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All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 2,169 expeditions and cruises around South America traveling with the world's leading cruise lines.
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347 Cruises (2,169 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Oct 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 264
From (per person) 11,439
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Aug 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 165
From (per person) 7,708
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 111
From (per person) 5,199
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Buenos Aires to Santiago
Operated By: Viking Cruises
Ship: Viking Jupiter
Departures: Nov 2025 to Feb 2027
Countries Visited: Argentina, Uruguay, Falkland Islands, Chile
Viking $1,799 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,499
SUITE
$11,999
Save (per person) 500
From (per person) 7,499
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 226
From (per person) 10,555
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2026
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 1,281
From (per person) 6,584
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Aug 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 227
From (per person) 9,738
View Trip
10 Day Galapagos Encounter (Itinerary B) with Exodus Adventure Travels
Cruise

10 Days (9 Nights) Quito to Guayaquil
Departures: Jul 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,067
From (per person) 7,333
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Chile to Panama with Scenic
New ReleaseCruise

14 Days (13 Nights) Santiago to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 21 March 2027
Countries Visited: Chile, Peru, Ecuador, Colombia (+1 more), Panama
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$11,235
SUITE
$15,285
Save (per person) 12,755
From (per person) 11,235
View Trip
9 Day Galapagos - Central & West Islands Aboard the Solaris with Explore!
Cruise

9 Days (8 Nights) Quito to Quito
Operated By: Explore!
Departures: Jun 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,024
From (per person) 7,656
View Trip
16 Day Galápagos Islands - Nine Of The Best Isles Plus Machu Picchu with HX Hurtigruten Expeditions
Cruise

16 Days (15 Nights) Lima to Quito
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Countries Visited: Peru, Ecuador, Galapagos
Anniversary Offers
INSIDE
-
OCEANVIEW
$13,515
BALCONY
-
SUITE
$16,921
Save (per person) 5,680
From (per person) 13,515
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 13 March 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$594
OCEANVIEW
$664
BALCONY
$914
SUITE
$1,074
From (per person) 594
View Trip
17 Day Peru Splendors with Peru's Amazon & Galapagos Cruise with Globus
Tour + Cruise

17 Days Lima to Guayaquil
Operated By: Globus
Departures: Aug 2025 to Dec 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Flash Sale
Save (per person) 213
From (per person) 8,295
View Trip
27 Day South American Discovery with Brazil's Amazon & Galápagos Cruise with Globus
Tour + Cruise

27 Days Manaus to Guayaquil
Operated By: Globus
Departures: May 2026 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 357
From (per person) 14,750
View Trip
17 Day Patagonia & the Chilean Fjords with Scenic
New ReleaseCruise

17 Days (16 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 November 2027
Countries Visited: Argentina, Uruguay, Chile
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$16,530
SUITE
$21,480
Save (per person) 18,460
From (per person) 16,530
View Trip
15 Day South America Passage with Holland America
Cruise
 (2)

15 Days (14 Nights) Buenos Aires to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departure: 08 March 2026
Countries Visited: Argentina, Uruguay, Falkland Islands, Chile
Exclusive Deal
INSIDE
$2,239
OCEANVIEW
$2,339
BALCONY
$3,409
SUITE
$4,489
From (per person) 2,239
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Sep 2025 to Mar 2027
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$12,900
SUITE
$18,300
From (per person) 12,900
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Sep 2025 to Feb 2026
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$13,800
SUITE
$19,100
From (per person) 13,800
View Trip
16 Day Chilean Fjords – Discovering The Heart Of Patagonia (Northbound) with HX Hurtigruten Expeditions
Cruise
 (1)

16 Days (15 Nights) Buenos Aires to Valparaiso
Ship: MS Roald Amundsen
Departure: 26 March 2026
Countries Visited: Argentina, Chile
Anniversary Offers
INSIDE
-
OCEANVIEW
$7,135
BALCONY
$10,606
SUITE
$10,607
Save (per person) 4,025
From (per person) 7,135
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,364
OCEANVIEW
$2,614
BALCONY
$3,564
SUITE
$4,564
From (per person) 2,364
View Trip
19 Day Buenos Aires to Valparaiso with Silversea
Cruise

19 Days (18 Nights) Buenos Aires to Valparaiso
Cruise Line: Silversea
Ship: Silver Whisper
Departure: 26 February 2026
Countries Visited: Argentina, Uruguay, Falkland Islands, Chile
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$12,700
BALCONY
$15,200
SUITE
$26,900
From (per person) 12,700
View Trip
21 Day South America Revealed with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departure: 07 November 2025
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Sign Up Savings
Save (per person) 270
From (per person) 10,501
View Trip
7 Day Galápagos - South & East Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jul 2025 to Dec 2026
Countries Visited: Ecuador
Exclusive Deal
Save (per person) 849
From (per person) 3,700
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,579
OCEANVIEW
$1,852
BALCONY
$2,126
SUITE
$2,948
From (per person) 1,579
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 February 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$594
OCEANVIEW
$654
BALCONY
$914
SUITE
$1,074
From (per person) 594
View Trip
18 Day Inca & Panama Canal Discovery with Holland America
Cruise
 (2)

18 Days (17 Nights) San Antonio to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 22 March 2026
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$2,244
OCEANVIEW
$2,344
BALCONY
$3,514
SUITE
$5,044
From (per person) 2,244
View Trip
19 Day Valparaiso to Buenos Aires with Silversea
Cruise

19 Days (18 Nights) Valparaiso to Buenos Aires
Cruise Line: Silversea
Ship: Silver Whisper
Departure: 15 January 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$13,100
BALCONY
-
SUITE
$27,300
From (per person) 13,100
View Trip
15 Day Galapagos & Amazon (Archipel I) with Exodus Adventure Travels
Tour + Cruise

15 Days Quito to Guayaquil
Departures: Jun 2025 to Oct 2025
Trip Styles: Adventure, Small Group, Island Hopping, Wildlife
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 1,619
From (per person) 11,131
View Trip
27 Day Treasures of South America: Chilean Fjords to the Iguazu falls - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

27 Days Buenos Aires to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 28 February 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Argentina, Chile, Brazil
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$21,348
SUITE
$45,348
Save (per person) 14,607
From (per person) 21,348
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$19,103
SUITE
$25,403
Save (per person) 19,287
From (per person) 19,103
View Trip
Results: 1-30 of 347

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South & Central America Cruises

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Travel Styles

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Cities

Baltra Island Barcelona Bridgetown Buenos Aires Lima Lisbon Manaus Montevideo Panama City Quito Rio de Janeiro San Antonio Santiago Santiago Santiago Santos Sao Paulo Tahiti Ushuaia Valparaiso

Routes

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Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from USA to Germany Cruises from Germany to England Cruises from Canada to Japan Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to Barbados Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from France to USA Cruises from England to Canada Cruises from England to Germany Cruises from Brazil to Portugal Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Canada to England Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Italy Cruises from USA to Japan Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

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