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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 286 departures available from fifteen of the world's leading cruise lines.
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137 Cruises (286 Cruise Departures)
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Libra (+9 more), Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Sep 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$2,799
SUITE
$3,799
Save (per person) 1,050
From (per person) 2,799
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: Jul 2025 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
INSIDE
$1,195
OCEANVIEW
$1,675
BALCONY
$2,225
SUITE
$2,555
From (per person) 1,195
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (5)

13 Days (12 Nights) Venice to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Oct 2025 to Aug 2027
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,699
SUITE
$7,499
Save (per person) 500
From (per person) 5,699
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Countries Visited: Italy, France, Spain
One Way Cruise Offer
INSIDE
$479
OCEANVIEW
$559
BALCONY
$679
SUITE
$1,099
From (per person) 479
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Florence to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Malta, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$839
SUITE
$1,339
From (per person) 839
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 24 October 2026
Countries Visited: Italy, Sicily, Corsica, France (+1 more), Spain
Latest Offer
INSIDE
$1,099
OCEANVIEW
$1,439
BALCONY
$1,678
SUITE
$2,212
Save (per person) 560
From (per person) 1,099
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Fleetwide SaleExclusive Deal
INSIDE
$2,699
OCEANVIEW
$3,299
BALCONY
$5,099
SUITE
$6,899
Save (per person) 2,699
From (per person) 2,699
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 August 2025
Countries Visited: Italy, France, Sardinia, Sicily (+2 more), Corsica, Spain
Exclusive Deal
INSIDE
$1,165
OCEANVIEW
-
BALCONY
$3,305
SUITE
$4,375
From (per person) 1,165
View Trip
11 Day A Journey Through Coastal Jewels & Culture-filled Capitals with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 27 October 2027
Countries Visited: Italy, Croatia, Malta, Monaco (+2 more), France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$6,125
SUITE
$7,015
From (per person) 6,125
View Trip
22 Day Italy & Spain Cruise: Dubrovnik, Mykonos & Valletta with Azamara Cruises
Cruise
 (1)

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 October 2027
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+8 more), Greece, Sicily, Malta, Tunisia, Sardinia, France, Corsica, Spain
INSIDE
$8,289
OCEANVIEW
$9,029
BALCONY
$10,949
SUITE
$14,709
From (per person) 8,289
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Aug 2026 to Jul 2027
Countries Visited: Italy, Corsica, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$1,109
OCEANVIEW
$1,189
BALCONY
$1,619
SUITE
$2,489
From (per person) 1,109
View Trip
11 Day Spanish Sapphire Shores with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 24 March 2027
Countries Visited: Italy, France, Spain
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$8,099
SUITE
$9,599
Save (per person) 13,499
From (per person) 8,099
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (3)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 16 August 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive DealBonus Instant Savings
INSIDE
$2,623
OCEANVIEW
-
BALCONY
$4,694
SUITE
$13,434
From (per person) 2,623
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 27 August 2027
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), Corsica, Spain
Exclusive Deal
INSIDE
$2,749
OCEANVIEW
$2,999
BALCONY
$3,649
SUITE
$8,149
From (per person) 2,749
View Trip
21 Day Adriatic & Iberia Discovery with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Venice to Bilbao
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Spain, Morocco, Portugal
Exclusive Deal
INSIDE
$6,099
OCEANVIEW
$6,799
BALCONY
$10,099
SUITE
$13,899
Save (per person) 6,099
From (per person) 6,099
View Trip
8 Day A Journey of Volcanic Vistas & Catalonian Culture with Explora Journeys
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Best Available FareUnique Summer Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,130
SUITE
$6,220
From (per person) 5,130
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departures: Oct 2026 to Oct 2027
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$1,799
OCEANVIEW
$2,149
BALCONY
$2,789
SUITE
$4,069
From (per person) 1,799
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,619
OCEANVIEW
$2,819
BALCONY
-
SUITE
-
From (per person) 2,619
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 13 May 2026
Countries Visited: Italy, France, Spain, Portugal
One Way Cruise Offer
INSIDE
$539
OCEANVIEW
$699
BALCONY
$1,069
SUITE
$1,639
From (per person) 539
View Trip
8 Day Italy, France & Spain Cruise: Florence, Nice & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 27 May 2027
Countries Visited: Italy, France, Spain
INSIDE
$1,759
OCEANVIEW
$2,029
BALCONY
$2,669
SUITE
$4,029
From (per person) 1,759
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Amalfi to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 30 September 2025
Countries Visited: Italy, Sicily, Malta, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$639
SUITE
$949
From (per person) 639
View Trip
22 Day An Extended Journey Of Awe-inspiring Artistry And Dramatic Shores with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 21 July 2025
Countries Visited: Italy, Sicily, Sardinia, Spain (+2 more), France, Tunisia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$24,905
From (per person) 24,905
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain
Fleetwide SaleExclusive Deal
INSIDE
$1,999
OCEANVIEW
$2,199
BALCONY
$3,199
SUITE
$4,499
Save (per person) 1,999
From (per person) 1,999
View Trip
22 Day Antiquities of the Mediterranean with Viking Cruises
Cruise
 (4)

22 Days (21 Nights) Venice to Barcelona
Operated By: Viking Cruises
Ship: Viking Jupiter
Departure: 21 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+5 more), Turkey, Sicily, Monaco, France, Spain
Viking $1,499 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,447
SUITE
$19,797
From (per person) 13,447
View Trip
19 Day Italy Intensive Cruise: Taranto, Amalfi & Sorrento with Azamara Cruises
Cruise
 (3)

19 Days (18 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 16 May 2027
Countries Visited: Italy, Montenegro, Sicily, France (+1 more), Spain
INSIDE
$4,809
OCEANVIEW
$5,539
BALCONY
$7,059
SUITE
$10,339
From (per person) 4,809
View Trip
22 Day An Extended Journey To Epicurean Delights And Vintage Allure On Sun-drenched Shores with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 15 September 2025
Countries Visited: Italy, Sicily, Sardinia, Spain (+2 more), France, Tunisia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$19,995
From (per person) 19,995
View Trip
11 Day Italy, France & Spain Cruise: Florence, Marseille & Barcelona with Azamara Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 July 2027
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,429
OCEANVIEW
$2,849
BALCONY
$3,729
SUITE
$5,649
From (per person) 2,429
View Trip
8 Day Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Italy, Sicily, France, Spain
INSIDE
$1,009
OCEANVIEW
$1,359
BALCONY
$1,439
SUITE
$1,559
From (per person) 1,009
View Trip
22 Day An Extended Journey Of Ancient Medinas, Striking Ruins And Paradise Landscapes with Explora Journeys
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 01 September 2025
Countries Visited: Italy, Sicily, Tunisia, Spain (+4 more), Monaco, France, Corsica, Sardinia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$26,120
From (per person) 26,120
View Trip
8 Day A Journey through Italian Treasures & French Riviera Elegance with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Countries Visited: Italy, Corsica, Monaco, France (+1 more), Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$4,670
SUITE
$5,395
From (per person) 4,670
View Trip
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