2026
Visit: Italy, France, Spain, Germany
Bonus Onboard Credit
Inside
-
Oceanview
$1,590
Balcony
$2,059
Suite
-
From
US$1,590
Per Person
View Trip
12 Day Western Europe with MSC Cruises
Cruise

12 Days (11 Nights) Rome to London
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 May 2027
Visit: Italy, Spain, Portugal, France, England
Bonus Onboard Credit
Inside
$1,184
Oceanview
$1,434
Balcony
$1,714
Suite
$3,515
From
US$1,184
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departures: Apr 2027 to May 2027
Visit: Italy, France, Spain, Morocco, Portugal
Bonus Onboard Credit
Inside
$1,642
Oceanview
$1,842
Balcony
$2,444
Suite
$2,658
From
US$1,642
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise

14 Days (13 Nights) Rome to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,094
Oceanview
$1,324
Balcony
$1,564
Suite
$2,683
From
US$1,094
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 08 April 2027
Visit: Italy, Spain, France
Bonus Onboard Credit
Inside
$731
Oceanview
$881
Balcony
$1,131
Suite
$1,331
From
US$731
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 22 October 2027
Visit: Italy, Greece, Turkey, France, Spain, Brazil
Bonus Onboard Credit
Inside
$2,200
Oceanview
$2,495
Balcony
$2,913
Suite
$4,736
From
US$2,200
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 16 November 2027
Visit: Italy, Spain, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,869
Oceanview
$2,265
Balcony
$2,469
Suite
$3,846
From
US$1,869
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Bonus Onboard Credit
Inside
$1,220
Oceanview
$1,369
Balcony
$1,674
Suite
$2,832
From
US$1,220
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Rome to La Romana
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 29 October 2026
Visit: Italy, France, Spain, Morocco (+8 more), Antigua and Barbuda, Saint Martin, Saint Kitts and Nevis, Dominican Republic, Barbados, Martinique, Guadeloupe, Virgin Islands
Bonus Onboard Credit
Inside
$1,874
Oceanview
$2,324
Balcony
$3,663
Suite
$5,759
From
US$1,874
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 23 April 2027
Visit: Italy, Greece, Turkey
Inside
$614
Oceanview
$734
Balcony
$854
Suite
$2,075
From
US$614
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 30 October 2026
Visit: Italy, Spain, Brazil
Bonus Onboard Credit
Inside
$1,254
Oceanview
$1,373
Balcony
$1,724
Suite
$2,946
From
US$1,254
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departures: Dec 2026 to Dec 2027
Visit: Italy, France, Spain, Morocco
Bonus Onboard Credit
Exclusive Savings
Inside
$2,306
Oceanview
$1,212
Balcony
$1,412
Suite
$2,367
From
US$1,212
Save 63
Per Person
View Trip
11 Day Mediterranean with MSC Cruises
Cruise

11 Days (10 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departures: May 2027 to Oct 2027
Visit: Italy, France, Spain, Morocco, Gibraltar
Bonus Onboard Credit
Inside
$1,572
Oceanview
$1,772
Balcony
$2,377
Suite
$2,590
From
US$1,572
Per Person
View Trip
Results: 31-60 of 61

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