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Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? September is the most popular month to cruise between Rome and Barcelona and there are 212 departures available from fifteen of the world's leading cruise lines.
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79 Cruises (212 Cruise Departures)
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+11 more), Viking Libra, Viking Lyra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Mar 2026 to Sep 2028
Visit: Italy, Monaco, France, Spain
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,599
Suite
$3,999
From
US$2,599
Save 800
Per Person
View Trip
8 Day Coastal Kaleidoscope with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 September 2027
Visit: Italy, Monaco, France, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$1,899
Oceanview
$2,049
Balcony
$3,222
Suite
$4,677
From
US$1,899
Save 1,899
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,148
Oceanview
$1,409
Balcony
$1,821
Suite
$2,890
From
US$1,148
Save 588
Per Person
View Trip
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 October 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$9,700
Suite
$10,965
From
US$9,700
Per Person
View Trip
8 Day Rome To Romance with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2028
Visit: Italy, Corsica, Monaco, France, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,099
Oceanview
$2,785
Balcony
$3,415
Suite
$4,676
From
US$2,099
Save 2,099
Per Person
View Trip
8 Day Christmas Cruise: Florence, Mahon & Palma with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Visit: Italy, Spain
Azamara Always Included
Inside
$1,449
Oceanview
$1,659
Balcony
$1,919
Suite
$3,063
From
US$1,449
Per Person
View Trip
8 Day Regards From The Riviera with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 09 September 2027
Visit: Italy, France, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$1,999
Oceanview
$2,149
Balcony
$3,319
Suite
$4,774
From
US$1,999
Save 1,999
Per Person
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,900
Oceanview
$2,090
Balcony
$2,968
Suite
$4,166
From
US$1,900
Save 2,098
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$5,700
Suite
$7,560
From
US$5,700
Per Person
View Trip
9 Day Monaco, Italy, France & Spain with Seabourn
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 June 2027
Visit: Italy, Monaco, France, Spain
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,386
Suite
$8,594
From
US$5,386
Save 95
Per Person
View Trip
22 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Visit: Italy, Sicily, Greece, Montenegro (+4 more), Croatia, Malta, Spain, France
Inside
$3,699
Oceanview
-
Balcony
$6,563
Suite
-
From
US$3,699
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,291
Oceanview
$1,499
Balcony
$1,720
Suite
$4,236
From
US$1,291
Save 852
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Italy, Corsica, Spain
Inside
$919
Oceanview
$1,019
Balcony
$1,169
Suite
$2,949
From
US$919
Per Person
View Trip
8 Day Riviera Reverie with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 30 September 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,090
Suite
$6,384
From
US$6,090
Save 11,308
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 June 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,629
Oceanview
$2,028
Balcony
$2,154
Suite
$4,896
From
US$1,629
Save 950
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Visit: Italy, Greece, Montenegro, Croatia, Malta, Spain
Inside
$2,469
Oceanview
$2,619
Balcony
$3,219
Suite
$5,995
From
US$2,469
Per Person
View Trip
15 Day Spain, Italy And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 28 May 2027
Visit: Italy, Malta, Montenegro, Croatia, Sicily, Spain
Inside
$2,429
Oceanview
$2,679
Balcony
$3,329
Suite
$6,648
From
US$2,429
Per Person
View Trip
11 Day Renaissance & Rivieras with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 June 2027
Visit: Italy, Sicily, Sardinia, Corsica, France, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,129
Oceanview
$3,371
Balcony
$5,360
Suite
$7,397
From
US$3,129
Save 3,269
Per Person
View Trip
8 Day Amalfi Coast, Africa & Iberia with Viking Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Libra (+4 more), Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Oct 2026 to Jun 2028
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,999
Suite
$4,799
From
US$2,999
Save 500
Per Person
View Trip
21 Day Ode On A Grecian Journey with Oceania Cruises
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 July 2027
Visit: Italy, Sicily, Malta, Greece, Montenegro, Croatia, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,543
Suite
$13,538
From
US$8,543
Save 8,955
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 06 July 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,617
Oceanview
$1,917
Balcony
$2,142
Suite
$4,883
From
US$1,617
Save 949
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2026 to Sep 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,451
Oceanview
$1,599
Balcony
$1,770
Suite
$5,648
From
US$1,451
Save 1,260
Per Person
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 23 February 2026
Visit: Italy, France, Spain
Last Minute Fare
All-Inclusive Fare
Inside
-
Oceanview
$4,550
Balcony
$5,050
Suite
$12,100
From
US$4,550
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
-
Oceanview
$469
Balcony
$529
Suite
$819
From
US$469
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (6)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 23 May 2026
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Sanctuary Collection
Inside
$2,263
Oceanview
$3,260
Balcony
$3,868
Suite
$5,019
From
US$2,263
Per Person
View Trip
22 Day Mediterranean, Adriatic And Greece with Cunard
Cruise
 (13)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 30 July 2027
Visit: Italy, Malta, Croatia, Greece, Sicily, Corsica, Spain
Inside
$4,259
Oceanview
$4,849
Balcony
$5,809
Suite
$11,997
From
US$4,259
Per Person
View Trip
8 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 November 2027
Visit: Italy, France, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,300
Suite
$6,720
From
US$6,720
Save 1,680
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2027 to Oct 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,616
Oceanview
$1,716
Balcony
$1,842
Suite
$4,594
From
US$1,616
Save 1,070
Per Person
View Trip
8 Day Mediterranean Cruise From Rome To Barcalona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2027 to Aug 2027
Visit: Italy, Sicily, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,612
From
US$3,612
Save 124
Per Person
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 14 January 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Last Minute Fare
All-Inclusive Fare
Inside
-
Oceanview
$4,450
Balcony
$4,950
Suite
$11,900
From
US$4,450
Per Person
View Trip
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