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All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 1,886 expeditions and cruises around South America traveling with the world's leading cruise lines.
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146 Days
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336 Cruises (1,886 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Oct 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 264
From (per person) 11,439
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departure: 30 September 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 906
From (per person) 6,958
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 854
From (per person) 4,451
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Buenos Aires to Santiago
Operated By: Viking Cruises
Ship: Viking Jupiter
Departures: Nov 2025 to Feb 2027
Countries Visited: Argentina, Uruguay, Falkland Islands, Chile
Viking $1,799 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,499
SUITE
$11,999
From (per person) 7,499
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departure: 15 November 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 733
From (per person) 10,037
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Exclusive Deal
Save (per person) 1,281
From (per person) 6,584
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Aug 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 227
From (per person) 9,738
View Trip
8 Day Galapagos Inner Loop Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Cruise Line: Celebrity Cruises
Ship: Celebrity Flora
Departures: Jun 2025 to Dec 2027
Countries Visited: Galapagos
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$5,719
Save (per person) 4,148
From (per person) 5,719
View Trip
12 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery Plus Machu Picchu with HX Hurtigruten Expeditions
Cruise

12 Days (11 Nights) Lima to Quito
Ship: MS Santa Cruz II
Departures: Mar 2026 to Dec 2026
Countries Visited: Peru, Ecuador, Galapagos
Anniversary Offers
INSIDE
-
OCEANVIEW
$10,255
BALCONY
-
SUITE
$12,226
Save (per person) 3,307
From (per person) 10,255
View Trip
27 Day South American Discovery with Brazil's Amazon & Galápagos Cruise with Globus
Tour + Cruise

27 Days Manaus to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Flash Sale
Save (per person) 357
From (per person) 13,766
View Trip
23 Day South American Discovery with Galápagos Cruise with Globus
Tour + Cruise

23 Days Rio de Janeiro to Guayaquil
Operated By: Globus
Departures: Jul 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Flash Sale
Save (per person) 311
From (per person) 11,916
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2025 to Mar 2026
Trip Styles: Adventure, Coach, Small Group, Cruise, Scenic
Countries Visited: Argentina, Chile
50% Off Air
Save (per person) 199
From (per person) 9,324
View Trip
15 Day Peru & the Galapagos Islands with Tauck
Tour + Cruise

15 Days Lima to Guayaquil
Operated By: Tauck
Departures: Mar 2026 to Sep 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
From (per person) 14,190
View Trip
10 Day Galapagos - Central, North, South & East Islands aboard the Archipel I with Explore!
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Explore!
Departures: May 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 903
From (per person) 6,747
View Trip
13 Day Rio De Janeiro to Buenos Aires with Silversea
Cruise

13 Days (12 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Silversea
Ship: Silver Whisper
Departure: 16 December 2025
Countries Visited: Brazil, Uruguay, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$9,000
BALCONY
$10,000
SUITE
$17,700
From (per person) 9,000
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Nov 2025 to Apr 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$649
OCEANVIEW
$819
BALCONY
$1,049
SUITE
$1,529
From (per person) 649
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,314
OCEANVIEW
$2,564
BALCONY
$3,564
SUITE
$4,664
From (per person) 2,314
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Nov 2025 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea
INSIDE
$1,128
OCEANVIEW
$1,581
BALCONY
$1,745
SUITE
$2,413
From (per person) 1,128
View Trip
18 Day Panama Canal & Inca Discovery with Holland America
Cruise
 (2)

18 Days (17 Nights) Fort Lauderdale to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departure: 17 November 2025
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+2 more), Peru, Chile
Exclusive Deal
INSIDE
$2,904
OCEANVIEW
$2,149
BALCONY
$3,704
SUITE
$5,004
From (per person) 2,149
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Jul 2025 to Mar 2027
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$12,900
SUITE
$18,500
From (per person) 12,900
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,364
OCEANVIEW
$2,614
BALCONY
$3,564
SUITE
$4,564
From (per person) 2,364
View Trip
22 Day Patagonian Panorama with Oceania Cruises
Cruise

22 Days (21 Nights) Lima to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 03 January 2027
Countries Visited: Peru, Chile, Argentina, Falkland Islands (+1 more), Uruguay
Exclusive Deal
INSIDE
$6,499
OCEANVIEW
$7,099
BALCONY
$9,199
SUITE
$12,699
Save (per person) 6,499
From (per person) 6,499
View Trip
15 Day San Cristóbal to San Cristóbal with Silversea
Cruise

15 Days (14 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Jun 2025 to Mar 2027
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$21,400
SUITE
$32,100
From (per person) 21,400
View Trip
8 Day Galápagos - West & Central Islands aboard the Eden with G Adventures
Cruise

8 Days (7 Nights) Quito to Quito
Operated By: G Adventures
Departures: Jun 2025 to Dec 2027
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 92
From (per person) 4,193
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 13 February 2026
Countries Visited: Brazil
Escape To Sea
INSIDE
$928
OCEANVIEW
$1,098
BALCONY
$1,538
SUITE
$1,808
From (per person) 928
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 16 December 2025
Countries Visited: Brazil
Escape To Sea
INSIDE
$852
OCEANVIEW
$1,020
BALCONY
$1,233
SUITE
$2,102
From (per person) 852
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Brazil
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$23,368
SUITE
$27,168
Save (per person) 21,787
From (per person) 23,368
View Trip
17 Day Galapagos Wildlife Cruise (Archipel I) with Exodus Adventure Travels
Cruise

17 Days (16 Nights) Quito to Guayaquil
Departures: Jul 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Sign Up Savings
Save (per person) 2,000
From (per person) 13,748
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea
INSIDE
$2,484
OCEANVIEW
$2,809
BALCONY
$3,017
SUITE
$4,278
From (per person) 2,484
View Trip
12 Day Valparaiso to Puerto Williams with Silversea
Cruise

12 Days (11 Nights) Valparaiso to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 12 October 2025
Countries Visited: Chile, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,800
From (per person) 12,800
View Trip
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South & Central America Cruises

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Travel Styles

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Cities

Baltra Island Barcelona Bridgetown Buenos Aires Lima Lisbon Los Angeles Manaus Montevideo Panama City Quito Rio de Janeiro San Antonio Santiago Santiago Santiago Santos Sao Paulo Tahiti Valparaiso

Routes

Cruises from Baltra Island to Baltra Island Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to London Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Fort Lauderdale to San Diego Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to London Cruises from Lisbon to Miami Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to Copenhagen Cruises from London to London Cruises from London to New York Cruises from Los Angeles to Miami Cruises from Los Angeles to Fort Lauderdale Cruises from Los Angeles to Los Angeles Cruises from Miami to San Juan Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Paris to Paris Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to Miami Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Juan to Bridgetown Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from USA to Germany Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to Barbados Cruises from Puerto Rico to USA Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from France to USA Cruises from England to Germany Cruises from Brazil to Portugal Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Canada to England Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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