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Panama Cruises Starting In December 2026, 2027 and 2028

If you're looking at joining a cruise to Panama in December 2026, 2027 or 2028, we have 22 unique cruise itineraries and 86 departures available, operated by seven of the world's leading cruise lines departing in December.
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22 Cruises (86 Departures)
22 Cruises (86 Departures)
Departures
Duration
7 Days
18 Days
Countries Visited
Start & End Cities
Ship Size
Ship Features
Operators
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Price
$1,200pp
$39,400pp
Countries
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11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$11,080
Suite
$18,510
From (Per Person)
A$11,080
Save 1,140
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Operator: Ponant
Ship: Le Bellot
Departure: 18 December 2026
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$14,698
Suite
$22,420
From (Per Person)
A$14,698
Save 412
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (1)

8 Days (7 Nights) Colon to Puntarenas
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Nov 2026 to Dec 2027
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$7,750
Suite
$14,143
From (Per Person)
A$7,750
Save 288
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Dec 2026 to Apr 2028
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$10,789
Suite
$17,996
From (Per Person)
A$10,789
Save 433
Per Person
View Trip
7 Day Callao (Lima) to Fuerte Amador with Crystal Cruises
Cruise

7 Days (6 Nights) Lima to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 05 December 2027
Visits: Peru, Ecuador, Panama
Exclusive Savings
Oceanview
$4,800
Balcony
$5,677
Suite
$5,589
From (Per Person)
A$4,800
Save 600
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Mar 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,354
Oceanview
$1,449
Balcony
$1,790
Suite
$2,411
From (Per Person)
A$1,354
Save 1,830
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,506
Oceanview
$1,603
Balcony
$2,113
Suite
$2,581
From (Per Person)
A$1,506
Save 1,254
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Jan 2027
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,590
Oceanview
$1,596
Balcony
$2,180
Suite
$2,624
From (Per Person)
A$1,590
Save 1,474
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,386
Oceanview
$1,502
Balcony
$2,050
Suite
$2,589
From (Per Person)
A$1,386
Save 1,156
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,334
Oceanview
$1,386
Balcony
$1,883
Suite
$2,532
From (Per Person)
A$1,334
Save 1,905
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Jan 2027
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,493
Oceanview
$1,795
Balcony
$3,599
Suite
$4,292
From (Per Person)
A$1,493
Save 1,502
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ship: Island Princess
Departure: 28 December 2026
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
$2,744
Oceanview
$2,853
Balcony
$3,853
Suite
$5,972
From (Per Person)
A$2,744
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Island Princess
Departure: 12 December 2026
Visits: USA, Aruba, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$1,656
Oceanview
$1,745
Balcony
$2,121
Suite
$5,630
From (Per Person)
A$1,656
Per Person
View Trip
16 Day Panama Canal Holiday with Holland America
Cruise
 (5)

16 Days (15 Nights) San Diego to Miami
Operator: Holland America
Ship: Zaandam
Departure: 18 December 2027
Visits: USA, Mexico, Costa Rica, Panama, Colombia
Exclusive Savings
Inside
$4,153
Oceanview
$4,608
Balcony
$7,677
Suite
$14,736
From (Per Person)
A$4,153
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (12)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ship: Crown Princess
Departure: 03 December 2026
Visits: USA, Mexico, Costa Rica, Panama, Curacao
Exclusive Savings
Inside
$1,884
Oceanview
$2,092
Balcony
$2,607
Suite
$5,252
From (Per Person)
A$1,884
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Island Princess
Departure: 13 December 2027
Visits: USA, Aruba, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$1,814
Oceanview
$1,932
Balcony
$3,012
Suite
$4,645
From (Per Person)
A$1,814
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Operator: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visits: USA, Jamaica, Panama, Costa Rica, Colombia
Exclusive Savings
Suite
$8,487
From (Per Person)
A$8,487
Save 173
Per Person
View Trip
9 Day Cartagena to Fuerte Amador with Crystal Cruises
New ReleaseCruise

9 Days (8 Nights) Cartagena to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 02 December 2026
Visits: Colombia, Curacao, Bonaire, Aruba, Panama
Exclusive Savings
Oceanview
$5,880
Balcony
$7,050
Suite
$7,537
From (Per Person)
A$5,880
Save 1,120
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Fort Lauderdale to Panama City
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: USA, Mexico, Belize, Costa Rica, Panama
Exclusive Savings
Balcony
$8,129
Suite
$11,461
From (Per Person)
A$8,129
Save 186
Per Person
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Operator: Viking
Ship: Viking Vesta
Departures: Dec 2027 to Dec 2028
Visits: USA, Mexico, Colombia, Panama, Costa Rica
Exclusive Savings
Balcony
$12,049
Suite
$20,379
From (Per Person)
A$12,049
Save 246
Per Person
View Trip
12 Day Fuerte Amador to San Diego with Crystal Cruises
New ReleaseCruise

12 Days (11 Nights) Panama City to San Diego
Operator: Crystal
Ship: Crystal Serenity
Departure: 10 December 2026
Visits: Panama, Costa Rica, El Salvador, Mexico, USA
Exclusive Savings
Oceanview
$7,632
Balcony
$8,510
Suite
$9,680
From (Per Person)
A$7,632
Save 1,168
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Panama City to Fort Lauderdale
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: Panama, Costa Rica, Belize, Mexico, USA
Exclusive Savings
Balcony
$8,129
Suite
$11,461
From (Per Person)
A$8,129
Save 192
Per Person
View Trip
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