South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 118 cruises around South America. Compare cruises, read past passenger reviews and enjoy exclusive savings on every departure.

  118 Cruises Found

South America & the Chilean Fjords

18 Days Buenos Aires to Santiago
Operated By: Viking (Cruise)
Visit 4 different countries on this 18 day cruise with Viking, beginning your journey in Buenos Aires and travelling through to Santiago.
Departures: Dec 2019 to Feb 2021   (6 Departures)
Visits: South America
Save
$324
From
$9,695

Highlights of South America & Chilean Fjords Cruise

33 Days Rio de Janeiro to Lima
Operated By: Travelmarvel (Guided Tour & Cruise)
Tour through 5 different countries on this 33 day guided tour & cruise with Travelmarvel, beginning your journey in Rio de Janeiro and travelling through to Lima....
Departures: Feb 2020 to Nov 2020   (2 Departures)
Countries Visited: Brazil, Argentina, Uruguay, Chile, Peru
Save
$431
From
$12,200

Chilean Fjords & Cape Horn

19 Days Lima to Buenos Aires
Operated By: Scenic (Discovery Voyage)
Embark on a 19 day discovery voyage with Scenic visiting Peru, Chile & Argentina, beginning your journey in Lima and travelling through to Buenos Aires.
Departures: Nov 2019 to Nov 2019   (1 Departure)
Visits: South America
Save
$416
From
$15,879

Patagonia & Chilean Fjords Explorer

14 Days Santiago to Buenos Aires
Operated By: APT (Cruise)
Embark on a 14 day cruise with APT visiting Chile & Argentina, beginning your journey in Santiago and travelling through to Buenos Aires.
Departures: Nov 2020 to Nov 2020   (1 Departure)
Visits: South America
Save
$581
From
$16,364
 (2 Reviews)

Best of South America & Galapagos (Flights Included)

36 Days Buenos Aires to Buenos Aires
Operated By: Bunnik (Small Group Tour & Cruise)
“Our tour guide Pepe (Jose Valdivia) was one of the best tour guides we've ever had. His caring, cheerful and positive attitude made this tour more enjoyable.”
Departures: Nov 2019 to Feb 2020   (2 Departures)
Countries Visited: Chile, Galapagos, Peru, Argentina, Brazil
Save
$348
From
$19,157

Spirit of Peru with Antarctica Cruise

22 Days Lima to Buenos Aires
Operated By: APT (Guided Tour & Cruise)
Travel to South & Central America and journey through Peru, Argentina & Antarctica on this 22 day guided tour & cruise with APT.
Departures: Feb 2020 to Feb 2020   (1 Departure)
Countries Visited: Peru, Argentina, Antarctica
Save
$808
From
$22,187

Galápagos - East, Central, & West Islands aboard the Eden

10 Days Quito to Quito
Operated By: G Adventures (Cruise)
Embark on a 10 day cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Oct 2019 to Dec 2020   (18 Departures)
Visits: South America
Save
$234
From
$5,106

A Taste of Galapagos

6 Days Santa Cruz Island to Baltra Island
Operated By: Exodus (Adventure Cruise)
Embark on a 6 day adventure cruise with Exodus visiting Ecuador & Galapagos, beginning your journey in Santa Cruz Island and travelling through to Baltra Island....
Departures: Nov 2019 to Dec 2020   (20 Departures)
Visits: South America
Save
$653
From
$3,956

Complete Galápagos - Eden

17 Days Quito to Quito
Operated By: G Adventures (Cruise)
Embark on a 17 day cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Nov 2019 to Dec 2020   (11 Departures)
Visits: South America
Save
$420
From
$9,311

Galápagos – Western & Central Islands aboard the Reina Silvia Voyager

10 Days Quito to Quito
Operated By: G Adventures (Cruise)
Embark on a 10 day cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Jul 2020 to Dec 2021   (36 Departures)
Visits: South America
Save
$355
From
$8,015

