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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? November is the most popular month to cruise between USA and Panama and there are 22 departures available from seven of the world's leading cruise lines.
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23 Days
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16 Cruises (22 Cruise Departures)
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Fleetwide SaleExclusive Deal
INSIDE
$2,590
OCEANVIEW
$2,905
BALCONY
$4,235
SUITE
$5,950
Save (per person) 4,808
From (per person) 2,590
View Trip
23 Day Palms To Andean Peaks with Oceania Cruises
Cruise

23 Days (22 Nights) Miami to Santiago
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+6 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile
Exclusive DealSolo Offer
INSIDE
$5,699
OCEANVIEW
$6,999
BALCONY
$8,399
SUITE
$12,499
Save (per person) 5,699
From (per person) 5,699
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (8)

11 Days (10 Nights) Fort Lauderdale to Panama City
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$3,499
SUITE
$5,499
Save (per person) 300
From (per person) 3,499
View Trip
23 Day Atlantic Crossing & Panama Canal Passage with Seabourn
Cruise

23 Days (22 Nights) Lisbon to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 20 November 2025
Countries Visited: Portugal, Bermuda, USA, Bonaire (+3 more), Curacao, Colombia, Panama
A Sail To Remember
INSIDE
-
OCEANVIEW
-
BALCONY
$8,499
SUITE
$20,509
From (per person) 8,499
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Fleetwide SaleExclusive Deal
INSIDE
$2,970
OCEANVIEW
$3,330
BALCONY
$4,950
SUITE
$6,750
Save (per person) 3,628
From (per person) 2,970
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
FLY FREE With VikingViking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,195
SUITE
$14,995
Save (per person) 1,500
From (per person) 8,195
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Fleetwide SaleExclusive Deal
INSIDE
$2,970
OCEANVIEW
$3,240
BALCONY
$4,680
SUITE
$6,480
Save (per person) 3,628
From (per person) 2,970
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$9,199
SUITE
$9,849
Save (per person) 15,399
From (per person) 9,199
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$3,999
BALCONY
$4,699
SUITE
$6,899
Save (per person) 3,199
From (per person) 3,199
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+2 more), Peru, Chile
Exclusive Deal
INSIDE
$2,459
OCEANVIEW
$2,709
BALCONY
$3,409
SUITE
$5,109
From (per person) 2,459
View Trip
11 Day Passage To Panama with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 17 January 2026
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Fleetwide SaleExclusive Deal
INSIDE
$2,970
OCEANVIEW
$3,240
BALCONY
$4,680
SUITE
$6,570
Save (per person) 3,628
From (per person) 2,970
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) New York to Santiago
Operated By: Viking Cruises
Ship: Viking Polaris
Departure: 25 October 2026
Countries Visited: USA, Bahamas, Jamaica, Panama (+2 more), Peru, Chile
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,995
SUITE
$15,995
From (per person) 10,995
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Countries Visited: USA, Jamaica, Curacao, Aruba (+2 more), Colombia, Panama
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$6,160
SUITE
$7,160
From (per person) 6,160
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$13,099
SUITE
$13,849
Save (per person) 19,499
From (per person) 13,099
View Trip
21 Day Andes & South America with Princess
Cruise

21 Days (20 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+3 more), Ecuador, Peru, Chile
Bonus Instant Savings
INSIDE
$1,799
OCEANVIEW
$1,827
BALCONY
$2,415
SUITE
$2,899
From (per person) 1,799
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Countries Visited: USA, Bonaire, Curacao, Colombia (+1 more), Panama
Exclusive DealBonus Onboard Credit
INSIDE
-
OCEANVIEW
-
BALCONY
$6,709
SUITE
$10,899
From (per person) 6,709
View Trip
Results: 16 results

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Country Routes

Cruises from Chile to USA Cruises from Portugal to USA Cruises from USA to Chile Cruises from USA to Panama

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