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All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 1,857 expeditions and cruises around South America traveling with the world's leading cruise lines.
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323 Cruises (1,857 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Oct 2026 to Oct 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$9,416
Save 344
Per Person
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (6)

18 Days (17 Nights) Buenos Aires to Santiago
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2026 to Feb 2028
Visit: Argentina, Uruguay, Falkland Islands, Chile
Viking $1,799 Air Deal
Inside
-
Oceanview
-
Balcony
$8,099
Suite
$12,999
From
US$8,099
Per Person
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,944
Save 258
Per Person
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Apr 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,661
Save 167
Per Person
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 21 February 2027
Trip Styles: Coach, Cruise, Scenic
Visit: Chile, Argentina, Falkland Islands, Uruguay, Brazil, Peru
Exclusive Savings
Inside
-
Oceanview
$13,572
Balcony
$14,836
Suite
-
From
US$13,572
Save 223
Per Person
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jul 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$10,791
Save 350
Per Person
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jun 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$7,954
Save 258
Per Person
View Trip
26 Day Ultimate South America with Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Jul 2026 to Nov 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Black Friday Sale
Exclusive Savings
From
US$9,872
Save 540
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$423
Oceanview
$453
Balcony
$513
Suite
$825
From
US$423
Per Person
View Trip
10 Day Galápagos - North, West & Central Islands aboard the Yolita with G Adventures
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
G's February Sale
Exclusive Savings
From
US$5,315
Save 1,534
Per Person
View Trip
9 Day Island Hopping in the Galapagos with Exodus Tours
New ReleaseCruise

9 Days (8 Nights) Quito to Quito
Operated By: Exodus Tours
Departures: Mar 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$4,889
Save 1,409
Per Person
View Trip
7 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery (Western Route) with HX Expeditions
Cruise

7 Days (6 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Jul 2026 to Nov 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$5,810
Balcony
-
Suite
$7,938
From
US$5,810
Save 1,680
Per Person
View Trip
9 Day Cruising the Galapagos Islands with Tauck
Tour + Cruise

9 Days Guayaquil to Guayaquil
Operated By: Tauck
Departures: Jan 2027 to Dec 2027
Visit: Ecuador, Galapagos
From
US$9,490
Per Person
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Inside
$2,119
Oceanview
$2,319
Balcony
$3,369
Suite
$4,251
From
US$2,119
Per Person
View Trip
11 Day Brazilian Brilliance with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 March 2026
Visit: Argentina, Uruguay, Brazil
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,202
Suite
$5,706
From
US$4,202
Save 4,396
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 January 2027
Visit: Brazil
Inside
$891
Oceanview
$931
Balcony
$1,031
Suite
-
From
US$891
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Dec 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$575
Suite
-
From
US$475
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Jan 2027 to Feb 2027
Visit: Brazil
Inside
$811
Oceanview
$851
Balcony
$951
Suite
-
From
US$811
Per Person
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama, Aruba, USA
Bonus Onboard Credit
Inside
$3,399
Oceanview
$4,699
Balcony
$5,299
Suite
$12,418
From
US$3,399
Per Person
View Trip
15 Day Highlights of Ecuador & the Galapagos with Exodus Tours
New ReleaseTour + Cruise

15 Days Quito to Quito
Operated By: Exodus Tours
Departures: Mar 2026 to Dec 2027
Visit: Ecuador, Galapagos
Sign Up Savings
Exclusive Savings
From
US$5,354
Save 1,544
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Drinks & WiFi Package
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$1,489
From
US$475
Per Person
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Itajai to Itajai
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 24 January 2027
Visit: Brazil
Inside
$891
Oceanview
$931
Balcony
$1,031
Suite
-
From
US$891
Per Person
View Trip
13 Day Brazil Intensive Cruise: Sao Paulo, Poto Belo & Rio De Janeiro with Azamara Cruises
Cruise
 (4)

13 Days (12 Nights) Buenos Aires to Rio de Janeiro
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 16 February 2028
Visit: Argentina, Uruguay, Brazil
Azamara Always Included
Exclusive Savings
Inside
$4,149
Oceanview
$4,886
Balcony
$5,847
Suite
$8,417
From
US$4,149
Save 90
Per Person
View Trip
10 Day South America with MSC Cruises
Cruise
 (2)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 March 2026
Visit: Argentina, Brazil, Uruguay
Inside
$1,904
Oceanview
$2,210
Balcony
-
Suite
$3,862
From
US$1,904
Per Person
View Trip
18 Day Fjords & Glaciers of Southern Chile & Patagonia with Scenic
New ReleaseCruise

