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Panama Cruises Starting In September 2026 and 2027

If you're looking at joining a cruise to Panama in September 2026 or 2027, we have 8 unique cruise itineraries and 85 departures available, operated by three of the world's leading cruise lines departing in September.
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8 Cruises (85 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jun 2026 to Apr 2028
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$831
Oceanview
$894
Balcony
$1,172
Suite
$1,160
From
US$831
Save 913
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jul 2026 to Mar 2028
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$943
Oceanview
$1,037
Balcony
$1,337
Suite
$1,437
From
US$943
Save 1,140
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 27 September 2027
Visit: USA, Mexico, Panama, Colombia
Inside
$1,989
Oceanview
$2,179
Balcony
$2,819
Suite
$9,099
From
US$1,989
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,078
Oceanview
$1,228
Balcony
$1,730
Suite
$1,775
From
US$1,078
Save 733
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Sep 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Princess Standard
Inside
$1,429
Oceanview
$1,789
Balcony
$1,909
Suite
$2,539
From
US$1,429
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Inside
$849
Oceanview
$1,029
Balcony
$1,399
Suite
$10,709
From
US$849
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Sep 2026 to Apr 2028
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$1,014
Oceanview
$1,160
Balcony
$1,623
Suite
$1,668
From
US$1,014
Save 583
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Panama, Aruba
Princess Standard
Sanctuary Collection
Inside
$2,068
Oceanview
$3,085
Balcony
$3,837
Suite
$4,358
From
US$2,068
Per Person
View Trip
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