Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to Spain

Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? October is the most popular month to cruise between Italy and Spain and there are 192 departures available from fourteen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
3 Days
31 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$100pp
$59,690pp
Countries
Show More...
Filter Results
114 Cruises (192 Cruise Departures)
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,692
OCEANVIEW
$4,441
BALCONY
$5,104
SUITE
$6,770
From 3,692
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 August 2025
Countries Visited: Italy, France, Sardinia, Sicily (+2 more), Corsica, Spain
INSIDE
$2,974
OCEANVIEW
$3,370
BALCONY
$3,964
SUITE
$8,221
From 2,974
View Trip
29 Day Mediterranean Highlights with Cunard
Cruise

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 16 September 2024
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, Turkey
INSIDE
$4,018
OCEANVIEW
$4,315
BALCONY
$4,959
SUITE
$11,344
From 4,018
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 02 November 2024
Countries Visited: Italy, France, Spain
INSIDE
$346
OCEANVIEW
$436
BALCONY
$525
SUITE
$861
From 346
View Trip
19 Day Malta & Mediterranean Romance with Holland America
Cruise
 (1)

19 Days (18 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 01 September 2024
Countries Visited: Italy, Sicily, Malta, Greece (+5 more), Turkey, Albania, Corsica, France, Spain
Have It All Offer
INSIDE
$5,723
OCEANVIEW
$6,218
BALCONY
$7,406
SUITE
$9,980
From 5,723
View Trip
12 Day Best Of The Med Voyage with Azamara Cruises
Cruise

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 12 May 2024
Countries Visited: Italy, Croatia, Montenegro, France (+1 more), Spain
INSIDE
$3,831
OCEANVIEW
$3,831
BALCONY
$4,637
SUITE
$7,407
From 3,831
View Trip
22 Day Mediterranean Highlights with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 June 2024
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, France, Spain
INSIDE
$3,224
OCEANVIEW
$3,719
BALCONY
$4,164
SUITE
$9,362
From 3,224
View Trip
22 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 26 May 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Corsica, Spain
INSIDE
$4,263
OCEANVIEW
$4,758
BALCONY
$5,451
SUITE
$11,589
From 4,263
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Venice to Barcelona
Cruise Line: Royal Caribbean
Ship: Enchantment of the Seas
Departure: 16 October 2023
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,437
OCEANVIEW
$1,976
BALCONY
-
SUITE
-
From 1,437
View Trip
8 Day Trieste To Barcelona with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 23 September 2024
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,140
OCEANVIEW
$1,338
BALCONY
$1,437
SUITE
$3,367
From 1,140
View Trip
8 Day Rome To Barcelona with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,140
OCEANVIEW
$1,338
BALCONY
$1,486
SUITE
$3,367
From 1,140
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Lirica (+3 more), MSC Musica, MSC Seashore, MSC Sinfonia
Departures: Oct 2023 to Jan 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$158
OCEANVIEW
$217
BALCONY
$297
SUITE
$490
From 158
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Genoa to Malaga
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 24 April 2024
Countries Visited: Italy, France, Spain
INSIDE
$376
OCEANVIEW
$475
BALCONY
$614
SUITE
$1,079
From 376
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 13 November 2023
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$639
SUITE
-
From 639
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: Jul 2024 to Jun 2025
Countries Visited: Italy, Malta, Tunisia, France (+3 more), Spain, Gibraltar, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,878
SUITE
$28,233
From 13,878
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Genoa to Malaga
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 21 April 2024
Countries Visited: Italy, France, Sardinia, Spain
INSIDE
$734
OCEANVIEW
$912
BALCONY
$1,180
SUITE
-
From 734
View Trip
15 Day Charming Coasts & Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Corsica, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$20,814
SUITE
$22,557
From 20,814
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (4)

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sea (+2 more), Viking Sky, Viking Star
Departures: Oct 2023 to Sep 2025
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Air Credit Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,325
SUITE
$11,559
Save 284
From 8,325
View Trip
12 Day Grand Mediterranean with Princess
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$2,900
OCEANVIEW
$3,544
BALCONY
$4,336
SUITE
$5,237
From 2,900
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$22,797
SUITE
-
From 22,797
View Trip
20 Day Mediterranean, Greece & Italy Explorer with Princess
Cruise

20 Days (19 Nights) Trieste to Barcelona
Cruise Line: Princess
Ship: Star Princess
Departure: 21 September 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), Turkey, Spain
INSIDE
$5,359
OCEANVIEW
$5,933
BALCONY
$7,814
SUITE
$9,170
From 5,359
View Trip
10 Day Ultimate Italy, France & Spain Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 01 July 2024
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$2,528
OCEANVIEW
$2,638
BALCONY
$5,115
SUITE
-
From 2,528
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
INSIDE
$2,772
OCEANVIEW
$3,069
BALCONY
$4,079
SUITE
$5,190
From 2,772
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,229
SUITE
$4,654
From 1,684
View Trip
8 Day Rome To Barcelona with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 July 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,189
OCEANVIEW
$1,387
BALCONY
$1,585
SUITE
$3,615
From 1,189
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,339
OCEANVIEW
$4,799
BALCONY
$5,489
SUITE
$7,558
From 4,339
View Trip
7 Day Mediterranean & Western Europe with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Santa Cruz de Tenerife
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 13 October 2023
Countries Visited: Italy, Spain, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
$1,035
BALCONY
$1,332
SUITE
-
From 1,035
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
INSIDE
$1,585
OCEANVIEW
$1,833
BALCONY
$2,080
SUITE
$4,258
From 1,585
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 30 October 2024
Countries Visited: Italy, Sardinia, Corsica, Monaco (+2 more), France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,929
SUITE
$15,453
From 7,929
View Trip
15 Day Italy And The Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 16 September 2024
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$2,083
OCEANVIEW
$2,429
BALCONY
$2,677
SUITE
$6,934
From 2,083
View Trip
Results: 1-30 of 114

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Black Sea Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Corsica Croatia France Gibraltar Italy Malta Monaco Montenegro Morocco Portugal Sicily Slovenia Spain Turkey

Cities

Genoa Rome Trieste Venice

Routes

Cruises from Rome to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Med Cruises

© 2010-2023. Global Journeys. You're viewing our site in Australian dollars.

        

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Pty Ltd. Member of the Australian Federation of Travel Agents (AFTA) & ATAS Travel Accredited (No. A11351).

Travel Industry Associations