All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 250 cruises around South America. Compare cruises, read past passenger reviews and enjoy exclusive savings on every departure.

  250 Cruises Found
Cruise  

18 Days Buenos Aires to Santiago
Operated By: Viking (Cruise)
Visit 4 different countries on this 17 night cruise with Viking, beginning your journey in Buenos Aires and travelling through to Santiago.
Exclusive: Discovery Cruise Sale
Departures: Dec 2021 to Feb 2023 (6 Departures)
Regions: South America
Save
$ 1,761
From
$ 8,434
Cruise  

8 Days Baltra Island to San Cristobal Island
Operated By: Silversea (Expedition Cruise)
Join Silversea on this 7 night Galapagos expedition cruise, beginning your journey in Baltra Island and travelling through to San Cristobal Island.
Exclusive: Fly Offer Available
Departures: May 2021 to Sep 2021 (11 Departures)
Regions: South America
 
From
$ 13,770
Cruise  

18 Days Valparaiso to Buenos Aires
Operated By: Hurtigruten (Expedition Cruise)
Embark on a 17 night expedition cruise with Hurtigruten visiting Chile, Antarctica & Argentina, beginning your journey in Valparaiso and travelling through to Buenos...
Departs: 02 November 2021
Regions: Antarctica, South America
 
From
$ 13,661
Cruise  

11 Days Buenos Aires to Buenos Aires
Operated By: MSC Cruises (Cruise)
Embark on a 10 night cruise with MSC Cruises visiting Argentina, Uruguay & Brazil, beginning and ending your journey in Buenos Aires.
Exclusive: Early Booking
Departs: 26 December 2021
Regions: South America
 
From
$ 1,479
Cruise  

15 Days Buenos Aires to Fortaleza
Operated By: Silversea (Cruise)
Ship: Silver Wind
Embark on a 14 night cruise with Silversea visiting Argentina, Uruguay & Brazil, beginning your journey in Buenos Aires and travelling through to Fortaleza....
Exclusive: Fly Offers Available
Departs: 21 March 2022
Regions: South America
 
From
$ 10,350
Cruise  

9 Days Sao Paulo to Sao Paulo
Operated By: MSC Cruises (Cruise)
Ship: MSC Seaside
Join MSC Cruises on this 8 night Brazil cruise, beginning and ending your journey in Sao Paulo.
Exclusive: Early Booking
Departs: 30 December 2021
Regions: South America
 
From
$ 1,899
Cruise  

18 Days Buenos Aires to Buenos Aires
Operated By: Azamara (Cruise)
Visit 4 different countries on this 17 night cruise with Azamara, beginning and ending your journey in Buenos Aires.
Exclusive: Onboard Credit US $600
Departs: 24 January 2023
Regions: South America
 
From
$ 8,356
Cruise  

4 Days Rio de Janeiro to Rio de Janeiro
Operated By: MSC Cruises (Cruise)
Ship: MSC Preziosa
Join MSC Cruises on this 3 night Brazil cruise, beginning and ending your journey in Rio de Janeiro.
Exclusive: Early Booking
Departs: 05 March 2022
Regions: South America
 
From
$ 449
Cruise  

11 Days Buenos Aires to Rio de Janeiro
Operated By: Regent Seven Seas (Cruise)
Embark on a 10 night cruise with Regent Seven Seas visiting Argentina, Uruguay & Brazil, beginning your journey in Buenos Aires and travelling through to Rio de Jane...
Exclusive: Mutiple Deals Available
Departs: 05 March 2023
Regions: South America
Save
$ 4,600
From
$ 10,270
Cruise  

20 Days Buenos Aires to Valparaiso
Operated By: Hurtigruten (Expedition Cruise)
Ship: MS Fram
Embark on a 19 night expedition cruise with Hurtigruten visiting Argentina, Antarctica & Chile, beginning your journey in Buenos Aires and travelling through to Valp...
Departs: 17 March 2022
Regions: Antarctica, South America
 
From
$ 12,734
Cruise  

9 Days Salvador to Salvador
Operated By: MSC Cruises (Cruise)
Ship: MSC Seaside
Join MSC Cruises on this 8 night Brazil cruise, beginning and ending your journey in Salvador.
Exclusive: Early Booking
Departs: 26 December 2021
Regions: South America
 
From
$ 1,899
Cruise  

10 Days Quito to Guayaquil
Operated By: Exodus (Expedition Cruise)
Embark on a 9 night expedition cruise with Exodus visiting Ecuador & Galapagos, beginning your journey in Quito and travelling through to Guayaquil.
Departures: May 2021 to Dec 2022 (17 Departures)
Regions: South America
Save
$ 398
From
$ 9,071
Cruise  

7 Days Rio de Janeiro to Rio de Janeiro
Operated By: MSC Cruises (Cruise)
Ship: MSC Preziosa
Join MSC Cruises on this 6 night Brazil cruise, beginning and ending your journey in Rio de Janeiro.
Exclusive: Early Booking
Departures: Dec 2021 to Feb 2022 (5 Departures)
Regions: South America
 
From
$ 699
Cruise  

7 Days Quito to Quito
Operated By: Intrepid (Expedition Cruise)
Embark on a 6 night expedition cruise with Intrepid visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: May 2021 to Dec 2022 (37 Departures)
Regions: South America
Save
$ 130
From
$ 5,658
Cruise  

6 Days Rio de Janeiro to Rio de Janeiro
Operated By: MSC Cruises (Cruise)
Ship: MSC Preziosa
Join MSC Cruises on this 5 night Brazil cruise, beginning and ending your journey in Rio de Janeiro.
Exclusive: Early Booking
Departs: 07 December 2021
Regions: South America
 
