Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to Spain

Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 373 departures available from seventeen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
4 Days
32 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$500pp
$41,320pp
Countries
Show More...
Filter Results
195 Cruises (373 Cruise Departures)
8 Day Coastal Kaleidoscope with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 26 September 2027
Visit: Italy, Monaco, France, Spain
Your World Inclusions
Exclusive Savings
Inside
$2,731
Oceanview
$3,002
Balcony
$4,632
Suite
$6,320
From
A$2,731
Save 2,049
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 26 October 2026
Visit: Italy, Corsica, France, Spain
Exclusive Deal
Exclusive Savings
Inside
$2,137
Oceanview
$1,860
Balcony
$2,702
Suite
$7,213
From
A$1,860
Save 707
Per Person
View Trip
7 Day A Journey Through Cliffs, Islands And Andalusian Light with Explora Journeys
Cruise
 (1)

7 Days (6 Nights) Rome to Malaga
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 14 January 2027
Visit: Italy, Sardinia, Colombia, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$5,042
From
A$5,042
Save 103
Per Person
View Trip
15 Day Mediterranean And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 27 August 2027
Visit: Italy, Croatia, Greece, Sicily, Corsica, Spain
First Come, First Served Offer
Exclusive Savings
Inside
$3,875
Oceanview
$4,211
Balcony
$4,716
Suite
$10,627
From
A$3,875
Per Person
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 31 October 2026
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$3,051
Oceanview
$3,678
Balcony
$4,472
Suite
$5,961
From
A$3,051
Save 48
Per Person
View Trip
8 Day Spain, Italy And Croatia with Cunard
Cruise
 (13)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 04 June 2027
Visit: Italy, Croatia, Sicily, Spain
First Come, First Served Offer
Exclusive Savings
Inside
$2,259
Oceanview
$2,536
Balcony
$2,764
Suite
$5,644
From
A$2,259
Per Person
View Trip
11 Day Italy, France & Spain Cruise: Florence, Marseille & Barcelona with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 17 July 2027
Visit: Italy, Monaco, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$4,626
Oceanview
$4,479
Balcony
$5,861
Suite
$9,370
From
A$4,479
Save 70
Per Person
View Trip
11 Day Dalmatian & Italian Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Your World Inclusions
Exclusive Savings
Inside
$3,605
Oceanview
$3,757
Balcony
$5,860
Suite
$14,354
From
A$3,605
Save 3,285
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Aug 2026 to Jul 2027
Visit: Italy, Corsica, France, Gibraltar, Spain
Fare Saver
Exclusive Savings
Inside
$2,012
Oceanview
$1,868
Balcony
$2,358
Suite
$3,051
From
A$1,868
Per Person
View Trip
11 Day A Journey Through Coastal Jewels & Culture-filled Capitals with Explora Journeys
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 27 October 2027
Visit: Italy, Croatia, Malta, Monaco, France, Spain
Sky & Sea
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$9,334
From
A$9,334
Save 191
Per Person
View Trip
22 Day The Best of the Mediterranean with Princess
Cruise
 (2)

