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Panama Cruises Starting In March 2026, 2027 and 2028

If you're looking at joining a cruise to Panama in March 2026, 2027 or 2028, we have 26 unique cruise itineraries and 149 departures available, operated by six of the world's leading cruise lines departing in March.
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26 Cruises (149 Cruise Departures)
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,300
Suite
$8,950
From
US$5,300
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Mar 2027
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$9,460
Suite
$14,480
From
US$9,460
Per Person
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Visit: French Polynesia, Costa Rica, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,457
Suite
$16,688
From
US$14,457
Save 18,333
Per Person
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (4)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Visit: Chile, Peru, Panama
Azamara Always Included
Inside
-
Oceanview
-
Balcony
$2,359
Suite
-
From
US$2,359
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 March 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$966
Oceanview
$1,097
Balcony
$1,556
Suite
$1,606
From
US$966
Save 538
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$861
Oceanview
$981
Balcony
$1,178
Suite
$1,233
From
US$861
Save 635
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$683
Oceanview
$745
Balcony
$1,020
Suite
$1,016
From
US$731
Save 758
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 18 March 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$919
Oceanview
$1,049
Balcony
$1,469
Suite
$1,499
From
US$919
Save 508
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$839
Oceanview
$949
Balcony
$1,329
Suite
$1,348
From
US$839
Save 542
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Visit: Panama, Colombia, Aruba, Bonaire
Exclusive Savings
Inside
$1,233
Oceanview
$1,213
Balcony
$1,304
Suite
$2,319
From
US$1,213
Save 674
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 08 March 2026
Visit: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,234
Oceanview
$1,294
Balcony
$1,304
Suite
$1,449
From
US$1,234
Save 686
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2028 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$866
Oceanview
$997
Balcony
$1,406
Suite
$1,436
From
US$866
Save 572
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2026
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,027
Oceanview
$1,407
Balcony
$1,127
Suite
$1,812
From
US$1,027
Save 592
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Feb 2026 to Mar 2026
Visit: Colombia, Bonaire, Aruba, Panama
Exclusive Savings
Inside
$1,319
Oceanview
-
Balcony
$1,829
Suite
$1,929
From
US$1,319
Save 785
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$769
Oceanview
$888
Balcony
$1,198
Suite
$1,151
From
US$769
Save 1,320
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 29 March 2026
Visit: Colombia, Aruba, Bonaire, Panama
Exclusive Savings
Inside
$1,448
Oceanview
$1,489
Balcony
$1,509
Suite
$1,484
From
US$1,448
Save 781
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Apr 2028
Visit: Panama, Colombia, Curacao, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$841
Oceanview
$951
Balcony
$1,228
Suite
$1,316
From
US$841
Save 1,317
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Apr 2028
Visit: Colombia, Curacao, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$868
Oceanview
$998
Balcony
$1,165
Suite
$1,310
From
US$868
Save 710
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Mar 2026 to Jan 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$898
Oceanview
$1,028
Balcony
$1,115
Suite
$1,300
From
US$898
Save 636
Per Person
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2028
Visit: Chile, Peru, Panama, Jamaica, Bahamas
Flights Included
Viking $999 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,495
Suite
$15,995
From
US$11,495
Save 3,000
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Mar 2027 to Mar 2027
Visit: Panama, Colombia, Curacao, Bonaire, Aruba
Bonus Onboard Credit
Exclusive Savings
Inside
$936
Oceanview
$1,057
Balcony
$1,509
Suite
$1,469
From
US$936
Save 553
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2028
Visit: USA, Colombia, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,650
Oceanview
$1,869
Balcony
$3,009
Suite
$3,990
From
US$1,650
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,399
Oceanview
$1,459
Balcony
$1,639
Suite
$2,549
From
US$1,399
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Visit: Chile, Peru, Ecuador, Colombia, Panama
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,233
Suite
$12,640
From
US$11,233
Save 14,957
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departure: 18 March 2027
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Princess Standard
Inside
$1,449
Oceanview
$1,699
Balcony
$1,999
Suite
$2,699
From
US$1,449
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Mar 2027 to Mar 2027
Visit: Colombia, Curacao, Bonaire, Aruba, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$990
Oceanview
$1,130
Balcony
$1,603
Suite
$1,558
From
US$990
Save 566
Per Person
View Trip
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