Galápagos - West & Central Islands aboard the Monserrat

10 Days Quito to Quito
Operated By: G Adventures (Cruise)
Embark on a 10 day cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Oct 2019 to Dec 2020   (19 Departures)
Visits: South America
Save
$1,302
From
$4,367

Galapagos Explorer: Southern Islands (Grand Queen Beatriz)

7 Days Quito to Quito
Operated By: Intrepid (Adventure Cruise)
Embark on a 7 day adventure cruise with Intrepid visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Oct 2019 to Dec 2020   (20 Departures)
Visits: South America
Save
$126
From
$5,157

Brazil Highlights with Antarctica Cruise

20 Days Rio de Janeiro to Buenos Aires
Operated By: APT (Guided Tour & Cruise)
Travel to South & Central America and journey through Brazil, Argentina & Antarctica on this 20 day guided tour & cruise with APT.
Departures: Feb 2020 to Feb 2020   (1 Departure)
Countries Visited: Brazil, Argentina, Antarctica
Save
$802
From
$21,743

Brazil Highlights with Antarctica Cruise

20 Days Buenos Aires to Rio de Janeiro
Operated By: APT (Guided Tour & Cruise)
Travel to South & Central America and journey through Argentina, Antarctica & Brazil on this 20 day guided tour & cruise with APT.
Departures: Feb 2020 to Feb 2020   (1 Departure)
Countries Visited: Argentina, Antarctica, Brazil
Save
$802
From
$21,743

Galapagos Voyager: Central Islands (Grand Queen Beatriz)

14 Days Quito to Quito
Operated By: Intrepid (Adventure Cruise)
Embark on a 14 day adventure cruise with Intrepid visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Dec 2019 to Dec 2020   (12 Departures)
Visits: South America
Save
$267
From
$12,115

Antarctic Peninsula, Falkland Islands & South Georgia

20 Days Ushuaia to Ushuaia
Operated By: Peregrine (Adventure Cruise)
Visit 4 different countries on this 20 day adventure cruise with Peregrine, beginning and ending your journey in Ushuaia.
Departures: Feb 2020 to Feb 2021   (4 Departures)
Visits: Antarctica, South America
Save
$10,415
From
$19,271

Galápagos – Western & Central Islands aboard the Reina Silvia Voyager

8 Days Baltra Island to Baltra Island
Operated By: G Adventures (Cruise)
Join G Adventures on this 8 day Galapagos cruise, beginning and ending your journey in Baltra Island.
Departures: Jul 2020 to Dec 2021   (36 Departures)
Visits: South America
Save
$324
From
$7,199

Galapagos Encounter (Itinerary D)

10 Days Quito to Guayaquil
Operated By: Exodus (Adventure Cruise)
Embark on a 10 day adventure cruise with Exodus visiting Ecuador & Galapagos, beginning your journey in Quito and travelling through to Guayaquil.
Departures: Jun 2020 to Dec 2020   (10 Departures)
Visits: South America
Save
$1,339
From
$8,510

Antarctica in Depth with Highlights of Peru

21 Days Buenos Aires to Lima
Operated By: Scenic (Discovery Voyage)
Travel to South & Central America and journey through Argentina, Antarctica & Peru on this 21 day discovery voyage with Scenic.
Departures: Feb 2020 to Feb 2020   (1 Departure)
Countries Visited: Argentina, Antarctica, Peru
Save
$729
From
$23,561

Exploring the Americas

48 Days Buenos Aires to Los Angeles
Operated By: Viking (Cruise)
Ship: Viking Sun
Visit 11 different countries on this 48 day cruise with Viking, beginning your journey in Buenos Aires and travelling through to Los Angeles.
Departures: Nov 2019 to Nov 2019   (1 Departure)
Visits: South America
Save
$831
From
$26,864

Galápagos – Central & Eastern Islands aboard the Reina Silvia Voyager

10 Days Quito to Quito
Operated By: G Adventures (Cruise)
Embark on a 10 day cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Jul 2020 to Dec 2021   (36 Departures)
Visits: South America
Save
$355
From
$8,015
 (1 Reviews)

Ultimate Galapagos: Central Islands (Daphne)

10 Days Quito to Quito
Operated By: Intrepid (Adventure Cruise)
“Excellent trip of a lifetime. The wildlife is amazing and we would recommend it to anybody who loves seeing new and interesting...”
Departures: Oct 2019 to Jun 2020   (15 Departures)
Visits: South America
Save
$2,116
From
$4,777

Galápagos - Central Islands aboard the Xavier III

7 Days Quito to Quito
Operated By: G Adventures (Cruise)
Embark on a 7 day cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Nov 2019 to Dec 2020   (25 Departures)
Visits: South America
Save
$902
From
$3,166

Galapagos at a Glance: Southern Islands (Daphne)

6 Days Quito to Quito
Operated By: Intrepid (Adventure Cruise)
Embark on a 6 day adventure cruise with Intrepid visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Oct 2019 to Dec 2021   (44 Departures)
Visits: South America
Save
$1,111
From
$2,582
 (1 Reviews)

Complete Galapagos (Daphne)

10 Days Quito to Quito
Operated By: Intrepid (Adventure Cruise)
“Fantastic trip, accommodation was really good - small family operated hotel so got a real feel of staying local instead of...”
Departures: Oct 2019 to Dec 2021   (44 Departures)
Visits: South America
Save
$2,116
From
$4,777

Patagonia & Chilean Fjords Explorer

22 Days Santiago to Rio de Janeiro
Operated By: APT (Guided Tour & Cruise)
Travel to South & Central America and journey through Chile, Argentina & Brazil on this 22 day guided tour & cruise with APT.
Departures: Nov 2020 to Nov 2020   (1 Departure)
Countries Visited: Chile, Argentina, Brazil
Save
$847
From
$20,328

Galapagos Adventure (Itinerary A)

10 Days Quito to Guayaquil
Operated By: Exodus (Adventure Cruise)
Embark on a 10 day adventure cruise with Exodus visiting Ecuador & Galapagos, beginning your journey in Quito and travelling through to Guayaquil.
Departures: Nov 2019 to Dec 2020   (21 Departures)
Visits: South America
Save
$1,142
From
$6,911

Chilean Fjords & Cape Horn with Highlights of Peru

28 Days Lima to Buenos Aires
Operated By: Scenic (Discovery Voyage)
Embark on a 28 day discovery voyage with Scenic visiting Peru, Chile & Argentina, beginning your journey in Lima and travelling through to Buenos Aires.
Departures: Oct 2019 to Oct 2019   (1 Departure)
Visits: South America
Save
$660
From
$21,330

Galapagos Encounter (Itinerary B)

10 Days Quito to Guayaquil
Operated By: Exodus (Adventure Cruise)
Embark on a 10 day adventure cruise with Exodus visiting Ecuador & Galapagos, beginning your journey in Quito and travelling through to Guayaquil.
Departures: Jan 2020 to Oct 2020   (8 Departures)
Visits: South America
Save
$1,339
From
$8,510

Classic Galapagos: Central Eastern Islands (Grand Queen Beatriz)

10 Days Quito to Quito
Operated By: Peregrine (Adventure Cruise)
Embark on a 10 day adventure cruise with Peregrine visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: Dec 2019 to Dec 2020   (20 Departures)
Visits: South America
Save
$192
From
$8,263

Peru and Chile Explorer

18 Days Lima to Ushuaia
Operated By: Scenic (Discovery Voyage)
Embark on a 18 day discovery voyage with Scenic visiting Peru, Chile & Argentina, beginning your journey in Lima and travelling through to Ushuaia.
Departures: Oct 2021 to Oct 2021   (1 Departure)
Visits: South America
Save
$2,153
From
$16,717

Results 1-30 of 118