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Panama Luxury Cruises

Explore Panama on one of 33 luxury cruises, departing from Cartagena, Colon, Los Angeles, Miami, Nassau and more. January is the most popular month to cruise to Panama and we have over 41 departures available from ten of the world's leading cruise lines specialising in luxury cruises.
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8 Days
22 Days
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33 Cruises (41 Cruise Departures)
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$6,610
Suite
$10,150
From
US$6,610
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Dumont d’Urville
Departures: Dec 2025 to Nov 2026
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,290
Suite
$8,940
From
US$5,290
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Dumont d’Urville, Le Laperouse
Departures: Dec 2025 to Feb 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,630
Suite
$9,540
From
US$5,630
Per Person
View Trip
8 Day Coastal Adventures: Costa Rica & Panama with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) San Jose to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama
Fly Free Economy
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$7,040
Balcony
-
Suite
$8,738
From
US$7,040
Save 7,450
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Fly Free Economy
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$7,021
Balcony
-
Suite
$8,718
From
US$7,021
Save 7,469
Per Person
View Trip
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 10 February 2028
Visit: Costa Rica, Panama
Fly Free Economy
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$11,200
Balcony
-
Suite
$13,868
From
US$11,200
Save 11,790
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Tour + Cruise

12 Days Panama City to San Jose
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Panama, Costa Rica
From
US$9,290
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Eastbound with Tauck
Tour + Cruise

12 Days Puntarenas to Panama City
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Costa Rica, Panama
From
US$9,290
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,157
Suite
$8,970
From
US$6,157
Save 12,833
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Champlain, Le Laperouse
Departures: Feb 2026 to Feb 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$6,610
Suite
$11,060
From
US$6,610
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$5,880
Balcony
$6,360
Suite
$10,010
From
US$5,880
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 January 2026
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$11,840
Suite
$17,390
From
US$11,840
Per Person
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Visit: French Polynesia, Costa Rica, Panama
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,517
Suite
$16,688
From
US$12,517
Save 20,273
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Wave Offer
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,263
Suite
$11,475
From
US$10,263
Save 14,827
Per Person
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (4)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Visit: Chile, Peru, Panama
Azamara Always Included
Inside
$2,679
Oceanview
$2,389
Balcony
$2,816
Suite
$4,388
From
US$2,389
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Exclusive Savings
Inside
$3,006
Oceanview
$3,540
Balcony
$4,374
Suite
$6,178
From
US$3,006
Save 73
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$23,597
Suite
$54,050
From
US$23,597
Save 24,793
Per Person
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Visit: Panama, Costa Rica, Mexico, USA
Black Friday Bonus
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,813
Suite
$8,107
From
US$7,813
Save 12,285
Per Person
View Trip
13 Day World Cruise: Panama Canal To Callao with Seabourn
Cruise

13 Days (12 Nights) Miami to Lima
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru
Explore More
Exclusive Savings
Inside
-
Oceanview
$5,284
Balcony
$6,367
Suite
$13,614
From
US$5,284
Per Person
View Trip
16 Day Central America Tapestry Voyage with Azamara Cruises
Cruise
 (8)

16 Days (15 Nights) Miami to Lima
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 January 2026
Visit: USA, Mexico, Panama, Ecuador, Peru
Azamara Always Included
Exclusive Savings
Inside
-
Oceanview
$3,655
Balcony
-
Suite
-
From
US$3,655
Save 64
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Inside
$3,129
Oceanview
$3,629
Balcony
$4,529
Suite
-
From
US$3,129
Per Person
View Trip
21 Day Miami To Seattle with Cunard
Cruise
 (13)

21 Days (20 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Inside
$1,589
Oceanview
$1,699
Balcony
$1,999
Suite
$6,535
From
US$1,589
Per Person
View Trip
11 Day A Journey from Miami to Miami with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 05 January 2026
Visit: USA, Colombia, Panama, Costa Rica, Cayman Islands
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$5,820
Suite
$8,965
From
US$5,820
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$5,100
Suite
$5,850
From
US$5,100
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 April 2026
Visit: USA, Guatemala, Panama, Curacao, Aruba
Inside
$1,689
Oceanview
$2,039
Balcony
$2,909
Suite
$6,068
From
US$1,689
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile
Early Booking Savings
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,611
Suite
$12,630
From
US$11,611
Save 12,379
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,958
Suite
$8,448
From
US$7,958
Save 14,240
Per Person
View Trip
21 Day Seattle to Miami with Silversea
Cruise
 (1)

21 Days (20 Nights) Seattle to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 11 May 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Last Minute Fare
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$7,800
Suite
$19,400
From
US$7,800
Per Person
View Trip
18 Day New York To Los Angeles with Cunard
Cruise
 (1)

18 Days (17 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador, Mexico
Inside
$2,519
Oceanview
$3,429
Balcony
$3,609
Suite
$14,564
From
US$2,519
Per Person
View Trip
15 Day Cartagena to Valparaiso with Silversea
Cruise

15 Days (14 Nights) Cartagena to Valparaiso
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 15 January 2028
Visit: Colombia, Panama, Ecuador, Peru, Chile
All-Inclusive Fare
Inside
-
Oceanview
$8,000
Balcony
$9,600
Suite
-
From
US$8,000
Per Person
View Trip
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