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340 Cruises (1,816 Cruise Departures)
9 Day Galapagos Voyage: Back in Time - Premium Adventure with Exodus Adventure Travels
New ReleaseCruise

9 Days (8 Nights) Quito to Quito
Departures: Aug 2024 to Dec 2024
Trip Styles: Group, Cruise, Island Hopping, Wildlife
Countries Visited: Ecuador
Exclusive Savings
Save 326
From 15,974
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Nov 2024 to Dec 2024
Countries Visited: Brazil
Early Booking Offer
INSIDE
$697
OCEANVIEW
$777
BALCONY
$895
SUITE
$1,470
From 697
View Trip
7 Day Galapagos Express - Central, South & East Islands aboard the Archipel I with Explore!
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: Explore!
Departures: May 2024 to Dec 2025
Trip Styles: Small Group, Cruise, Island Hopping, Wildlife
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save 155
From 7,428
View Trip
7 Day Galapagos Express - Central & West Islands aboard the Archipel I with Explore!
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: Explore!
Departures: Jun 2024 to Dec 2024
Trip Styles: Small Group, Cruise, Island Hopping, Wildlife
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save 152
From 7,428
View Trip
13 Day Rio De Janeiro to Buenos Aires with Silversea
Cruise

13 Days (12 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Silversea
Ship: Silver Whisper
Departure: 28 December 2025
Countries Visited: Brazil, Uruguay, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$12,375
BALCONY
$13,464
SUITE
$26,235
From 12,375
View Trip
13 Day Valparaiso to Buenos Aires with Silversea
Cruise

13 Days (12 Nights) Valparaiso to Buenos Aires
Cruise Line: Silversea
Ship: Silver Ray
Departure: 09 February 2025
Countries Visited: Argentina, Chile
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$13,711
From 13,711
View Trip
17 Day Mysteries of the Inca Empire with a Galapagos Cruise with Cosmos
Tour + Cruise

17 Days Lima to Quito
Operated By: Cosmos
Departures: Sep 2024 to Dec 2024
Trip Styles: Coach, Group, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Peru, Ecuador, Galapagos
Last Chance Deal
Save 197
From 9,871
View Trip
10 Day Classic Galapagos: Central Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Apr 2024 to Dec 2024
Trip Styles: Group, Cruise, Island Hopping, Wildlife
Countries Visited: Ecuador, Galapagos
Limited Time Sale
Save 3,115
From 7,389
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Maceio to Maceio
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2024 to Mar 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$1,307
OCEANVIEW
$1,485
BALCONY
$1,733
SUITE
$3,248
From 1,307
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Jan 2025 to Feb 2025
Countries Visited: Argentina, Uruguay, Brazil
Early Booking Offer
INSIDE
$1,944
OCEANVIEW
$2,211
BALCONY
$2,518
SUITE
$4,043
From 1,944
View Trip
15 Day Treasures Of The Pacific Coast - Panama To Chile with Hurtigruten
Cruise

15 Days (14 Nights) Colon to Valparaiso
Cruise Line: Hurtigruten
Ships: MS Fram, MS Roald Amundsen
Departures: Oct 2024 to Oct 2024
Countries Visited: Panama, Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$11,486
OCEANVIEW
$6,549
BALCONY
-
SUITE
$9,145
Save 3,984
From 6,549
View Trip
15 Day San Cristóbal to San Cristóbal with Silversea
Cruise

15 Days (14 Nights) Guayaquil to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Oct 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$30,987
SUITE
$47,421
From 30,987
View Trip
9 Day South America with MSC Cruises
Cruise

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Dec 2024 to Mar 2025
Countries Visited: Uruguay, Brazil, Argentina
Early Booking Offer
INSIDE
$1,625
OCEANVIEW
$1,833
BALCONY
$2,229
SUITE
-
From 1,625
View Trip
13 Day Ushuaia to Valparaiso with Silversea
Cruise

