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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 373 departures available from seventeen of the world's leading cruise lines.
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195 Cruises (373 Cruise Departures)
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 June 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,148
Oceanview
$2,908
Balcony
$3,393
Suite
$8,627
From
A$2,148
Save 1,477
Per Person
View Trip
8 Day Greece, Italy And Spain with Cunard
Cruise
 (13)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 22 October 2027
Visit: Italy, Greece, Sicily, Spain
Exclusive Savings
Inside
$2,278
Oceanview
$2,476
Balcony
$2,872
Suite
$5,347
From
A$2,278
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 27 July 2026
Visit: Italy, France, Spain
Exclusive Deal
Exclusive Savings
Inside
$2,319
Oceanview
$2,474
Balcony
$2,751
Suite
$9,773
From
A$2,319
Save 966
Per Person
View Trip
5 Day A Journey From Italy’s Cultural Heart To The Western Mediterranean with Explora Journeys
Cruise
 (1)

5 Days (4 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 05 December 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$3,361
From
A$3,361
Save 69
Per Person
View Trip
32 Day The Best of the Mediterranean with Princess
Cruise
 (2)

32 Days (31 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 05 August 2028
Visit: Italy, Corsica, Malta, Montenegro (+5 more), Croatia, Greece, Cyprus, Turkey, Spain
Princess Standard
Exclusive Savings
Inside
$5,978
Oceanview
-
Balcony
$6,764
Suite
$9,072
From
A$5,978
Per Person
View Trip
22 Day The Best of the Mediterranean with Princess
Cruise
 (2)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 16 May 2028
Visit: Italy, Croatia, Montenegro, Greece, Turkey, Malta, Spain
Princess Standard
Exclusive Savings
Inside
$3,823
Oceanview
$4,796
Balcony
$4,514
Suite
$6,134
From
A$3,823
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Visit: Italy, Greece, Montenegro, Croatia, Malta, Spain
Exclusive Savings
Inside
$4,221
Oceanview
-
Balcony
$7,657
Suite
$25,170
From
A$4,221
Per Person
View Trip
8 Day A Journey Of Mediterranean Colour, Cuisine & Remarkable Landmarks with Explora Journeys
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 October 2028
Visit: Italy, Corsica, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,595
From
A$6,595
Save 135
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (7)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 17 October 2026
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$2,443
Oceanview
$2,878
Balcony
$4,251
Suite
$4,541
From
A$2,443
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 20 July 2026
Visit: Italy, France, Corsica, Spain
Exclusive Savings
Inside
$1,813
Oceanview
$1,813
Balcony
$2,229
Suite
$4,367
From
A$1,813
Per Person
View Trip
22 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 July 2028
Visit: Italy, Spain, France, Corsica (+5 more), Malta, Montenegro, Croatia, Greece, Sicily
Exclusive Savings
Inside
$6,243
Oceanview
$6,936
Balcony
$7,926
Suite
$14,658
From
A$6,243
Per Person
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

12 Days (11 Nights) Rome to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Exclusive Savings
Inside
$1,498
Oceanview
$1,736
Balcony
$2,042
Suite
$4,230
From
A$1,498
Per Person
View Trip
8 Day Mediterranean Cruise From Rome To Barcalona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2027
Visit: Italy, Sicily, France, Spain
Just Cruise Fare
Exclusive Savings
Inside
$2,032
Oceanview
$2,613
Balcony
$2,688
Suite
$2,955
From
A$2,032
Per Person
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Visit: Italy, Croatia, Malta, Spain, France
Exclusive Savings
Inside
$3,964
Oceanview
$4,409
Balcony
$5,102
Suite
$9,627
From
A$3,964
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Nice & Barcelona with Azamara Cruises
Cruise
 (4)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 December 2027
Visit: Italy, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,300
Oceanview
$2,868
Balcony
$3,682
Suite
$5,505
From
A$2,300
Per Person
View Trip
8 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 November 2027
Visit: Italy, France, Spain
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,468
Suite
$11,858
From
A$5,468
Save 3,832
Per Person
View Trip
11 Day Adriatic Splendor: Croatia & Italy with Holland America
Cruise
 (3)

