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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 373 departures available from seventeen of the world's leading cruise lines.
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195 Cruises (373 Cruise Departures)
17 Day An Extended Journey Of Island Chic & Riviera Glamour with Explora Journeys
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 05 October 2026
Visit: Italy, Monaco, France, Spain, Sicily
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$20,203
From
A$20,203
Save 412
Per Person
View Trip
13 Day Adriatic To The Balearics with Oceania Cruises
Cruise

13 Days (12 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 13 June 2026
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Malta, Tunisia, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$10,282
Suite
-
From
A$10,282
Save 2,268
Per Person
View Trip
11 Day Mediterranean Highlights: The Riviera, Sardinia and Ibiza with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Rome to Palma de Mallorca
Cruise Line: Emerald Cruises
Ship: Emerald Kaia
Departure: 07 May 2028
Visit: Italy, Sardinia, Monaco, Corsica, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
$12,715
Balcony
-
Suite
$16,635
From
A$12,715
Save 3,230
Per Person
View Trip
15 Day Dalmatian Gems, Malta & Southern France with Seabourn
Cruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 22 July 2028
Visit: Italy, Croatia, Malta, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,111
Suite
$44,261
From
A$15,111
Save 278
Per Person
View Trip
17 Day France, Italy, Tunisia, Monaco & Spain with Seabourn
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 21 June 2027
Visit: Italy, Corsica, Sardinia, Tunisia (+4 more), Sicily, Monaco, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,597
Suite
$26,593
From
A$17,597
Save 337
Per Person
View Trip
18 Day Sun, Sea & Saffron with Regent Seven Seas
Cruise

18 Days (17 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 05 July 2028
Visit: Italy, Sicily, Croatia, Slovenia (+4 more), Montenegro, Greece, Malta, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$30,490
Suite
$32,303
From
A$30,490
Save 2,560
Per Person
View Trip
12 Day Idyllic Islands of the Mediterranean with Scenic
New ReleaseCruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 13 September 2028
Visit: Italy, Sardinia, Corsica, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,829
Suite
$23,710
From
A$19,829
Save 5,866
Per Person
View Trip
10 Day Mediterranean Rivieras: Rome to Barcelona with Scenic
New ReleaseCruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 04 October 2028
Visit: Italy, Corsica, Monaco, France, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,183
Suite
$20,358
From
A$17,183
Save 4,812
Per Person
View Trip
11 Day Old World Exploration with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 01 November 2026
Visit: Italy, Malta, Tunisia, Sicily, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,370
Suite
$13,909
From
A$13,370
Save 2,240
Per Person
View Trip
15 Day Dalmatian Gems, Malta & Southern France with Seabourn
Cruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 04 November 2028
Visit: Italy, Croatia, Malta, Monaco, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,494
Suite
$22,255
From
A$14,494
Save 265
Per Person
View Trip
9 Day Knights & Sunsets with Regent Seven Seas
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 20 November 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$12,479
Suite
$13,920
From
A$12,479
Save 2,231
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 16 August 2027
Visit: Italy, France, Spain
Exclusive Deal
Exclusive Savings
Inside
$1,775
Oceanview
$2,183
Balcony
$2,637
Suite
$5,777
From
A$1,775
Save 724
Per Person
View Trip
11 Day Cadence In Kotor with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 12 July 2028
Visit: Italy, Croatia, Montenegro, Greece, Malta, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,697
Suite
$19,373
From
A$17,697
Save 2,323
Per Person
View Trip
8 Day Classic Mediterranean From Bologna To Barcelona with Norwegian Cruise Line
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 17 October 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Just Cruise Fare
Exclusive Savings
Inside
$2,213
Oceanview
$2,585
Balcony
$3,895
Suite
$4,297
From
A$2,213
Per Person
View Trip
29 Day Mediterranean Medley: Greece, Ephesus & Spain with Seabourn
Cruise

29 Days (28 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 09 October 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+6 more), Greece, Turkey, Malta, Sicily, Sardinia, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$32,192
Suite
$43,771
From
A$32,192
Save 617
Per Person
View Trip
19 Day Icons of Italy & the French Riviera - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

19 Days Milan to Barcelona
Operated By: Scenic
Ship: Scenic Ikon
Departure: 19 June 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Italy, Monaco, France, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$31,584
Suite
$35,112
From
A$31,584
Save 5,606
Per Person
View Trip
8 Day Yacht Harbors Of The Cote D'azur with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: Jul 2028 to Sep 2028
Visit: Italy, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,040
Suite
$11,921
From
A$8,040
Save 149
Per Person
View Trip
10 Day Fairytales Afloat with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 03 September 2027
Visit: Italy, Sicily, Sardinia, Corsica, Monaco, France, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,306
Suite
$8,420
From
A$5,306
Save 2,124
Per Person
View Trip
11 Day Western Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Dawn
Departure: 29 April 2027
Visit: Italy, Sicily, Malta, Tunisia, France, Spain
Just Cruise Fare
Exclusive Savings
Inside
$2,878
Oceanview
$2,967
Balcony
$4,351
Suite
$4,501
From
A$2,878
Per Person
View Trip
12 Day A Grecian Summer with Regent Seven Seas
Cruise

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 02 June 2027
Visit: Italy, Croatia, Greece, Malta, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,958
Suite
$17,908
From
A$16,958
Save 2,302
Per Person
View Trip
10 Day Glories Of The Adriatic with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 01 April 2029
Visit: Italy, France, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,293
Suite
$8,746
From
A$5,293
Save 2,147
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Bari to Valencia
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 24 October 2026
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
$1,732
Oceanview
$2,059
Balcony
$2,712
Suite
$3,098
From
A$1,732
Per Person
View Trip
11 Day Elegant Arrivals with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Explorer
Departure: 11 July 2028
Visit: Italy, Monaco, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,387
Suite
$20,984
From
A$18,387
Save 2,343
Per Person
View Trip
15 Day Mediterranean Montage with Oceania Cruises
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 29 April 2029
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, Corsica, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,090
Suite
$14,503
From
A$9,090
Save 2,260
Per Person
View Trip
10 Day Fountains To Flamenco with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 09 November 2027
Visit: Italy, Sardinia, Corsica, France, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,053
Suite
$9,002
From
A$6,053
Save 2,147
Per Person
View Trip
16 Day Mediterranean Pilgrimage with Regent Seven Seas
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 20 November 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain, France
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,173
Suite
$22,878
From
A$20,173
Save 2,367
Per Person
View Trip
7 Day A Journey Of Sunset Shores & Mediterranean Icons with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 08 June 2027
Visit: Italy, Corsica, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,918
From
A$7,918
Save 162
Per Person
View Trip
10 Day Mediterranean Glory with Oceania Cruises
Cruise

10 Days (9 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sonata
Departure: 21 August 2027
Visit: Italy, Croatia, Corsica, France, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,062
Suite
$9,681
From
A$7,062
Save 2,178
Per Person
View Trip
8 Day A Journey Of Treasured Secrets & Chic Promenades with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 10 August 2026
Visit: Italy, Monaco, France, Spain
A Spontaneous Summer Invitation
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,080
From
A$7,080
Save 145
Per Person
View Trip
13 Day Classical Shores with Regent Seven Seas
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 21 April 2028
Visit: Italy, Slovenia, Croatia, Sicily, Monaco, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,299
Suite
$19,101
From
A$16,299
Save 2,291
Per Person
View Trip
Results: 121-150 of 195

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