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Cruises From Panama City

Choose from 25 unique cruises starting in Panama City, and traveling to Bridgetown, Fort Lauderdale, Hong Kong, Honolulu, Lisbon and more. December, April and March are the most popular months to join a cruise from Panama City and you can select from 27 departures available from eight leading cruise lines.
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Duration
8 Days
38 Days
End City
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$2,400pp
$50,398pp
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25 Cruises (27 Cruise Departures)
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Countries Visited: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Fly Free Premium EconomyFly Free Business Class
Inside
-
Oceanview
-
Balcony
$11,910
Suite
$15,310
Save
12,080
From
11,910
per person
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Countries Visited: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$13,599
Suite
$14,699
Save
19,799
From
13,599
per person
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
From
9,390
per person
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$7,849
Suite
$8,249
Save
12,049
From
7,849
per person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Summer Of ChoiceExclusive Deal
Inside
$2,970
Oceanview
$3,330
Balcony
$4,680
Suite
$6,750
Save
3,628
From
2,970
per person
View Trip
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao, Aruba, Jamaica, USA
Summer Of Choice
Inside
$2,970
Oceanview
$3,060
Balcony
$4,680
Suite
$5,265
From
2,970
per person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Countries Visited: Panama, Colombia, Ecuador, Peru, Chile
Exclusive Deal
Inside
-
Oceanview
-
Balcony
$11,925
Suite
$15,975
Save
12,065
From
11,925
per person
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras, Mexico, USA
Summer Of ChoiceExclusive Deal
Inside
$2,475
Oceanview
$2,550
Balcony
$2,925
Suite
$4,312
From
2,475
per person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Countries Visited: Panama, Costa Rica, Belize, Mexico, USA
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,699
Suite
$5,899
From
3,699
per person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize, Mexico, USA
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,399
Suite
$4,999
Save
200
From
3,399
per person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Countries Visited: Panama, Costa Rica
Mutiple Deals Available
Inside
-
Oceanview
$7,150
Balcony
-
Suite
$8,883
Save
7,340
From
7,150
per person
View Trip
12 Day Panama Canal Transit, Colombia & the Grenadines with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 29 February 2028
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Saint Vincent, Grenada, Barbados
Mutiple Deals Available
Inside
-
Oceanview
$11,403
Balcony
-
Suite
$14,126
Save
11,587
From
11,403
per person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Fly Free Premium EconomyFly Free Business Class
Inside
-
Oceanview
-
Balcony
$9,480
Suite
$12,180
Save
9,510
From
9,480
per person
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA, Japan
Sail Into Savings
Inside
-
Oceanview
-
Balcony
$6,629
Suite
$12,324
From
6,629
per person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Countries Visited: Panama, Colombia, Aruba, Curacao (+7 more), Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$15,799
Suite
$16,699
Save
28,799
From
15,799
per person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Countries Visited: Panama, Colombia, Aruba, Curacao (+6 more), Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$8,499
Suite
$9,249
Save
15,499
From
8,499
per person
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao, Saint Vincent, Barbados
Fly Free Premium EconomyFly Free Business Class
Inside
-
Oceanview
-
Balcony
$13,325
Suite
$16,035
Save
13,465
From
13,325
per person
View Trip
38 Day Central America, Hawaiian Nights & Pacific Crossing with Seabourn
Cruise

38 Days (37 Nights) Panama City to Hong Kong
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA, Japan, Taiwan, China
Sail Into Savings
Inside
-
Oceanview
-
Balcony
$10,454
Suite
$16,404
From
10,454
per person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Countries Visited: Panama, El Salvador, Guatemala, Mexico, USA
Early Booking BenefitUnique Summer Special
Inside
-
Oceanview
-
Balcony
$6,760
Suite
$7,865
From
6,760
per person
View Trip
12 Day Crescent Beaches & Colorful Towns with Regent Seven Seas
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 22 February 2027
Countries Visited: Panama, Costa Rica, Honduras, Belize (+5 more), Guatemala, Mexico, Cayman Islands, Jamaica, USA
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$7,399
Suite
$7,799
Save
13,399
From
7,399
per person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Countries Visited: Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas, USA
Exclusive Deal
Inside
$3,199
Oceanview
$3,999
Balcony
$4,699
Suite
$6,899
Save
3,199
From
3,199
per person
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Countries Visited: Panama, Costa Rica, El Salvador, Guatemala, Mexico, USA, French Polynesia
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$20,999
Suite
$22,199
Save
29,399
From
20,999
per person
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Sail Into Savings
Inside
-
Oceanview
-
Balcony
$4,504
Suite
$6,374
From
4,504
per person
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Countries Visited: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Exclusive Deal
Inside
$3,199
Oceanview
$3,999
Balcony
$4,699
Suite
$6,899
Save
3,199
From
3,199
per person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Early Booking Saving
Inside
-
Oceanview
-
Balcony
$8,099
Suite
$8,499
Save
14,099
From
8,099
per person
View Trip
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