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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 373 departures available from seventeen of the world's leading cruise lines.
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32 Days
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195 Cruises (373 Cruise Departures)
11 Day Heavenly Mediterranean Islands with Regent Seven Seas
Cruise

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 25 October 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,962
Suite
$17,776
From
A$16,962
Save 2,308
Per Person
View Trip
25 Day Mediterranean Mosaic: Croatia, Italy, France & Spain with Seabourn
Cruise

25 Days (24 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 13 June 2027
Visit: Italy, Croatia, Malta, Sicily (+6 more), Corsica, Sardinia, Tunisia, Monaco, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,271
Suite
$57,333
From
A$27,271
Save 523
Per Person
View Trip
12 Day Melody Of Messina with Regent Seven Seas
Cruise

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 27 May 2028
Visit: Italy, Croatia, Malta, Sicily, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$16,855
Suite
$18,610
From
A$16,855
Save 2,305
Per Person
View Trip
10 Day Greece & Italy Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 28 August 2027
Visit: Italy, Greece, Sicily, Spain
Exclusive Deal
Exclusive Savings
Inside
$2,338
Oceanview
$2,926
Balcony
$3,448
Suite
$8,507
From
A$2,338
Save 929
Per Person
View Trip
8 Day Monaco, Italy, France & Spain with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 18 September 2027
Visit: Italy, Monaco, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,338
Suite
$14,419
From
A$9,338
Save 181
Per Person
View Trip
8 Day A Journey Of Riviera Glamour & Island Serenity with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 15 April 2028
Visit: Italy, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,409
From
A$6,409
Save 131
Per Person
View Trip
8 Day A Journey Through Italy's Rich Heritage to Catalan Elegance with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora V
Departure: 19 December 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,262
From
A$7,262
Save 148
Per Person
View Trip
8 Day A Journey Of Glorious Legacies & Enchanting Discovery with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora VI
Departure: 04 September 2028
Visit: Italy, Corsica, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,992
From
A$7,992
Save 163
Per Person
View Trip
22 Day Legacy Of Civilizations with Regent Seven Seas
Cruise

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Explorer
Departure: 30 June 2028
Visit: Italy, Croatia, Montenegro, Greece (+6 more), Malta, Sicily, Sardinia, Monaco, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$38,602
Suite
$41,817
From
A$38,602
Save 2,718
Per Person
View Trip
10 Day A Journey Of Spirited Mediterranean Cities & Sunlit Islands with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departures: Jul 2027 to Aug 2027
Visit: Italy, Corsica, Monaco, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,448
From
A$7,448
Save 162
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 08 November 2026
Visit: Italy, Sicily, Malta, Spain
Exclusive Savings
Inside
$804
Oceanview
$933
Balcony
$1,121
Suite
$1,804
From
A$803
Per Person
View Trip
15 Day Italy, Africa & Iberia Discovery with Viking Cruises
New ReleaseCruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Vela
Departures: Jun 2027 to Jun 2028
Visit: Italy, Croatia, Sicily, Tunisia, Sardinia, Spain
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$13,176
Suite
$20,232
From
A$13,176
Save 1,547
Per Person
View Trip
11 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 29 May 2027
Visit: Italy, France, Corsica, Monaco, Spain
All-Inclusive Fare
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,602
Suite
$20,874
From
A$14,602
Save 298
Per Person
View Trip
8 Day A Journey Of Mediterranean Wonders From Ancient Secrets To Modren Buzzing Vibes with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 05 October 2026
Visit: Italy, Monaco, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,800
From
A$9,800
Save 200
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 24 October 2026
Visit: Italy, Sicily, Corsica, France, Spain
Exclusive Deal
Exclusive Savings
Inside
$1,663
Oceanview
$2,310
Balcony
$2,498
Suite
$6,579
From
A$1,663
Save 643
Per Person
View Trip
Results: 181-195 of 195

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Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O (UK) Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

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