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 15 August 2028
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Cyprus, Turkey, Malta, Spain
Princess Standard
Exclusive Savings
Inside
$4,072
Oceanview
$4,873
Balcony
$4,561
Suite
$6,166
From
A$4,072
Per Person
View Trip
10 Day Italian Riviera, France & Spain with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 06 July 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
$2,174
Oceanview
$2,903
Balcony
$3,208
Suite
$7,872
From
A$2,174
Save 1,506
Per Person
View Trip
11 Day Southern European Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Your World Inclusions
Exclusive Savings
Inside
$3,401
Oceanview
$3,686
Balcony
$5,723
Suite
$7,475
From
A$3,401
Save 3,539
Per Person
View Trip
10 Day A Journey From Italian Gems To Spain’s Southern Coast with Explora Journeys
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 05 March 2027
Visit: Italy, France, Corsica, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$8,085
From
A$8,085
Save 165
Per Person
View Trip
21 Day Adriatic & Iberia Discovery with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Venice to Bilbao
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Spain, Morocco, Portugal
Your World Inclusions
Exclusive Savings
Inside
$9,434
Oceanview
$9,774
Balcony
$16,476
Suite
$29,019
From
A$9,434
Save 2,196
Per Person
View Trip
12 Day Treasures Through Time with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 17 April 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+4 more), Greece, Sicily, France, Spain
Your World Inclusions
Exclusive Savings
Inside
$3,730
Oceanview
$4,762
Balcony
$5,577
Suite
$8,068
From
A$3,730
Save 3,020
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (7)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Aug 2026 to Oct 2027
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$2,838
Oceanview
$3,571
Balcony
$4,185
Suite
$4,917
From
A$2,838
Per Person
View Trip
8 Day Mediterranean, Greece And Croatia with Cunard
Cruise
 (13)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2028 to Sep 2028
Visit: Italy, Croatia, Greece, Sicily, Spain
Exclusive Savings
Inside
$2,229
Oceanview
$2,526
Balcony
$2,773
Suite
$5,941
From
A$2,229
Per Person
View Trip
8 Day Rome To Romance with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2028
Visit: Italy, Corsica, Monaco, France, Spain
Your World Inclusions
Exclusive Savings
Inside
$3,340
Oceanview
$4,320
Balcony
$5,300
Suite
$7,259
From
A$3,340
Save 2,070
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 19 February 2028
Visit: Italy, France, Gibraltar, Spain
Fare Saver
Exclusive Savings
Inside
$1,250
Oceanview
$1,507
Balcony
$1,745
Suite
$2,428
From
A$1,250
Per Person
View Trip
22 Day Antiquities of the Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ship: Viking Sky
Departure: 21 October 2027
Visit: Italy, Croatia, Montenegro, Greece (+5 more), Turkey, Sicily, Monaco, France, Spain
Viking Savings Event
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$19,840
Suite
$30,424
From
A$19,840
Save 1,655
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Nice & Barcelona with Azamara Cruises
Cruise
 (4)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 March 2028
Visit: Italy, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,191
Oceanview
$2,750
Balcony
$3,573
Suite
$5,386
From
A$2,191
Per Person
View Trip
15 Day Mediterranean, Greek Islands And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 15 October 2027
Visit: Italy, Sicily, Greece, Croatia, Spain
First Come, First Served Offer
Exclusive Savings
Inside
$3,647
Oceanview
$3,984
Balcony
$4,499
Suite
$8,894
From
A$3,647
Per Person
View Trip
7 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 15 November 2027
Visit: Italy, Spain
Exclusive Savings
Inside
$922
Oceanview
$1,060
Balcony
$1,179
Suite
$1,833
From
A$922
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Visit: Italy, France, Spain
Exclusive Deal
Exclusive Savings
Inside
$2,296
Oceanview
$2,670
Balcony
$2,439
Suite
$11,053
From
A$2,296
Save 953
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (7)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 04 June 2028
Visit: Italy, Sicily, Greece, Turkey, Montenegro, Spain
Princess Standard
Sanctuary Collection
Exclusive Savings
Inside
$2,706
Oceanview
$3,270
Balcony
$4,493
Suite
$4,983
From
A$2,706
Per Person
View Trip
11 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Lanzarote
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 07 December 2026
Visit: Italy, Spain, Portugal
Exclusive Savings
Inside
$1,213
Oceanview
$1,510
Balcony
$1,737
Suite
$5,272
From
A$1,213
Per Person
View Trip
11 Day Italy & Spain Cruise: Florence, Marseille & Barcelona with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 03 March 2027
Visit: Italy, France, Spain
Azamara Circle Member - Quarterly Saving
Azamara Always Included
Exclusive Savings
Inside
$2,955
Oceanview
$3,396
Balcony
$3,856
Suite
$5,846
From
A$2,955
Per Person
View Trip
8 Day Italy, Greece And Croatia with Cunard
Cruise
 (13)

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 08 September 2028
Visit: Italy, Croatia, Greece, Sicily, Spain
Exclusive Savings
Inside
$2,625
Oceanview
$2,724
Balcony
$3,070
Suite
$6,238
From
A$2,625
Per Person
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2026 to Aug 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,583
Oceanview
$1,778
Balcony
$2,072
Suite
$7,301
From
A$1,583
Save 1,357
Per Person
View Trip
Results: 31-60 of 195

No trips found. Try adjusting the search filters.




Cruises found! Scroll up to view.

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Albania Corsica Croatia Cyprus Egypt England France Gibraltar Italy Malta Mexico Monaco Montenegro Morocco Portugal Sardinia Sicily Slovenia Spain Tunisia Turkey USA

Cities

Cruises from Amalfi Cruises from Bari Cruises from Bologna Cruises from Florence Cruises from Genoa Cruises from Naples Cruises from Rome Cruises from Trieste Cruises from Venice

Routes

Cruises from Bologna to Barcelona Cruises from Rome to Barcelona Cruises from Trieste to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O (UK) Med Cruises Ponant Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2026. Global Journeys. You're viewing our site in Australian dollars.

    

Global Journeys | Terms & Conditions

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (ATIA). No. A11351.

Travel Industry Associations