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Panama Cruises Starting In December 2026, 2027 and 2028

If you're looking at joining a cruise to Panama in December 2026, 2027 or 2028, we have 24 unique cruise itineraries and 92 departures available, operated by eight of the world's leading cruise lines departing in December.
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24 Cruises (92 Departures)
24 Cruises (92 Departures)
Departures
Duration
7 Days
18 Days
Countries Visited
Start & End Cities
Ship Size
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Operators
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Price
$1,400pp
$28,890pp
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11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Operator: Ponant
Ship: Le Bougainville
Departure: 02 December 2027
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$12,235
Suite
$18,510
From (Per Person)
A$12,235
Save 335
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ship: Le Bellot
Departure: 08 December 2026
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$12,031
Suite
$20,208
From (Per Person)
A$12,031
Save 329
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Operator: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2029
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$10,692
Suite
$18,093
From (Per Person)
A$10,692
Save 433
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Operator: Ponant
Ships: Le Bougainville, Le Laperouse
Departures: Feb 2027 to Dec 2027
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$7,750
Suite
$14,162
From (Per Person)
A$7,750
Save 288
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Colon to Puntarenas
Operator: Ponant
Ship: Le Bellot
Departure: 17 December 2028
Visits: Panama, Costa Rica
Exclusive Savings
Balcony
$10,712
Suite
$18,113
From (Per Person)
A$10,712
Save 288
Per Person
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (1)

11 Days (10 Nights) Puntarenas to Colon
Operator: Ponant
Ships: Le Bellot, Le Bougainville, Le Laperouse
Departures: Jan 2027 to Mar 2029
Visits: Costa Rica, Panama
Exclusive Savings
Balcony
$10,692
Suite
$17,996
From (Per Person)
A$10,692
Save 368
Per Person
View Trip
7 Day Callao (Lima) to Fuerte Amador with Crystal Cruises
Cruise

7 Days (6 Nights) Lima to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 05 December 2027
Visits: Peru, Ecuador, Panama
Exclusive Savings
Oceanview
$4,680
Balcony
$5,531
Suite
$6,202
From (Per Person)
A$4,680
Save 1,220
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Jan 2027
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,966
Oceanview
$2,121
Balcony
$2,774
Suite
$3,294
From (Per Person)
A$1,966
Save 1,354
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Colombia, Curacao, Aruba, Panama
Exclusive Savings
Inside
$1,582
Oceanview
$1,721
Balcony
$2,360
Suite
$2,988
From (Per Person)
A$1,582
Save 1,027
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Jan 2027
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,914
Oceanview
$1,656
Balcony
$3,446
Suite
$3,636
From (Per Person)
A$1,898
Save 1,483
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Mar 2028
Visits: Colombia, Aruba, Curacao, Panama
Exclusive Savings
Inside
$1,522
Oceanview
$1,704
Balcony
$2,427
Suite
$2,959
From (Per Person)
A$1,522
Save 4,004
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Dec 2026 to Apr 2028
Visits: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
$1,458
Oceanview
$1,656
Balcony
$2,310
Suite
$2,938
From (Per Person)
A$1,458
Save 1,895
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Operator: Royal Caribbean
Ship: Grandeur of the Seas
Departures: Jan 2027 to Apr 2028
Visits: Panama, Colombia, Curacao, Aruba
Exclusive Savings
Inside
$1,559
Oceanview
$1,646
Balcony
$2,297
Suite
$2,954
From (Per Person)
A$1,559
Save 1,078
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (12)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ship: Crown Princess
Departure: 03 December 2026
Visits: USA, Mexico, Costa Rica, Panama, Curacao
Exclusive Savings
Inside
$1,879
Oceanview
-
Balcony
-
Suite
$4,795
From (Per Person)
A$1,879
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Operator: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visits: USA, Jamaica, Panama, Costa Rica, Colombia
Exclusive Savings
Suite
$8,369
From (Per Person)
A$8,369
Save 171
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Operator: Princess
Ship: Island Princess
Departure: 28 December 2026
Visits: USA, Mexico, Costa Rica, Panama, Aruba
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,821
Suite
-
From (Per Person)
A$4,821
Per Person
View Trip
17 Day Panama Canal Holiday & New Year's Cruise: Cartagena, Panama Canal & Puerto Quetzal with Azamara Cruises
Cruise
 (6)

17 Days (16 Nights) Miami to San Diego
Operator: Azamara
Ship: Azamara Quest
Departure: 18 December 2028
Visits: USA, Colombia, Panama, Guatemala, Mexico
Azamara Always Included
Exclusive Savings
Inside
$7,053
Oceanview
$7,631
Balcony
$8,807
Suite
$11,414
From (Per Person)
A$7,053
Save 106
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (6)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Operator: Princess
Ship: Island Princess
Departure: 13 December 2027
Visits: USA, Aruba, Panama, Costa Rica, Mexico
Exclusive Savings
Inside
$2,041
Oceanview
$2,190
Balcony
$2,853
Suite
$4,101
From (Per Person)
A$2,041
Per Person
View Trip
16 Day Panama Canal Holiday with Holland America
Cruise
 (5)

16 Days (15 Nights) San Diego to Miami
Operator: Holland America
Ship: Zaandam
Departure: 18 December 2027
Visits: USA, Mexico, Costa Rica, Panama, Colombia
Exclusive Savings
Inside
$4,153
Oceanview
$4,608
Balcony
$7,677
Suite
$14,736
From (Per Person)
A$4,153
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Fort Lauderdale to Panama City
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: USA, Mexico, Belize, Costa Rica, Panama
Exclusive Savings
Balcony
$8,129
Suite
$11,461
From (Per Person)
A$8,129
Save 184
Per Person
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Operator: Viking
Ship: Viking Vesta
Departures: Dec 2027 to Dec 2028
Visits: USA, Mexico, Colombia, Panama, Costa Rica
Exclusive Savings
Balcony
$12,049
Suite
$20,379
From (Per Person)
A$12,049
Save 248
Per Person
View Trip
9 Day Cartagena to Fuerte Amador with Crystal Cruises
New ReleaseCruise

9 Days (8 Nights) Cartagena to Panama City
Operator: Crystal
Ship: Crystal Serenity
Departure: 02 December 2026
Visits: Colombia, Curacao, Bonaire, Aruba, Panama
Exclusive Savings
Oceanview
$6,742
Balcony
$7,888
Suite
$8,768
From (Per Person)
A$5,786
Save 1,214
Per Person
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise

11 Days (10 Nights) Panama City to Fort Lauderdale
Operator: Viking
Ship: Viking Mars
Departures: Nov 2027 to Dec 2028
Visits: Panama, Costa Rica, Belize, Mexico, USA
Exclusive Savings
Balcony
$8,129
Suite
$11,461
From (Per Person)
A$8,129
Save 192
Per Person
View Trip
12 Day Fuerte Amador to San Diego with Crystal Cruises
New ReleaseCruise

12 Days (11 Nights) Panama City to San Diego
Operator: Crystal
Ship: Crystal Serenity
Departure: 10 December 2026
Visits: Panama, Costa Rica, El Salvador, Mexico, USA
Exclusive Savings
Oceanview
$6,986
Balcony
$7,673
Suite
$8,973
From (Per Person)
A$7,502
Save 1,298
Per Person
View Trip
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