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Cruises from Panama City

Choose from 27 unique cruises starting in Panama City, and travelling to Bridgetown, Buenos Aires, Fort Lauderdale, Lisbon, Los Angeles and more. January is the most popular month to join a cruise from Panama City and you can select from 33 departures available from nine leading cruise lines.
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8 Days
37 Days
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$203,150pp
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27 Cruises (33 Cruise Departures)
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ships: Emerald Azzurra
Departures: Jan 2028 to Jan 2029
Visit: Panama, Costa Rica
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$8,150
Balcony
-
Suite
$10,301
From
A$8,150
Save 2,647
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: Panama, Costa Rica, Belize, Mexico, USA
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,022
Suite
$9,354
From
A$6,022
Save 1,391
Per Person
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
$4,813
Balcony
$5,511
Suite
$13,966
From
A$4,813
Save 3,317
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: Panama, Costa Rica, Honduras, Belize, Mexico, USA
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,630
Suite
$8,864
From
A$5,630
Save 1,381
Per Person
View Trip
11 Day Spanish Lullaby with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2028
Visit: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Inclusions
Exclusive Savings
Inside
$4,568
Oceanview
$6,081
Balcony
$7,284
Suite
$10,436
From
A$4,568
Save 2,082
Per Person
View Trip
12 Day Panama Canal Transit, Colombia & the Grenadines with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Ships: Emerald Azzurra
Departures: Feb 2028 to Mar 2029
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Saint Vincent, Grenada, Barbados
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$14,332
Balcony
-
Suite
$17,209
From
A$14,332
Save 4,227
Per Person
View Trip
19 Day Discover Panama, Costa Rica and Barbados with Emerald Cruises
New ReleaseCruise
 (3)

19 Days (18 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 01 March 2029
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Saint Vincent, Grenada, Barbados
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$21,400
Balcony
-
Suite
$25,938
From
A$21,400
Save 7,340
Per Person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$3,982
Oceanview
$4,741
Balcony
$5,565
Suite
$7,676
From
A$3,982
Save 2,778
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (5)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$4,666
Oceanview
$5,214
Balcony
$6,400
Suite
$9,370
From
A$4,666
Save 73
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 16 January 2028
Visit: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Your World Inclusions
Exclusive Savings
Inside
$4,721
Oceanview
$6,225
Balcony
$7,428
Suite
$10,435
From
A$4,721
Save 2,089
Per Person
View Trip
37 Day Ultimate Voyage: South America & Antarctica with Scenic
New ReleaseCruise

37 Days (36 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 24 October 2028
Visit: Panama, Colombia, Ecuador, Peru, Chile, Argentina, Antarctica
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$60,700
Suite
$83,025
From
A$60,700
Save 17,065
Per Person
View Trip
12 Day Crescent Beaches & Colorful Towns with Regent Seven Seas
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 22 February 2027
Visit: Panama, Costa Rica, Honduras, Belize (+5 more), Guatemala, Mexico, Cayman Islands, Jamaica, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$197,177
From
A$197,177
Save 5,973
Per Person
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Visit: Panama, Costa Rica, El Salvador, Guatemala, Mexico, USA, French Polynesia
Exquisite Escapes
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,212
Suite
$19,974
From
A$19,212
Save 17,268
Per Person
View Trip
12 Day Canal Gates To Leeward Light with Oceania Cruises
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 11 February 2029
Visit: Panama, Aruba, Grenada, Dominica, Saint Kitts and Nevis, Virgin Islands, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,348
Suite
$11,394
From
A$8,348
Save 2,232
Per Person
View Trip
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,716
Suite
$15,729
From
A$12,716
Save 4,199
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$10,858
From
A$10,858
Save 222
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,290
Suite
$10,701
From
A$8,290
Save 3,105
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Tour + Cruise

12 Days Panama City to San Jose
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Panama, Costa Rica
From
A$14,140
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Oct 2027 to Oct 2028
Visit: Panama, Colombia, Ecuador, Peru, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,406
Suite
$18,649
From
A$14,406
Save 6,239
Per Person
View Trip
26 Day Ultimate Ancient Treasures, Fjords & Wonders of South America with Scenic
New ReleaseCruise

26 Days (25 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile, Argentina
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$44,213
Suite
$63,725
From
A$44,213
Save 8,782
Per Person
View Trip
10 Day Panama and Costa Rica: Crossing the Canal with Aurora Expeditions
New ReleaseCruise

10 Days (9 Nights) Panama City to San Jose
Cruise Line: Aurora Expeditions
Ship: Douglas Mawson
Departure: 20 October 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
$17,995
Balcony
$18,995
Suite
$28,595
From
A$17,995
Per Person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+7 more), Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$33,599
Suite
$34,785
From
A$33,599
Save 2,601
Per Person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Visit: Panama, Colombia, Aruba, Curacao (+6 more), Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Single Supplement Special
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,336
Suite
$17,884
From
A$17,336
Save 2,294
Per Person
View Trip
13 Day Panama Canal& Island Gems with Oceania Cruises
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 19 January 2029
Visit: Panama, Costa Rica, Cayman Islands, Jamaica (+4 more), Dominican Republic, Virgin Islands, Puerto Rico, USA
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,804
Suite
$11,673
From
A$6,804
Save 2,176
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA, Canada
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$17,679
From
A$17,679
Save 361
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,434
Suite
$15,993
From
A$15,434
Save 2,266
Per Person
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Visit: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$33,720
Suite
$35,102
From
A$33,720
Save 2,600
Per Person
View Trip
Results: 27 results

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