Home > Cruises > Central America Cruises > Panama Cruises > Panama Luxury Cruises

Panama Luxury Cruises

Explore Panama on one of 31 luxury cruises, departing from Cartagena, Colon, Fort-de-France, Los Angeles, Miami and more. January is the most popular month to cruise to Panama and we have over 50 departures available from ten of the world's leading cruise lines specialising in luxury cruises.
Filter Results
Departures
Show More...
Duration
8 Days
22 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$2,500pp
$56,695pp
Countries
Show More...
Filter Results
31 Cruises (50 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 23 February 2028
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$8,290
Suite
$13,140
From
US$8,290
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$7,790
Suite
$13,140
From
US$7,790
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,970
Suite
$10,140
From
US$5,970
Per Person
View Trip
8 Day Coastal Adventures: Costa Rica & Panama with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) San Jose to Panama City
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 22 February 2028
Visit: Costa Rica, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$5,310
Balcony
-
Suite
$6,885
From
US$5,310
Save 1,635
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$6,040
Suite
$9,440
From
US$6,040
Per Person
View Trip
8 Day Coastal Adventures: Panama & Costa Rica with Emerald Cruises
Cruise
 (3)

8 Days (7 Nights) Panama City to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 24 January 2028
Visit: Panama, Costa Rica
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$5,460
Balcony
-
Suite
$7,035
From
US$5,460
Save 1,635
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Jan 2028
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,640
Suite
$9,550
From
US$5,640
Per Person
View Trip
13 Day Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal with Emerald Cruises
New ReleaseCruise
 (3)

13 Days (12 Nights) San Jose to San Jose
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 10 February 2028
Visit: Costa Rica, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
$10,551
Balcony
-
Suite
$13,026
From
US$10,551
Save 1,974
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$6,320
Suite
$10,750
From
US$6,320
Per Person
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 19 February 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$7,440
Suite
$12,530
From
US$7,440
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$6,250
Balcony
$6,760
Suite
$10,670
From
US$6,250
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Eastbound with Tauck
Tour + Cruise

12 Days Puntarenas to Panama City
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Costa Rica, Panama
From
US$9,290
Per Person
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Tour + Cruise

12 Days Panama City to San Jose
Operated By: Tauck
Ship: Le Lapérouse
Departures: Jan 2027 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Panama, Costa Rica
From
US$9,290
Per Person
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Visit: Panama, Chile
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,494
Suite
$7,789
From
US$5,494
Save 2,351
Per Person
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Visit: Bahamas, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,943
Suite
$12,653
From
US$10,943
Save 2,052
Per Person
View Trip
11 Day Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao) with Azamara Cruises
Cruise
 (5)

11 Days (10 Nights) Panama City to Valparaiso
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 14 January 2028
Visit: Panama, Ecuador, Peru, Chile
Azamara Always Included
Inside
$3,239
Oceanview
$3,799
Balcony
$4,669
Suite
$6,839
From
US$3,239
Per Person
View Trip
13 Day World Cruise: Panama Canal To Callao with Seabourn
Cruise
 (1)

13 Days (12 Nights) Miami to Lima
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 05 January 2027
Visit: USA, Panama, Ecuador, Peru
Inside
-
Oceanview
-
Balcony
$7,598
Suite
$16,298
From
US$7,598
Per Person
View Trip
22 Day America's Historic Journey to Panama with Scenic
New ReleaseCruise

22 Days (21 Nights) New York to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 05 October 2026
Visit: USA, Bahamas, Colombia, Panama
Inside
-
Oceanview
-
Balcony
-
Suite
$56,695
From
US$56,695
Per Person
View Trip
12 Day Voyage of the Tropics: Bahamas, Caribbean & Panama Canal with Scenic
New ReleaseCruise

12 Days (11 Nights) Miami to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 October 2028
Visit: USA, Bahamas, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,683
Suite
$17,554
From
US$9,683
Save 2,412
Per Person
View Trip
18 Day New York To Los Angeles with Cunard
Cruise
 (1)

18 Days (17 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador, Mexico
Bonus Onboard Credit
Value Fare
Inside
$2,599
Oceanview
$3,559
Balcony
$3,719
Suite
-
From
US$2,599
Per Person
View Trip
10 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise
 (1)

10 Days (9 Nights) Fort-de-France to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departure: 19 November 2027
Visit: Martinique, Saint Vincent, Curacao, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$5,880
Suite
$9,270
From
US$5,880
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise
 (13)

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 13 April 2028
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Value Fare
Inside
$3,119
Oceanview
$3,619
Balcony
$4,309
Suite
-
From
US$3,119
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
Inside
-
Oceanview
-
Balcony
-
Suite
$5,215
From
US$5,215
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,349
Suite
$11,699
From
US$11,349
Save 11,349
Per Person
View Trip
16 Day Miami To Los Angeles with Cunard
Cruise

16 Days (15 Nights) Miami to Los Angeles
Cruise Line: Cunard
Ship: Queen Anne
Departure: 23 January 2028
Visit: USA, Colombia, Panama, Guatemala, Mexico
Value Fare
Inside
$3,419
Oceanview
$4,269
Balcony
$4,839
Suite
$9,099
From
US$3,419
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,536
Suite
$11,962
From
US$8,536
Save 3,009
Per Person
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Visit: Panama, El Salvador, Guatemala, Mexico, USA
Inside
-
Oceanview
-
Balcony
-
Suite
$6,915
From
US$6,915
Per Person
View Trip
15 Day Cartagena to Valparaiso with Silversea
Cruise

15 Days (14 Nights) Cartagena to Valparaiso
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 15 January 2028
Visit: Colombia, Panama, Ecuador, Peru, Chile
All-Inclusive Fare
Inside
-
Oceanview
$8,000
Balcony
$9,600
Suite
-
From
US$8,000
Per Person
View Trip
21 Day Ultimate Voyage: Caribbean Islands & the Panama Canal with Scenic
New ReleaseCruise

21 Days (20 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 October 2028
Visit: Bahamas, Turks and Caicos Islands, USA, Colombia, Panama
Inside
-
Oceanview
-
Balcony
$20,890
Suite
$32,605
From
US$20,890
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ships: Scenic Eclipse I
Departures: Oct 2027 to Oct 2028
Visit: Panama, Colombia, Ecuador, Peru, Chile
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,650
Suite
$15,511
From
US$11,650
Save 2,745
Per Person
View Trip
Results: 1-30 of 31

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Trip Lengths

10 Day 2 Week 3 Week 7 Day

Departure Months

October November December January February March April

Cities

Colon Panama City Santiago

Routes

Colon to Colon Miami to Panama City

Country Routes

Panama to USA USA to Panama

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

Central America Tours

All Central America Tours Belize Tours Costa Rica Tours Guatemala Tours Mexico Tours Panama Tours

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations