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MSC South America Cruises

Join MSC on one of 90 cruises visiting the coastal ports and cities of South America this season. March is the most popular month to begin your cruise and MSC have 232 cruises departing between February 2026 and January 2028.
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122 Days
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90 Cruises (232 Cruise Departures)
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 March 2026
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$3,289
Oceanview
-
Balcony
$4,378
Suite
$6,150
From
A$3,289
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 16 February 2026
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$3,061
Oceanview
-
Balcony
$4,496
Suite
$6,259
From
A$3,061
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Exclusive Savings
Inside
$836
Oceanview
$885
Balcony
$994
Suite
-
From
A$836
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Feb 2026 to Mar 2026
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$2,840
Oceanview
$3,226
Balcony
$3,790
Suite
$5,424
From
A$2,840
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (2)

20 Days (19 Nights) Buenos Aires to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 March 2026
Visit: Argentina, Brazil, Spain, Morocco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,511
Suite
$5,144
From
A$4,511
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 17 February 2026
Visit: Argentina, Brazil, Uruguay
Drinks Package
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,670
From
A$9,670
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Exclusive Savings
Inside
$915
Oceanview
$984
Balcony
$1,301
Suite
-
From
A$915
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visit: Italy, France, Spain, Portugal, Brazil
Exclusive Savings
Inside
$2,073
Oceanview
$2,370
Balcony
$2,875
Suite
-
From
A$2,073
Per Person
View Trip
21 Day South America with MSC Cruises
Cruise
 (2)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Visit: Uruguay, Argentina, Brazil, Spain, Morocco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,613
Suite
$5,702
From
A$3,613
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Exclusive Savings
Inside
$836
Oceanview
$885
Balcony
$974
Suite
$2,033
From
A$836
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$3,269
Oceanview
$3,348
Balcony
$3,497
Suite
-
From
A$3,269
Per Person
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Marseille to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 07 November 2027
Visit: France, Spain, Portugal, Brazil
Exclusive Savings
Inside
$1,945
Oceanview
$2,133
Balcony
$2,718
Suite
-
From
A$1,945
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Jan 2027
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,899
Oceanview
$1,969
Balcony
$2,088
Suite
-
From
A$1,899
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Exclusive Savings
Inside
$836
Oceanview
$885
Balcony
$974
Suite
$1,865
From
A$836
Save 18
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Exclusive Savings
Inside
$1,701
Oceanview
$1,949
Balcony
$2,365
Suite
-
From
A$1,701
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Exclusive Savings
Inside
$2,795
Oceanview
$3,201
Balcony
$3,903
Suite
-
From
A$2,795
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Feb 2026 to Mar 2026
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$2,840
Oceanview
$3,384
Balcony
$3,949
Suite
$5,800
From
A$2,840
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Exclusive Savings
Inside
$1,574
Oceanview
$1,802
Balcony
$2,208
Suite
-
From
A$1,574
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Feb 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$1,500
Oceanview
$1,609
Balcony
$1,826
Suite
-
From
A$1,500
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 29 December 2026
Visit: Brazil
Exclusive Savings
Inside
$2,618
Oceanview
$2,708
Balcony
$2,846
Suite
$3,430
From
A$2,618
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Exclusive Savings
Inside
$3,385
Oceanview
$3,761
Balcony
$4,335
Suite
$13,925
From
A$3,385
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 26 December 2026
Visit: Brazil
Exclusive Savings
Inside
$2,589
Oceanview
$2,688
Balcony
$2,866
Suite
$3,410
From
A$2,589
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 January 2027
Visit: Italy, France, Spain, Gibraltar (+20 more), Morocco, Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin
World Cruise Inclusions
Exclusive Savings
Inside
$30,207
Oceanview
$34,830
Balcony
$48,977
Suite
-
From
A$30,207
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Exclusive Savings
Inside
$2,487
Oceanview
$2,962
Balcony
$3,437
Suite
$5,467
From
A$2,487
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 15 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Exclusive Savings
Inside
$2,240
Oceanview
$2,646
Balcony
$3,082
Suite
$5,210
From
A$2,240
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Feb 2026 to Mar 2026
Visit: Brazil
Exclusive Savings
Inside
$1,381
Oceanview
$1,539
Balcony
$2,292
Suite
$2,727
From
A$1,381
Save 23
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 18 November 2027
Visit: Spain, Brazil, Uruguay, Argentina
Exclusive Savings
Inside
$2,766
Oceanview
$3,370
Balcony
$3,607
Suite
$5,944
From
A$2,766
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 06 January 2027
Visit: France, Spain, Gibraltar, Morocco (+20 more), Cape Verde, Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy
World Cruise Inclusions
Exclusive Savings
Inside
$30,207
Oceanview
$34,830
Balcony
$48,977
Suite
-
From
A$30,207
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Mar 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Exclusive Savings
Inside
$1,490
Oceanview
$1,609
Balcony
$1,787
Suite
$2,213
From
A$1,490
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Buenos Aires to Trieste
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 31 March 2027
Visit: Argentina, Brazil, Spain, Corsica, Italy, Greece
Exclusive Savings
Inside
$3,203
Oceanview
$3,807
Balcony
$4,154
Suite
$6,550
From
A$3,203
Per Person
View Trip
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