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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November is the most popular month to cruise between USA and Panama and there are 25 departures available from eight of the world's leading cruise lines.
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20 Cruises (25 Cruise Departures)
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Countries Visited: USA, Bahamas, Jamaica, Panama, Peru, Chile
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$10,995
Suite
$15,995
From
10,995
per person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
3,799
per person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Countries Visited: USA, Mexico, Belize, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,699
Suite
$5,899
From
3,699
per person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Countries Visited: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$8,299
Suite
$8,699
Save
14,299
From
8,299
per person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador, Peru, Chile
Viking $999 Air DealFlights Included
Inside
-
Oceanview
-
Balcony
$8,195
Suite
$12,995
Save
1,500
From
8,195
per person
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Inside
$2,210
Oceanview
$2,405
Balcony
$3,575
Suite
$4,875
Save
4,588
From
2,210
per person
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Inside
$2,890
Oceanview
$3,060
Balcony
$4,420
Suite
$6,120
Save
3,908
From
2,890
per person
View Trip
11 Day Passage To Panama with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Countries Visited: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Inside
$2,145
Oceanview
$2,340
Balcony
$3,510
Suite
$4,745
Save
4,453
From
2,145
per person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Countries Visited: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Inside
$2,159
Oceanview
$2,409
Balcony
$3,209
Suite
$5,109
From
2,159
per person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$13,399
Suite
$14,149
Save
19,799
From
13,399
per person
View Trip
23 Day Palms To Andean Peaks with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Miami to Santiago
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+6 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Inside
$5,999
Oceanview
-
Balcony
$6,300
Suite
$9,375
Save
5,999
From
5,999
per person
View Trip
23 Day Atlantic Crossing & Panama Canal Passage with Seabourn
Cruise

23 Days (22 Nights) Lisbon to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 20 November 2025
Countries Visited: Portugal, Bermuda, USA, Bonaire, Curacao, Colombia, Panama
Sail Into Savings Offer
Inside
-
Oceanview
-
Balcony
$9,998
Suite
-
From
9,998
per person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Countries Visited: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Inside
$3,199
Oceanview
$3,999
Balcony
$4,699
Suite
$6,899
Save
3,199
From
3,199
per person
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica, Panama
Inside
$3,699
Oceanview
$4,149
Balcony
$6,049
Suite
-
Save
3,699
From
3,699
per person
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama, Ecuador, Peru, Chile
Inside
$1,749
Oceanview
$1,843
Balcony
$2,199
Suite
$2,849
From
1,749
per person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Fly Free Premium Economy
Inside
-
Oceanview
-
Balcony
$24,605
Suite
-
Save
24,625
From
24,605
per person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Countries Visited: USA, Mexico, Guatemala, Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$7,999
Suite
$8,499
Save
13,999
From
7,999
per person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$9,499
Suite
$10,149
Save
15,699
From
9,499
per person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Countries Visited: USA, Jamaica, Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$5,875
Suite
$7,160
From
5,875
per person
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Countries Visited: USA, Bonaire, Curacao, Colombia, Panama
Sail Into Savings Offer
Inside
-
Oceanview
-
Balcony
$6,573
Suite
$17,551
From
6,573
per person
View Trip
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