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Panama Cruises Starting In September 2026 and 2027

If you're looking at joining a cruise to Panama in September 2026 or 2027, we have 8 unique cruise itineraries and 97 departures available, operated by three of the world's leading cruise lines departing in September.
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8 Cruises (97 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$719
Oceanview
$819
Balcony
$1,241
Suite
$1,301
From
US$768
Save 656
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 27 September 2027
Visit: USA, Mexico, Panama, Colombia
Bonus Onboard Credit
Inside
$1,949
Oceanview
$2,139
Balcony
$2,701
Suite
$6,417
From
US$1,949
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$707
Oceanview
$755
Balcony
$1,094
Suite
$1,210
From
US$707
Save 583
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$939
Oceanview
$960
Balcony
$1,282
Suite
$1,617
From
US$939
Save 525
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Bonus Onboard Credit
Inside
$1,779
Oceanview
$2,029
Balcony
$2,478
Suite
$10,626
From
US$1,779
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,016
Oceanview
$1,160
Balcony
$1,640
Suite
$1,750
From
US$1,016
Save 555
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$2,618
Oceanview
$3,038
Balcony
$4,283
Suite
$6,899
From
US$2,618
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,249
Oceanview
$1,399
Balcony
$1,849
Suite
$2,349
From
US$1,249
Per Person
View Trip
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