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 15 May 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Fare Saver
Exclusive Savings
Inside
$2,964
Oceanview
$3,191
Balcony
$4,122
Suite
$5,874
From
A$2,964
Per Person
View Trip
10 Day Venetian & Roman Revelry with Oceania Cruises
Cruise
 (1)

10 Days (9 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departures: Apr 2027 to Aug 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, France, Spain
Your World Inclusions
Exclusive Savings
Inside
$2,995
Oceanview
$3,166
Balcony
$4,858
Suite
$7,054
From
A$2,995
Save 2,805
Per Person
View Trip
8 Day Italy, Algeria & Spain Cruise: Trapani, Algiers & Granada with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Malaga
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 02 December 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,474
Oceanview
$2,768
Balcony
$3,680
Suite
$5,218
From
A$2,474
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Florence, Nice & Barcelona with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 27 May 2027
Visit: Italy, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,869
Oceanview
$3,281
Balcony
$4,319
Suite
$6,897
From
A$2,869
Per Person
View Trip
11 Day A Journey From Amalfi’s Cliffs To Andalusian Sun with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 January 2027
Visit: Italy, Sardinia, Spain, Morocco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,379
From
A$8,379
Save 171
Per Person
View Trip
10 Day A Journey To Spain's Icons & North Africa's Sunlit Shores with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 February 2027
Visit: Italy, Sicily, Tunisia, Algeria, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,531
From
A$7,531
Save 154
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (7)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2027 to Aug 2027
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$2,859
Oceanview
$3,354
Balcony
$4,146
Suite
$4,858
From
A$2,859
Per Person
View Trip
8 Day Mediterranean, Croatia And Greece with Cunard
Cruise
 (13)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 16 June 2028
Visit: Italy, Croatia, Greece, Sicily, Spain
Exclusive Savings
Inside
$2,427
Oceanview
$2,724
Balcony
$3,120
Suite
$6,238
From
A$2,427
Per Person
View Trip
9 Day A Journey From Rugged Landscapes To Cosmopolitan Allure with Explora Journeys
Cruise
 (1)

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 15 May 2028
Visit: Italy, Corsica, Monaco, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,909
From
A$6,909
Save 141
Per Person
View Trip
8 Day Italy And France with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain
Exclusive Savings
Inside
$2,031
Oceanview
$2,278
Balcony
$2,526
Suite
$4,951
From
A$2,031
Per Person
View Trip
19 Day Italy Intensive Cruise: Taranto, Amalfi & Sorrento with Azamara Cruises
Cruise
 (8)

19 Days (18 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 16 May 2027
Visit: Italy, Montenegro, Sicily, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$7,807
Oceanview
$8,160
Balcony
-
Suite
$20,449
From
A$7,807
Per Person
View Trip
10 Day Classic Mediterranean From Bologna To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Jul 2027 to Sep 2027
Visit: Italy, Croatia, Montenegro, France, Spain
Just Cruise Fare
Exclusive Savings
Inside
$4,012
Oceanview
$4,623
Balcony
$5,738
Suite
$7,302
From
A$4,012
Per Person
View Trip
22 Day Adriatic & Western Mediterranean: Italy & Spain with Holland America
Cruise
 (3)

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 15 May 2027
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Morocco, Sardinia, Corsica, France
Fare Saver
Exclusive Savings
Inside
$5,899
Oceanview
$6,622
Balcony
$8,255
Suite
$11,730
From
A$5,899
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jun 2027
Visit: Italy, France, Gibraltar, Spain
Fare Saver
Exclusive Savings
Inside
$1,665
Oceanview
$1,814
Balcony
$2,556
Suite
$4,279
From
A$1,665
Per Person
View Trip
Results: 61-90 of 195

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