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Cruises from Panama City

Choose from 25 unique cruises starting in Panama City, and traveling to Bridgetown, Buenos Aires, Fort Lauderdale, Lisbon, Los Angeles and more. January is the most popular month to join a cruise from Panama City and you can select from 29 departures available from eight leading cruise lines.
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25 Cruises (29 Cruise Departures)
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Visit: Panama, Colombia, Bonaire, Curacao, Aruba, Jamaica, USA
Your World Inclusions
Exclusive Savings
Inside
$3,239
Oceanview
$3,724
Balcony
-
Suite
-
From
US$3,239
Save 3,359
Per Person
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Visit: Panama, Costa Rica, El Salvador, Guatemala, Mexico, USA, French Polynesia
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$21,043
Suite
$22,219
From
US$21,043
Save 30,155
Per Person
View Trip
19 Day An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders with Explora Journeys
Cruise

19 Days (18 Nights) Panama City to Vancouver
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA, Canada
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$10,795
Suite
$12,495
From
US$10,795
Per Person
View Trip
11 Day Panama To Caribbean Joy with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 January 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Cayman Islands, USA
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,948
Oceanview
$3,821
Balcony
$4,500
Suite
$6,343
From
US$2,948
Save 3,050
Per Person
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Visit: Panama, Aruba, Trinidad and Tobago, Brazil, Grenada, Curacao
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,619
Suite
$17,305
From
US$16,619
Save 23,379
Per Person
View Trip
12 Day Panama Canal Transit, Colombia & the Grenadines with Emerald Cruises
New ReleaseCruise
 (3)

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 29 February 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Saint Vincent, Grenada, Barbados
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$10,249
Balcony
-
Suite
$12,917
From
US$10,249
Save 12,741
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$6,051
Balcony
-
Suite
$7,748
From
US$6,051
Save 8,439
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: Panama, Costa Rica, Honduras, Belize, Mexico, USA
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,399
Suite
$5,499
From
US$3,399
Save 200
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Visit: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,720
Oceanview
$2,960
Balcony
$4,074
Suite
$5,859
From
US$2,720
Save 4,078
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: Panama, Costa Rica, Belize, Mexico, USA
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
US$3,799
Per Person
View Trip
11 Day Spanish Lullaby with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2028
Visit: Panama, Costa Rica, Honduras, Guatemala, Mexico, USA
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,946
Oceanview
$3,916
Balcony
$4,692
Suite
$6,729
From
US$2,946
Save 3,052
Per Person
View Trip
27 Day Azure To Iberia with Regent Seven Seas
Cruise

27 Days (26 Nights) Panama City to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+7 more), Grenada, Dominica, Virgin Islands, USA, Bermuda, Portugal, Spain
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,418
Suite
$17,398
From
US$16,418
Save 29,980
Per Person
View Trip
11 Day Panama & Pristine Isles with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 March 2027
Visit: Panama, Colombia, Aruba, Curacao, Jamaica, Bahamas, USA
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,046
Oceanview
$3,822
Balcony
$4,404
Suite
$6,344
From
US$3,046
Save 3,152
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$3,165
Oceanview
$3,708
Balcony
$4,552
Suite
$6,657
From
US$3,165
Save 74
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 16 January 2028
Visit: Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands, USA
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,043
Oceanview
$4,013
Balcony
$4,789
Suite
$6,729
From
US$3,043
Save 3,155
Per Person
View Trip
15 Day Carnival Of Caribbean Colors with Regent Seven Seas
Cruise

15 Days (14 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 31 March 2027
Visit: Panama, Colombia, Aruba, Curacao (+6 more), Bonaire, Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, USA
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,003
Suite
$9,493
From
US$9,003
Save 16,295
Per Person
View Trip
26 Day Ultimate Ancient Treasures, Fjords & Wonders of South America with Scenic
New ReleaseCruise

26 Days (25 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$71,899
Suite
$97,604
From
US$71,899
Save 2,081
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$6,940
Suite
$8,075
From
US$6,940
Per Person
View Trip
12 Day Crescent Beaches & Colorful Towns with Regent Seven Seas
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 22 February 2027
Visit: Panama, Costa Rica, Honduras, Belize (+5 more), Guatemala, Mexico, Cayman Islands, Jamaica, USA
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,605
From
US$8,605
Save 14,893
Per Person
View Trip
12 Day Pristine islands of the Caribbean & the Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 April 2027
Visit: Panama, Colombia, Curacao, Saint Vincent, Saint Lucia, Barbados
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,140
Suite
$12,002
From
US$9,140
Save 16,750
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Tour + Cruise

12 Days Panama City to San Jose
Operated By: Tauck
Ships: Le Champlain, Le Lapérouse
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Panama, Costa Rica
From
US$9,290
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,521
Suite
$16,995
From
US$14,521
Save 18,469
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,157
Suite
$8,970
From
US$6,157
Save 12,833
Per Person
View Trip
13 Day Bon Bini Aruba with Regent Seven Seas
Cruise

13 Days (12 Nights) Panama City to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 14 March 2028
Visit: Panama, Colombia, Aruba, Curacao (+4 more), Grenada, Dominica, Virgin Islands, USA
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,458
Suite
$8,850
From
US$8,458
Save 14,740
Per Person
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Visit: Panama, Colombia, Aruba, Curacao, Saint Vincent, Barbados
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,421
Suite
$12,706
From
US$10,421
Save 16,479
Per Person
View Trip
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