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Panama Cruises Starting In December (2025, 2026 and 2027)

If you're looking at joining a cruise to Panama in December, we have 18 unique cruise itineraries and 97 departures available, operated by six of the world's leading cruise lines departing in December.
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18 Cruises (97 Cruise Departures)
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Dumont d’Urville, Le Laperouse
Departures: Dec 2025 to Feb 2027
Visit: Panama, Costa Rica
Inside
-
Oceanview
-
Balcony
$5,630
Suite
$9,540
From
US$5,630
Per Person
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Bellot, Le Dumont d’Urville
Departures: Dec 2025 to Nov 2026
Visit: Costa Rica, Panama
Inside
-
Oceanview
-
Balcony
$5,290
Suite
$8,940
From
US$5,290
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2027
Visit: Colombia, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$770
Oceanview
$880
Balcony
$1,240
Suite
$1,326
From
US$819
Save 629
Per Person
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 20 December 2026
Visit: Colombia, Aruba, Bonaire, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,074
Oceanview
$1,214
Balcony
$1,683
Suite
$1,733
From
US$1,074
Save 544
Per Person
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Visit: Panama, Colombia, Aruba, Curacao
Exclusive Savings
Inside
-
Oceanview
$1,042
Balcony
$1,272
Suite
-
From
US$1,562
Save 50
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departures: May 2026 to Apr 2027
Visit: Panama, Colombia, Aruba, Curacao
Bonus Onboard Credit
Exclusive Savings
Inside
$678
Oceanview
$746
Balcony
$1,108
Suite
$1,256
From
US$706
Save 565
Per Person
View Trip
8 Day Southern Caribbean Holiday Cruise with Royal Caribbean
Cruise
 (1)

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Grandeur of the Seas
Departure: 19 December 2026
Visit: Panama, Colombia, Aruba, Bonaire
Bonus Onboard Credit
Exclusive Savings
Inside
$974
Oceanview
$1,052
Balcony
$1,611
Suite
$1,696
From
US$974
Save 537
Per Person
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Visit: Panama, Costa Rica, Mexico, USA
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,222
Suite
$7,378
From
US$5,222
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Dec 2025 to Feb 2027
Visit: Colombia, Aruba, Bonaire, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$814
Oceanview
$934
Balcony
$1,162
Suite
$1,431
From
US$814
Save 705
Per Person
View Trip
11 Day A Journey Through Caribbean Havens & the Tropical Gems of Seaside Cities with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Miami to Miami
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 December 2027
Visit: USA, Jamaica, Panama, Costa Rica, Colombia
The Exclusive Invitation Offer
Inside
-
Oceanview
-
Balcony
$5,100
Suite
$5,850
From
US$5,100
Per Person
View Trip
11 Day Caribbean & Panama Canal Passage with Seabourn
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 02 December 2025
Visit: USA, Bonaire, Curacao, Colombia, Panama
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,206
Suite
-
From
US$6,206
Per Person
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise
 (5)

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Viking Cruises
Ships: Viking Sky, Viking Vesta
Departures: Dec 2026 to Dec 2027
Visit: USA, Mexico, Colombia, Panama, Costa Rica
Viking $499 Air Deal
Inside
-
Oceanview
-
Balcony
$6,199
Suite
$11,999
From
US$6,199
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (5)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 28 December 2026
Visit: USA, Mexico, Costa Rica, Panama, Aruba
Black Friday Sale
Inside
$1,549
Oceanview
$1,649
Balcony
$2,499
Suite
$3,574
From
US$1,549
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (5)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Island Princess
Departures: Dec 2025 to Dec 2026
Visit: USA, Aruba, Panama, Costa Rica, Mexico
Black Friday Sale
Princess Standard
Inside
$1,523
Oceanview
$1,509
Balcony
$1,779
Suite
$3,435
From
US$1,509
Per Person
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (6)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Crown Princess
Departure: 03 December 2026
Visit: USA, Mexico, Costa Rica, Panama, Curacao
Black Friday Sale
Inside
$1,549
Oceanview
$1,749
Balcony
$2,349
Suite
$3,524
From
US$1,549
Per Person
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Visit: Panama, Colombia, Bonaire, Aruba, Curacao
Exclusive Savings
Inside
$1,653
Oceanview
$1,328
Balcony
$1,538
Suite
$3,509
From
US$1,328
Save 688
Per Person
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Visit: Panama, Costa Rica, Mexico, USA, Japan
Black Friday Sail
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,573
Suite
$20,235
From
US$8,573
Per Person
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Grandeur of the Seas, Serenade of the Seas
Departures: Dec 2025 to Sep 2026
Visit: Colombia, Bonaire, Aruba, Curacao, Panama
Bonus Onboard Credit
Exclusive Savings
Inside
$1,136
Oceanview
$1,196
Balcony
$1,643
Suite
$1,728
From
US$1,136
Save 3,059
Per Person
View Trip
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Departure Months

Cruises to Panama starting in December

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Routes

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Country Routes

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Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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