Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 234 departures available from sixteen of the world's leading cruise lines.
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31 Days
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129 Cruises (234 Cruise Departures)
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Departures: Jul 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$7,074
SUITE
$10,390
Save 1,372
From 7,074
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,012
OCEANVIEW
-
BALCONY
$4,378
SUITE
$5,308
From 3,012
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Departures: Nov 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,232
Save 2,350
From 4,450
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Departures: Oct 2024 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
INSIDE
$3,465
OCEANVIEW
$4,076
BALCONY
$4,993
SUITE
$5,376
From 3,465
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,207
OCEANVIEW
$4,697
BALCONY
$5,387
SUITE
$7,456
From 4,207
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Departure: 01 June 2026
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
$5,093
OCEANVIEW
$5,928
BALCONY
$6,848
SUITE
$9,377
From 5,093
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
Circle Club Voyage
INSIDE
$2,560
OCEANVIEW
$3,987
BALCONY
$4,762
SUITE
$6,831
From 2,560
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Have It All Offer
INSIDE
$3,793
OCEANVIEW
$3,991
BALCONY
$4,981
SUITE
$6,862
From 3,793
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Greece, Malta (+2 more), France, Spain
Exclusive Solo Offer
INSIDE
$2,507
OCEANVIEW
$3,882
BALCONY
$3,958
SUITE
$4,417
From 2,507
Cruise
 (1)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 June 2025
Countries Visited: Italy, Sicily, Greece, Malta (+6 more), Tunisia, Sardinia, Spain, Morocco, Portugal, Gibraltar
Have It All Offer
INSIDE
$6,769
OCEANVIEW
$7,561
BALCONY
$8,997
SUITE
$12,066
From 6,769
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,398
SUITE
$9,091
Save 2,052
From 6,398
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
$3,830
BALCONY
$5,006
SUITE
$5,927
Save 7,440
From 3,830
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Departures: Jun 2026 to Aug 2026
Countries Visited: Italy, Croatia, Malta, Spain
Exclusive Deal
INSIDE
$1,585
OCEANVIEW
$1,783
BALCONY
$1,932
SUITE
$4,456
From 1,585
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Departure: 18 June 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Deal
INSIDE
$2,954
OCEANVIEW
-
BALCONY
$4,758
SUITE
-
Save 3,920
From 2,954
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Departure: 03 August 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$3,221
BALCONY
$3,617
SUITE
$8,914
From 2,924
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Departure: 25 August 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), France, Spain
Exclusive Deal
INSIDE
$2,677
OCEANVIEW
$3,122
BALCONY
$3,469
SUITE
$8,518
From 2,677
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$4,204
OCEANVIEW
$5,101
BALCONY
$6,665
SUITE
$7,279
From 4,204
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Departure: 14 November 2025
Countries Visited: Italy, France, Spain, Corsica (+1 more), Sardinia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,468
SUITE
$15,824
Save 6,472
From 13,468
Cruise

21 Days (20 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Departure: 28 April 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$25,664
SUITE
-
Save 9,136
From 25,664
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 19 August 2024
Countries Visited: Italy, Sicily, Sardinia, Spain
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,014
SUITE
$7,311
From 6,014
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$3,221
BALCONY
$3,617
SUITE
$8,914
From 2,924
Cruise

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 26 July 2024
Countries Visited: Italy, Croatia, Montenegro, Albania (+5 more), Malta, Sicily, Sardinia, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$22,572
BALCONY
$23,265
SUITE
-
From 22,572
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Departure: 22 September 2025
Countries Visited: Italy, Croatia, Malta, Spain (+2 more), Greece, Turkey
Exclusive Deal
INSIDE
$3,422
OCEANVIEW
$3,867
BALCONY
$4,412
SUITE
$11,193
From 3,422
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Departure: 18 May 2025
Countries Visited: Italy, Corsica, France, Spain
Cabin Upgrade Offer
INSIDE
$4,734
OCEANVIEW
$5,417
BALCONY
$6,338
SUITE
$8,545
From 4,734
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 30 October 2024
Countries Visited: Italy, Sardinia, Corsica, Monaco (+2 more), France, Spain
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$9,919
SUITE
$16,146
From 9,919
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 23 September 2025
Countries Visited: Italy, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,642
Save 858
From 10,642
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Departure: 23 September 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$8,821
OCEANVIEW
$4,171
BALCONY
$7,344
SUITE
$11,476
Save 4,806
From 4,098
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Departure: 12 July 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+3 more), Sicily, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,197
SUITE
$15,455
Save 6,183
From 14,197
Results: 1-30 of 129

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