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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 358 departures available from seventeen of the world's leading cruise lines.
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169 Cruises (358 Cruise Departures)
10 Day Pasta To Paella with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 15 April 2028
Visit: Italy, Sardinia, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,699
Suite
$6,299
From
US$3,699
Save 3,699
Per Person
View Trip
8 Day Coastal Kaleidoscope with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 September 2027
Visit: Italy, Monaco, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$1,899
Oceanview
$2,199
Balcony
$3,299
Suite
$4,799
From
US$1,899
Save 1,899
Per Person
View Trip
8 Day Italy And France with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain
Bonus Onboard Credit
Inside
$1,239
Oceanview
$1,289
Balcony
$1,429
Suite
$3,029
From
US$1,239
Per Person
View Trip
8 Day Greece, Spain, Croatia & Malta with Royal Caribbean
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 13 August 2027
Visit: Italy, Croatia, Greece, Malta, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,120
Oceanview
$1,440
Balcony
$1,699
Suite
$2,559
From
US$1,120
Save 546
Per Person
View Trip
8 Day Riviera Reverie with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 30 September 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,799
Suite
$10,449
From
US$9,799
Save 9,799
Per Person
View Trip
13 Day Mediterranean with MSC Cruises
Cruise

13 Days (12 Nights) Trieste to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 06 November 2027
Visit: Italy, Croatia, Greece, Turkey, Spain
Inside
$1,179
Oceanview
$1,489
Balcony
$1,709
Suite
$4,609
From
US$1,179
Per Person
View Trip
12 Day Spanish Flavors & Rhythms with Regent Seven Seas
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 11 October 2027
Visit: Italy, Monaco, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,249
Suite
$12,999
From
US$11,249
Save 11,249
Per Person
View Trip
12 Day Treasures Through Time with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 17 April 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+4 more), Greece, Sicily, France, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$3,399
Oceanview
$4,249
Balcony
$5,299
Suite
$7,649
From
US$3,399
Save 3,399
Per Person
View Trip
15 Day Dalmatian Gems, Malta, Southern France with Seabourn
Cruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 27 May 2028
Visit: Italy, Croatia, Malta, France, Spain
Inside
-
Oceanview
-
Balcony
$10,499
Suite
$16,799
From
US$10,499
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 26 October 2026
Visit: Italy, Corsica, France, Spain
Exclusive Savings
Inside
$915
Oceanview
$1,173
Balcony
$1,397
Suite
$2,782
From
US$915
Save 497
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Italy, Corsica, Spain
Bonus Onboard Credit
Inside
$1,069
Oceanview
$1,159
Balcony
$1,309
Suite
$2,899
From
US$1,069
Per Person
View Trip
11 Day Treasures of the Western Mediterranean with Ponant
Cruise
 (2)

11 Days (10 Nights) Florence to Malaga
Cruise Line: Ponant
Ship: Le Boreal
Departure: 03 October 2027
Visit: Italy, Monaco, France, Spain
Inside
-
Oceanview
$6,990
Balcony
$7,350
Suite
$13,610
From
US$6,990
Per Person
View Trip
22 Day Adriatic & Western Mediterranean: Italy & Spain with Holland America
Cruise
 (3)

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 15 May 2027
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Morocco, Sardinia, Corsica, France
Book Early & Have It All Fare Option
Inside
$3,804
Oceanview
$4,284
Balcony
$5,514
Suite
$7,604
From
US$3,804
Per Person
View Trip
17 Day An Extended Journey Of Island Chic & Riviera Glamour with Explora Journeys
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 05 October 2026
Visit: Italy, Monaco, France, Spain, Sicily
Sky & Sea
Inside
-
Oceanview
-
Balcony
-
Suite
$12,825
From
US$12,825
Per Person
View Trip
11 Day Shimmering Shores with Oceania Cruises
Cruise

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 July 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,999
Suite
$7,699
From
US$4,999
Save 4,999
Per Person
View Trip
22 Day Mediterranean, Adriatic And Greece with Cunard
Cruise
 (13)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 30 July 2027
Visit: Italy, Malta, Croatia, Greece, Sicily, Corsica, Spain
Inside
$4,259
Oceanview
$4,849
Balcony
$5,809
Suite
$12,109
From
US$4,259
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Visit: Italy, Croatia, Malta, Spain, France
Inside
$2,719
Oceanview
$3,009
Balcony
$3,489
Suite
$6,259
From
US$2,719
Per Person
View Trip
10 Day Western Mediterranean Cruise From Rome To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Prima
Departure: 28 April 2027
Visit: Italy, France, Sicily, Sardinia, Spain
Inside
$1,929
Oceanview
$2,289
Balcony
$2,829
Suite
$3,619
From
US$1,929
Per Person
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Last Minute Fare
All-Inclusive Plus Fare
All-Inclusive Fare
Inside
-
Oceanview
$4,950
Balcony
$5,350
Suite
$11,800
From
US$4,950
Per Person
View Trip
11 Day Old World Exploration with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 01 November 2026
Visit: Italy, Malta, Tunisia, Sicily, France, Spain
Exclusive Savings
Inside
-
Oceanview
$8,599
Balcony
$9,599
Suite
$10,249
From
US$8,599
Save 8,599
Per Person
View Trip
21 Day Adriatic & Iberia Discovery with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Venice to Bilbao
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Spain, Morocco, Portugal
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$6,649
Oceanview
$6,799
Balcony
$11,499
Suite
$13,699
From
US$6,649
Save 6,649
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,300
Oceanview
$1,347
Balcony
$1,507
Suite
$6,030
From
US$1,300
Save 932
Per Person
View Trip
15 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 15 October 2027
Visit: Italy, Sicily, Greece, Croatia, Spain
Inside
$2,629
Oceanview
$2,929
Balcony
$3,679
Suite
$7,979
From
US$2,629
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 06 July 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,246
Oceanview
$3,057
Balcony
$2,949
Suite
$5,424
From
US$2,246
Save 1,367
Per Person
View Trip
7 Day A Journey From The Eternal City To Catalan Shores with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 09 June 2026
Visit: Italy, Sicily, Malta, Spain
Inside
-
Oceanview
-
Balcony
-
Suite
$5,130
From
US$5,130
Per Person
View Trip
11 Day Artists & Aristocrats with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,310
Suite
$7,245
From
US$5,310
Save 6,488
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Visit: Italy, France, Corsica, Spain
Inside
$2,289
Oceanview
$2,379
Balcony
$2,809
Suite
$5,409
From
US$2,289
Per Person
View Trip
7 Day Amalfi Coast, Cannes & Ibiza with Virgin Voyages
Cruise
 (1)

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Valiant Lady
Departure: 25 May 2026
Visit: Italy, France, Spain
Limited Time Offer
Inside
$1,399
Oceanview
$1,628
Balcony
$1,571
Suite
-
From
US$1,399
Per Person
View Trip
8 Day Western Mediterranean From Trieste To Barcelona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Aura
Departure: 21 May 2027
Visit: Italy, Malta, Spain
Inside
-
Oceanview
$2,525
Balcony
$2,825
Suite
$3,425
From
US$2,525
Per Person
View Trip
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Inside
$1,889
Oceanview
$2,029
Balcony
$2,369
Suite
$4,944
From
US$1,889
Per Person
View Trip
Results: 61-90 of 169

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