Home > Cruises > Central America Cruises > Panama > Cruises From Panama City

Cruises From Panama City

Choose from 19 unique cruises starting in Panama City, and travelling to Bridgetown, Fort Lauderdale, Galveston, Los Angeles, Miami and more. December, February and April are the most popular months to join a cruise from Panama City and you can select from 23 departures available from eight leading cruise lines.
Filter Results
Departures
Show More...
Duration
8 Days
14 Days
Countries Visited
End City
Ship Features
Operators
Show More...
Price
$1,800pp
$24,995pp
Countries
Show More...
Filter Results
19 Cruises (23 Cruise Departures)
10 Day Panama Canal Voyage with Azamara Cruises
Save Map View
Cruise
 (1)

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$3,445
OCEANVIEW
$3,492
BALCONY
$4,009
SUITE
$5,820
From 3,445
12 Day Classic Panama Canal with Oceania Cruises
Save Map View
Cruise
 (2)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Exclusive Deal
INSIDE
$5,835
OCEANVIEW
$6,281
BALCONY
$8,764
SUITE
-
Save 2,115
From 5,835
11 Day Captivating Panama Canal with Oceania Cruises
Save Map View
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
$5,065
OCEANVIEW
$5,579
BALCONY
$7,849
SUITE
$10,429
Save 2,095
From 5,065
12 Day Caribbean Quest Voyage with Azamara Cruises
Save Map View
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$4,128
OCEANVIEW
$5,078
BALCONY
$5,998
SUITE
$6,918
From 4,128
11 Day Classic Panama Canal Passage with Viking Cruises
Save Map View
Cruise
 (5)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,638
SUITE
$8,212
Save 2,461
From 5,638
8 Day Panama City to Fort Lauderdale with Silversea
Save Map View
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$5,395
BALCONY
$6,286
SUITE
-
Save 805
From 5,395
11 Day Panama Canal - Panama City with Norwegian Cruise Line
Save Map View
Cruise

11 Days (10 Nights) Panama City to Miami
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea OfferExclusive Solo Offer
INSIDE
$3,133
OCEANVIEW
$3,593
BALCONY
$4,815
SUITE
$5,197
From 3,133
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
Save Map View
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,727
SUITE
$14,538
Save 3,618
From 11,727
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Save Map View
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,767
SUITE
$10,361
Save 6,583
From 9,767
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Save Map View
Cruise

10 Days (9 Nights) Panama City to Miami
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
Free At Sea Offer
INSIDE
$1,842
OCEANVIEW
$2,070
BALCONY
$3,142
SUITE
$3,294
From 1,842
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Save Map View
Cruise

12 Days (11 Nights) Panama City to Miami
Departure: 16 February 2026
Countries Visited: Panama, Colombia, Aruba, Saint Lucia (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea OfferExclusive Solo Offer
INSIDE
$3,269
OCEANVIEW
$3,804
BALCONY
$5,303
SUITE
$5,686
From 3,269
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Save Map View
Cruise

12 Days (11 Nights) Panama City to Miami
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea Offer
INSIDE
$3,121
OCEANVIEW
$3,503
BALCONY
$5,338
SUITE
$5,674
From 3,121
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Save Map View
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
11 Day Classic Canal & Tropics with Oceania Cruises
Save Map View
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,911
OCEANVIEW
$5,357
BALCONY
$7,695
SUITE
$10,566
Save 2,099
From 4,911
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Save Map View
Cruise

11 Days (10 Nights) Panama City to Tampa
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$2,741
OCEANVIEW
$2,955
BALCONY
$4,347
SUITE
$4,775
From 2,741
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Save Map View
Cruise

12 Days (11 Nights) Panama City to Galveston
Departure: 26 January 2026
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$3,304
OCEANVIEW
$3,840
BALCONY
$5,216
SUITE
$5,721
From 3,304
11 Day Canal & Coral Isles with Oceania Cruises
Save Map View
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$4,767
OCEANVIEW
$5,213
BALCONY
$7,551
SUITE
$10,422
Save 2,093
From 4,767
14 Day Panama Canal - Panama City with Norwegian Cruise Line
Save Map View
Cruise

14 Days (13 Nights) Panama City to New York
Departure: 22 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+5 more), Saint Lucia, Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea Offer
INSIDE
$4,565
OCEANVIEW
$5,329
BALCONY
$7,241
SUITE
$8,388
From 4,565
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
Save Map View
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Departure: 26 October 2026
Countries Visited: Panama, Chile
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,311
SUITE
$10,746
Save 3,084
From 8,311
Results: 19 results

No Results found. Try changing your search filters.

Travel Styles

Trip Lengths

Country Routes