Home > Cruises > USA Cruises > Cruises from USA to Panama

Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November is the most popular month to cruise between USA and Panama and there are 24 departures available from eight of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
8 Days
23 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$1,800pp
$27,140pp
Countries
Show More...
Filter Results
19 Cruises (24 Cruise Departures)
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Limited Time Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,638
SUITE
$8,608
Save (per person) 862
From (per person) 5,638
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 08 February 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Flex FaresExclusive Deal
INSIDE
$4,329
OCEANVIEW
$4,766
BALCONY
-
SUITE
-
Save (per person) 2,791
From (per person) 4,329
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 23 March 2025
Countries Visited: USA, Bahamas, Mexico, Guatemala (+4 more), Belize, Honduras, Costa Rica, Panama
Black Friday Sale
INSIDE
$4,792
OCEANVIEW
$4,792
BALCONY
-
SUITE
-
From (per person) 4,792
View Trip
11 Day Passage To Panama with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Flex FaresExclusive Deal
INSIDE
$4,263
OCEANVIEW
$4,696
BALCONY
$6,953
SUITE
$9,643
Save (per person) 2,247
From (per person) 4,263
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+3 more), Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$3,715
OCEANVIEW
$3,771
BALCONY
$4,240
SUITE
$5,230
From (per person) 3,715
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 04 January 2025
Countries Visited: USA, Dominican Republic, Puerto Rico, Saint Martin (+6 more), Virgin Islands, Saint Lucia, Aruba, Colombia, Panama, Costa Rica
INSIDE
$2,143
OCEANVIEW
$2,220
BALCONY
$3,320
SUITE
$3,626
From (per person) 2,143
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Countries Visited: USA, Bonaire, Curacao, Colombia (+1 more), Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,445
SUITE
$12,494
From (per person) 7,445
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$4,642
OCEANVIEW
$5,088
BALCONY
$7,464
SUITE
$10,295
Save (per person) 2,028
From (per person) 4,642
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,033
SUITE
$13,993
Save (per person) 7,357
From (per person) 13,033
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Countries Visited: USA, Bahamas, Colombia, Panama
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$20,005
SUITE
$25,193
Save (per person) 7,135
From (per person) 20,005
View Trip
23 Day Palms To Andean Peaks with Oceania Cruises
Cruise

23 Days (22 Nights) Miami to Santiago
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+6 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Black Friday Sale
INSIDE
$8,369
OCEANVIEW
$10,458
BALCONY
$10,458
SUITE
$13,289
From (per person) 8,369
View Trip
8 Day Fort Lauderdale to Panama City with Silversea
Cruise

8 Days (7 Nights) Fort Lauderdale to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 17 December 2024
Countries Visited: USA, Colombia, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
$5,148
BALCONY
$7,425
SUITE
$15,840
From (per person) 5,148
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Tampa to Panama City
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 29 January 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+3 more), Colombia, Panama, Costa Rica
INSIDE
$1,884
OCEANVIEW
$2,114
BALCONY
$3,292
SUITE
$3,902
From (per person) 1,884
View Trip
13 Day Majestic Beaches & Canal Crossing with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 03 January 2026
Countries Visited: USA, Cayman Islands, Jamaica, Bonaire (+5 more), Curacao, Aruba, Colombia, Costa Rica, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,581
SUITE
$13,175
Save (per person) 6,309
From (per person) 12,581
View Trip
23 Day Atlantic Crossing & Panama Canal Passage with Seabourn
Cruise

23 Days (22 Nights) Lisbon to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 20 November 2025
Countries Visited: Portugal, Bermuda, USA, Bonaire (+3 more), Curacao, Colombia, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,054
SUITE
$22,404
From (per person) 14,054
View Trip
12 Day San Diego to Panama City with Silversea
Cruise

12 Days (11 Nights) San Diego to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$9,207
SUITE
-
From (per person) 9,207
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Flex FaresExclusive Deal
INSIDE
$4,261
OCEANVIEW
$4,694
BALCONY
$6,951
SUITE
$9,641
Save (per person) 2,249
From (per person) 4,261
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Limited Time Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$15,043
SUITE
$20,983
Save (per person) 952
From (per person) 15,043
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Black Friday Sale
INSIDE
$5,534
OCEANVIEW
$5,534
BALCONY
$6,653
SUITE
$12,682
From (per person) 5,534
View Trip
Results: 19 results

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

North American Cruises

USA Cruises Canada & New England Cruises Alaska Cruises Hawaii Cruises

Travel Styles

Food & Wine Cruises Luxury Cruises Short Cruise Breaks

Countries

Bahamas Bermuda Canada Mexico USA

Cities

Fort Lauderdale Los Angeles Miami New York San Diego Tampa

Routes

Cruises from Baltimore to Baltimore Cruises from Boston to Boston Cruises from Cape Liberty to Cape Liberty Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Fort Lauderdale to San Diego Cruises from Galveston to Galveston Cruises from Los Angeles to Miami Cruises from Los Angeles to Los Angeles Cruises from Miami to Los Angeles Cruises from Miami to Panama City Cruises from Miami to Miami Cruises from New Orleans to New Orleans Cruises from New York to New York Cruises from Orlando to Orlando Cruises from San Diego to Fort Lauderdale Cruises from San Diego to San Diego Cruises from San Francisco to San Francisco Cruises from Seattle to Seattle Cruises from Tampa to Tampa

Country Routes

Cruises from Portugal to USA Cruises from USA to Chile Cruises from USA to Panama

© 2010-2024. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (AITA). No. A11351.

Travel Industry Associations