18 Days (17 Nights) Buenos Aires to Buenos Aires
Cruise Line: Scenic
Ships: Scenic Eclipse I, Scenic Ikon
Departures: Feb 2027 to Feb 2029
Visit: Argentina, Chile, Uruguay
Early Booking Savings
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,851
Suite
$25,684
From
US$12,851
Save 26,113
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Buenos Aires to Santiago
Cruise Line: Holland America
Ship: Oosterdam
Departure: 09 March 2027
Visit: Argentina, Uruguay, Falkland Islands, Chile
Fare Saver
Inside
$2,429
Oceanview
$2,629
Balcony
$3,674
Suite
$4,752
From
US$2,429
Per Person
View Trip
15 Day San Cristobal to San Cristobal with Silversea
Cruise

15 Days (14 Nights) Quito to Quito
Cruise Line: Silversea
Ship: Silver Origin
Departures: Aug 2026 to Dec 2026
Visit: Galapagos, Ecuador
All-Inclusive Plus Fare
Inside
-
Oceanview
-
Balcony
$21,400
Suite
$34,200
From
US$21,400
Per Person
View Trip
17 Day Machu Picchu & the Galápagos Islands aboard the Yolita with G Adventures
New ReleaseTour + Cruise

17 Days Lima to Quito
Operated By: G Adventures
Departures: Aug 2026 to Dec 2026
Visit: Peru, Ecuador, Galapagos
G's February Sale
Exclusive Savings
From
US$7,856
Save 1,143
Per Person
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (3)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ships: Nieuw Amsterdam, Oosterdam
Departures: Dec 2026 to Nov 2027
Visit: Chile, Argentina, Falkland Islands, Uruguay
Fare Saver
Book Early & Have It All Fare Option
Inside
$2,284
Oceanview
$2,484
Balcony
$3,384
Suite
$4,482
From
US$2,284
Per Person
View Trip
14 Day Ancient Kingdoms and Natural Treasures: Panama to Chile with Scenic
New ReleaseCruise

14 Days (13 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,521
Suite
$16,995
From
US$14,521
Save 18,469
Per Person
View Trip
Results: 1-30 of 323

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South & Central America Cruises

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Travel Styles

Active Adventures Coach Cruises Luxury Cruises Short Cruise Breaks Wellness Cruises Wildlife Cruises

Cities

Cruises from Baltra Island Cruises from Barcelona Cruises from Bridgetown Cruises from Buenos Aires Cruises from Colon Cruises from Lima Cruises from Lisbon Cruises from Maceio Cruises from Manaus Cruises from Marseille Cruises from Montevideo Cruises from Panama City Cruises from Puerto Williams Cruises from Quito Cruises from Rio de Janeiro Cruises from Salvador Cruises from San Cristobal Island Cruises from Santiago Cruises from Santiago Cruises from Santos Cruises from Sao Paulo Cruises from Tahiti Cruises from Ushuaia Cruises from Valencia Cruises from Valparaiso

Routes

Cruises from Baltra Island to Baltra Island Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Trieste Cruises from Barcelona to Lisbon Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to San Antonio Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Buenos Aires to Santiago Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Fort Lauderdale Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Marseille to Marseille Cruises from Miami to San Juan Cruises from Miami to Lisbon Cruises from Miami to Rome Cruises from Miami to Bridgetown Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from New York to New York Cruises from New York to London Cruises from Panama City to Miami Cruises from Quito to Quito Cruises from Rio de Janeiro to Buenos Aires Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rome to Trieste Cruises from Rome to Lisbon Cruises from Rome to Miami Cruises from Rome to Barcelona Cruises from Rome to Fort Lauderdale Cruises from Rome to Rome Cruises from San Cristobal Island to San Cristobal Island Cruises from San Juan to Miami Cruises from San Juan to San Juan Cruises from Santiago to Buenos Aires Cruises from Santiago to Santiago Cruises from Santos to Santos Cruises from Sao Paulo to Sao Paulo Cruises from Tahiti to Tahiti Cruises from Ushuaia to Ushuaia Cruises from Venice to Barcelona Cruises from Venice to Rome

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from England to Holland Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from Portugal to France Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from England to Canada Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

South America Tours

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