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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 373 departures available from seventeen of the world's leading cruise lines.
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195 Cruises (373 Cruise Departures)
8 Day Italy, France & Spain Cruise: Rome, Florence & Barcelona with Azamara Cruises
Cruise
 (4)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 15 May 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,906
Oceanview
$3,338
Balcony
$4,425
Suite
$7,130
From
A$2,906
Per Person
View Trip
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Exclusive Savings
Inside
-
Oceanview
$1,882
Balcony
$2,625
Suite
$4,654
From
A$1,882
Per Person
View Trip
15 Day Mediterranean, Croatia And Greece with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 06 August 2027
Visit: Italy, Croatia, Greece, Sicily, Corsica, Spain
Exclusive Savings
Inside
$4,558
Oceanview
$4,954
Balcony
$5,894
Suite
$11,191
From
A$4,558
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Jun 2028 to Aug 2028
Visit: Italy, Malta, Montenegro, Croatia, Greece, Sicily, Spain
Exclusive Savings
Inside
$4,261
Oceanview
$4,954
Balcony
$5,597
Suite
$10,894
From
A$4,261
Per Person
View Trip
15 Day Spain, Italy And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 28 May 2027
Visit: Italy, Malta, Montenegro, Croatia, Sicily, Spain
First Come, First Served Offer
Exclusive Savings
Inside
$4,330
Oceanview
$4,895
Balcony
$5,300
Suite
$10,349
From
A$4,330
Per Person
View Trip
9 Day A Journey Of Italian Grandeur, Riviera Glamour & Catalan Style with Explora Journeys
Cruise
 (1)

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jul 2028 to Sep 2028
Visit: Italy, France, Corsica, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,120
From
A$7,120
Save 156
Per Person
View Trip
15 Day Mediterranean And Croatia with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 22 September 2028
Visit: Italy, Malta, Croatia, Greece, Sicily, Spain
Exclusive Savings
Inside
$4,261
Oceanview
$4,756
Balcony
$5,597
Suite
$10,894
From
A$4,261
Per Person
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Venice to Valencia
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 14 November 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
$1,248
Oceanview
$1,437
Balcony
$1,862
Suite
$2,149
From
A$1,248
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Visit: Italy, France, Corsica, Spain
Exclusive Savings
Inside
$3,429
Oceanview
$3,786
Balcony
$4,459
Suite
$8,775
From
A$3,429
Per Person
View Trip
21 Day An Extended Journey Between Continents & Coastlines with Explora Journeys
Cruise
 (1)

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 04 January 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain, Morocco
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$15,876
From
A$15,876
Save 324
Per Person
View Trip
8 Day Mediterranean Cruise From Rome To Barcalona with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: Jun 2026 to Oct 2027
Visit: Italy, Sicily, France, Spain
Just Cruise Fare
Exclusive Savings
Inside
$1,362
Oceanview
$1,660
Balcony
$1,958
Suite
$2,151
From
A$1,362
Per Person
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Venice to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 14 November 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
$990
Oceanview
$1,188
Balcony
$1,821
Suite
$2,217
From
A$990
Per Person
View Trip
15 Day An Extended Journey Of Italian Splendour, Balearic Serenity & Catalan Culture with Explora Journeys
Cruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Explora Journeys
Ship: Explora VI
Departure: 28 August 2028
Visit: Italy, Croatia, Montenegro, Sicily, Corsica, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$14,700
From
A$14,700
Save 300
Per Person
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
All-Inclusive Plus Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
$11,819
Balcony
$12,701
Suite
$20,678
From
A$11,819
Save 1,581
Per Person
View Trip
18 Day Icons of Italy & Mediterranean Rivieras - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

18 Days Milan to Barcelona
Operated By: Scenic
Ship: Scenic Ikon
Departure: 26 September 2028
Trip Styles: Coach, Cruise, Scenic
Visit: Italy, Corsica, France, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$30,065
Suite
$33,240
From
A$30,065
Save 5,575
Per Person
View Trip
9 Day Monaco, Italy, France & Spain with Seabourn
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 29 June 2027
Visit: Italy, Monaco, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,756
Suite
$13,171
From
A$8,756
Save 168
Per Person
View Trip
8 Day A Journey Of Shimmering Shores & Timeless Mediterranean Treasures with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departures: Jun 2026 to Sep 2026
Visit: Italy, Corsica, France, Spain
A Spontaneous Summer Invitation
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,860
From
A$6,860
Save 172
Per Person
View Trip
11 Day Moonlight Over The Mediterranean with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 19 July 2027
Visit: Italy, Croatia, Spain
Single Supplement Special
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,523
Suite
$16,954
From
A$15,523
Save 2,277
Per Person
View Trip
11 Day Iconic Italy & the French Riviera with Scenic
New ReleaseCruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Scenic
Ship: Scenic Ikon
Departure: 27 June 2028
Visit: Italy, Monaco, France, Spain
Early Booking Savings
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$18,702
Suite
$22,230
From
A$18,702
Save 4,843
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Sinfonia
Departure: 29 October 2026
Visit: Italy, Spain
Exclusive Savings
Inside
$847
Oceanview
$946
Balcony
$1,223
Suite
$1,392
From
A$847
Per Person
View Trip
10 Day Mediterranean Masterpieces with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 28 February 2028
Visit: Italy, Sicily, Sardinia, Corsica, France, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,385
Suite
$8,014
From
A$5,385
Save 2,125
Per Person
View Trip
11 Day Shimmering Shores with Oceania Cruises
Cruise

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 July 2027
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,338
Suite
$9,752
From
A$6,338
Save 2,152
Per Person
View Trip
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 October 2026
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Last Minute Fare
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,163
Suite
$20,188
From
A$9,163
Save 187
Per Person
View Trip
8 Day Riviera Reverie with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 30 September 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$14,145
Suite
$15,027
From
A$14,145
Save 2,265
Per Person
View Trip
8 Day A Journey Of Antique Treasures To Sumptuous Catalan with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 13 July 2026
Visit: Italy, Monaco, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,726
From
A$9,726
Save 199
Per Person
View Trip
8 Day A Journey Through Italian Treasures & French Riviera Elegance with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Visit: Italy, Corsica, Monaco, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$6,982
From
A$6,982
Save 172
Per Person
View Trip
8 Day Yacht Harbors Of The Cote D'azur with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 03 June 2028
Visit: Italy, France, Spain
Exclusive Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$9,010
Suite
$13,597
From
A$9,010
Save 169
Per Person
View Trip
8 Day Greece, Spain, Croatia & Malta with Royal Caribbean
Cruise

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Mariner of the Seas
Departure: 13 August 2027
Visit: Italy, Croatia, Greece, Malta, Spain
Exclusive Deal
Exclusive Savings
Inside
$1,777
Oceanview
$2,178
Balcony
$2,549
Suite
$6,269
From
A$1,777
Save 664
Per Person
View Trip
10 Day Pasta To Paella with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 15 April 2028
Visit: Italy, Sardinia, Monaco, France, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,608
Suite
$9,517
From
A$5,608
Save 2,132
Per Person
View Trip
11 Day Timeless Tableaux with Oceania Cruises
Cruise

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2027
Visit: Italy, Slovenia, Croatia, Greece, Sicily, Malta, Spain
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,981
Suite
$8,521
From
A$4,981
Save 2,109
Per Person
View Trip
Results: 91-120 of 195

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