Home > Cruises > USA Cruises > Cruises from USA to Panama

Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November and January are the most popular months to cruise between USA and Panama and there are 23 departures available from eight of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
8 Days
22 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$400pp
$48,390pp
Countries
Show More...
Filter Results
19 Cruises (23 Cruise Departures)
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba, Curacao, Colombia, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,949
Oceanview
$3,919
Balcony
$4,695
Suite
$6,732
From
US$2,949
Save 3,049
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departures: Nov 2026 to Nov 2027
Visit: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,059
Oceanview
$2,159
Balcony
$3,059
Suite
$4,692
From
US$2,059
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: USA, Mexico, Belize, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
US$3,799
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 May 2026
Visit: USA, Cayman Islands, Aruba, Curacao, Panama
Exclusive Savings
Inside
$424
Oceanview
$436
Balcony
$893
Suite
$1,443
From
US$424
Save 281
Per Person
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,980
Oceanview
$2,160
Balcony
$3,120
Suite
$4,236
From
US$1,980
Save 4,618
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,480
Suite
$14,215
From
US$13,480
Save 20,318
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 06 November 2026
Visit: USA, Mexico, Panama, Ecuador, Peru, Chile
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Per Person
View Trip
11 Day Central American Seas with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,047
Oceanview
$4,017
Balcony
$4,793
Suite
$6,733
From
US$3,047
Save 3,151
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,637
Suite
$10,274
From
US$9,637
Save 16,161
Per Person
View Trip
18 Day A Grand Journey Through Balmy Shores & Enchanting Nature to Panama’s Wonders with Explora Journeys
Cruise

18 Days (17 Nights) San Juan to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 05 April 2027
Visit: Puerto Rico, Saint Barthelemy, Montserrat, Saint Kitts and Nevis (+6 more), USA, Jamaica, Curacao, Aruba, Colombia, Panama
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$8,995
Suite
$10,395
From
US$8,995
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,999
Suite
$6,799
From
US$3,999
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,595
Suite
$9,281
From
US$8,595
Save 14,903
Per Person
View Trip
10 Day Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City with Azamara Cruises
Cruise
 (4)

10 Days (9 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Azamara Always Included
Exclusive Savings
Inside
$3,371
Oceanview
$3,914
Balcony
$4,690
Suite
$6,592
From
US$3,371
Save 68
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,726
Balcony
$4,405
Suite
$6,345
From
US$2,999
Save 2,999
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Visit: USA, Bahamas, Jamaica, Panama, Peru, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,495
Suite
$15,995
From
US$9,495
Save 1,500
Per Person
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,450
Oceanview
$2,590
Balcony
-
Suite
-
From
US$2,450
Save 4,548
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$6,780
Suite
$7,870
From
US$6,780
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$47,076
Suite
$107,982
From
US$47,076
Save 1,314
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visit: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,655
Suite
$9,047
From
US$8,655
Save 14,943
Per Person
View Trip
Results: 19 results

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

North American Cruises

USA Cruises Canada & New England Cruises Alaska Cruises Hawaii Cruises

Travel Styles

Food & Wine Cruises Luxury Cruises Short Cruise Breaks

Countries

Bahamas Bermuda Canada Mexico USA

Cities

Cruises from Fort Lauderdale Cruises from Los Angeles Cruises from Miami Cruises from New York Cruises from San Juan Cruises from Tampa

Routes

Cruises from Baltimore to Baltimore Cruises from Boston to Boston Cruises from Cape Liberty to Cape Liberty Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Fort Lauderdale to San Diego Cruises from Fort Lauderdale to Vancouver Cruises from Galveston to Galveston Cruises from Jacksonville to Jacksonville Cruises from Los Angeles to Miami Cruises from Los Angeles to Los Angeles Cruises from Miami to Los Angeles Cruises from Miami to Panama City Cruises from Miami to Miami Cruises from New Orleans to New Orleans Cruises from New York to New York Cruises from Orlando to Orlando Cruises from Philadelphia to Philadelphia Cruises from San Diego to Fort Lauderdale Cruises from San Diego to San Diego Cruises from San Francisco to San Francisco Cruises from Seattle to Seattle Cruises from Tampa to Tampa

Country Routes

Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from Dominican Republic to USA Cruises from USA to Dominican Republic Cruises from USA to Chile Cruises from USA to Panama Cruises from USA to Peru

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Operators | Terms & Conditions | Site Map | We're hiring!

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations