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332 Cruises (1,772 Cruise Departures)
10 Day South America with MSC Cruises
Cruise

10 Days (9 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 22 December 2026
Visit: Brazil, Uruguay, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$1,889
Suite
$2,611
From
US$1,889
Save 50
Per Person
View Trip
12 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery Plus Machu Picchu with HX Expeditions
Cruise

12 Days (11 Nights) Lima to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Jun 2026 to Dec 2026
Visit: Peru, Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$9,960
Balcony
-
Suite
$12,088
From
US$9,960
Save 1,680
Per Person
View Trip
11 Day From Panama’s Wild Beauty to Peruvian Shores with Ponant
Cruise

11 Days (10 Nights) Colon to Lima
Cruise Line: Ponant
Ship: L'Austral
Departure: 20 October 2026
Visit: Panama, Peru
Inside
-
Oceanview
$6,250
Balcony
$6,760
Suite
$10,670
From
US$6,250
Per Person
View Trip
6 Day Galapagos at a Glance: Southern Islands (Grand Daphne) with Intrepid Travel
Cruise

6 Days (5 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: May 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$4,132
Save 134
Per Person
View Trip
12 Day Rhythms of the Brazilian Coastline with Scenic
New ReleaseCruise

12 Days (11 Nights) Rio de Janeiro to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 03 November 2027
Visit: Brazil, Uruguay, Argentina
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,932
Suite
$14,093
From
US$11,932
Save 1,498
Per Person
View Trip
7 Day Galápagos Islands – Iconic Wildlife & Sublime Scenery (Western Route) with HX Expeditions
Cruise

7 Days (6 Nights) Quito to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: Aug 2026 to Dec 2026
Visit: Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$6,370
Balcony
-
Suite
-
From
US$6,370
Save 1,120
Per Person
View Trip
13 Day Highlights of Peru with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

13 Days Lima to Quito
Operated By: Trafalgar
Departures: Jul 2026 to Nov 2026
Visit: Peru, Ecuador, Galapagos
Sign Up Savings
Today's Deal
Exclusive Savings
From
US$7,124
Save 351
Per Person
View Trip
12 Day Wellness Retreat: Barbados to Rio de Janeiro with Scenic
New ReleaseCruise

12 Days (11 Nights) Bridgetown to Rio de Janeiro
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 23 October 2027
Visit: Barbados, Brazil
Preferred Plus Fare + Air Credit
Select Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,712
Suite
$9,689
From
US$6,712
Save 883
Per Person
View Trip
18 Day Land of the Incas with Galápagos Legend East Cruise with Trafalgar
Tour + Cruise

18 Days Lima to Quito
Operated By: Trafalgar
Departures: Oct 2026 to Dec 2026
Visit: Peru, Ecuador, Galapagos
Today's Deal
Exclusive Savings
From
US$9,192
Save 639
Per Person
View Trip
13 Day Chairman’s Voyage: Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 13 November 2027
Visit: Chile, Argentina
Select Fare
Preferred Plus Fare + Air Credit
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$22,170
Suite
$29,744
From
US$22,170
Save 1,605
Per Person
View Trip
14 Day Galápagos Islands – In Darwin’s Footsteps Plus Machu Picchu with HX Expeditions
Cruise

14 Days (13 Nights) Lima to Quito
Cruise Line: HX Expeditions
Ship: MS Santa Cruz II
Departures: May 2026 to Dec 2026
Visit: Peru, Ecuador, Galapagos
Bonus Onboard Credit
Exclusive Savings
Inside
-
Oceanview
$10,802
Balcony
-
Suite
$13,172
From
US$10,802
Save 3,057
Per Person
View Trip
12 Day Puerto Williams to Valparaiso with Silversea
Cruise

12 Days (11 Nights) Puerto Williams to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 27 February 2027
Visit: Chile, Argentina
All-Inclusive Plus Fare
Exclusive Savings
Inside
-
Oceanview
$9,400
Balcony
$12,300
Suite
$18,800
From
US$9,400
Save 1,500
Per Person
View Trip
27 Day South American Discovery with Brazil's Amazon & Galápagos Cruise with Globus
Tour + Cruise

27 Days Manaus to Guayaquil
Operated By: Globus
Departures: Nov 2026 to Oct 2027
Visit: Brazil, Argentina, Peru, Ecuador, Galapagos
Exclusive Savings
From
US$13,862
Save 502
Per Person
View Trip
22 Day Lima (Callao) to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Lima to Buenos Aires
Cruise Line: Silversea
Ship: Silver Ray
Departure: 27 January 2028
Visit: Peru, Chile, Argentina, Falkland Islands
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$19,700
Suite
$30,900
From
US$19,700
Per Person
View Trip
14 Day Patagonia: Edge of the World with Collette
Tour + Cruise

14 Days Buenos Aires to Buenos Aires
Operated By: Collette
Departures: Oct 2026 to Mar 2027
Visit: Argentina, Chile
Exclusive Savings
From
US$10,010
Save 209
Per Person
View Trip
7 Day Galápagos Land & Sea - Central & South Islands aboard the Yolita with G Adventures
Cruise

7 Days (6 Nights) Quito to Quito
Operated By: G Adventures
Departures: Apr 2026 to Dec 2027
Visit: Ecuador, Galapagos
Exclusive Savings
From
US$3,181
Save 974
Per Person
View Trip
26 Day Peru, Amazon & the Chilean Fjords Expedition - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

26 Days Lima to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 22 October 2026
Trip Styles: Coach, Cruise, Wildlife, Scenic
Visit: Peru, Chile, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$49,341
Suite
-
From
US$49,341
Save 1,414
Per Person
View Trip
26 Day Ultimate Ancient Treasures, Fjords & Wonders of South America with Scenic
New ReleaseCruise

26 Days (25 Nights) Panama City to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 31 October 2027
Visit: Panama, Colombia, Ecuador, Peru, Chile, Argentina
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$36,814
Suite
-
From
US$36,814
Save 996
Per Person
View Trip
37 Day Inca Coast Discovery Collectors' Voyage with Holland America
Cruise
 (3)

37 Days (36 Nights) San Diego to Buenos Aires
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 12 October 2027
Visit: USA, Mexico, Guatemala, Costa Rica (+6 more), Ecuador, Peru, Chile, Argentina, Falkland Islands, Uruguay
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,848
Oceanview
$5,191
Balcony
$7,347
Suite
$10,875
From
US$4,848
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Barcelona to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 November 2027
Visit: Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$5,153
From
US$1,290
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil, Portugal, Spain
Inside
-
Oceanview
-
Balcony
$1,990
Suite
-
From
US$1,990
Per Person
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Visit: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Bonus Onboard Credit
Inside
$5,209
Oceanview
$7,216
Balcony
$8,048
Suite
$17,948
From
US$5,209
Per Person
View Trip
22 Day South America, Canary Islands & Spain with Seabourn
Cruise

22 Days (21 Nights) Rio de Janeiro to Seville
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 06 April 2027
Visit: Brazil, Cape Verde, Spain, Morocco
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$11,801
From
US$11,801
Save 198
Per Person
View Trip
16 Day Repo - Transatlantic with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Buenos Aires to Lisbon
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departure: 17 March 2028
Visit: Argentina, Brazil, Cape Verde, Portugal
Inside
$1,559
Oceanview
$1,829
Balcony
$2,385
Suite
$2,743
From
US$1,559
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Barcelona to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 18 November 2027
Visit: Spain, Brazil, Uruguay, Argentina
Inside
$1,784
Oceanview
$2,073
Balcony
$2,219
Suite
$3,722
From
US$1,784
Per Person
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Marseille to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 31 October 2027
Visit: France, Spain, Brazil
Inside
$1,290
Oceanview
$1,540
Balcony
$1,790
Suite
$3,087
From
US$1,290
Per Person
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) Lisbon to Buenos Aires
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Star
Departure: 02 December 2027
Visit: Portugal, Cape Verde, Brazil, Uruguay, Argentina
Inside
$1,559
Oceanview
$1,779
Balcony
$2,366
Suite
$2,657
From
US$1,559
Per Person
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Valencia to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 08 November 2027
Visit: Spain, Portugal, Brazil
Inside
$1,011
Oceanview
$1,301
Balcony
$1,801
Suite
-
From
US$1,011
Per Person
View Trip
14 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

14 Days (13 Nights) Lisbon to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 10 November 2027
Visit: Portugal, Brazil
Inside
-
Oceanview
$1,310
Balcony
$1,670
Suite
-
From
US$1,310
Per Person
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Santos to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 03 April 2027
Visit: Brazil, Spain, Morocco
Inside
$1,394
Oceanview
$1,664
Balcony
$1,894
Suite
$5,265
From
US$1,394
Per Person
View Trip
Results: 151-180 of 332

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South & Central America Cruises

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Travel Styles

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Cities

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Routes

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Country Routes

Cruises from USA to Portugal Cruises from USA to Germany Cruises from England to Holland Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Puerto Rico to USA Cruises from Portugal to France Cruises from Chile to USA Cruises from France to Brazil Cruises from Brazil to France Cruises from England to Canada Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from USA to Puerto Rico Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from USA to Dominican Republic Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Greece Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Greece Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Argentina Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Peru Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Ponant Central America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking Central America Cruises Viking South America Cruises

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