13 Days (12 Nights) Ushuaia to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 19 March 2025
Countries Visited: Argentina, Chile
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$9,405
BALCONY
$12,870
SUITE
$19,107
From 9,405
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departures: Jan 2025 to Feb 2025
Countries Visited: Uruguay, Brazil, Argentina
Early Booking Offer
INSIDE
$1,944
OCEANVIEW
$2,211
BALCONY
$2,647
SUITE
-
From 1,944
View Trip
9 Day Cartagena to Lima with Silversea
Cruise

9 Days (8 Nights) Cartagena to Lima
Cruise Line: Silversea
Ship: Silver Ray
Departure: 27 December 2024
Countries Visited: Colombia, Ecuador, Panama, Peru
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$8,563
From 8,563
View Trip
8 Day San Cristóbal to San Cristóbal with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departure: 18 October 2025
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$17,919
SUITE
$40,095
From 17,919
View Trip
6 Day Galapagos at a Glance: Southern Islands (Grand Daphne) with Intrepid Travel
Cruise

6 Days (5 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Apr 2024 to Dec 2025
Trip Styles: Group, Cruise, Island Hopping, Short Break, Wildlife
Countries Visited: Ecuador, Galapagos
Limited Time Sale
Save 1,548
From 3,820
View Trip
10 Day Heart Of The Amazon with Seabourn
Cruise

10 Days (9 Nights) Manaus to Manaus
Cruise Line: Seabourn
Ship: Venture
Departure: 12 October 2025
Countries Visited: Brazil
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,870
SUITE
$34,502
From 17,870
View Trip
8 Day San Cristóbal, Galapagos to San Cristóbal, Galapagos with Silversea
Cruise

8 Days (7 Nights) Quito to Guayaquil
Cruise Line: Silversea
Ship: Silver Origin
Departures: Apr 2025 to Feb 2026
Countries Visited: Ecuador, Galapagos
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$17,919
SUITE
$26,334
From 17,919
View Trip
7 Day Galápagos - South & East Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: May 2024 to Jun 2025
Trip Styles: Group, Cruise, Wildlife
Countries Visited: Ecuador
Exclusive Deal
Save 1,431
From 5,211
View Trip
15 Day The Best of Chilean Fjords with Ponant
Cruise

15 Days (14 Nights) Valparaiso to Buenos Aires
Cruise Line: Ponant
Ships: Le Boreal, Le Lyrial
Departures: Oct 2024 to Nov 2025
Countries Visited: Chile, Argentina
Exclusive Savings
INSIDE
-
OCEANVIEW
$11,206
BALCONY
$12,000
SUITE
$19,438
Save 229
From 11,206
View Trip
8 Day San Cristóbal, Galapagos to San Cristóbal, Galapagos with Silversea
CruiseFlights Included

8 Days (7 Nights) Quito to Quito
Cruise Line: Silversea
Ship: Silver Origin
Departures: Jun 2024 to Aug 2025
Countries Visited: Ecuador, Galapagos
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$17,226
SUITE
$22,473
From 17,226
View Trip
31 Day South America Connoisseur with Oceania Cruises
Cruise

31 Days (30 Nights) San Antonio to Rio de Janeiro
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 06 March 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+1 more), Brazil
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$16,732
SUITE
$22,662
Save 2,128
From 16,732
View Trip
8 Day Galapagos Northern Loop with Celebrity Cruises
Cruise

8 Days (7 Nights) Baltra Island to Baltra Island
Cruise Line: Celebrity Cruises
Ship: Celebrity Xpedition
Departures: Apr 2024 to Dec 2025
Countries Visited: Galapagos, Ecuador
Exclusive Deal
INSIDE
-
OCEANVIEW
$7,516
BALCONY
-
SUITE
$9,132
Save 4,321
From 7,516
View Trip
22 Day Radiant Brazil & Argentina with Oceania Cruises
Cruise

22 Days (21 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 January 2025
Countries Visited: Brazil, Uruguay, Argentina
Mutiple Deals Available
INSIDE
$7,480
OCEANVIEW
$8,173
BALCONY
$9,015
SUITE
$12,559
Save 2,050
From 7,480
View Trip
11 Day Brazilian Rhythms with Oceania Cruises
Cruise

