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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 220 departures available from sixteen of the world's leading cruise lines.
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114 Cruises (220 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sky (+2 more), Viking Star, Viking Vesta
Departures: Oct 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$8,031
SUITE
$11,265
Save (per person) 1,121
From (per person) 8,031
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$2,927
OCEANVIEW
-
BALCONY
$2,842
SUITE
$3,779
From (per person) 2,842
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+7 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Dec 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,143
SUITE
$6,232
Save (per person) 2,460
From (per person) 5,143
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
More At Sea OfferExclusive Solo Offer
INSIDE
$4,225
OCEANVIEW
$4,836
BALCONY
$5,754
SUITE
$6,443
From (per person) 4,225
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (2)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 01 June 2026
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
$6,663
OCEANVIEW
$8,613
BALCONY
$9,950
SUITE
$13,613
From (per person) 6,663
View Trip
22 Day Western Mediterranean: Lisbon Overnight with Holland America
Cruise
 (2)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 June 2025
Countries Visited: Italy, Sicily, Greece, Malta (+6 more), Tunisia, Sardinia, Spain, Morocco, Portugal, Gibraltar
Exclusive Deal
INSIDE
-
OCEANVIEW
$6,295
BALCONY
$8,225
SUITE
$10,453
From (per person) 6,295
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 August 2026
Countries Visited: Italy, Corsica, France, Gibraltar (+1 more), Spain
Have It All Offer
INSIDE
$1,913
OCEANVIEW
$2,210
BALCONY
$2,705
SUITE
$4,190
From (per person) 1,913
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$4,716
OCEANVIEW
$5,986
BALCONY
$7,191
SUITE
$7,933
From (per person) 4,716
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,935
OCEANVIEW
$4,832
BALCONY
$5,614
SUITE
$7,079
From (per person) 3,935
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$429
OCEANVIEW
$507
BALCONY
$613
SUITE
$1,001
From (per person) 429
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$5,011
OCEANVIEW
$4,734
BALCONY
$6,417
SUITE
$7,278
From (per person) 4,734
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Sep 2026 to Oct 2026
Countries Visited: Italy, Sicily, Greece, Montenegro (+2 more), Turkey, Spain
Exclusive Deal
INSIDE
$3,911
OCEANVIEW
$5,168
BALCONY
$6,337
SUITE
$7,792
From (per person) 3,911
View Trip
10 Day Europe - Classic Mediterranean with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 15 June 2026
Countries Visited: Italy, Montenegro, Croatia, France (+1 more), Spain
More At Sea Offer
INSIDE
$4,452
OCEANVIEW
$5,063
BALCONY
$5,751
SUITE
$7,128
From (per person) 4,452
View Trip
11 Day Mediterranean with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 29 October 2025
Countries Visited: Italy, Croatia, Greece, Malta (+2 more), Sicily, Spain
Early Booking Offer
INSIDE
$1,336
OCEANVIEW
$1,559
BALCONY
$1,733
SUITE
$2,694
From (per person) 1,336
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (2)

12 Days (11 Nights) Trieste to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Exclusive Deal
INSIDE
$2,543
OCEANVIEW
$2,840
BALCONY
$3,805
SUITE
$5,092
From (per person) 2,543
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$6,553
SUITE
-
From (per person) 6,553
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Bonus SavingsExclusive Deal
INSIDE
$3,973
OCEANVIEW
$4,405
BALCONY
$6,803
SUITE
$9,352
Save (per person) 2,237
From (per person) 3,973
View Trip
8 Day Europe - Mediterranean with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Italy, Sicily, France, Spain
More At Sea Offer
INSIDE
$2,651
OCEANVIEW
-
BALCONY
$3,262
SUITE
$3,568
From (per person) 2,651
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Escape
Departure: 10 October 2024
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
More At Sea Offer
INSIDE
$1,839
OCEANVIEW
-
BALCONY
$3,048
SUITE
$3,537
From (per person) 1,839
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,670
OCEANVIEW
$3,086
BALCONY
$3,967
SUITE
$5,482
From (per person) 2,670
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 03 November 2024
Countries Visited: Italy, Sicily, Malta, Spain
Exclusive Deal
INSIDE
$667
OCEANVIEW
$1,114
BALCONY
$1,017
SUITE
$3,210
From (per person) 667
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 14 June 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$3,554
OCEANVIEW
$4,564
BALCONY
$5,885
SUITE
$6,920
From (per person) 3,554
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$4,364
OCEANVIEW
$5,037
BALCONY
$6,542
SUITE
$6,938
From (per person) 4,364
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Bonus SavingsExclusive Deal
INSIDE
$3,690
OCEANVIEW
$4,255
BALCONY
$6,662
SUITE
$9,070
Save (per person) 2,220
From (per person) 3,690
View Trip
9 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 09 October 2025
Countries Visited: Italy, France, Spain
INSIDE
$2,453
OCEANVIEW
$3,245
BALCONY
$3,998
SUITE
$6,275
From (per person) 2,453
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 28 October 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$1,123
SUITE
-
From (per person) 1,123
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jul 2026
Countries Visited: Italy, France, Gibraltar, Spain
Have It All Offer
INSIDE
$1,863
OCEANVIEW
$2,160
BALCONY
$2,606
SUITE
$4,091
From (per person) 1,863
View Trip
10 Day Europe - Classic Mediterranean with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Aug 2026 to Oct 2026
Countries Visited: Italy, Croatia, Montenegro, France (+1 more), Spain
More At Sea OfferExclusive Solo Offer
INSIDE
$4,494
OCEANVIEW
$5,150
BALCONY
$5,914
SUITE
$7,323
From (per person) 4,494
View Trip
12 Day Grand Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,509
OCEANVIEW
$4,122
BALCONY
$5,657
SUITE
$6,716
From (per person) 3,509
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$2,808
OCEANVIEW
$3,967
BALCONY
$4,076
SUITE
$5,145
From (per person) 2,808
View Trip
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