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All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 2,163 expeditions and cruises around South America traveling with the world's leading cruise lines.
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371 Cruises (2,163 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Feb 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Black Friday Sale
Exclusive Savings
From
US$9,416
Save 592
Per Person
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,173
Save 258
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,661
Save 167
Per Person
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Exclusive Savings
Inside
-
Oceanview
$13,572
Balcony
$14,836
Suite
-
From
US$13,572
Save 223
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (5)

18 Days (17 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$7,399
Suite
$12,999
From
US$7,399
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$9,734
Save 350
Per Person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Feb 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,183
Save 258
Per Person
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Feb 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Black Friday Sale
Exclusive Savings
From
US$9,939
Save 543
Per Person
View Trip
16 Day Chilean Fjords – Discovering The Heart Of Patagonia (Northbound) with HX Expeditions
Cruise
 (1)

16 Days (15 Nights) Buenos Aires to Valparaiso
Cruise Line: HX Expeditions
Ship: MS Roald Amundsen
Departure: 26 March 2026
Visit: Argentina, Chile
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,380
Balcony
$7,384
Suite
$11,134
From
US$6,380
Save 2,264
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Dec 2025 to Mar 2026
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
$1,799
Oceanview
$2,046
Balcony
$2,310
Suite
$3,348
From
US$1,799
Save 63
Per Person
View Trip
10 Day Classic Galapagos: Central Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departure: 05 January 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$8,895
Save 275
Per Person
View Trip
7 Day South America with MSC Cruises
Cruise

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 04 January 2026
Visit: Brazil
Inside
$800
Oceanview
$1,008
Balcony
-
Suite
-
From
US$800
Per Person
View Trip
15 Day Chilean Heritage & Fjords with Oceania Cruises
Cruise
 (3)

15 Days (14 Nights) Lima to Punta Arenas
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 January 2028
Visit: Peru, Chile
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$4,305
Oceanview
$4,693
Balcony
$6,148
Suite
$8,670
From
US$4,305
Save 4,493
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 16 February 2026
Visit: Uruguay, Argentina, Brazil
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,435
Suite
$3,624
From
US$2,435
Save 66
Per Person
View Trip
15 Day Chilean Fjords — Discovering The Heart Of Patagonia (Southbound) with HX Expeditions
Cruise
 (1)

15 Days (14 Nights) Valparaiso to Buenos Aires
Cruise Line: HX Expeditions
Ship: MS Fridtjof Nansen
Departure: 17 October 2026
Visit: Chile, Argentina
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,416
Balcony
$7,502
Suite
$9,101
From
US$6,416
Save 1,904
Per Person
View Trip
17 Day Buenos Aires to Valparaiso with Silversea
Cruise
 (1)

17 Days (16 Nights) Buenos Aires to Valparaiso
Cruise Line: Silversea
Ship: Silver Nova
Departure: 17 February 2027
Visit: Argentina, Falkland Islands, Chile
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$13,600
Suite
-
From
US$13,600
Per Person
View Trip
10 Day Galápagos – West & Central Islands aboard the Reina Silvia Voyager with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jan 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,662
Save 258
Per Person
View Trip
13 Day Brazil Intensive Cruise: Sao Paulo, Poto Belo & Rio De Janeiro with Azamara Cruises
Cruise
 (4)

13 Days (12 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 16 February 2028
Visit: Argentina, Uruguay, Brazil
Azamara Always Included
Exclusive Savings
Inside
$3,865
Oceanview
$4,592
Balcony
$5,562
Suite
$7,754
From
US$3,865
Save 84
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Book Early & Have It All Fare Option
Inside
$2,424
Oceanview
$2,614
Balcony
$3,605
Suite
$4,491
From
US$2,424
Per Person
View Trip
8 Day Galapagos Inner Loop Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Cruise Line: Celebrity Cruises
Ship: Celebrity Flora
Departures: Jan 2026 to Dec 2027
Visit: Galapagos
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,970
From
US$7,970
Save 5,586
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$363
Oceanview
$393
Balcony
$463
Suite
$703
From
US$363
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
7 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery (Western Route) with HX Expeditions
Cruise

7 Days (6 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,003
Balcony
-
Suite
$8,341
From
US$6,003
Save 1,120
Per Person
View Trip
12 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery Plus Machu Picchu with HX Expeditions
Cruise

12 Days (11 Nights) Lima to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Visit: Peru, Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$9,960
Balcony
-
Suite
$12,088
From
US$9,960
Save 1,680
Per Person
View Trip
9 Day South America with MSC Cruises
Cruise
 (2)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Dec 2025 to Mar 2027
Visit: Argentina, Brazil, Uruguay
Inside
$884
Oceanview
$1,094
Balcony
$1,214
Suite
$1,804
From
US$884
Per Person
View Trip
11 Day Rio De Janeiro to Buenos Aires with Silversea
Cruise
 (1)

11 Days (10 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 February 2027
Visit: Brazil, Uruguay, Argentina
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$12,100
Suite
$16,700
From
US$12,100
Per Person
View Trip
21 Day South America Revealed with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

21 Days Rio de Janeiro to Quito
Operated By: Trafalgar
Departures: Apr 2026 to Nov 2026
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$11,454
Save 396
Per Person
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Apr 2026 to Mar 2028
Visit: Ecuador, Galapagos
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,200
Suite
$18,335
From
US$12,200
Save 1,405
Per Person
View Trip
7 Day Galapagos Express - Central, South & East Islands aboard the Archipel I with Explore Worldwide
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: Explore Worldwide
Departure: 24 December 2025
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,102
Save 158
Per Person
View Trip
14 Day Argentina & the Chilean Fjords with Viking Cruises
Cruise
 (1)

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2028
Visit: Argentina, Chile
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Save 500
Per Person
View Trip
Results: 1-30 of 371

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South & Central America Cruises

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Travel Styles

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Cities

Cruises from Baltra Island Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Malaga Cruises from Manaus Cruises from Montevideo Cruises from Panama City Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Antonio Cruises from San Cristobal Island Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Tahiti Cruises from Ushuaia Cruises from Valparaiso

Routes

Cruises from Baltra Island to Baltra Island Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Athens Cruises from Barcelona to Rome Cruises from Barcelona to Venice Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to Copenhagen Cruises from London to London Cruises from London to New York Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Trieste Cruises from Rome to Miami Cruises from Rome to Athens Cruises from Rome to Barcelona Cruises from Rome to Venice Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Cristobal Island to San Cristobal Island Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santos to Santos Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Venice to Venice Cruises from Venice to Athens Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from USA to Germany Cruises from England to Holland Cruises from Germany to England Cruises from Canada to Japan Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from France to USA Cruises from England to Canada Cruises from England to Germany Cruises from Brazil to Portugal Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from England to Norway Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from USA to Japan Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

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