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Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? September is the most popular month to cruise between Rome and Barcelona and there are 211 departures available from fifteen of the world's leading cruise lines.
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80 Cruises (211 Cruise Departures)
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2027 to Oct 2027
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$2,044
Oceanview
$2,312
Balcony
$2,484
Suite
$7,075
From
US$3,091
Save 99
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (3)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Visit: Italy, France, Spain
Inside
-
Oceanview
-
Balcony
$536
Suite
-
From
US$536
Per Person
View Trip
8 Day Amalfi Coast, Africa & Iberia with Viking Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Libra (+4 more), Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Dec 2026 to Jun 2028
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,999
Suite
$4,799
From
US$2,999
Save 300
Per Person
View Trip
8 Day Mediterranean Cruise From Rome To Barcalona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2027 to Aug 2027
Visit: Italy, Sicily, France, Spain
Inside
$1,169
Oceanview
$1,709
Balcony
$1,679
Suite
$1,837
From
US$1,169
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 June 2027
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$2,236
Oceanview
$2,808
Balcony
$3,043
Suite
$8,778
From
US$3,383
Save 86
Per Person
View Trip
8 Day Regards From The Riviera with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 09 September 2027
Visit: Italy, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,099
Oceanview
$2,249
Balcony
$3,319
Suite
$4,774
From
US$2,099
Save 2,099
Per Person
View Trip
8 Day Coastal Kaleidoscope with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 September 2027
Visit: Italy, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$1,899
Oceanview
$2,049
Balcony
$3,222
Suite
$4,677
From
US$1,899
Save 1,899
Per Person
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,700
Oceanview
$1,870
Balcony
$2,658
Suite
$3,730
From
US$1,700
Save 2,298
Per Person
View Trip
11 Day Spanish Sapphire Shores with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 24 March 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,642
Suite
$10,161
From
US$8,642
Save 14,356
Per Person
View Trip
10 Day Mediterranean Rivieras: Rome to Barcelona with Scenic
New ReleaseCruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 04 October 2028
Visit: Italy, Corsica, Monaco, France, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,269
Suite
$15,312
From
US$14,269
Save 18,171
Per Person
View Trip
8 Day European Yearnings with Oceania Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 02 July 2027
Visit: Italy, Monaco, France, Spain
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,981
Suite
$4,921
From
US$2,981
Save 3,117
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: May 2027 to Sep 2027
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,075
Oceanview
$1,425
Balcony
$1,687
Suite
$2,162
From
US$1,137
Save 592
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,735
Oceanview
$1,804
Balcony
$1,921
Suite
$5,059
From
US$2,649
Per Person
View Trip
12 Day Idyllic Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 13 September 2028
Visit: Italy, Sardinia, Corsica, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,021
Suite
$17,640
From
US$15,021
Save 18,969
Per Person
View Trip
10 Day Mediterranean Masterpieces with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 28 February 2028
Visit: Italy, Sicily, Sardinia, Corsica, France, Spain
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,369
Suite
$5,164
From
US$3,369
Save 3,529
Per Person
View Trip
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 October 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,930
Suite
$9,760
From
US$6,930
Save 2,970
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Italy, Corsica, Spain
Inside
$919
Oceanview
$1,019
Balcony
$1,169
Suite
$2,889
From
US$919
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
-
Oceanview
-
Balcony
$529
Suite
$1,259
From
US$529
Per Person
View Trip
11 Day Mediterranean Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$3,322
Oceanview
$4,001
Balcony
$3,750
Suite
$5,302
From
US$3,322
Save 3,476
Per Person
View Trip
8 Day Riviera Radiance with Oceania Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 22 October 2027
Visit: Italy, France, Spain
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,543
Suite
$4,483
From
US$2,543
Save 2,655
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,560
Suite
$4,240
From
US$4,240
Save 4,160
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2026 to Sep 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,948
Oceanview
$2,049
Balcony
$2,123
Suite
$5,448
From
US$2,938
Save 85
Per Person
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (6)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Sep 2026 to Oct 2026
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Sanctuary Collection
Inside
$2,197
Oceanview
$2,727
Balcony
$3,276
Suite
$4,184
From
US$2,197
Per Person
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departures: Oct 2026 to Oct 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$1,779
Oceanview
$2,109
Balcony
$2,684
Suite
$3,935
From
US$1,779
Save 52
Per Person
View Trip
7 Day Amalfi Coast, Cannes & Ibiza with Virgin Voyages
Cruise
 (1)

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Valiant Lady
Departure: 25 May 2026
Visit: Italy, France, Spain
With Love From the World
Inside
-
Oceanview
$1,719
Balcony
$1,794
Suite
-
From
US$1,719
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Visit: Italy, Greece, Montenegro, Croatia, Malta, Spain
Inside
$2,469
Oceanview
$2,619
Balcony
$4,029
Suite
$6,440
From
US$2,469
Per Person
View Trip
10 Day Latin Languages Of Love with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 March 2028
Visit: Italy, Sicily, Sardinia, Monaco, France, Spain
Your World Inclusions
Your World Included Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,515
Suite
$6,037
From
US$3,515
Save 3,683
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Aug 2026 to Jul 2027
Visit: Italy, Corsica, France, Gibraltar, Spain
Fare Saver
Book Early & Have It All Fare Option
Inside
$1,269
Oceanview
$1,319
Balcony
$1,719
Suite
$2,219
From
US$1,269
Per Person
View Trip
15 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 15 October 2027
Visit: Italy, Sicily, Greece, Croatia, Spain
Inside
$2,629
Oceanview
$2,929
Balcony
$3,579
Suite
$7,905
From
US$2,629
Per Person
View Trip
8 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 November 2027
Visit: Italy, France, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,380
Suite
$6,680
From
US$4,380
Save 2,920
Per Person
View Trip
Results: 31-60 of 80

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