From
$ 579
Cruise  

11 Days Montevideo to Montevideo
Operated By: MSC Cruises (Cruise)
Embark on a 10 night cruise with MSC Cruises visiting Uruguay, Argentina & Brazil, beginning and ending your journey in Montevideo.
Exclusive: Early Booking
Departs: 25 December 2021
Regions: South America
 
From
$ 1,479
Cruise  

14 Days Quito to Quito
Operated By: Intrepid (Expedition Cruise)
Embark on a 13 night expedition cruise with Intrepid visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: May 2021 to Dec 2022 (32 Departures)
Regions: South America
Save
$ 298
From
$ 12,910
Cruise  

20 Days Ushuaia to Ushuaia
Operated By: Peregrine (Expedition Cruise)
Visit 4 different countries on this 19 night expedition cruise with Peregrine, beginning and ending your journey in Ushuaia.
Departs: 14 November 2021
Regions: Antarctica, South America
Save
$ 610
From
$ 29,890
Cruise  

22 Days Rio de Janeiro to Miami
Operated By: Oceania (Cruise)
Visit 4 different countries on this 21 night cruise with Oceania, beginning your journey in Rio de Janeiro and travelling through to Miami.
Exclusive: Early Booking Savings + OLife Choice
Departs: 26 February 2022
Regions: South America
Save
$ 6,100
From
$ 9,240
Cruise  

10 Days Quito to Quito
Operated By: G Adventures (Expedition Cruise)
Embark on a 9 night expedition cruise with G Adventures visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Exclusive: Great Adventure Sale
Departures: Apr 2021 to Jan 2022 (8 Departures)
Regions: South America
Save
$ 1,078
From
$ 4,585
Cruise  

11 Days Buenos Aires to Rio de Janeiro
Operated By: Silversea (Cruise)
Ship: Silver Moon
Embark on a 10 night cruise with Silversea visiting Argentina, Uruguay & Brazil, beginning your journey in Buenos Aires and travelling through to Rio de Janeiro....
Exclusive: Early Booking Bonus
Departs: 12 February 2023
Regions: South America
 
From
$ 7,920
Cruise  

18 Days Santiago to Buenos Aires
Operated By: Viking (Cruise)
Visit 4 different countries on this 17 night cruise with Viking, beginning your journey in Santiago and travelling through to Buenos Aires.
Exclusive: Discovery Cruise Sale
Departures: Dec 2021 to Feb 2023 (6 Departures)
Regions: South America
Save
$ 1,303
From
$ 8,919
Cruise  

11 Days Buenos Aires to Rio de Janeiro
Operated By: Regent Seven Seas (Cruise)
Embark on a 10 night cruise with Regent Seven Seas visiting Argentina, Uruguay & Brazil, beginning your journey in Buenos Aires and travelling through to Rio de Jane...
Exclusive: Mutiple Deals Available
Departs: 19 February 2022
Regions: South America
Save
$ 4,450
From
$ 10,000
Cruise  

15 Days Rio de Janeiro to Bridgetown
Operated By: Viking (Cruise)
Embark on a 14 night cruise with Viking visiting Brazil, French Guiana & Barbados, beginning your journey in Rio de Janeiro and travelling through to Bridgetown....
Exclusive: Discovery Cruise Sale
Departs: 26 March 2022
Regions: South America
Save
$ 830
From
$ 10,665
Cruise  

10 Days Quito to Guayaquil
Operated By: Exodus (Expedition Cruise)
Embark on a 9 night expedition cruise with Exodus visiting Ecuador & Galapagos, beginning your journey in Quito and travelling through to Guayaquil.
Departures: Jul 2021 to Dec 2021 (4 Departures)
Regions: South America
Save
$ 419
From
$ 10,060
Cruise  

5 Days Santos to Santos
Operated By: MSC Cruises (Cruise)
Ship: MSC Preziosa
Join MSC Cruises on this 4 night Brazil cruise, beginning and ending your journey in Santos.
Exclusive: Early Booking
Departures: Mar 2021 to Nov 2021 (2 Departures)
Regions: South America
 
From
$ 419
Cruise  

15 Days Buenos Aires to San Antonio
Operated By: Norwegian Cruise Line (Cruise)
Visit 4 different countries on this 14 night cruise with Norwegian Cruise Line, beginning your journey in Buenos Aires and travelling through to San Antonio.
Exclusive: Free At Sea
Departs: 18 December 2022
Regions: South America
 
From
$ 2,212
Cruise  

7 Days Salvador to Salvador
Operated By: MSC Cruises (Cruise)
Ship: MSC Seaside
Join MSC Cruises on this 6 night Brazil cruise, beginning and ending your journey in Salvador.
Exclusive: Early Booking
Departures: Dec 2021 to Dec 2021 (2 Departures)
Regions: South America
 
From
$ 769
Cruise  

63 Days Miami to Miami
Operated By: Regent Seven Seas (Cruise)
Visit 17 different countries on this 62 night cruise with Regent Seven Seas, beginning and ending your journey in Miami.
Exclusive: Early Booking Savings + Bonus
Departs: 05 November 2021
Regions: South America
Save
$ 17,100
From
$ 45,380
Cruise  

7 Days Quito to Quito
Operated By: Intrepid (Expedition Cruise)
Embark on a 6 night expedition cruise with Intrepid visiting Ecuador & Galapagos, beginning and ending your journey in Quito.
Departures: May 2021 to Dec 2022 (11 Departures)
Regions: South America
Save
$ 115
From
$ 5,364

Results 1-30 of 250