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Panama Luxury Cruises

Explore Panama on one of 40 luxury cruises, departing from Cartagena, Colon, London, Los Angeles, Miami and more. January is the most popular month to cruise to Panama and we have over 46 departures available from nine of the world's leading cruise lines specialising in luxury cruises.
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8 Days
30 Days
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$48,390pp
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40 Cruises (46 Cruise Departures)
15 Day Cartagena to Valparaiso with Silversea
Cruise

15 Days (14 Nights) Cartagena to Valparaiso
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 15 January 2028
Visit: Colombia, Panama, Ecuador, Peru, Chile
All-Inclusive Fare
Inside
-
Oceanview
$7,500
Balcony
$8,600
Suite
$18,900
From
US$7,500
Per Person
View Trip
18 Day New York To Los Angeles with Cunard
Cruise
 (1)

18 Days (17 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 19 January 2027
Visit: USA, Aruba, Panama, El Salvador, Mexico
Black Friday Sale
Inside
$2,399
Oceanview
$3,249
Balcony
$3,499
Suite
$13,772
From
US$2,399
Per Person
View Trip
13 Day Sapphire Sojourn with Regent Seven Seas
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 10 February 2027
Visit: USA, Mexico, Guatemala, Costa Rica, Panama
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,958
Suite
$8,448
From
US$7,958
Save 14,240
Per Person
View Trip
21 Day Miami To Seattle with Cunard
Cruise
 (13)

21 Days (20 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 April 2026
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Black Friday Sale
Inside
$1,699
Oceanview
$1,899
Balcony
$2,099
Suite
$7,041
From
US$1,699
Per Person
View Trip
11 Day A Journey from Miami to Miami with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 05 January 2026
Visit: USA, Colombia, Panama, Costa Rica, Cayman Islands
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$5,270
Suite
$6,075
From
US$5,270
Per Person
View Trip
21 Day Seattle to Miami with Silversea
Cruise
 (1)

21 Days (20 Nights) Seattle to Miami
Cruise Line: Silversea
Ship: Silver Nova
Departure: 11 May 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Last Minute Fare
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$7,800
Suite
$22,400
From
US$7,800
Per Person
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Visit: USA, Bonaire, Curacao, Colombia, Panama
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,206
Suite
-
From
US$6,206
Per Person
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 April 2026
Visit: USA, Guatemala, Panama, Curacao, Aruba
Inside
$1,709
Oceanview
$2,039
Balcony
$3,559
Suite
$6,068
From
US$1,709
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Black Friday Sale
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,808
Suite
$12,640
From
US$8,808
Save 17,382
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile
Black Friday Sale
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,731
Suite
$12,630
From
US$7,731
Save 16,259
Per Person
View Trip
Results: 31-40 of 40

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Trip Lengths

2 Week 3 Week 7 Day

Departure Months

November December January February March April May October

Cities

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Routes

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Country Routes

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