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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November and January are the most popular months to cruise between USA and Panama and there are 20 departures available from eight of the world's leading cruise lines.
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17 Cruises (20 Cruise Departures)
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Visit: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Fare Saver
Inside
$2,099
Oceanview
$2,199
Balcony
$3,099
Suite
$4,599
From
US$2,099
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 May 2026
Visit: USA, Cayman Islands, Aruba, Curacao, Panama
Exclusive Savings
Inside
$423
Oceanview
$481
Balcony
$994
Suite
$1,112
From
US$423
Save 281
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Visit: USA, Bahamas, Jamaica, Panama, Peru, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,995
Suite
$14,995
From
US$8,995
Save 2,000
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba, Curacao, Colombia, Panama
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,999
Balcony
$4,799
Suite
$6,899
From
US$2,999
Save 2,999
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: USA, Mexico, Belize, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
US$3,799
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,999
Balcony
$4,275
Suite
$5,850
From
US$2,999
Save 3,149
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,299
Suite
$17,999
From
US$17,299
Save 17,299
Per Person
View Trip
10 Day Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City with Azamara Cruises
Cruise
 (5)

10 Days (9 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Azamara Always Included
Inside
$2,999
Oceanview
$3,479
Balcony
$4,159
Suite
$5,819
From
US$2,999
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
-
Balcony
-
Suite
$7,105
From
US$7,105
Per Person
View Trip
11 Day Central American Seas with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,099
Oceanview
$4,099
Balcony
$4,899
Suite
$6,899
From
US$3,099
Save 3,099
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 06 November 2026
Visit: USA, Mexico, Panama, Ecuador, Peru, Chile
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,995
Suite
$14,995
From
US$8,995
Save 1,000
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$4,099
Suite
$6,799
From
US$4,099
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,399
Suite
$13,849
From
US$13,399
Save 13,399
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$26,140
Suite
$56,695
From
US$26,140
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visit: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,799
Suite
$12,199
From
US$11,799
Save 11,799
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,849
Suite
$12,099
From
US$11,849
Save 11,849
Per Person
View Trip
18 Day A Grand Journey Through Balmy Shores & Enchanting Nature to Panama’s Wonders with Explora Journeys
Cruise

18 Days (17 Nights) San Juan to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 05 April 2027
Visit: Puerto Rico, Saint Barthelemy, Montserrat, Saint Kitts and Nevis (+6 more), USA, Jamaica, Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
-
Balcony
-
Suite
$9,415
From
US$9,415
Per Person
View Trip
Results: 17 results

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