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Cruises from Panama City

Choose from 28 unique cruises starting in Panama City, and travelling to Bridgetown, Buenos Aires, Fort Lauderdale, Lisbon, Los Angeles and more. January is the most popular month to join a cruise from Panama City and you can select from 34 departures available from ten leading cruise lines.
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28 Cruises (34 Departures)
28 Cruises (34 Departures)
Departures
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Duration
8 Days
37 Days
Countries Visited
End City
Ship Features
Operators
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Price
$3,300pp
$205,420pp
Countries
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New ReleaseCruise
 (3)

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Departures: Feb 2028 to Mar 2029
Visits: Panama, Colombia, Aruba, Curacao +4 more, Bonaire, Saint Vincent, Grenada, Barbados
Exclusive Savings
Oceanview
$14,332
Suite
$17,209
From (Per Person)
A$14,332
Save 4,227
Per Person
New ReleaseCruise
 (3)

19 Days (18 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Departure: 01 March 2029
Visits: Panama, Colombia, Aruba, Curacao +4 more, Bonaire, Saint Vincent, Grenada, Barbados
Exclusive Savings
Oceanview
$21,400
Suite
$25,938
From (Per Person)
A$21,400
Save 7,340
Per Person
Cruise
 (5)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara
Departure: 14 January 2028
Visits: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$4,666
Oceanview
$5,214
Balcony
$6,400
Suite
$9,370
From (Per Person)
A$4,666
Save 73
Per Person
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania
Departure: 15 January 2027
Visits: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,186
Suite
-
From (Per Person)
A$7,186
Save 2,164
Per Person
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania
Departure: 15 March 2028
Visits: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Inclusions
Exclusive Savings
Inside
$4,568
Oceanview
$6,081
Balcony
$7,284
Suite
$10,436
From (Per Person)
A$4,568
Save 2,082
Per Person
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania
Departure: 16 January 2028
Visits: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$4,721
Oceanview
$6,225
Balcony
$7,428
Suite
$10,435
From (Per Person)
A$4,721
Save 2,089
Per Person
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Departures: Jan 2028 to Jan 2029
Visits: Panama, Costa Rica
Exclusive Savings
Oceanview
$8,150
Suite
$11,281
From (Per Person)
A$8,150
Save 2,647
Per Person
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania
Departure: 15 March 2027
Visits: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$3,368
Oceanview
$4,190
Balcony
$4,917
Suite
$6,779
From (Per Person)
A$3,368
Save 3,182
Per Person
New ReleaseCruise

15 Days (14 Nights) Panama City to New York
Cruise Line: Crystal
Departure: 20 August 2027
Visits: Panama, Colombia, Jamaica, Cayman Islands, USA
Exclusive Savings
Oceanview
$9,490
Balcony
$12,100
Suite
$12,280
From (Per Person)
A$9,490
Save 810
Per Person
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania
Departure: 11 February 2029
Visits: Panama, Aruba, Grenada, Dominica, Saint Kitts and Nevis, Virgin Islands, USA
Your World Inclusions
Exclusive Savings
Balcony
$8,348
Suite
$11,394
From (Per Person)
A$8,348
Save 2,232
Per Person
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Departure: 09 March 2027
Visits: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Balcony
$34,103
Suite
$36,132
From (Per Person)
A$34,103
Save 2,607
Per Person
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Departure: 03 April 2027
Visits: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Exclusive Savings
Balcony
$11,422
Suite
$15,729
From (Per Person)
A$11,422
Save 4,173
Per Person
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Departure: 26 October 2026
Visits: Panama, Chile
Exclusive Savings
Balcony
$8,290
Suite
$10,701
From (Per Person)
A$8,290
Save 3,105
Per Person
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA
Exclusive Savings
Suite
$10,858
From (Per Person)
A$10,858
Save 222
Per Person
New ReleaseCruise

37 Days (36 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Departure: 24 October 2028
Visits: Panama, Colombia, Ecuador, Peru, Chile, Argentina, Antarctica
Exclusive Savings
Balcony
$60,700
Suite
$83,025
From (Per Person)
A$60,700
Save 17,065
Per Person
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Oceania
Departure: 19 January 2029
Visits: Panama, Costa Rica, Cayman Islands, Jamaica +4 more, Dominican Republic, Virgin Islands, Puerto Rico, USA
Your World Inclusions
Exclusive Savings
Balcony
$6,804
Suite
$11,673
From (Per Person)
A$6,804
Save 2,176
Per Person
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Departures: Oct 2027 to Oct 2028
Visits: Panama, Colombia, Ecuador, Peru, Chile
Exclusive Savings
Balcony
$13,769
Suite
$18,649
From (Per Person)
A$13,769
Save 6,226
Per Person
New ReleaseCruise

12 Days (11 Nights) Panama City to Fort Lauderdale
Cruise Line: Crystal
Departure: 11 December 2027
Visits: Panama, Costa Rica, Honduras, Guatemala, Belize, Mexico, USA
Exclusive Savings
Oceanview
$7,470
Balcony
$9,400
Suite
$9,900
From (Per Person)
A$7,470
Save 630
Per Person
Tour + Cruise

12 Days Panama City to San Jose
Cruise Line: Tauck
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visits: Panama, Costa Rica
From (Per Person)
A$13,999
Per Person
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Departure: 22 February 2027
Visits: Panama, Costa Rica, Honduras, Belize +5 more, Guatemala, Mexico, Cayman Islands, Jamaica, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$199,401
From (Per Person)
A$199,401
Save 6,019
Per Person
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Departure: 31 March 2027
Visits: Panama, Colombia, Aruba, Curacao +6 more, Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Exclusive Savings
Balcony
$8,187
Suite
$8,763
From (Per Person)
A$8,187
Save 11,163
Per Person
Cruise

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visits: Panama, Costa Rica, Honduras, Belize, Mexico, USA
Exclusive Savings
Balcony
$5,728
Suite
$8,864
From (Per Person)
A$5,728
Save 1,395
Per Person
New ReleaseCruise

10 Days (9 Nights) Panama City to San Jose
Cruise Line: Aurora Expeditions
Departure: 04 October 2027
Visits: Panama, Costa Rica
Exclusive Savings
Oceanview
$17,815
Balcony
$18,805
Suite
$28,309
From (Per Person)
A$17,815
Per Person
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Departure: 14 March 2028
Visits: Panama, Colombia, Aruba, Curacao +7 more, Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$33,599
Suite
$34,785
From (Per Person)
A$33,599
Save 2,601
Per Person
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visits: Panama, El Salvador, Guatemala, Mexico, USA, Canada
Exclusive Savings
Suite
$17,679
From (Per Person)
A$17,679
Save 361
Per Person
Cruise

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visits: Panama, Costa Rica, Belize, Mexico, USA
Exclusive Savings
Balcony
$5,924
Suite
$9,648
From (Per Person)
A$5,924
Save 1,391
Per Person
New ReleaseCruise

26 Days (25 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Departure: 31 October 2027
Visits: Panama, Colombia, Ecuador, Peru, Chile, Argentina
Exclusive Savings
Balcony
$44,213
Suite
$63,725
From (Per Person)
A$44,213
Save 8,782
Per Person
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Departure: 14 March 2028
Visits: Panama, Colombia, Aruba, Curacao +4 more, Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,434
Suite
$15,993
From (Per Person)
A$15,434
Save 2,266
Per Person
Results: 28 results

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