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MSC South America Cruises

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89 Cruises (231 Cruise Departures)
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia, MSC Virtuosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Bonus Onboard Credit
Inside
$423
Oceanview
$453
Balcony
$513
Suite
$842
From
US$423
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 06 November 2027
Visit: Italy, France, Spain, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,234
Oceanview
$1,424
Balcony
$1,774
Suite
-
From
US$1,234
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

24 Days (23 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 31 October 2027
Visit: Italy, Sicily, Spain, France, Portugal, Brazil
Bonus Onboard Credit
Inside
$1,589
Oceanview
$1,859
Balcony
$2,279
Suite
-
From
US$1,589
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 15 March 2027
Visit: Brazil, Spain, Morocco, Gibraltar, Italy
Bonus Onboard Credit
Inside
$1,247
Oceanview
$1,527
Balcony
$1,847
Suite
$3,088
From
US$1,247
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Feb 2026 to Mar 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$1,032
Oceanview
$1,072
Balcony
$1,626
Suite
$1,914
From
US$1,032
Per Person
View Trip
21 Day South America with MSC Cruises
Cruise
 (2)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Visit: Uruguay, Argentina, Brazil, Spain, Morocco
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,295
Suite
$4,109
From
US$2,295
Save 54
Per Person
View Trip
122 Day MSC World Cruise with MSC Cruises
Cruise

122 Days (121 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 07 January 2027
Visit: Spain, Gibraltar, Morocco, Cape Verde (+20 more), Brazil, Argentina, Falkland Islands, Chile, French Polynesia, Cook Islands, New Zealand, Australia, New Caledonia, Vanuatu, American Samoa, USA, Mexico, Costa Rica, Panama, Jamaica, Virgin Islands, Saint Martin, Italy, France
Exclusive Savings
Inside
$17,572
Oceanview
$19,493
Balcony
$28,272
Suite
$43,937
From
US$17,572
Save 457
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,007
Oceanview
$1,098
Balcony
$1,248
Suite
$1,547
From
US$1,007
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Rio de Janeiro to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 04 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Bonus Onboard Credit
Inside
$1,884
Oceanview
$2,223
Balcony
$2,650
Suite
$8,092
From
US$1,884
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Bonus Onboard Credit
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Maceio to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$408
Oceanview
$489
Balcony
$569
Suite
$949
From
US$408
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: Feb 2027 to Mar 2027
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,001
Oceanview
$1,070
Balcony
$1,220
Suite
-
From
US$1,001
Per Person
View Trip
116 Day MSC World Cruise with MSC Cruises
Cruise

116 Days (115 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 January 2028
Visit: Italy, France, Spain, Turks and Caicos Islands (+24 more), Bahamas, Mexico, Costa Rica, Panama, Ecuador, Peru, Chile, French Polynesia, Tonga, New Caledonia, New Zealand, Australia, Indonesia, Vietnam, Thailand, Cambodia, Singapore, Malaysia, Sri Lanka, India, United Arab Emirates, Oman, Jordan, Egypt
Exclusive Savings
Inside
$18,267
Oceanview
$21,041
Balcony
$27,152
Suite
-
From
US$18,267
Save 482
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Bonus Onboard Credit
Inside
$944
Oceanview
$1,104
Balcony
$1,384
Suite
-
From
US$944
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Florence to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 10 November 2026
Visit: Italy, Sardinia, Sicily, Malta (+6 more), Spain, Gibraltar, Morocco, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,803
Suite
$4,132
From
US$2,803
Save 66
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 29 October 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,454
Oceanview
$1,724
Balcony
$2,004
Suite
$3,199
From
US$1,454
Per Person
View Trip
24 Day MSC Grand Voyages with MSC Cruises
Cruise

24 Days (23 Nights) Santos to Marseille
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco, Tunisia, Sicily, Italy, France
Bonus Onboard Credit
Inside
$1,949
Oceanview
$2,209
Balcony
$2,550
Suite
$8,438
From
US$1,949
Per Person
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Buenos Aires to Trieste
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 31 March 2027
Visit: Argentina, Brazil, Spain, Corsica, Italy, Greece
Bonus Onboard Credit
Inside
$1,844
Oceanview
$2,223
Balcony
$2,485
Suite
$3,824
From
US$1,844
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 16 November 2027
Visit: Italy, Spain, Brazil, Uruguay, Argentina
Bonus Onboard Credit
Inside
$1,869
Oceanview
$2,265
Balcony
$2,469
Suite
$3,846
From
US$1,869
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Feb 2026 to Mar 2026
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Inside
$1,680
Oceanview
$1,958
Balcony
$2,258
Suite
$3,199
From
US$1,680
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Amalfi to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 13 November 2027
Visit: Italy, France, Spain, Brazil
Drinks, WiFi & Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,955
From
US$7,955
Save 228
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,087
From
US$1,290
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 28 December 2026
Visit: Brazil, Uruguay, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
$2,303
Oceanview
$2,359
Balcony
$2,470
Suite
-
From
US$2,303
Save 62
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Preziosa
Departures: Mar 2026 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Bonus Onboard Credit
Drinks & WiFi Package
Inside
$908
Oceanview
$998
Balcony
$1,108
Suite
$1,388
From
US$908
Per Person
View Trip
26 Day MSC Grand Voyages with MSC Cruises
Cruise

26 Days (25 Nights) Rome to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 22 October 2027
Visit: Italy, Greece, Turkey, France, Spain, Brazil
Bonus Onboard Credit
Inside
$2,200
Oceanview
$2,495
Balcony
$2,913
Suite
$4,736
From
US$2,200
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Feb 2026 to Mar 2026
Visit: Uruguay, Argentina, Brazil
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$2,058
Balcony
$2,361
Suite
$3,406
From
US$2,058
Save 67
Per Person
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Rio de Janeiro to Oslo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Visit: Brazil, Portugal, Spain, England (+4 more), France, Belgium, Denmark, Norway
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,461
From
US$4,461
Save 120
Per Person
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Genoa to Santos
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 04 November 2027
Visit: Italy, France, Spain, Brazil
Bonus Onboard Credit
Inside
$1,337
Oceanview
$2,007
Balcony
$2,971
Suite
$3,679
From
US$1,337
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 22 February 2026
Visit: Brazil, Argentina, Uruguay
Bonus Onboard Credit
Inside
$1,034
Oceanview
$1,259
Balcony
$1,470
Suite
$2,061
From
US$1,034
Per Person
View Trip
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