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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June and October are the most popular months to cruise between Italy and Spain and there are 344 departures available from seventeen of the world's leading cruise lines.
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29 Days
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154 Cruises (344 Cruise Departures)
11 Day Old World Exploration with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 01 November 2026
Visit: Italy, Malta, Tunisia, Sicily, France, Spain
Exclusive Savings
Inside
-
Oceanview
$7,664
Balcony
-
Suite
$10,604
From
US$7,664
Save 7,934
Per Person
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Amalfi to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Visit: Italy, France, Spain
Inside
$449
Oceanview
$379
Balcony
$449
Suite
-
From
US$379
Per Person
View Trip
11 Day Moonlight Over The Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 19 July 2027
Visit: Italy, Croatia, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,490
Suite
$12,519
From
US$11,490
Save 11,908
Per Person
View Trip
8 Day Riviera Radiance with Oceania Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 22 October 2027
Visit: Italy, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,174
Suite
$4,532
From
US$3,174
Save 3,324
Per Person
View Trip
Results: 151-154 of 154

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Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Albania Colombia Corsica Croatia Cyprus Egypt England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Slovenia Spain Tunisia Turkey USA

Cities

Cruises from Amalfi Cruises from Bari Cruises from Bologna Cruises from Florence Cruises from Genoa Cruises from Naples Cruises from Rome Cruises from Trieste Cruises from Venice

Routes

Cruises from Rome to Barcelona Cruises from Trieste to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

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