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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? January and October are the most popular months to cruise between USA and Panama and there are 31 departures available from eight of the world's leading cruise lines.
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20 Cruises (31 Departures)
20 Cruises (31 Departures)
Departures
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Duration
10 Days
24 Days
Start & End Cities
Ship Size
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Price
$1,900pp
$34,998pp
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10 Day Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City with Azamara Cruises
Cruise
 (5)

10 Days (9 Nights) Miami to Panama City
Operator: Azamara
Ship: Azamara Quest
Departure: 05 January 2028
Visits: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Azamara Always Included
Exclusive Savings
Inside
$4,027
Oceanview
$4,673
Balcony
$5,595
Suite
$7,856
From (Per Person)
US$4,027
Save 212
Per Person
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Marina
Departures: Jan 2027 to Mar 2027
Visits: USA, Mexico, Belize, Guatemala, Honduras, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Inside
$2,287
Oceanview
$3,000
Balcony
$3,637
Suite
$5,475
From (Per Person)
US$2,287
Save 4,018
Per Person
View Trip
11 Day Central American Seas with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Marina
Departure: 06 January 2028
Visits: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Inside
$3,199
Oceanview
$4,099
Balcony
$4,899
Suite
$6,899
From (Per Person)
US$3,199
Save 3,199
Per Person
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Marina
Departure: 05 March 2028
Visits: USA, Cayman Islands, Jamaica, Aruba, Curacao, Colombia, Panama
Your World Inclusions
Exclusive Savings
Inside
$2,999
Oceanview
$3,999
Balcony
$4,799
Suite
$6,899
From (Per Person)
US$2,999
Save 2,999
Per Person
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (3)

17 Days (16 Nights) Fort Lauderdale to Santiago
Operator: Holland America
Ship: Oosterdam
Departure: 18 November 2026
Visits: USA, Cayman Islands, Panama, Ecuador, Peru, Chile
Have It All Fare Option
Inside
$1,979
Oceanview
$2,029
Balcony
$2,879
Suite
$4,379
From (Per Person)
US$1,979
Per Person
View Trip
11 Day A Journey Through Enchanting Nature & The Marvels Of The Panama Canal with Explora Journeys
Cruise

11 Days (10 Nights) Miami to Panama City
Operator: Explora Journeys
Ship: Explora III
Departure: 12 April 2027
Visits: USA, Jamaica, Curacao, Aruba, Colombia, Panama
Suite
$7,400
From (Per Person)
US$7,400
Per Person
View Trip
13 Day Flavors Of Cartagena with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 02 March 2028
Visits: USA, Cayman Islands, Jamaica, Dominican Republic, Colombia, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,099
Suite
$8,499
From (Per Person)
US$8,099
Save 14,099
Per Person
View Trip
24 Day Classic Caribbean & Canal with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Vista
Departure: 28 December 2028
Visits: USA, Cayman Islands, Guatemala, Belize +8 more, Mexico, Virgin Islands, Saint Martin, Saint Kitts and Nevis, Curacao, Aruba, Colombia, Panama
Your World Inclusions
Exclusive Savings
Balcony
$9,499
Suite
$15,299
From (Per Person)
US$9,499
Save 9,499
Per Person
View Trip
15 Day Exotic Coasts & Casco Viejo with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 23 February 2027
Visits: USA, Mexico, Belize, Honduras +5 more, Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Balcony
$9,399
Suite
$10,249
From (Per Person)
US$9,399
Save 15,599
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
CruiseFlights Included

20 Days (19 Nights) New York to Santiago
Operator: Viking
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2026 to Oct 2029
Visits: USA, Bahamas, Jamaica, Panama, Peru, Chile
Exclusive Savings
Balcony
$10,999
Suite
$15,999
From (Per Person)
US$10,999
Save 1,000
Per Person
View Trip
12 Day Voyage of the Tropics: Bahamas, Caribbean & Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Miami to Panama City
Operator: Scenic
Ship: Scenic Eclipse I
Departure: 13 October 2028
Visits: USA, Bahamas, Colombia, Panama
Exclusive Savings
Balcony
$9,683
Suite
$17,554
From (Per Person)
US$9,683
Save 2,412
Per Person
View Trip
13 Day Azure ABCs & Panama Passage with Oceania Cruises
Cruise

13 Days (12 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Sonata
Departure: 30 January 2029
Visits: USA, Dominican Republic, Bonaire, Curacao +4 more, Aruba, Colombia, Costa Rica, Panama
Your World Inclusions
Exclusive Savings
Balcony
$6,849
Suite
$9,199
From (Per Person)
US$6,849
Save 6,849
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visits: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,199
From (Per Person)
US$8,199
Save 14,199
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Fort Lauderdale to Panama City
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: USA, Mexico, Belize, Costa Rica, Panama
Balcony
$3,799
Suite
$6,299
From (Per Person)
US$3,799
Per Person
View Trip
12 Day San Diego to Fuerte Amador with Crystal Cruises
New ReleaseCruise

12 Days (11 Nights) San Diego to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 09 August 2027
Visits: USA, Mexico, El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Savings
Oceanview
$4,485
Balcony
$5,451
Suite
$5,714
From (Per Person)
US$4,485
Save 1,015
Per Person
View Trip
15 Day Tropical Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Miami to Panama City
Operator: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 January 2027
Visits: USA, Mexico, Belize, Honduras +5 more, Cayman Islands, Jamaica, Costa Rica, Colombia, Panama
Exclusive Savings
Balcony
$14,299
Suite
$14,999
From (Per Person)
US$14,299
Save 20,699
Per Person
View Trip
18 Day A Grand Journey Through Balmy Shores & Enchanting Nature to Panama’s Wonders with Explora Journeys
Cruise

18 Days (17 Nights) San Juan to Panama City
Operator: Explora Journeys
Ship: Explora III
Departure: 05 April 2027
Visits: Puerto Rico, Saint Barthelemy, Montserrat, Saint Kitts and Nevis +6 more, USA, Jamaica, Curacao, Aruba, Colombia, Panama
Suite
$11,515
From (Per Person)
US$11,515
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Fort Lauderdale to Panama City
Operator: Viking
Ship: Viking Mars
Departure: 07 December 2026
Visits: USA, Mexico, Belize, Honduras, Costa Rica, Panama
Balcony
$4,499
From (Per Person)
US$4,499
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Operator: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visits: USA, Bahamas, Colombia, Panama
Exclusive Savings
Balcony
-
Suite
$24,320
From (Per Person)
US$24,320
Save 4,970
Per Person
View Trip
13 Day Azure Islestopanama with Oceania Cruises
Cruise

13 Days (12 Nights) Miami to Panama City
Operator: Oceania
Ship: Oceania Vista
Departure: 07 January 2029
Visits: USA, Virgin Islands, Saint Martin, Saint Kitts and Nevis +4 more, Curacao, Aruba, Colombia, Panama
Your World Inclusions
Exclusive Savings
Balcony
$4,999
Suite
$8,599
From (Per Person)
US$4,999
Save 4,999
Per Person
View Trip
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