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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 236 departures available from sixteen of the world's leading cruise lines.
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127 Cruises (236 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sea (+3 more), Viking Sky, Viking Star, Viking Vesta
Departures: May 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$6,925
SUITE
$10,390
Save 1,570
From 6,925
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ships: Majestic Princess, Star Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$2,775
OCEANVIEW
$3,768
BALCONY
$4,022
SUITE
$4,924
From 2,775
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Jul 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,279
From 4,450
View Trip
10 Day Islands Of The Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 18 October 2024
Countries Visited: Italy, Corsica, Sardinia, Spain
INSIDE
$2,201
OCEANVIEW
$2,869
BALCONY
$4,571
SUITE
-
From 2,201
View Trip
19 Day Malta & Mediterranean Romance with Holland America
Cruise
 (1)

19 Days (18 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 01 September 2024
Countries Visited: Italy, Sicily, Malta, Greece (+5 more), Turkey, Albania, Corsica, France, Spain
Have It All Offer
INSIDE
$5,178
OCEANVIEW
$5,822
BALCONY
$6,802
SUITE
$9,594
From 5,178
View Trip
11 Day Renaissance Triumphs with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,398
SUITE
$9,091
Save 2,052
From 6,398
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Have It All Offer
INSIDE
$3,793
OCEANVIEW
$3,991
BALCONY
$4,981
SUITE
$6,862
From 3,793
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 May 2024
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,645
From 9,645
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,368
OCEANVIEW
$4,829
BALCONY
$5,519
SUITE
$7,588
From 4,368
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 04 June 2024
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,239
OCEANVIEW
$5,630
BALCONY
$2,775
SUITE
$7,088
Save 2,992
From 2,239
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$3,830
BALCONY
$3,993
SUITE
$4,953
Save 7,440
From 3,830
View Trip
2 Day Mediterranean with MSC Cruises
Cruise

2 Days (1 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 11 October 2024
Countries Visited: Italy, Spain
Early Booking With Easy Drink Packages
INSIDE
$161
OCEANVIEW
$210
BALCONY
$270
SUITE
$537
From 161
View Trip
13 Day Rome to Barcelona with Silversea
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 16 May 2024
Countries Visited: Italy, Monaco, Spain, Malta
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$17,523
BALCONY
$19,107
SUITE
$38,412
From 17,523
View Trip
12 Day Italy, Greece & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Venice to Barcelona
Ship: Norwegian Escape
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Greece, Malta (+2 more), France, Spain
Free At Sea Offer
INSIDE
$2,715
OCEANVIEW
$3,246
BALCONY
$3,550
SUITE
$3,868
From 2,715
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Malta, France (+1 more), Spain
INSIDE
$2,895
OCEANVIEW
$3,192
BALCONY
$4,310
SUITE
$7,686
From 2,895
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$3,958
OCEANVIEW
$4,925
BALCONY
$6,212
SUITE
$7,321
From 3,958
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 23 April 2024
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$314
OCEANVIEW
-
BALCONY
-
SUITE
-
From 314
View Trip
22 Day Venice to Barcelona with Silversea
Cruise

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 26 July 2024
Countries Visited: Italy, Croatia, Montenegro, Albania (+5 more), Malta, Sicily, Sardinia, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,582
BALCONY
$23,265
SUITE
$59,994
From 21,582
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 September 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, Turkey
INSIDE
$5,741
OCEANVIEW
$6,305
BALCONY
$7,058
SUITE
$15,334
From 5,741
View Trip
12 Day Greece, Turkey & Italy Cruise with Celebrity Cruises
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 18 June 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$3,340
OCEANVIEW
$3,636
BALCONY
$4,286
SUITE
$11,812
Save 4,035
From 3,340
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 28 July 2025
Countries Visited: Italy, Croatia, Malta, France (+4 more), Sardinia, Sicily, Corsica, Spain
INSIDE
$3,927
OCEANVIEW
$4,283
BALCONY
$4,996
SUITE
$10,698
From 3,927
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Genoa to Malaga
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$550
OCEANVIEW
-
BALCONY
-
SUITE
-
From 550
View Trip
8 Day Mediterranean Marvels & Matches: Barcelona Open with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Venture
Departure: 13 April 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,116
SUITE
$21,689
From 9,116
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 17 August 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$2,238
OCEANVIEW
$2,407
BALCONY
$3,082
SUITE
$7,102
Save 3,190
From 2,238
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
The Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,197
SUITE
$6,341
From 5,197
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
The Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
10 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
The Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,049
SUITE
$8,593
From 7,049
View Trip
15 Day Charming Coasts & Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Corsica, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,161
SUITE
$19,002
Save 6,959
From 17,161
View Trip
Results: 1-30 of 127

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