Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Rome to Barcelona

Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? September is the most popular month to cruise between Rome and Barcelona and there are 239 departures available from sixteen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
4 Days
22 Days
Regions
Ship Size
Ship Features
Operators
Show More...
Price
$300pp
$28,198pp
Countries
Show More...
Filter Results
105 Cruises (239 Cruise Departures)
7 Day Amalfi Coast, Cannes & Ibiza with Virgin Voyages
Cruise
 (1)

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Valiant Lady
Departure: 25 May 2026
Visit: Italy, France, Spain
Limited Time Offer
Inside
$1,399
Oceanview
$1,628
Balcony
$1,571
Suite
-
From
US$1,399
Per Person
View Trip
11 Day Spanish Sapphire Shores with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 24 March 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,299
Suite
$11,649
From
US$10,299
Save 10,299
Per Person
View Trip
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Inside
$1,889
Oceanview
$2,029
Balcony
$2,369
Suite
$4,419
From
US$1,889
Per Person
View Trip
7 Day A Journey From The Eternal City To Catalan Shores with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 09 June 2026
Visit: Italy, Sicily, Malta, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$5,130
From
US$5,130
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Aug 2026 to Jul 2027
Visit: Italy, Corsica, France, Gibraltar, Spain
Fare Saver
Book Early & Have It All Fare Option
Inside
$774
Oceanview
$824
Balcony
$1,124
Suite
$1,674
From
US$774
Per Person
View Trip
8 Day Yacht Harbors Of The Cote D'azur with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Jul 2028 to Sep 2028
Visit: Italy, France, Spain
Inside
-
Oceanview
-
Balcony
$5,799
Suite
$9,299
From
US$5,799
Per Person
View Trip
11 Day Artists & Aristocrats with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,310
Suite
$7,245
From
US$5,310
Save 6,488
Per Person
View Trip
11 Day Iconic Italy & the French Riviera with Scenic
New ReleaseCruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 27 June 2028
Visit: Italy, Monaco, France, Spain
Preferred Fare + Bonus Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,998
Suite
$16,326
From
US$13,998
Save 2,247
Per Person
View Trip
22 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Visit: Italy, Sicily, Greece, Montenegro (+4 more), Croatia, Malta, Spain, France
Inside
-
Oceanview
-
Balcony
$6,049
Suite
-
From
US$6,049
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
-
Oceanview
$429
Balcony
$579
Suite
$1,259
From
US$429
Per Person
View Trip
8 Day Rome To Romance with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2028
Visit: Italy, Corsica, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,199
Oceanview
$2,849
Balcony
$3,499
Suite
$4,799
From
US$2,199
Save 2,199
Per Person
View Trip
10 Day Western Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Prima
Departure: 28 April 2027
Visit: Italy, France, Sicily, Sardinia, Spain
Inside
$1,929
Oceanview
$2,289
Balcony
$2,829
Suite
$3,619
From
US$1,929
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,100
Suite
$8,100
From
US$5,100
Save 1,500
Per Person
View Trip
8 Day Regards From The Riviera with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 09 September 2027
Visit: Italy, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,099
Oceanview
$2,249
Balcony
$3,499
Suite
$4,899
From
US$2,099
Save 2,099
Per Person
View Trip
21 Day An Extended Journey Between Continents & Coastlines with Explora Journeys
Cruise
 (1)

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 04 January 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain, Morocco
Inside
-
Oceanview
-
Balcony
-
Suite
$10,220
From
US$10,220
Per Person
View Trip
10 Day A Journey From Italian Gems To Spain’s Southern Coast with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 05 March 2027
Visit: Italy, France, Corsica, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$5,180
From
US$5,180
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (7)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2026 to Oct 2027
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Princess Premier
Sanctuary Collection
Inside
$1,996
Oceanview
$2,449
Balcony
$3,076
Suite
$3,599
From
US$1,996
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Florence & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 May 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Inside
$2,119
Oceanview
$2,439
Balcony
$3,229
Suite
$5,219
From
US$2,119
Per Person
View Trip
8 Day Essential Mediterranean with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 June 2026
Visit: Italy, Monaco, France, Spain
Your World Inclusions
Exclusive Savings
Inside
$1,955
Oceanview
$2,125
Balcony
-
Suite
-
From
US$1,955
Save 2,643
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Florence, Nice & Barcelona with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 27 May 2027
Visit: Italy, France, Spain
Azamara Always Included
Inside
$2,099
Oceanview
$2,399
Balcony
$3,159
Suite
$5,049
From
US$2,099
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2026 to Aug 2026
Visit: Italy, Greece, Montenegro, Croatia, Malta, Spain
Bonus Onboard Credit
Inside
$2,499
Oceanview
$2,649
Balcony
$2,759
Suite
$6,119
From
US$2,499
Per Person
View Trip
7 Day A Journey Of Sunset Shores & Mediterranean Icons with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 08 June 2027
Visit: Italy, Corsica, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$5,365
From
US$5,365
Per Person
View Trip
8 Day Coastal Kaleidoscope with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 September 2027
Visit: Italy, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$1,899
Oceanview
$2,199
Balcony
$3,299
Suite
$4,799
From
US$1,899
Save 1,899
Per Person
View Trip
10 Day A Journey To Spain's Icons & North Africa's Sunlit Shores with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 February 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$4,865
From
US$4,865
Per Person
View Trip
8 Day Mediterranean Cruise From Rome To Barcalona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2027
Visit: Italy, Sicily, France, Spain
Inside
$559
Oceanview
$1,559
Balcony
$789
Suite
$1,009
From
US$559
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 15 June 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$970
Oceanview
$1,188
Balcony
$1,632
Suite
$3,807
From
US$970
Save 544
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,117
Oceanview
-
Balcony
$1,709
Suite
$2,216
From
US$1,117
Save 762
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 June 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,058
Oceanview
$2,768
Balcony
$2,948
Suite
$6,631
From
US$2,058
Save 1,246
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,300
Oceanview
$1,347
Balcony
$1,507
Suite
$4,788
From
US$1,300
Save 932
Per Person
View Trip
11 Day A Journey From Amalfi’s Cliffs To Andalusian Sun with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 January 2027
Visit: Italy, Sardinia, Spain, Morocco
Inside
-
Oceanview
-
Balcony
-
Suite
$5,390
From
US$5,390
Per Person
View Trip
Results: 31-60 of 105

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Albania Colombia Corsica Croatia Cyprus Egypt England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Slovenia Spain Tunisia Turkey USA

Cities

Cruises from Rome

Routes

Cruises from Rome to Barcelona Cruises from Trieste to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations