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Panama Luxury Cruises

Explore Panama on one of 40 luxury cruises, departing from Cartagena, Colon, London, Los Angeles, Miami and more. January is the most popular month to cruise to Panama and we have over 46 departures available from nine of the world's leading cruise lines specialising in luxury cruises.
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40 Cruises (46 Cruise Departures)
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 10 February 2028
Visit: Costa Rica, Panama
Black Friday Sale
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$10,031
Balcony
-
Suite
$12,699
From
US$10,031
Save 12,959
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Black Friday Sale
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$5,808
Balcony
-
Suite
$7,506
From
US$5,808
Save 8,682
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Champlain, Le Laperouse
Departures: Feb 2026 to Feb 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$6,610
Suite
$11,060
From
US$6,610
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,980
Suite
$10,150
From
US$5,980
Per Person
View Trip
8 Day Coastal Adventures: Costa Rica & Panama with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) San Jose to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama
Black Friday Sale
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$5,876
Balcony
-
Suite
$7,574
From
US$5,876
Save 8,614
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Black Friday Sale
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,157
Suite
$8,970
From
US$6,157
Save 12,833
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Dumont d’Urville
Departures: Dec 2025 to Nov 2026
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,290
Suite
$8,940
From
US$5,290
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$6,790
Suite
-
From
US$6,790
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$7,010
Balcony
$7,580
Suite
$12,770
From
US$7,010
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Dumont d’Urville, Le Laperouse
Departures: Dec 2025 to Feb 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,630
Suite
$9,540
From
US$5,630
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 January 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$11,840
Suite
$17,390
From
US$11,840
Per Person
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (4)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Visit: Chile, Peru, Panama
Azamara Always Included
Inside
$2,339
Oceanview
$2,549
Balcony
$3,000
Suite
$4,679
From
US$2,339
Per Person
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Visit: Curacao, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$5,670
Suite
$8,130
From
US$5,670
Per Person
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Visit: French Polynesia, Costa Rica, Panama
Black Friday Sale
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,226
Suite
$16,688
From
US$12,226
Save 20,564
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Black Friday Sale
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,196
Suite
$11,475
From
US$9,196
Save 15,894
Per Person
View Trip
19 Day New York To San Francisco with Cunard
Cruise
 (6)

19 Days (18 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Visit: USA, Curacao, Panama, Mexico
Inside
$1,819
Oceanview
$2,519
Balcony
-
Suite
$9,169
From
US$1,819
Per Person
View Trip
16 Day New York To Los Angeles with Cunard
Cruise
 (6)

16 Days (15 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Visit: USA, Curacao, Panama, Mexico
Inside
-
Oceanview
-
Balcony
$3,259
Suite
-
From
US$3,259
Per Person
View Trip
13 Day World Cruise: Panama Canal To Callao with Seabourn
Cruise

13 Days (12 Nights) Miami to Lima
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
$6,209
Balcony
$7,483
Suite
$16,009
From
US$6,209
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$3,006
Oceanview
$3,540
Balcony
$4,374
Suite
$6,178
From
US$3,006
Save 73
Per Person
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Visit: Panama, Costa Rica, Mexico, USA
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,222
Suite
$7,378
From
US$5,222
Per Person
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Visit: Panama, Costa Rica, Mexico, USA
Black Friday Bonus
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,715
Suite
$8,107
From
US$7,715
Save 12,183
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,597
Suite
-
From
US$23,597
Save 24,793
Per Person
View Trip
16 Day Central America Tapestry Voyage with Azamara Cruises
Cruise
 (8)

16 Days (15 Nights) Miami to Lima
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 January 2026
Visit: USA, Mexico, Panama, Ecuador, Peru
Azamara Always Included
Inside
-
Oceanview
$3,189
Balcony
$3,471
Suite
-
From
US$3,189
Per Person
View Trip
24 Day Southampton To Los Angeles with Cunard
Cruise
 (6)

24 Days (23 Nights) London to Los Angeles
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 11 January 2026
Visit: England, USA, Curacao, Panama, Mexico
Inside
$3,399
Oceanview
-
Balcony
-
Suite
-
From
US$3,399
Per Person
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Visit: Panama, Costa Rica, Mexico, USA, Japan
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,573
Suite
$20,235
From
US$8,573
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$7,240
Suite
$8,400
From
US$7,240
Per Person
View Trip
16 Day Miami To Los Angeles with Cunard
Cruise

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 23 January 2028
Visit: USA, Colombia, Panama, Guatemala, Mexico
Inside
$3,729
Oceanview
$4,679
Balcony
$5,579
Suite
$10,435
From
US$3,729
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Inside
$3,129
Oceanview
$3,629
Balcony
$4,529
Suite
-
From
US$3,129
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$5,100
Suite
$5,850
From
US$5,100
Per Person
View Trip
27 Day Southampton To San Francisco with Cunard
Cruise
 (6)

27 Days (26 Nights) London to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 11 January 2026
Visit: England, USA, Curacao, Panama, Mexico
Inside
$3,149
Oceanview
$4,249
Balcony
$4,549
Suite
-
From
US$3,149
Per Person
View Trip
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