11 Days (10 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 24 January 2026
Countries Visited: Brazil, Uruguay, Argentina
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$8,955
Save 2,050
From 6,420
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Nov 2024 to Oct 2025
Countries Visited: Chile, Argentina
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$13,855
SUITE
$19,795
Save 1,140
From 13,855
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departures: Dec 2024 to Mar 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$1,307
OCEANVIEW
$1,485
BALCONY
$1,733
SUITE
$2,762
From 1,307
View Trip
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 28 February 2025
Countries Visited: Argentina, Uruguay, Brazil
Early Booking Offer
INSIDE
$1,983
OCEANVIEW
$2,241
BALCONY
$2,558
SUITE
$4,072
From 1,983
View Trip
Results: 121-150 of 340

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South & Central America Cruises

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Travel Styles

Coach Tours Locally Guided Tours Luxury Cruises Short Cruise Breaks Wildlife Tours

Cities

Barcelona Bridgetown Buenos Aires Lima Lisbon Malaga Manaus Marseille Papeete Puerto Williams Quito Rio de Janeiro San Antonio Santiago Santiago Sao Paulo Ushuaia Valparaiso

Routes

Cruises from Barcelona to Fort Lauderdale Cruises from Barcelona to Lisbon Cruises from Barcelona to London Cruises from Barcelona to Rome Cruises from Barcelona to Barcelona Cruises from Barcelona to Miami Cruises from Bridgetown to Miami Cruises from Bridgetown to Bridgetown Cruises from Buenos Aires to San Antonio Cruises from Buenos Aires to Rio de Janeiro Cruises from Buenos Aires to Buenos Aires Cruises from Dover to Dover Cruises from Fort Lauderdale to Los Angeles Cruises from Fort Lauderdale to London Cruises from Fort Lauderdale to Barcelona Cruises from Fort Lauderdale to Fort Lauderdale Cruises from Fort Lauderdale to San Diego Cruises from Genoa to Genoa Cruises from Hamburg to London Cruises from Hamburg to Hamburg Cruises from Lima to Buenos Aires Cruises from Lima to Quito Cruises from Lisbon to Lisbon Cruises from Lisbon to London Cruises from Lisbon to Miami Cruises from Lisbon to Barcelona Cruises from Lisbon to Rome Cruises from London to Hamburg Cruises from London to Barcelona Cruises from London to Fort Lauderdale Cruises from London to Copenhagen Cruises from London to Rome Cruises from London to London Cruises from London to Lisbon Cruises from London to New York Cruises from Los Angeles to Miami Cruises from Los Angeles to Fort Lauderdale Cruises from Los Angeles to Los Angeles Cruises from Malaga to Malaga Cruises from Marseille to Marseille Cruises from Miami to Los Angeles Cruises from Miami to Rome Cruises from Miami to Panama City Cruises from Miami to Barcelona Cruises from Miami to Miami Cruises from Miami to London Cruises from Montreal to New York Cruises from New York to New York Cruises from New York to London Cruises from Papeete to Papeete Cruises from Puerto Williams to Puerto Williams Cruises from Quito to Guayaquil Cruises from Quito to Quito Cruises from Rio de Janeiro to Rio de Janeiro Cruises from Rio de Janeiro to Barcelona Cruises from Rome to London Cruises from Rome to Lisbon Cruises from Rome to Miami Cruises from Rome to Barcelona Cruises from Rome to Rome Cruises from San Antonio to Buenos Aires Cruises from San Juan to San Juan Cruises from Santiago to Santiago Cruises from Sao Paulo to Sao Paulo

Country Routes

Cruises from Peru to Argentina Cruises from USA to Portugal Cruises from USA to Germany Cruises from Italy to England Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from France to Brazil Cruises from France to USA Cruises from England to Canada Cruises from England to Germany Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Canada to England Cruises from Argentina to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Barbados to USA Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to Italy Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises Hurtigruten South America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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