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Panama Cruises Starting In September 2026

If you're looking at joining a cruise to Panama in September 2026, we have 7 unique cruise itineraries and 80 departures available, operated by three of the world's leading cruise lines departing in September.
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7 Cruises (80 Cruise Departures)
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2027
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$678
Oceanview
$746
Balcony
$1,108
Suite
$1,256
From
US$678
Save 565
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2027
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$770
Oceanview
$880
Balcony
$1,240
Suite
$1,326
From
US$770
Save 631
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Dec 2025 to Sep 2026
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,136
Oceanview
$1,196
Balcony
$1,643
Suite
$1,728
From
US$1,136
Save 3,059
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 05 September 2026
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$939
Oceanview
$954
Balcony
$1,282
Suite
$1,367
From
US$939
Save 515
Per Person
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

20 Days (19 Nights) Seattle to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 September 2026
Visit: USA, Mexico, Costa Rica, Panama, Colombia
Inside
$1,779
Oceanview
$2,029
Balcony
$2,478
Suite
$10,510
From
US$1,779
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Coral Princess, Island Princess
Departures: Jan 2026 to Apr 2027
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Black Friday Sale
Princess Standard
Inside
$1,049
Oceanview
$1,049
Balcony
$2,079
Suite
$2,874
From
US$1,049
Per Person
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Star Princess
Departure: 27 September 2026
Visit: Canada, USA, Mexico, Panama, Aruba
Black Friday Sale
Sanctuary Collection
Inside
$2,673
Oceanview
$3,193
Balcony
$4,484
Suite
$7,399
From
US$2,673
Per Person
View Trip
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