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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November is the most popular month to cruise between USA and Panama and there are 20 departures available from nine of the world's leading cruise lines.
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22 Days
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17 Cruises (20 Cruise Departures)
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,597
Suite
-
From
US$23,597
Save 24,793
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departures: Nov 2026 to Nov 2027
Visit: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Book Early & Have It All Fare Option
Inside
$2,159
Oceanview
$2,409
Balcony
$3,209
Suite
$5,035
From
US$2,159
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,899
Suite
$6,499
From
US$3,899
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Visit: USA, Bahamas, Jamaica, Panama, Peru, Chile
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$10,995
Suite
$15,995
From
US$10,995
Per Person
View Trip
18 Day A Grand Journey Through Balmy Shores & Enchanting Nature to Panama’s Wonders with Explora Journeys
Cruise

18 Days (17 Nights) San Juan to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 05 April 2027
Visit: Puerto Rico, Saint Barthelemy, Montserrat, Saint Kitts and Nevis (+6 more), USA, Jamaica, Curacao, Aruba, Colombia, Panama
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$10,200
Suite
$11,305
From
US$10,200
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: USA, Mexico, Belize, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,699
Suite
$5,899
From
US$3,699
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 06 November 2026
Visit: USA, Mexico, Panama, Ecuador, Peru, Chile
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Per Person
View Trip
10 Day Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City with Azamara Cruises
Cruise
 (4)

10 Days (9 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Azamara Always Included
Exclusive Savings
Inside
$2,981
Oceanview
$3,514
Balcony
$4,290
Suite
$5,900
From
US$2,981
Save 58
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$7,400
Suite
$8,200
From
US$7,400
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 May 2026
Visit: USA, Cayman Islands, Aruba, Curacao, Panama
Exclusive Savings
Inside
$472
Oceanview
$575
Balcony
$1,099
Suite
$1,363
From
US$472
Save 373
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,958
Suite
$8,448
From
US$7,958
Save 14,240
Per Person
View Trip
13 Day Majestic Beaches & Canal Crossing with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 03 January 2026
Visit: USA, Cayman Islands, Jamaica, Bonaire (+5 more), Curacao, Aruba, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,070
Suite
-
From
US$10,070
Save 14,428
Per Person
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Visit: USA, Bonaire, Curacao, Colombia, Panama
More Moments On Us Offer
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,206
Suite
-
From
US$6,206
Per Person
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Visit: USA, Mexico, Costa Rica, Panama, Ecuador, Peru, Chile
Princess Standard
Inside
$1,349
Oceanview
-
Balcony
$2,093
Suite
$2,599
From
US$1,349
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,186
Suite
$13,921
From
US$13,186
Save 20,012
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,441
Suite
$10,078
From
US$9,441
Save 15,957
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visit: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,165
Suite
$8,557
From
US$8,165
Save 14,433
Per Person
View Trip
Results: 17 results

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