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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November and January are the most popular months to cruise between USA and Panama and there are 24 departures available from eight of the world's leading cruise lines.
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20 Cruises (24 Cruise Departures)
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departures: Nov 2026 to Nov 2027
Visit: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,059
Oceanview
$2,159
Balcony
$3,059
Suite
$4,692
From
US$2,059
Per Person
View Trip
18 Day A Grand Journey Through Balmy Shores & Enchanting Nature to Panama’s Wonders with Explora Journeys
Cruise

18 Days (17 Nights) San Juan to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 05 April 2027
Visit: Puerto Rico, Saint Barthelemy, Montserrat, Saint Kitts and Nevis (+6 more), USA, Jamaica, Curacao, Aruba, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$14,100
Suite
$15,700
From
US$14,100
Per Person
View Trip
10 Day Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City with Azamara Cruises
Cruise
 (4)

10 Days (9 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 05 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Azamara Always Included
Exclusive Savings
Inside
$3,301
Oceanview
$3,844
Balcony
$4,620
Suite
$6,230
From
US$3,301
Save 68
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,154
Suite
$8,644
From
US$8,154
Save 14,444
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visit: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,655
Suite
$13,163
From
US$8,655
Save 14,943
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2026 to Dec 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,499
From
US$3,799
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,480
Suite
$24,015
From
US$13,480
Save 20,318
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,726
Balcony
$4,405
Suite
$6,345
From
US$2,999
Save 2,999
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visit: USA, Jamaica, Curacao, Aruba, Colombia, Panama
A Suite Invitation
Inside
-
Oceanview
-
Balcony
$7,105
Suite
$7,870
From
US$7,105
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Tampa to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 02 May 2026
Visit: USA, Cayman Islands, Aruba, Curacao, Panama
Exclusive Savings
Inside
$431
Oceanview
$469
Balcony
$939
Suite
$1,493
From
US$431
Save 284
Per Person
View Trip
11 Day Central American Seas with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 January 2028
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,047
Oceanview
$4,017
Balcony
$4,793
Suite
$6,733
From
US$3,047
Save 3,151
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2027 to Jan 2028
Visit: USA, Mexico, Belize, Costa Rica, Panama
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$3,799
Suite
$6,299
From
US$3,799
Per Person
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,450
Oceanview
$2,590
Balcony
-
Suite
-
From
US$2,450
Save 4,548
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 05 March 2028
Visit: USA, Cayman Islands, Jamaica, Aruba, Curacao, Colombia, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,949
Oceanview
$3,919
Balcony
$4,695
Suite
$6,732
From
US$2,949
Save 3,049
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Cruise Line: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Visit: USA, Bahamas, Jamaica, Panama, Peru, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$15,995
From
US$9,995
Save 1,000
Per Person
View Trip
11 Day Passage To Panama with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Visit: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,247
Oceanview
$3,538
Balcony
-
Suite
-
From
US$3,247
Save 3,351
Per Person
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Visit: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,246
Oceanview
$3,537
Balcony
$5,283
Suite
$7,029
From
US$3,246
Save 3,352
Per Person
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 06 November 2026
Visit: USA, Mexico, Panama, Ecuador, Peru, Chile
Viking $999 Air Deal
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$47,076
Suite
$107,982
From
US$47,076
Save 1,314
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visit: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Upgrade Your Horizon
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,637
Suite
$17,869
From
US$9,637
Save 16,161
Per Person
View Trip
Results: 20 results

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