Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to Spain

Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June and October are the most popular months to cruise between Italy and Spain and there are 316 departures available from sixteen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
3 Days
29 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$200pp
$33,990pp
Countries
Show More...
Filter Results
131 Cruises (316 Cruise Departures)
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 October 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,930
Suite
$9,760
From
US$6,930
Save 2,970
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,560
Suite
$4,240
From
US$4,240
Save 4,160
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2026
Visit: Italy, Spain
Inside
-
Oceanview
-
Balcony
$529
Suite
$1,259
From
US$529
Per Person
View Trip
15 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 15 October 2027
Visit: Italy, Sicily, Greece, Croatia, Spain
Inside
$2,629
Oceanview
$2,929
Balcony
$3,579
Suite
$7,905
From
US$2,629
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Aug 2026 to Jul 2027
Visit: Italy, Corsica, France, Gibraltar, Spain
Fare Saver
Book Early & Have It All Fare Option
Inside
$1,269
Oceanview
$1,319
Balcony
$1,719
Suite
$2,219
From
US$1,269
Per Person
View Trip
11 Day Italy, France & Spain Cruise: Florence, Marseille & Barcelona with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 July 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$3,747
Oceanview
$3,630
Balcony
$4,756
Suite
$7,627
From
US$3,630
Save 89
Per Person
View Trip
29 Day Mediterranean Medley: Greece, Ephesus & Spain with Seabourn
Cruise

29 Days (28 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 09 October 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+6 more), Greece, Turkey, Malta, Sicily, Sardinia, Spain
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,474
Suite
$30,802
From
US$19,474
Save 330
Per Person
View Trip
8 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 November 2027
Visit: Italy, France, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,380
Suite
$6,680
From
US$4,380
Save 2,920
Per Person
View Trip
22 Day Antiquities of the Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ship: Viking Sky
Departure: 21 October 2027
Visit: Italy, Croatia, Montenegro, Greece (+5 more), Turkey, Sicily, Monaco, France, Spain
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$13,797
Suite
$21,097
From
US$13,797
Per Person
View Trip
8 Day Essential Mediterranean with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 June 2026
Visit: Italy, Monaco, France, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$2,070
Oceanview
$2,250
Balcony
$3,337
Suite
$4,559
From
US$2,070
Save 2,528
Per Person
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 23 February 2026
Visit: Italy, France, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,160
Suite
-
From
US$7,480
Save 1,320
Per Person
View Trip
13 Day Adriatic To The Balearics with Oceania Cruises
Cruise

13 Days (12 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 13 June 2026
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Malta, Tunisia, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,100
Suite
$8,326
From
US$6,100
Save 7,798
Per Person
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Visit: Italy, Corsica, France, Spain
Upgrade Your Experience
Your World Inclusions
Exclusive Savings
Inside
$1,700
Oceanview
$1,870
Balcony
$2,658
Suite
$3,730
From
US$1,700
Save 2,298
Per Person
View Trip
11 Day Mediterranean Isles with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Your World Inclusions
Upgrade Your Experience
Exclusive Savings
Inside
$3,322
Oceanview
$4,001
Balcony
$3,750
Suite
$5,302
From
US$3,322
Save 3,476
Per Person
View Trip
8 Day Western Mediterranean From Trieste To Barcelona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Aura
Departure: 21 May 2027
Visit: Italy, Malta, Spain
Inside
$1,825
Oceanview
$2,165
Balcony
$2,553
Suite
$3,232
From
US$1,825
Per Person
View Trip
8 Day Classic Mediterranean with Norwegian Cruise Line
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 17 October 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Inside
$1,349
Oceanview
$1,529
Balcony
$2,343
Suite
$2,605
From
US$1,349
Per Person
View Trip
8 Day Amalfi Coast, Africa & Iberia with Viking Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Libra (+4 more), Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Dec 2026 to Jun 2028
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
Multiple Deals Available
Inside
-
Oceanview
-
Balcony
$2,999
Suite
$4,799
From
US$2,999
Save 300
Per Person
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 06 July 2026
Visit: Italy, Croatia, Malta, Sicily, France, Corsica, Spain
Inside
-
Oceanview
$3,629
Balcony
$4,279
Suite
$8,661
From
US$3,629
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain
Bonus Onboard Credit
Inside
$388
Oceanview
$514
Balcony
$577
Suite
$1,087
From
US$388
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,671
Oceanview
$1,718
Balcony
$1,762
Suite
$4,968
From
US$1,991
Save 740
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Bonus Onboard Credit
Inside
-
Oceanview
$1,114
Balcony
$1,249
Suite
$2,539
From
US$1,114
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 27 July 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$2,068
Suite
$3,881
From
US$3,001
Save 104
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 15 June 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,714
Oceanview
$2,325
Balcony
$2,886
Suite
$3,871
From
US$1,714
Save 828
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Nice & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 March 2028
Visit: Italy, France, Spain
Azamara Always Included
Inside
$1,599
Oceanview
$2,009
Balcony
$2,549
Suite
$3,839
From
US$1,599
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Florence & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 May 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Inside
$1,939
Oceanview
$2,229
Balcony
$2,878
Suite
$4,614
From
US$1,939
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Italy, Corsica, Spain
Inside
$919
Oceanview
$1,019
Balcony
$1,169
Suite
$2,949
From
US$919
Per Person
View Trip
8 Day Rome To Romance with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2028
Visit: Italy, Corsica, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,199
Oceanview
$2,785
Balcony
$3,415
Suite
$4,676
From
US$2,199
Save 2,199
Per Person
View Trip
11 Day Renaissance & Rivieras with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 June 2027
Visit: Italy, Sicily, Sardinia, Corsica, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,129
Oceanview
$3,371
Balcony
$5,360
Suite
$7,397
From
US$3,129
Save 3,269
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 June 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,019
Oceanview
$2,540
Balcony
$2,728
Suite
$7,722
From
US$2,397
Save 806
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Visit: Italy, Croatia, Malta, Spain, France
Inside
$2,669
Oceanview
$2,959
Balcony
$3,429
Suite
$6,628
From
US$2,669
Per Person
View Trip
Results: 61-90 of 131

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Food & Wine Cruises Luxury Cruises Short Cruise Breaks

Countries

Albania Corsica Croatia Cyprus Egypt England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Slovenia Spain Tunisia Turkey USA

Cities

Cruises from Amalfi Cruises from Bari Cruises from Bologna Cruises from Florence Cruises from Genoa Cruises from Rome Cruises from Trieste Cruises from Venice

Routes

Cruises from Rome to Barcelona Cruises from Trieste to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2026. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Operators | Terms & Conditions | Site Map | We're hiring!

Global Journeys Travel Inc. is a Member of the American Society of Travel Advisors (ASTA No: 900374670), CLIA (No. 00046729) & is TICO Accredited (No. 50027921).

Travel Industry Associations