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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 358 departures available from seventeen of the world's leading cruise lines.
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169 Cruises (358 Cruise Departures)
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+11 more), Viking Libra, Viking Lyra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Sep 2028
Visit: Italy, Monaco, France, Spain
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,599
Suite
$3,499
From
US$2,599
Save 800
Per Person
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+4 more), Viking Sea, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2026 to Sep 2028
Visit: Italy, Croatia, Greece, Monaco, France, Spain
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,999
Suite
$9,999
From
US$6,999
Save 1,000
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,300
Oceanview
$1,347
Balcony
$1,507
Suite
$6,030
From
US$1,300
Save 932
Per Person
View Trip
10 Day A Journey To Spain's Icons & North Africa's Sunlit Shores with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 February 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$4,865
From
US$4,865
Per Person
View Trip
11 Day Shimmering Shores with Oceania Cruises
Cruise

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 July 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,999
Suite
$7,699
From
US$4,999
Save 4,999
Per Person
View Trip
11 Day Heavenly Mediterranean Islands with Regent Seven Seas
Cruise

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 25 October 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,099
Suite
$12,699
From
US$12,099
Save 12,099
Per Person
View Trip
8 Day Rome To Romance with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2028
Visit: Italy, Corsica, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,199
Oceanview
$2,849
Balcony
$3,499
Suite
$4,799
From
US$2,199
Save 2,199
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 06 July 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,246
Oceanview
$3,057
Balcony
$2,949
Suite
$5,424
From
US$2,246
Save 1,367
Per Person
View Trip
8 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 November 2027
Visit: Italy, France, Spain
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,700
Suite
$7,900
From
US$4,700
Save 2,500
Per Person
View Trip
8 Day Western Mediterranean From Trieste To Barcelona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Aura
Departure: 21 May 2027
Visit: Italy, Malta, Spain
Inside
-
Oceanview
$2,525
Balcony
$2,825
Suite
$3,425
From
US$2,525
Per Person
View Trip
8 Day Greece, Italy, Croatia & Malta with Royal Caribbean
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 09 July 2027
Visit: Italy, Croatia, Greece, Malta, Sicily, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,083
Oceanview
$1,393
Balcony
$1,643
Suite
$2,462
From
US$1,083
Save 538
Per Person
View Trip
10 Day Greece & Italy Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 28 August 2027
Visit: Italy, Greece, Sicily, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,528
Oceanview
$1,998
Balcony
$2,378
Suite
$3,638
From
US$1,528
Save 727
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,117
Oceanview
$1,683
Balcony
$1,709
Suite
$2,216
From
US$1,117
Save 762
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2026 to Aug 2026
Visit: Italy, Greece, Montenegro, Croatia, Malta, Spain
Bonus Onboard Credit
Inside
$2,499
Oceanview
$2,649
Balcony
$2,759
Suite
$6,119
From
US$2,499
Per Person
View Trip
19 Day Italy Intensive Cruise: Taranto, Amalfi & Sorrento with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 16 May 2027
Visit: Italy, Montenegro, Sicily, France, Spain
Azamara Always Included
Inside
$5,179
Oceanview
$5,959
Balcony
-
Suite
$11,059
From
US$5,179
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 27 August 2027
Visit: Italy, Croatia, Greece, Sicily, Corsica, Spain
Bonus Onboard Credit
Inside
$1,989
Oceanview
$2,249
Balcony
$2,469
Suite
$5,549
From
US$1,989
Per Person
View Trip
10 Day Pasta To Paella with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 15 April 2028
Visit: Italy, Sardinia, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,699
Suite
$6,299
From
US$3,699
Save 3,699
Per Person
View Trip
8 Day European Yearnings with Oceania Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 02 July 2027
Visit: Italy, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,249
Suite
$5,049
From
US$3,249
Save 3,249
Per Person
View Trip
11 Day A Journey Through Coastal Jewels & Culture-filled Capitals with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 27 October 2027
Visit: Italy, Croatia, Malta, Monaco, France, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$6,125
From
US$6,125
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Florence, Nice & Barcelona with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 27 May 2027
Visit: Italy, France, Spain
Azamara Always Included
Inside
$2,099
Oceanview
$2,399
Balcony
$3,159
Suite
$5,049
From
US$2,099
Per Person
View Trip
10 Day Western Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Prima
Departure: 28 April 2027
Visit: Italy, France, Sicily, Sardinia, Spain
Inside
$1,929
Oceanview
$2,289
Balcony
$2,829
Suite
$3,619
From
US$1,929
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$761
Oceanview
$940
Balcony
$1,173
Suite
$2,349
From
US$761
Per Person
View Trip
11 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Lanzarote
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Inside
$746
Oceanview
$908
Balcony
$1,120
Suite
$3,679
From
US$746
Per Person
View Trip
11 Day Treasures of the Western Mediterranean with Ponant
Cruise
 (2)

11 Days (10 Nights) Florence to Malaga
Cruise Line: Ponant
Ship: Le Boreal
Departure: 03 October 2027
Visit: Italy, Monaco, France, Spain
Inside
-
Oceanview
$6,990
Balcony
$7,350
Suite
$13,610
From
US$6,990
Per Person
View Trip
11 Day Breathtaking Greek Isles with Regent Seven Seas
Cruise

11 Days (10 Nights) Bologna to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 05 July 2027
Visit: Italy, Greece, Sicily, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,299
Suite
$12,999
From
US$12,299
Save 12,299
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 17 September 2027
Visit: Italy, Croatia, Greece, Sicily, France, Corsica, Spain
Bonus Onboard Credit
Inside
$2,209
Oceanview
$2,409
Balcony
$2,769
Suite
$6,019
From
US$2,209
Per Person
View Trip
8 Day A Journey Of Shimmering Shores & Timeless Mediterranean Treasures with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departures: Jun 2026 to Sep 2026
Visit: Italy, Corsica, France, Spain
Sky & Sea
Inside
-
Oceanview
-
Balcony
-
Suite
$5,000
From
US$5,000
Per Person
View Trip
11 Day Western Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Dawn
Departure: 29 April 2027
Visit: Italy, Sicily, Malta, Tunisia, France, Spain
Inside
$1,489
Oceanview
$1,819
Balcony
$2,499
Suite
$2,759
From
US$1,489
Per Person
View Trip
22 Day Antiquities of the Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ship: Viking Sky
Departure: 21 October 2027
Visit: Italy, Croatia, Montenegro, Greece (+5 more), Turkey, Sicily, Monaco, France, Spain
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$13,797
Suite
$21,097
From
US$13,797
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 15 June 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$970
Oceanview
$1,188
Balcony
$1,232
Suite
$3,807
From
US$970
Save 544
Per Person
View Trip
Results: 1-30 of 169

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