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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? January and October are the most popular months to cruise between USA and Panama and there are 30 departures available from eight of the world's leading cruise lines.
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19 Cruises (30 Departures)
19 Cruises (30 Departures)
Departures
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Duration
10 Days
24 Days
Start & End Cities
Ship Size
Ship Features
Operators
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Price
$2,800pp
$47,840pp
Countries
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17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Fort Lauderdale to Santiago
Operator: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Visits: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Have It All Fare Option
Exclusive Savings
Inside
$2,856
Oceanview
$2,926
Balcony
$4,133
Suite
$6,252
From (Per Person)
A$2,856
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (4)

11 Days (10 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Marina
Departure: 05 March 2028
Visits: USA, Cayman Islands, Jamaica, Aruba, Curacao, Colombia, Panama
Your World Inclusions
Exclusive Savings
Inside
$4,568
Oceanview
$6,082
Balcony
$7,284
Suite
$10,437
From (Per Person)
A$4,568
Save 2,082
Per Person
View Trip
10 Day Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City with Azamara Cruises
Cruise
 (6)

10 Days (9 Nights) Miami to Panama City
Operator: Azamara
Ship: Azamara Quest
Departure: 05 January 2028
Visits: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Azamara Always Included
Exclusive Savings
Inside
$4,603
Oceanview
$5,311
Balcony
$6,316
Suite
$8,783
From (Per Person)
A$4,603
Save 306
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (4)

11 Days (10 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visits: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Inside
$3,090
Oceanview
$3,904
Balcony
$4,726
Suite
$6,844
From (Per Person)
A$3,090
Save 3,370
Per Person
View Trip
11 Day Central American Seas with Oceania Cruises
Cruise
 (4)

11 Days (10 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Marina
Departure: 06 January 2028
Visits: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Inside
$4,485
Oceanview
$5,726
Balcony
$6,832
Suite
$9,597
From (Per Person)
A$4,485
Save 2,075
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Operator: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visits: USA, Jamaica, Curacao, Aruba, Colombia, Panama
Exclusive Savings
Suite
$14,700
From (Per Person)
A$14,700
Save 300
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visits: USA, Mexico, Belize, Honduras +5 more, Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Balcony
$17,956
Suite
$19,151
From (Per Person)
A$17,956
Save 2,314
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visits: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,103
Suite
$16,652
From (Per Person)
A$16,103
Save 2,277
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$10,055
From (Per Person)
A$10,055
Save 8,675
Per Person
View Trip
13 Day Azure Islestopanama with Oceania Cruises
Cruise

13 Days (12 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Vista
Departure: 07 January 2029
Visits: USA, Virgin Islands, Saint Martin, Saint Kitts and Nevis +4 more, Curacao, Aruba, Colombia, Panama
Your World Inclusions
Exclusive Savings
Balcony
$6,805
Suite
$11,674
From (Per Person)
A$6,805
Save 2,175
Per Person
View Trip
18 Day A Grand Journey Through Balmy Shores & Enchanting Nature to Panama’s Wonders with Explora Journeys
Cruise

18 Days (17 Nights) San Juan to Panama City
Operator: Explora Journeys
Ship: Explora III
Departure: 05 April 2027
Visits: Puerto Rico, Saint Barthelemy, Montserrat, Saint Kitts and Nevis +6 more, USA, Jamaica, Curacao, Aruba, Colombia, Panama
Exclusive Savings
Suite
$20,751
From (Per Person)
A$20,751
Save 424
Per Person
View Trip
12 Day Voyage of the Tropics: Bahamas, Caribbean & Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Miami to Panama City
Operator: Scenic
Ship: Scenic Eclipse I
Departure: 13 October 2028
Visits: USA, Bahamas, Colombia, Panama
Exclusive Savings
Balcony
$14,042
Suite
$24,484
From (Per Person)
A$14,042
Save 2,703
Per Person
View Trip
13 Day Azure ABCs & Panama Passage with Oceania Cruises
Cruise

13 Days (12 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Sonata
Departure: 30 January 2029
Visits: USA, Dominican Republic, Bonaire, Curacao +4 more, Aruba, Colombia, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Balcony
$9,301
Suite
$12,473
From (Per Person)
A$9,301
Save 2,259
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) New York to Santiago
Operator: Viking
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2026 to Oct 2029
Visits: USA, Bahamas, Jamaica, Panama, Peru, Chile
Exclusive Savings
Balcony
$17,439
Suite
$22,584
From (Per Person)
A$17,439
Save 1,651
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visits: USA, Mexico, Belize, Honduras +5 more, Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Balcony
$12,201
Suite
$12,706
From (Per Person)
A$12,201
Save 15,429
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Operator: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visits: USA, Bahamas, Colombia, Panama
Exclusive Savings
Balcony
-
Suite
$38,196
From (Per Person)
A$38,196
Save 9,644
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Fort Lauderdale to Panama City
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: USA, Mexico, Belize, Costa Rica, Panama
Exclusive Savings
Balcony
$8,129
Suite
$11,461
From (Per Person)
A$8,129
Save 180
Per Person
View Trip
12 Day San Diego to Fuerte Amador with Crystal Cruises
New ReleaseCruise

12 Days (11 Nights) San Diego to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 09 August 2027
Visits: USA, Mexico, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
Oceanview
$6,891
Balcony
$8,997
Suite
$9,173
From (Per Person)
A$6,891
Save 1,809
Per Person
View Trip
24 Day Classic Caribbean & Canal with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Vista
Departure: 28 December 2028
Visits: USA, Cayman Islands, Guatemala, Belize +8 more, Mexico, Virgin Islands, Saint Martin, Saint Kitts and Nevis, Curacao, Aruba, Colombia, Panama
Your World Inclusions
Exclusive Savings
Balcony
$12,904
Suite
$20,751
From (Per Person)
A$12,904
Save 2,346
Per Person
View Trip
Results: 19 results

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Country Routes

Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from Dominican Republic to USA Cruises from USA to Dominican Republic Cruises from USA to Chile Cruises from USA to Panama Cruises from USA to Peru
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