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All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 1,589 expeditions and cruises around South America traveling with the world's leading cruise lines.
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334 Cruises (1,589 Cruise Departures)
15 Day Patagonia & Argentina Cruise with Celebrity Cruises
Cruise
 (1)

15 Days (14 Nights) Buenos Aires to Buenos Aires
Cruise Line: Celebrity Cruises
Ships: Celebrity Equinox
Departures: Dec 2026 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Exclusive Savings
Inside
$1,941
Oceanview
$2,469
Balcony
$2,734
Suite
$6,713
From
US$1,941
Save 2,225
Per Person
View Trip
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Nov 2026 to Oct 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
From
US$9,664
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (7)

18 Days (17 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,499
Suite
$12,999
From
US$8,499
Per Person
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$6,994
Save 1,256
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,850
Save 1,210
Per Person
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Inside
-
Oceanview
$13,795
Balcony
$15,085
Suite
-
From
US$13,795
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (7)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,299
Suite
$12,999
From
US$8,299
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$9,491
Save 1,634
Per Person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$5,847
Save 1,873
Per Person
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Nov 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$10,482
Per Person
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2026 to Nov 2028
Visit: Chile, Argentina
Flights Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,995
Suite
$14,995
From
US$9,995
Save 1,000
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Mar 2027 to Mar 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,499
Oceanview
$2,699
Balcony
$3,799
Suite
$4,999
From
US$2,499
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$931
Oceanview
$1,051
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
15 Day Patagonia & Argentina Holiday with Celebrity Cruises
Cruise
 (1)

15 Days (14 Nights) Buenos Aires to Buenos Aires
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 19 December 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Exclusive Savings
Inside
$2,565
Oceanview
$2,899
Balcony
$3,300
Suite
$11,016
From
US$2,565
Save 1,332
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$765
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 24 January 2027
Visit: Brazil
Inside
$931
Oceanview
$1,081
Balcony
$1,331
Suite
-
From
US$931
Per Person
View Trip
14 Day Argentina & the Chilean Fjords with Viking Cruises
Cruise
 (1)

14 Days (13 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2027 to Mar 2029
Visit: Argentina, Chile
Flights Included
Inside
-
Oceanview
-
Balcony
$9,999
Suite
$14,999
From
US$9,999
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Virtuosa
Departures: Nov 2026 to Nov 2026
Visit: Brazil
Inside
$508
Oceanview
$558
Balcony
$756
Suite
$1,119
From
US$508
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$525
Oceanview
$595
Balcony
$715
Suite
-
From
US$525
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Santos to Salvador
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 14 March 2027
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$642
Suite
$832
From
US$642
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 17 November 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Book Early & Have It All Fare Option
Inside
$2,024
Oceanview
$2,224
Balcony
$3,124
Suite
$4,624
From
US$2,024
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Princess Standard
Inside
$1,972
Oceanview
-
Balcony
$2,370
Suite
$2,972
From
US$1,972
Per Person
View Trip
16 Day Cape Horn & Glaciers of Patagonia with Princess
Cruise
 (8)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departures: Dec 2026 to Nov 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Princess Standard
Inside
$2,022
Oceanview
-
Balcony
$2,254
Suite
$2,922
From
US$2,022
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 10 January 2027
Visit: Brazil, Uruguay, Argentina
Inside
$1,069
Oceanview
$1,249
Balcony
$1,439
Suite
$1,549
From
US$1,069
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$525
Oceanview
$605
Balcony
$755
Suite
-
From
US$525
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Paranagua to Paranagua
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$851
Oceanview
$971
Balcony
$1,251
Suite
-
From
US$851
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Dec 2026 to Dec 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,124
Oceanview
$2,324
Balcony
$3,224
Suite
$4,599
From
US$2,124
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica, MSC Virtuosa
Departures: Mar 2027 to Apr 2027
Visit: Brazil
Inside
$99
Oceanview
$119
Balcony
$189
Suite
$379
From
US$99
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Dec 2026 to Feb 2027
Visit: Argentina, Brazil, Uruguay
Inside
$908
Oceanview
$1,088
Balcony
$1,338
Suite
$1,868
From
US$908
Per Person
View Trip
15 Day Chilean Heritage & Fjords with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Lima to Punta Arenas
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 19 January 2028
Visit: Peru, Chile
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$4,549
Oceanview
$4,799
Balcony
$6,299
Suite
-
From
US$4,549
Save 4,549
Per Person
View Trip
Results: 1-30 of 334

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Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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